UniProtKB - P49616 (UPAR_RAT)
Urokinase plasminogen activator surface receptor
Plaur
Functioni
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
GO - Molecular functioni
- enzyme binding Source: RGD
- protein domain specific binding Source: RGD
- signaling receptor binding Source: RGD
- urokinase plasminogen activator receptor activity Source: RGD
GO - Biological processi
- epithelial cell differentiation involved in prostate gland development Source: RGD
- mesenchymal cell differentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGD
- negative regulation of intrinsic apoptotic signaling pathway Source: RGD
- positive regulation of DNA binding Source: RGD
- positive regulation of epidermal growth factor receptor signaling pathway Source: RGD
- positive regulation of homotypic cell-cell adhesion Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of release of cytochrome c from mitochondria Source: RGD
- regulation of cell adhesion Source: RGD
- skeletal muscle tissue regeneration Source: RGD
- spermatogenesis Source: RGD
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-RNO-162791, Attachment of GPI anchor to uPAR R-RNO-6798695, Neutrophil degranulation R-RNO-75205, Dissolution of Fibrin Clot |
Names & Taxonomyi
Protein namesi | Recommended name: Urokinase plasminogen activator surface receptorShort name: U-PAR Short name: uPAR Alternative name(s): CD_antigen: CD87 |
Gene namesi | Name:Plaur |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620597, Plaur |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; GPI-anchor 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: RGD
- protein complex involved in cell-matrix adhesion Source: RGD
- serine-type endopeptidase complex Source: RGD
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000036099 | 25 – 299 | Urokinase plasminogen activator surface receptorAdd BLAST | 275 | |
PropeptideiPRO_0000036100 | 300 – 328 | Removed in mature formSequence analysisAdd BLAST | 29 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 48 | By similarity | ||
Disulfide bondi | 30 ↔ 36 | By similarity | ||
Disulfide bondi | 41 ↔ 69 | By similarity | ||
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 95 ↔ 100 | By similarity | ||
Disulfide bondi | 120 ↔ 147 | By similarity | ||
Disulfide bondi | 123 ↔ 130 | By similarity | ||
Disulfide bondi | 140 ↔ 169 | By similarity | ||
Disulfide bondi | 175 ↔ 192 | By similarity | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 193 ↔ 198 | By similarity | ||
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 216 ↔ 244 | By similarity | ||
Disulfide bondi | 219 ↔ 227 | By similarity | ||
Glycosylationi | 222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 237 ↔ 263 | By similarity | ||
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 269 ↔ 288 | By similarity | ||
Glycosylationi | 283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 289 ↔ 294 | By similarity | ||
Glycosylationi | 290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 299 | GPI-anchor amidated glycineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | P49616 |
PRIDEi | P49616 |
PTM databases
GlyGeni | P49616, 7 sites |
PhosphoSitePlusi | P49616 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Monomer (Probable).
Interacts (via the UPAR/Ly6 domains) with SRPX2.
Interacts with MRC2 (By similarity).
Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).
By similarityCuratedGO - Molecular functioni
- enzyme binding Source: RGD
- protein domain specific binding Source: RGD
- signaling receptor binding Source: RGD
Protein-protein interaction databases
IntActi | P49616, 1 interactor |
STRINGi | 10116.ENSRNOP00000063960 |
Chemistry databases
BindingDBi | P49616 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 118 | UPAR/Ly6 1Add BLAST | 94 | |
Domaini | 118 – 213 | UPAR/Ly6 2Add BLAST | 96 | |
Domaini | 214 – 299 | UPAR/Ly6 3Add BLAST | 86 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502S36D, Eukaryota |
InParanoidi | P49616 |
OrthoDBi | 1102918at2759 |
PhylomeDBi | P49616 |
Family and domain databases
CDDi | cd00117, LU, 3 hits |
Gene3Di | 2.10.60.10, 3 hits |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like IPR045860, Snake_toxin-like_sf IPR033084, U-PAR |
PANTHERi | PTHR10624:SF6, PTHR10624:SF6, 1 hit |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 3 hits |
SMARTi | View protein in SMART SM00134, LU, 3 hits |
SUPFAMi | SSF57302, SSF57302, 3 hits |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLLRRRLLL LVVVVTTCVP ASQGLRCIQC ESNQDCLVEE CALGQDLCRT
60 70 80 90 100
TVLREWEDAE ELEVVTRGCA HKEKTNRTMS YRMGSVIVSL TETVCATNLC
110 120 130 140 150
NRPRPGARGR PFPRGRYLEC ASCTSLDQSC ERGREQSLQC RYPTEHCIEV
160 170 180 190 200
VTLQSTERSV KDEPYTKGCG SLPGCPGTAG FHSNQTFHFL KCCNFTQCNG
210 220 230 240 250
GPVLDLQSLP PNGFQCYSCE GNSTFGCSYE ETSLIDCRGP MNQCLEATGL
260 270 280 290 300
DVLGNRSYTV RGCATASWCQ GSHVADSFQT HVNLSISCCN GSGCNRPTGG
310 320
APGPGPAHLI LIASLLLTLR LWGIPLWT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R3P2 | M0R3P2_RAT | Urokinase plasminogen activator sur... | Plaur | 328 | Annotation score: | ||
M0R6Z6 | M0R6Z6_RAT | Urokinase plasminogen activator sur... | Plaur | 326 | Annotation score: | ||
A0A8I6AVK8 | A0A8I6AVK8_RAT | Urokinase plasminogen activator sur... | Plaur | 220 | Annotation score: | ||
A0A8I6G5B8 | A0A8I6G5B8_RAT | Urokinase plasminogen activator sur... | Plaur | 395 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 232 – 234 | TSL → SSF in CAA50718 (PubMed:8307160).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 95 | C → S. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031840 | 159 – 220 | SVKDE…CYSCE → KLPAAGSPLGCPKEISKFQA CKQNSHSHATAHSVPGSSES LDQLESDQELSYLVVSHILL SF in isoform 2. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_031841 | 221 – 328 | Missing in isoform 2. 1 PublicationAdd BLAST | 108 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71898 mRNA Translation: CAA50717.1 Frameshift. X71899 mRNA Translation: CAA50718.1 Frameshift. X76129 Genomic DNA Translation: CAA53732.1 AF007789 mRNA Translation: AAB62974.1 BC127499 mRNA Translation: AAI27500.1 |
PIRi | S42152 S42429 |
RefSeqi | NP_059046.1, NM_017350.1 NP_599179.1, NM_134352.1 [P49616-1] |
Genome annotation databases
GeneIDi | 50692 |
KEGGi | rno:50692 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71898 mRNA Translation: CAA50717.1 Frameshift. X71899 mRNA Translation: CAA50718.1 Frameshift. X76129 Genomic DNA Translation: CAA53732.1 AF007789 mRNA Translation: AAB62974.1 BC127499 mRNA Translation: AAI27500.1 |
PIRi | S42152 S42429 |
RefSeqi | NP_059046.1, NM_017350.1 NP_599179.1, NM_134352.1 [P49616-1] |
3D structure databases
AlphaFoldDBi | P49616 |
SMRi | P49616 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P49616, 1 interactor |
STRINGi | 10116.ENSRNOP00000063960 |
Chemistry databases
BindingDBi | P49616 |
ChEMBLi | CHEMBL3638329 |
PTM databases
GlyGeni | P49616, 7 sites |
PhosphoSitePlusi | P49616 |
Proteomic databases
PaxDbi | P49616 |
PRIDEi | P49616 |
Genome annotation databases
GeneIDi | 50692 |
KEGGi | rno:50692 |
Organism-specific databases
CTDi | 5329 |
RGDi | 620597, Plaur |
Phylogenomic databases
eggNOGi | ENOG502S36D, Eukaryota |
InParanoidi | P49616 |
OrthoDBi | 1102918at2759 |
PhylomeDBi | P49616 |
Enzyme and pathway databases
Reactomei | R-RNO-162791, Attachment of GPI anchor to uPAR R-RNO-6798695, Neutrophil degranulation R-RNO-75205, Dissolution of Fibrin Clot |
Miscellaneous databases
PROi | PR:P49616 |
Family and domain databases
CDDi | cd00117, LU, 3 hits |
Gene3Di | 2.10.60.10, 3 hits |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like IPR045860, Snake_toxin-like_sf IPR033084, U-PAR |
PANTHERi | PTHR10624:SF6, PTHR10624:SF6, 1 hit |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 3 hits |
SMARTi | View protein in SMART SM00134, LU, 3 hits |
SUPFAMi | SSF57302, SSF57302, 3 hits |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | UPAR_RAT | |
Accessioni | P49616Primary (citable) accession number: P49616 Secondary accession number(s): O35771, P51573, Q7TN35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | October 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |