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Protein

Cytochrome b561

Gene

CYB561

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi91Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi109Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi121Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi160Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

  • electron transport chain Source: UniProtKB

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Protein family/group databases

TCDBi5.B.2.1.4 the eukaryotic cytochrome b561 (cytb561) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000008283.15
HGNCiHGNC:2571 CYB561
MIMi600019 gene
neXtProtiNX_P49447

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 251CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1534
OpenTargetsiENSG00000008283
PharmGKBiPA27069

Polymorphism and mutation databases

BioMutaiCYB561
DMDMi25453426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510271 – 251Cytochrome b561Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP49447
MaxQBiP49447
PaxDbiP49447
PeptideAtlasiP49447
PRIDEiP49447
ProteomicsDBi56011

PTM databases

iPTMnetiP49447
PhosphoSitePlusiP49447

Expressioni

Gene expression databases

BgeeiENSG00000008283 Expressed in 208 organ(s), highest expression level in oviduct epithelium
CleanExiHS_CYB561
ExpressionAtlasiP49447 baseline and differential
GenevisibleiP49447 HS

Organism-specific databases

HPAiHPA014753

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi107914, 6 interactors
IntActiP49447, 33 interactors
MINTiP49447
STRINGi9606.ENSP00000354028

Structurei

3D structure databases

ProteinModelPortaliP49447
SMRiP49447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 220Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619 Eukaryota
ENOG4111FKI LUCA
GeneTreeiENSGT00390000010986
HOVERGENiHBG054164
InParanoidiP49447
KOiK08360
PhylomeDBiP49447
TreeFamiTF314222

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
IPR028837 Cytochrome_b561
PANTHERiPTHR10106:SF14 PTHR10106:SF14, 1 hit
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49447-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF
60 70 80 90 100
NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV
110 120 130 140 150
GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF
160 170 180 190 200
SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL
210 220 230 240 250
ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS

Q
Length:251
Mass (Da):27,559
Last modified:November 25, 2002 - v2
Checksum:i8EE53AE4D2569B77
GO
Isoform 2 (identifier: P49447-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-251: WLVGFSFFLF...LTEGDSPGSQ → GQV

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,206
Checksum:iFC34B9D5326D4222
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H757F5H757_HUMAN
Cytochrome b561
CYB561
318Annotation score:
J3QRH5J3QRH5_HUMAN
Cytochrome b561
CYB561
258Annotation score:
J3QS47J3QS47_HUMAN
Cytochrome b561
CYB561
222Annotation score:
J3KSL5J3KSL5_HUMAN
Cytochrome b561
CYB561
305Annotation score:
J3QS09J3QS09_HUMAN
Cytochrome b561
CYB561
210Annotation score:
J3QKN3J3QKN3_HUMAN
Cytochrome b-561, isoform CRA_c
CYB561 hCG_41832
194Annotation score:
J3QRF9J3QRF9_HUMAN
Cytochrome b561
CYB561
142Annotation score:
J3QLS0J3QLS0_HUMAN
Cytochrome b561
CYB561
94Annotation score:
J3QR25J3QR25_HUMAN
Cytochrome b561
CYB561
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → S in AAH02976 (PubMed:15489334).Curated1
Sequence conflicti171S → P in AAC50212 (PubMed:7559396).Curated1
Sequence conflicti171S → P in AAA50952 (PubMed:7980462).Curated1
Sequence conflicti243 – 244TE → RQ in AAC50212 (PubMed:7559396).Curated2
Sequence conflicti243 – 244TE → RQ in AAA50952 (PubMed:7980462).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056950136 – 251WLVGF…SPGSQ → GQV in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29462
, U29460, U29461, U29464, U29469 Genomic DNA Translation: AAC50212.1
BT007096 mRNA Translation: AAP35760.1
AK301541 mRNA Translation: BAH13511.1
AK316606 mRNA Translation: BAG38193.1
AC005828 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94322.1
CH471109 Genomic DNA Translation: EAW94323.1
CH471109 Genomic DNA Translation: EAW94326.1
BC000021 mRNA Translation: AAH00021.1
BC002976 mRNA Translation: AAH02976.1
BC091485 mRNA Translation: AAH91485.1
U06715 mRNA Translation: AAA50952.1
CCDSiCCDS11636.1 [P49447-1]
PIRiS53321
RefSeqiNP_001017916.1, NM_001017916.1 [P49447-1]
NP_001017917.1, NM_001017917.1 [P49447-1]
NP_001317350.1, NM_001330421.1
NP_001906.3, NM_001915.3 [P49447-1]
XP_005257148.1, XM_005257091.1 [P49447-1]
UniGeneiHs.355264

Genome annotation databases

EnsembliENST00000360793; ENSP00000354028; ENSG00000008283 [P49447-1]
ENST00000392975; ENSP00000376701; ENSG00000008283 [P49447-1]
ENST00000392976; ENSP00000376702; ENSG00000008283 [P49447-1]
ENST00000448884; ENSP00000400350; ENSG00000008283 [P49447-2]
ENST00000581573; ENSP00000462325; ENSG00000008283 [P49447-1]
ENST00000584291; ENSP00000462543; ENSG00000008283 [P49447-1]
GeneIDi1534
KEGGihsa:1534
UCSCiuc002jap.4 human [P49447-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29462
, U29460, U29461, U29464, U29469 Genomic DNA Translation: AAC50212.1
BT007096 mRNA Translation: AAP35760.1
AK301541 mRNA Translation: BAH13511.1
AK316606 mRNA Translation: BAG38193.1
AC005828 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94322.1
CH471109 Genomic DNA Translation: EAW94323.1
CH471109 Genomic DNA Translation: EAW94326.1
BC000021 mRNA Translation: AAH00021.1
BC002976 mRNA Translation: AAH02976.1
BC091485 mRNA Translation: AAH91485.1
U06715 mRNA Translation: AAA50952.1
CCDSiCCDS11636.1 [P49447-1]
PIRiS53321
RefSeqiNP_001017916.1, NM_001017916.1 [P49447-1]
NP_001017917.1, NM_001017917.1 [P49447-1]
NP_001317350.1, NM_001330421.1
NP_001906.3, NM_001915.3 [P49447-1]
XP_005257148.1, XM_005257091.1 [P49447-1]
UniGeneiHs.355264

3D structure databases

ProteinModelPortaliP49447
SMRiP49447
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107914, 6 interactors
IntActiP49447, 33 interactors
MINTiP49447
STRINGi9606.ENSP00000354028

Protein family/group databases

TCDBi5.B.2.1.4 the eukaryotic cytochrome b561 (cytb561) family

PTM databases

iPTMnetiP49447
PhosphoSitePlusiP49447

Polymorphism and mutation databases

BioMutaiCYB561
DMDMi25453426

Proteomic databases

EPDiP49447
MaxQBiP49447
PaxDbiP49447
PeptideAtlasiP49447
PRIDEiP49447
ProteomicsDBi56011

Protocols and materials databases

DNASUi1534
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360793; ENSP00000354028; ENSG00000008283 [P49447-1]
ENST00000392975; ENSP00000376701; ENSG00000008283 [P49447-1]
ENST00000392976; ENSP00000376702; ENSG00000008283 [P49447-1]
ENST00000448884; ENSP00000400350; ENSG00000008283 [P49447-2]
ENST00000581573; ENSP00000462325; ENSG00000008283 [P49447-1]
ENST00000584291; ENSP00000462543; ENSG00000008283 [P49447-1]
GeneIDi1534
KEGGihsa:1534
UCSCiuc002jap.4 human [P49447-1]

Organism-specific databases

CTDi1534
DisGeNETi1534
EuPathDBiHostDB:ENSG00000008283.15
GeneCardsiCYB561
HGNCiHGNC:2571 CYB561
HPAiHPA014753
MIMi600019 gene
neXtProtiNX_P49447
OpenTargetsiENSG00000008283
PharmGKBiPA27069
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1619 Eukaryota
ENOG4111FKI LUCA
GeneTreeiENSGT00390000010986
HOVERGENiHBG054164
InParanoidiP49447
KOiK08360
PhylomeDBiP49447
TreeFamiTF314222

Miscellaneous databases

ChiTaRSiCYB561 human
GeneWikiiCYB561
GenomeRNAii1534
PROiPR:P49447
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008283 Expressed in 208 organ(s), highest expression level in oviduct epithelium
CleanExiHS_CYB561
ExpressionAtlasiP49447 baseline and differential
GenevisibleiP49447 HS

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
IPR028837 Cytochrome_b561
PANTHERiPTHR10106:SF14 PTHR10106:SF14, 1 hit
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCY561_HUMAN
AccessioniPrimary (citable) accession number: P49447
Secondary accession number(s): B2RE96
, B7Z775, D3DU11, Q5BJG9, Q9BU05, Q9BWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2002
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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