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Protein

Glutamate dehydrogenase 2, mitochondrial

Gene

GLUD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84SubstrateBy similarity1
Active sitei183PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:HS00018-MONOMER
BRENDAi1.4.1.3 2681
ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKiP49448

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 2, mitochondrial (EC:1.4.1.3)
Short name:
GDH 2
Gene namesi
Name:GLUD2
Synonyms:GLUDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000182890.4
HGNCiHGNC:4336 GLUD2
MIMi300144 gene
neXtProtiNX_P49448

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi2747
MalaCardsiGLUD2
OpenTargetsiENSG00000182890
PharmGKBiPA28738

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
DB00157 NADH

Polymorphism and mutation databases

BioMutaiGLUD2
DMDMi13432152

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53Mitochondrion1 PublicationAdd BLAST53
ChainiPRO_000000720854 – 558Glutamate dehydrogenase 2, mitochondrialAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172ADP-ribosylcysteine1 Publication1

Post-translational modificationi

Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiP49448
MaxQBiP49448
PaxDbiP49448
PeptideAtlasiP49448
PRIDEiP49448
ProteomicsDBi56012

2D gel databases

REPRODUCTION-2DPAGEiIPI00027146

PTM databases

iPTMnetiP49448
PhosphoSitePlusiP49448
SwissPalmiP49448

Expressioni

Tissue specificityi

Expressed in retina, testis and, at a lower level, brain.

Gene expression databases

BgeeiENSG00000182890 Expressed in 213 organ(s), highest expression level in amygdala
ExpressionAtlasiP49448 baseline and differential
GenevisibleiP49448 HS

Organism-specific databases

HPAiHPA042492
HPA044839
HPA061369

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

BioGridi109009, 13 interactors
IntActiP49448, 8 interactors
STRINGi9606.ENSP00000327589

Structurei

3D structure databases

ProteinModelPortaliP49448
SMRiP49448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2250 Eukaryota
COG0334 LUCA
GeneTreeiENSGT00390000000854
HOGENOMiHOG000243801
HOVERGENiHBG005479
InParanoidiP49448
KOiK00261
OMAiVMVIPDM
OrthoDBiEOG091G0KMT
PhylomeDBiP49448
TreeFamiTF313945

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR
60 70 80 90 100
RHYSELVADR EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN
110 120 130 140 150
RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI
160 170 180 190 200
RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTENELEK
210 220 230 240 250
ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY ASTIGHYDIN
260 270 280 290 300
AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR
310 320 330 340 350
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED
360 370 380 390 400
FKLQHGSILG FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI
410 420 430 440 450
IAEGANGPTT PEADKIFLER NILVIPDLYL NAGGVTVSYF EWLKNLNHVS
460 470 480 490 500
YGRLTFKYER DSNYHLLLSV QESLERKFGK HGGTIPIVPT AEFQDSISGA
510 520 530 540 550
SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV NAIEKVFKVY

SEAGVTFT
Length:558
Mass (Da):61,434
Last modified:April 27, 2001 - v2
Checksum:iF222B1B2CB74A6EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286E → Q in CAA46995 (PubMed:8207021).Curated1
Sequence conflicti286E → Q in AAA20969 (PubMed:8207021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048867498S → A. Corresponds to variant dbSNP:rs9697983EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66310 Genomic DNA Translation: CAA46995.1
U08997 Genomic DNA Translation: AAA20969.1
AK313356 mRNA Translation: BAG36157.1
AC006144 Genomic DNA Translation: AAD05030.1
BC050732 mRNA Translation: AAH50732.1
CCDSiCCDS14603.1
PIRiA53719
RefSeqiNP_036216.2, NM_012084.3
UniGeneiHs.368538

Genome annotation databases

EnsembliENST00000328078; ENSP00000327589; ENSG00000182890
GeneIDi2747
KEGGihsa:2747
UCSCiuc004eto.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66310 Genomic DNA Translation: CAA46995.1
U08997 Genomic DNA Translation: AAA20969.1
AK313356 mRNA Translation: BAG36157.1
AC006144 Genomic DNA Translation: AAD05030.1
BC050732 mRNA Translation: AAH50732.1
CCDSiCCDS14603.1
PIRiA53719
RefSeqiNP_036216.2, NM_012084.3
UniGeneiHs.368538

3D structure databases

ProteinModelPortaliP49448
SMRiP49448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109009, 13 interactors
IntActiP49448, 8 interactors
STRINGi9606.ENSP00000327589

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
DB00157 NADH

PTM databases

iPTMnetiP49448
PhosphoSitePlusiP49448
SwissPalmiP49448

Polymorphism and mutation databases

BioMutaiGLUD2
DMDMi13432152

2D gel databases

REPRODUCTION-2DPAGEiIPI00027146

Proteomic databases

EPDiP49448
MaxQBiP49448
PaxDbiP49448
PeptideAtlasiP49448
PRIDEiP49448
ProteomicsDBi56012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328078; ENSP00000327589; ENSG00000182890
GeneIDi2747
KEGGihsa:2747
UCSCiuc004eto.4 human

Organism-specific databases

CTDi2747
DisGeNETi2747
EuPathDBiHostDB:ENSG00000182890.4
GeneCardsiGLUD2
HGNCiHGNC:4336 GLUD2
HPAiHPA042492
HPA044839
HPA061369
MalaCardsiGLUD2
MIMi300144 gene
neXtProtiNX_P49448
OpenTargetsiENSG00000182890
PharmGKBiPA28738
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2250 Eukaryota
COG0334 LUCA
GeneTreeiENSGT00390000000854
HOGENOMiHOG000243801
HOVERGENiHBG005479
InParanoidiP49448
KOiK00261
OMAiVMVIPDM
OrthoDBiEOG091G0KMT
PhylomeDBiP49448
TreeFamiTF313945

Enzyme and pathway databases

BioCyciMetaCyc:HS00018-MONOMER
BRENDAi1.4.1.3 2681
ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKiP49448

Miscellaneous databases

GeneWikiiGLUD2
GenomeRNAii2747
PROiPR:P49448
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182890 Expressed in 213 organ(s), highest expression level in amygdala
ExpressionAtlasiP49448 baseline and differential
GenevisibleiP49448 HS

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHE4_HUMAN
AccessioniPrimary (citable) accession number: P49448
Secondary accession number(s): B2R8G0, Q9UDQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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