Plaur

Functionⁱ

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO - Molecular functionⁱ

urokinase plasminogen activator receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 11798065

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epithelial cell differentiation involved in prostate gland development
Source: RGD
Inferred from mutant phenotypeⁱ
- 11798065
mesenchymal cell differentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 11798065
negative regulation of apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 11798065
positive regulation of gene expression
Source: RGD
Inferred from mutant phenotypeⁱ
- 11798065
regulation of proteolysis Source: InterPro
skeletal muscle tissue regeneration
Source: RGD
Inferred from expression patternⁱ
- 12919869
spermatogenesis
Source: RGD
Inferred from expression patternⁱ
- 17712486

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Urokinase plasminogen activator surface receptor Short name: U-PAR Short name: uPAR Alternative name(s): CD_antigen: CD87
Gene namesⁱ	Name:Plaur
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	620597 Plaur

RGDⁱ

620597 Plaur

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3638329

ChEMBLⁱ

CHEMBL3638329

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST	24
ChainⁱPRO_0000036099	25 – 299	Urokinase plasminogen activator surface receptorAdd BLAST	275
PropeptideⁱPRO_0000036100	300 – 328	Removed in mature formSequence analysisAdd BLAST	29

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 48	By similarity
Disulfide bondⁱ	30 ↔ 36	By similarity
Disulfide bondⁱ	41 ↔ 69	By similarity
Glycosylationⁱ	76	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	95 ↔ 100	By similarity
Disulfide bondⁱ	120 ↔ 147	By similarity
Disulfide bondⁱ	123 ↔ 130	By similarity
Disulfide bondⁱ	140 ↔ 169	By similarity
Disulfide bondⁱ	175 ↔ 192	By similarity
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	193 ↔ 198	By similarity
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	216 ↔ 244	By similarity
Disulfide bondⁱ	219 ↔ 227	By similarity
Glycosylationⁱ	222	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	237 ↔ 263	By similarity
Glycosylationⁱ	255	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	269 ↔ 288	By similarity
Glycosylationⁱ	283	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	289 ↔ 294	By similarity
Glycosylationⁱ	290	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	299	GPI-anchor amidated glycineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	P49616
PRIDEⁱ	P49616

PTM databases

PhosphoSitePlusⁱ	P49616

PhosphoSitePlusⁱ

P49616

Expressionⁱ

Inductionⁱ

Up-regulated in transformed thyroid cell lines.1 Publication

Interactionⁱ

Subunit structureⁱ

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (By similarity).By similarityCurated

Protein-protein interaction databases

IntActⁱ	P49616, 1 interactor
STRINGⁱ	10116.ENSRNOP00000063960

Chemistry databases

BindingDBⁱ

P49616

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49616
SMRⁱ	P49616
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 118	UPAR/Ly6 1Add BLAST	94
Domainⁱ	118 – 213	UPAR/Ly6 2Add BLAST	96
Domainⁱ	214 – 299	UPAR/Ly6 3Add BLAST	86

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IJ50 Eukaryota ENOG410Z47S LUCA
HOVERGENⁱ	HBG000245
InParanoidⁱ	P49616
KEGG Orthology (KO) More...KOⁱ	K03985
PhylomeDBⁱ	P49616

Family and domain databases

InterProⁱ	View protein in InterPro IPR018363 CD59_antigen_CS IPR016054 LY6_UPA_recep-like IPR033084 U-PAR
PANTHERⁱ	PTHR10624:SF6 PTHR10624:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00021 UPAR_LY6, 3 hits
SMARTⁱ	View protein in SMART SM00134 LU, 3 hits
PROSITEⁱ	View protein in PROSITE PS00983 LY6_UPAR, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P49616-1) [UniParc]FASTA Add to basket

Also known as: GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLRRRLLL LVVVVTTCVP ASQGLRCIQC ESNQDCLVEE CALGQDLCRT 
        60         70         80         90        100
TVLREWEDAE ELEVVTRGCA HKEKTNRTMS YRMGSVIVSL TETVCATNLC 
       110        120        130        140        150
NRPRPGARGR PFPRGRYLEC ASCTSLDQSC ERGREQSLQC RYPTEHCIEV 
       160        170        180        190        200
VTLQSTERSV KDEPYTKGCG SLPGCPGTAG FHSNQTFHFL KCCNFTQCNG 
       210        220        230        240        250
GPVLDLQSLP PNGFQCYSCE GNSTFGCSYE ETSLIDCRGP MNQCLEATGL 
       260        270        280        290        300
DVLGNRSYTV RGCATASWCQ GSHVADSFQT HVNLSISCCN GSGCNRPTGG 
       310        320 
APGPGPAHLI LIASLLLTLR LWGIPLWT

Note: GPI-anchored form.

Length:328

Mass (Da):35,753

Last modified:October 23, 2007 - v2

Checksum:ⁱ9CF24A90B07B2E0A

GO

Isoform 2 (identifier: P49616-3) [UniParc] [UniParc]FASTA Add to basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
159-220: SVKDEPYTKG...PNGFQCYSCE → KLPAAGSPLG...LVVSHILLSF
221-328: Missing.

« Hide

        10         20         30         40         50
MGLLRRRLLL LVVVVTTCVP ASQGLRCIQC ESNQDCLVEE CALGQDLCRT 
        60         70         80         90        100
TVLREWEDAE ELEVVTRGCA HKEKTNRTMS YRMGSVIVSL TETVCATNLC 
       110        120        130        140        150
NRPRPGARGR PFPRGRYLEC ASCTSLDQSC ERGREQSLQC RYPTEHCIEV 
       160        170        180        190        200
VTLQSTERKL PAAGSPLGCP KEISKFQACK QNSHSHATAH SVPGSSESLD 
       210        220
QLESDQELSY LVVSHILLSF

Show »

Length:220

Mass (Da):24,417

Checksum:ⁱ224AB98959FE7F88

GO

Sequence cautionⁱ

The sequence CAA50717 differs from that shown. Reason: Frameshift at position 223.Curated

The sequence CAA50718 differs from that shown. Reason: Frameshift at position 223.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	232 – 234	TSL → SSF in CAA50718 (PubMed:8307160).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	95	C → S.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031840	159 – 220	SVKDE…CYSCE → KLPAAGSPLGCPKEISKFQA CKQNSHSHATAHSVPGSSES LDQLESDQELSYLVVSHILL SF in isoform 2. 1 PublicationAdd BLAST		62
Alternative sequenceⁱVSP_031841	221 – 328	Missing in isoform 2. 1 PublicationAdd BLAST		108

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71898 mRNA Translation: CAA50717.1 Frameshift. X71899 mRNA Translation: CAA50718.1 Frameshift. X76129 Genomic DNA Translation: CAA53732.1 AF007789 mRNA Translation: AAB62974.1 BC127499 mRNA Translation: AAI27500.1
PIRⁱ	S42152 S42429
NCBI Reference Sequences More...RefSeqⁱ	NP_059046.1, NM_017350.1 NP_599179.1, NM_134352.1
UniGeneⁱ	Rn.82711

Genome annotation databases

GeneIDⁱ	50692
KEGGⁱ	rno:50692

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P49616	Urokinase plasminogen activator surface receptor		RAT		329
UPI0000137CC7		RAT		328
UPI000016829B		RAT		328
Urokinase plasminogen activator surface receptor		RAT		327

Protein	Similar proteins		Species	Score	Length
P49616	Urokinase plasminogen activator surface receptor	)	MOUSE		327
UPI000A30D7BC		MUSPA		334
UPI00038C026D		MICOH		327
Plasminogen activator, urokinase receptor		LOXAF		335
Plasminogen activator, urokinase receptor		AOTNA		336
+101
P49616-3	Plasminogen activator, urokinase receptor, isoform CRA_a		MOUSE		222
P35456-2				222

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71898 mRNA Translation: CAA50717.1 Frameshift. X71899 mRNA Translation: CAA50718.1 Frameshift. X76129 Genomic DNA Translation: CAA53732.1 AF007789 mRNA Translation: AAB62974.1 BC127499 mRNA Translation: AAI27500.1
PIRⁱ	S42152 S42429
NCBI Reference Sequences More...RefSeqⁱ	NP_059046.1, NM_017350.1 NP_599179.1, NM_134352.1
UniGeneⁱ	Rn.82711

3D structure databases

ProteinModelPortalⁱ	P49616
SMRⁱ	P49616
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P49616, 1 interactor
STRINGⁱ	10116.ENSRNOP00000063960

Chemistry databases

BindingDBⁱ	P49616
ChEMBLⁱ	CHEMBL3638329

PTM databases

PhosphoSitePlusⁱ	P49616

PhosphoSitePlusⁱ

P49616

Proteomic databases

PaxDbⁱ	P49616
PRIDEⁱ	P49616

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	50692
KEGGⁱ	rno:50692

Organism-specific databases

CTDⁱ	5329
Rat genome database More...RGDⁱ	620597 Plaur

Phylogenomic databases

eggNOGⁱ	ENOG410IJ50 Eukaryota ENOG410Z47S LUCA
HOVERGENⁱ	HBG000245
InParanoidⁱ	P49616
KEGG Orthology (KO) More...KOⁱ	K03985
PhylomeDBⁱ	P49616

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P49616

PROⁱ

PR:P49616

Family and domain databases

InterProⁱ	View protein in InterPro IPR018363 CD59_antigen_CS IPR016054 LY6_UPA_recep-like IPR033084 U-PAR
PANTHERⁱ	PTHR10624:SF6 PTHR10624:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00021 UPAR_LY6, 3 hits
SMARTⁱ	View protein in SMART SM00134 LU, 3 hits
PROSITEⁱ	View protein in PROSITE PS00983 LY6_UPAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UPAR_RAT
Accessionⁱ	P49616Primary (citable) accession number: P49616 Secondary accession number(s): O35771, P51573, Q7TN35
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	October 23, 2007
	Last modified:	May 23, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49616 (UPAR_RAT)

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Urokinase plasminogen activator surface receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ