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Entry version 185 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Serine--tRNA ligase, cytoplasmic

Gene

SARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: selenocysteinyl-tRNA(Sec) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-seryl-tRNA(Sec) from L-serine and tRNA(Sec).
Proteins known to be involved in this subpathway in this organism are:
  1. Serine--tRNA ligase, mitochondrial (SARS2), Serine--tRNA ligase, cytoplasmic (SARS)
This subpathway is part of the pathway selenocysteinyl-tRNA(Sec) biosynthesis, which is itself part of Aminoacyl-tRNA biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-seryl-tRNA(Sec) from L-serine and tRNA(Sec), the pathway selenocysteinyl-tRNA(Sec) biosynthesis and in Aminoacyl-tRNA biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei271L-serineCombined sources1 Publication1
Binding sitei302L-serineCombined sources1 Publication1
Binding sitei325L-serineCombined sources1 Publication1
Binding sitei427L-serineCombined sources1 Publication1
Binding sitei429Important for serine binding1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi302 – 304ATPCombined sources2 Publications3
Nucleotide bindingi318 – 321ATPCombined sources2 Publications4
Nucleotide bindingi391 – 394ATPCombined sources2 Publications4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: ProtInc
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • serine-tRNA ligase activity Source: UniProtKB
  • tRNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, DNA-binding, Ligase
Biological processProtein biosynthesis, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.11 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2408557 Selenocysteine synthesis
R-HSA-379716 Cytosolic tRNA aminoacylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49591

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00906;UER00895

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine--tRNA ligase, cytoplasmic (EC:6.1.1.115 Publications)
Alternative name(s):
Seryl-tRNA synthetase
Short name:
SerRS
Seryl-tRNA(Ser/Sec) synthetase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SARS
Synonyms:SERS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10537 SARS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607529 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with microcephaly, ataxia, and seizures (NEDMAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by delayed psychomotor development, intellectual disability, seizures apparent in infancy, impaired speech, and aggressive behavior. Additional features include microcephaly, ataxia, and muscle weakness.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078434172D → N in NEDMAS; impaired serine-activation of enzyme resulting in a significant decrease in the first step of the aminoacylation reaction; reduced protein stability; reduced protein expression. 1 PublicationCorresponds to variant dbSNP:rs1553178049EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 14Missing : Abolishes DNA binding. 1 PublicationAdd BLAST13
Mutagenesisi9R → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi44R → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi51D → A: Abolishes enzyme activity. 1 Publication1
Mutagenesisi54N → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi55K → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi58N → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi61S → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi75 – 97Missing : Decreased enzyme activity. Abolishes DNA binding. 2 PublicationsAdd BLAST23
Mutagenesisi104K → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi107R → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi254 – 261Missing : Mildly decreased enzyme activity. Nearly abolishes DNA binding. 2 Publications8
Mutagenesisi378D → R: Retains nuclear location and abolishes enzyme activity; when associated with V-383. 1 Publication1
Mutagenesisi383F → V: Abolishes nuclear location. Decreases enzyme activity. Retains nuclear location and abolishes enzyme activity; when associated with R-378. 1 Publication1
Mutagenesisi413 – 420Missing : Abolishes DNA binding. 1 Publication8
Mutagenesisi429T → A: Catalytically inactive. Loss of serine binding. No effect on nuclear location. 2 Publications1
Mutagenesisi482 – 514Missing : Abolishes nuclear localization. 1 PublicationAdd BLAST33
Mutagenesisi482K → A: Abolishes nuclear localization; when associated with A-485 and A-493. 1 Publication1
Mutagenesisi485K → A: Abolishes nuclear localization; when associated with A-482 and A-493. 1 Publication1
Mutagenesisi493K → A: Abolishes nuclear localization; when associated with A-482 and A-485. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6301

MalaCards human disease database

More...
MalaCardsi
SARS
MIMi617709 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000031698

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49591

Chemistry databases

Drug and drug target database

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DrugBanki
DB00133 Serine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SARS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
19860217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001221911 – 514Serine--tRNA ligase, cytoplasmicAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei323N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-438
CPTAC-439

Encyclopedia of Proteome Dynamics

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EPDi
P49591

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P49591

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P49591

MaxQB - The MaxQuant DataBase

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MaxQBi
P49591

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49591

PeptideAtlas

More...
PeptideAtlasi
P49591

PRoteomics IDEntifications database

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PRIDEi
P49591

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56027

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1738

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P49591

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49591

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P49591

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P49591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000031698 Expressed in 228 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49591 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49591 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016939
HPA064668

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:22353712, PubMed:26433229). The tRNA molecule may bind across the dimer (PubMed:26433229).

Interacts with SIRT2 (PubMed:24940000).

Interacts with METTL6 (PubMed:28655767).

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112208, 65 interactors

Database of interacting proteins

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DIPi
DIP-38215N

Protein interaction database and analysis system

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IntActi
P49591, 21 interactors

Molecular INTeraction database

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MINTi
P49591

STRING: functional protein association networks

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STRINGi
9606.ENSP00000234677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49591

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni9 – 61Interaction with tRNA1 PublicationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi482 – 494Nuclear localization signal1 PublicationAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2509 Eukaryota
COG0172 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000035937

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49591

KEGG Orthology (KO)

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KOi
K01875

Database of Orthologous Groups

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OrthoDBi
726296at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P49591

TreeFam database of animal gene trees

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TreeFami
TF300762

Family and domain databases

Conserved Domains Database

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CDDi
cd00770 SerRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.287.40, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR002317 Ser-tRNA-ligase_type_1
IPR015866 Ser-tRNA-synth_1_N
IPR042103 SerRS_1_N_sf
IPR033729 SerRS_core
IPR010978 tRNA-bd_arm

The PANTHER Classification System

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PANTHERi
PTHR11778 PTHR11778, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02403 Seryl_tRNA_N, 1 hit
PF00587 tRNA-synt_2b, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001529 Ser-tRNA-synth_IIa, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00981 TRNASYNTHSER

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46589 SSF46589, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00414 serS, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA
60 70 80 90 100
DNLNKLKNLC SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV
110 120 130 140 150
SQIKKVRLLI DEAILKCDAE RIKLEAERFE NLREIGNLLH PSVPISNDED
160 170 180 190 200
VDNKVERIWG DCTVRKKYSH VDLVVMVDGF EGEKGAVVAG SRGYFLKGVL
210 220 230 240 250
VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL SQFDEELYKV
260 270 280 290 300
IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC
310 320 330 340 350
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE
360 370 380 390 400
FYQSLGIPYH IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD
410 420 430 440 450
YQARRLRIRY GQTKKMMDKV EFVHMLNATM CATTRTICAI LENYQTEKGI
460 470 480 490 500
TVPEKLKEFM PPGLQELIPF VKPAPIEQEP SKKQKKQHEG SKKKAAARDV
510
TLENRLQNME VTDA
Length:514
Mass (Da):58,777
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF59DA8E55F193ACB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T5C7Q5T5C7_HUMAN
Seryl-tRNA synthetase 1
SARS1
536Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54N → S in CAA62635 (PubMed:9431993).Curated1
Sequence conflicti435R → C in AAH09390 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078434172D → N in NEDMAS; impaired serine-activation of enzyme resulting in a significant decrease in the first step of the aminoacylation reaction; reduced protein stability; reduced protein expression. 1 PublicationCorresponds to variant dbSNP:rs1553178049EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X91257 mRNA Translation: CAA62635.1
D49914 mRNA Translation: BAA95602.1
AK312771 mRNA Translation: BAG35636.1
AL356389 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56369.1
BC000716 mRNA Translation: AAH00716.1
BC009390 mRNA Translation: AAH09390.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS795.1

Protein sequence database of the Protein Information Resource

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PIRi
G01026

NCBI Reference Sequences

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RefSeqi
NP_006504.2, NM_006513.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000234677; ENSP00000234677; ENSG00000031698

Database of genes from NCBI RefSeq genomes

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GeneIDi
6301

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6301

UCSC genome browser

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UCSCi
uc001dwu.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91257 mRNA Translation: CAA62635.1
D49914 mRNA Translation: BAA95602.1
AK312771 mRNA Translation: BAG35636.1
AL356389 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56369.1
BC000716 mRNA Translation: AAH00716.1
BC009390 mRNA Translation: AAH09390.1
CCDSiCCDS795.1
PIRiG01026
RefSeqiNP_006504.2, NM_006513.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VBBX-ray2.89A/B/C/D/E/F1-514[»]
4L87X-ray2.90A2-477[»]
4RQEX-ray4.00A/C1-514[»]
4RQFX-ray3.50A/B1-514[»]
SMRiP49591
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112208, 65 interactors
DIPiDIP-38215N
IntActiP49591, 21 interactors
MINTiP49591
STRINGi9606.ENSP00000234677

Chemistry databases

DrugBankiDB00133 Serine

PTM databases

GlyConnecti1738
iPTMnetiP49591
PhosphoSitePlusiP49591
SwissPalmiP49591

Polymorphism and mutation databases

BioMutaiSARS
DMDMi19860217

Proteomic databases

CPTACiCPTAC-438
CPTAC-439
EPDiP49591
jPOSTiP49591
MassIVEiP49591
MaxQBiP49591
PaxDbiP49591
PeptideAtlasiP49591
PRIDEiP49591
ProteomicsDBi56027

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6301

Genome annotation databases

EnsembliENST00000234677; ENSP00000234677; ENSG00000031698
GeneIDi6301
KEGGihsa:6301
UCSCiuc001dwu.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6301
DisGeNETi6301

GeneCards: human genes, protein and diseases

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GeneCardsi
SARS
HGNCiHGNC:10537 SARS
HPAiHPA016939
HPA064668
MalaCardsiSARS
MIMi607529 gene
617709 phenotype
neXtProtiNX_P49591
OpenTargetsiENSG00000031698
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA34945

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2509 Eukaryota
COG0172 LUCA
GeneTreeiENSGT00940000153792
HOGENOMiHOG000035937
InParanoidiP49591
KOiK01875
OrthoDBi726296at2759
PhylomeDBiP49591
TreeFamiTF300762

Enzyme and pathway databases

UniPathwayiUPA00906;UER00895
BRENDAi6.1.1.11 2681
ReactomeiR-HSA-2408557 Selenocysteine synthesis
R-HSA-379716 Cytosolic tRNA aminoacylation
SIGNORiP49591

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SARS human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SARS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6301
PharosiP49591
PMAP-CutDBiP49591

Protein Ontology

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PROi
PR:P49591

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000031698 Expressed in 228 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP49591 baseline and differential
GenevisibleiP49591 HS

Family and domain databases

CDDicd00770 SerRS_core, 1 hit
Gene3Di1.10.287.40, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR002317 Ser-tRNA-ligase_type_1
IPR015866 Ser-tRNA-synth_1_N
IPR042103 SerRS_1_N_sf
IPR033729 SerRS_core
IPR010978 tRNA-bd_arm
PANTHERiPTHR11778 PTHR11778, 1 hit
PfamiView protein in Pfam
PF02403 Seryl_tRNA_N, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PIRSFiPIRSF001529 Ser-tRNA-synth_IIa, 1 hit
PRINTSiPR00981 TRNASYNTHSER
SUPFAMiSSF46589 SSF46589, 1 hit
TIGRFAMsiTIGR00414 serS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYSC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49591
Secondary accession number(s): B2R6Y9, Q5T5C8, Q9NSE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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