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Protein

Fructose-bisphosphate aldolase 2

Gene

ALDO2

Organism
Plasmodium berghei (strain Anka)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PBANKA_100880)
  3. Probable ATP-dependent 6-phosphofructokinase (PBANKA_081640)
  4. Fructose-bisphosphate aldolase 2 (ALDO2), Fructose-bisphosphate aldolase (PBANKA_130860)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Active sitei184Proton acceptorBy similarity1
Active sitei226Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei358Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Protein family/group databases

MoonProtiP49577

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Short name:
ALDO-2
Gene namesi
Name:ALDO2
OrganismiPlasmodium berghei (strain Anka)
Taxonomic identifieri5823 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169311 – 358Fructose-bisphosphate aldolase 2Add BLAST358

Structurei

3D structure databases

ProteinModelPortaliP49577
SMRiP49577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P49577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN
60 70 80 90 100
RASYRDLLFG TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG
110 120 130 140 150
IKVDKGLVSI PCTDDEKSTQ GLDGLAERCK EYYKAGARFA KWRAVLVIDP
160 170 180 190 200
AKGKPTDLSI QEVSWGLARY ASICQQNKLV PIVEPEILAD GAHTIEVCAT
210 220 230 240 250
VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT KTDDIGFFTV
260 270 280 290 300
RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA
310 320 330 340 350
LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS

LYEKKYVY
Length:358
Mass (Da):38,733
Last modified:February 1, 1996 - v1
Checksum:i44D82D283FE4C47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81793 Unassigned DNA Translation: AAC37203.1

Genome annotation databases

GeneDBiPBANKA_1308600.1:pep

Similar proteinsi

Entry informationi

Entry nameiALF2_PLABA
AccessioniPrimary (citable) accession number: P49577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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