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Protein

Putative choline-phosphate cytidylyltransferase

Gene

F08C6.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphocholine = diphosphate + CDP-choline.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative choline-phosphate cytidylyltransferase (F08C6.2)
  2. no protein annotated in this organism
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126CTPBy similarity1
Binding sitei126SubstrateBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei177CTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 96CTPBy similarity9
Nucleotide bindingi172 – 173CTPBy similarity2
Nucleotide bindingi200 – 204CTPBy similarity5

GO - Molecular functioni

  • choline-phosphate cytidylyltransferase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1483191 Synthesis of PC
UniPathwayi
UPA00753;UER00739

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline-phosphate cytidylyltransferase (EC:2.7.7.15)
Alternative name(s):
CTP:phosphocholine cytidylyltransferase
Short name:
CCT
Short name:
CT
Phosphorylcholine transferase
Gene namesi
ORF Names:F08C6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF08C6.2a ; CE30937 ; WBGene00017241

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084581 – 362Putative choline-phosphate cytidylyltransferaseAdd BLAST362

Proteomic databases

EPDiP49583
PaxDbiP49583
PeptideAtlasiP49583
PRIDEiP49583

PTM databases

iPTMnetiP49583

Expressioni

Gene expression databases

BgeeiWBGene00017241 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F08C6.2a

Structurei

3D structure databases

ProteinModelPortaliP49583
SMRiP49583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG2804 Eukaryota
COG0615 LUCA
GeneTreeiENSGT00390000000269
HOGENOMiHOG000230945
InParanoidiP49583
KOiK00968
OMAiSKMPRCA
OrthoDBiEOG091G0DDW
PhylomeDBiP49583

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIHKQEKMP QRKRTMDSPQ EEDVEVKKKA TEVEYVVRSL ASDEPAPFSD
60 70 80 90 100
EALAITTREA VDYSKKITLA MAEANEAGRP VRIYADGIYD LFHHGHANQL
110 120 130 140 150
RQVKKMFPNV YLIVGVCGDR DTHKYKGRTV TSEEERYDGV RHCRYVDEVY
160 170 180 190 200
REAPWFCTVE FLKNLKVDFI AHDAIPYVAP GEEDLYEKFR REGMFLETER
210 220 230 240 250
TEGVSTSDVV CRIIRDYDKY VRRNLQRGYS PKELNVGFLA ASKYQIQNKV
260 270 280 290 300
DSLKSKGIEL LSTWKSKSDD IIRDFIDTFH KDGGLNAFGG RLKGIMSMSR
310 320 330 340 350
SPSPSPHEGS PTGIEHHLET QDEEEEEEAL EEEKVVEQKI VEKKEVVKKR
360
SSRNKAKTPL EY
Length:362
Mass (Da):41,769
Last modified:June 20, 2003 - v2
Checksum:iE2845D72C326C199
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3HKC4Q3HKC4_CAEEL
Choline-phosphate cytidylyltransfer...
pcyt-1 CELE_F08C6.2, F08C6.2
354Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080866 Genomic DNA Translation: CCD67344.1
PIRiT15975
RefSeqiNP_001033539.1, NM_001038450.2
UniGeneiCel.4920

Genome annotation databases

EnsemblMetazoaiF08C6.2a; F08C6.2a; WBGene00017241
GeneIDi181021
KEGGicel:CELE_F08C6.2
UCSCiF08C6.2a c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080866 Genomic DNA Translation: CCD67344.1
PIRiT15975
RefSeqiNP_001033539.1, NM_001038450.2
UniGeneiCel.4920

3D structure databases

ProteinModelPortaliP49583
SMRiP49583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F08C6.2a

PTM databases

iPTMnetiP49583

Proteomic databases

EPDiP49583
PaxDbiP49583
PeptideAtlasiP49583
PRIDEiP49583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08C6.2a; F08C6.2a; WBGene00017241
GeneIDi181021
KEGGicel:CELE_F08C6.2
UCSCiF08C6.2a c. elegans

Organism-specific databases

CTDi181021
WormBaseiF08C6.2a ; CE30937 ; WBGene00017241

Phylogenomic databases

eggNOGiKOG2804 Eukaryota
COG0615 LUCA
GeneTreeiENSGT00390000000269
HOGENOMiHOG000230945
InParanoidiP49583
KOiK00968
OMAiSKMPRCA
OrthoDBiEOG091G0DDW
PhylomeDBiP49583

Enzyme and pathway databases

UniPathwayi
UPA00753;UER00739

ReactomeiR-CEL-1483191 Synthesis of PC

Miscellaneous databases

PROiPR:P49583

Gene expression databases

BgeeiWBGene00017241 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCY1_CAEEL
AccessioniPrimary (citable) accession number: P49583
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 20, 2003
Last modified: October 10, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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