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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

Chrna7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:Chrna7
Synonyms:Acra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99779 Chrna7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 230ExtracellularSequence analysisAdd BLAST208
Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei296 – 317HelicalSequence analysisAdd BLAST22
Topological domaini318 – 469CytoplasmicSequence analysisAdd BLAST152
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3365

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000036823 – 502Neuronal acetylcholine receptor subunit alpha-7Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49582
PRIDEiP49582

PTM databases

iPTMnetiP49582
PhosphoSitePlusiP49582

Expressioni

Gene expression databases

BgeeiENSMUSG00000030525 Expressed in 55 organ(s), highest expression level in cerebral cortex marginal layer
ExpressionAtlasiP49582 baseline and differential
GenevisibleiP49582 MM

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. Interacts with the alpha-conotoxin RgIA (By similarity). Interacts with alpha-conotoxins ImI and ImII (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197934, 2 interactors
ComplexPortaliCPX-234 Neuronal nicotinic acetylcholine receptor complex, alpha7
CPX-238 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2
DIPiDIP-48732N
IntActiP49582, 3 interactors
STRINGi10090.ENSMUSP00000032738

Chemistry databases

BindingDBiP49582

Structurei

3D structure databases

ProteinModelPortaliP49582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP49582
KOiK04809
OMAiGHPSEGD
OrthoDBiEOG091G0R20
PhylomeDBiP49582
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49582-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNASGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL QMQEADISSY IPNGEWDLMG
210 220 230 240 250
IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT
410 420 430 440 450
PDSGVVCGRL ACSPTHDEHL MHGTHPSDGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEVICSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,632
Last modified:February 1, 1996 - v1
Checksum:iC9312E5226D120E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37663 mRNA Translation: AAC42053.1
CCDSiCCDS21329.1
PIRiA57175
RefSeqiNP_031416.3, NM_007390.3
UniGeneiMm.113464

Genome annotation databases

EnsembliENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525
GeneIDi11441
KEGGimmu:11441
UCSCiuc009vel.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37663 mRNA Translation: AAC42053.1
CCDSiCCDS21329.1
PIRiA57175
RefSeqiNP_031416.3, NM_007390.3
UniGeneiMm.113464

3D structure databases

ProteinModelPortaliP49582
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197934, 2 interactors
ComplexPortaliCPX-234 Neuronal nicotinic acetylcholine receptor complex, alpha7
CPX-238 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2
DIPiDIP-48732N
IntActiP49582, 3 interactors
STRINGi10090.ENSMUSP00000032738

Chemistry databases

BindingDBiP49582
ChEMBLiCHEMBL3365

PTM databases

iPTMnetiP49582
PhosphoSitePlusiP49582

Proteomic databases

PaxDbiP49582
PRIDEiP49582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525
GeneIDi11441
KEGGimmu:11441
UCSCiuc009vel.1 mouse

Organism-specific databases

CTDi1139
MGIiMGI:99779 Chrna7

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP49582
KOiK04809
OMAiGHPSEGD
OrthoDBiEOG091G0R20
PhylomeDBiP49582
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Miscellaneous databases

PROiPR:P49582
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030525 Expressed in 55 organ(s), highest expression level in cerebral cortex marginal layer
ExpressionAtlasiP49582 baseline and differential
GenevisibleiP49582 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA7_MOUSE
AccessioniPrimary (citable) accession number: P49582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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