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Entry version 178 (07 Oct 2020)
Sequence version 2 (25 Nov 2002)
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Protein

Cytochrome b561

Gene

CYB561

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secretory vesicle-specific electron transport protein.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi91Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi109Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi121Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi160Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P49447

Protein family/group databases

Transport Classification Database

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TCDBi
5.B.2.1.4, the eukaryotic cytochrome b561 (cytb561) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYB561
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000008283.15

Human Gene Nomenclature Database

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HGNCi
HGNC:2571, CYB561

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600019, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49447

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 251CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Orthostatic hypotension 2 (ORTHYP2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by severe orthostatic hypotension apparent from infancy or early childhood, low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia. Some patients may also have renal dysfunction and reduced life expectancy. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08173044 – 251Missing in ORTHYP2. 1 PublicationAdd BLAST208
Natural variantiVAR_08173188G → R in ORTHYP2. 1 PublicationCorresponds to variant dbSNP:rs772361572EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1534

MalaCards human disease database

More...
MalaCardsi
CYB561
MIMi618182, phenotype

Open Targets

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OpenTargetsi
ENSG00000008283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49447, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYB561

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25453426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001510271 – 251Cytochrome b561Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49447

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49447

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49447

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49447

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49447

PeptideAtlas

More...
PeptideAtlasi
P49447

PRoteomics IDEntifications database

More...
PRIDEi
P49447

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56011 [P49447-1]
6840

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49447

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49447

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues, in particular the brain especially in the cortex and hippocampus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000008283, Expressed in adrenal gland and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49447, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49447, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000008283, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P49447
With#Exp.IntAct
ANKRD46 - isoform 1 [Q86W74-2]3EBI-8646596,EBI-12109402
AQP6 [Q13520]3EBI-8646596,EBI-13059134
BEST2 [Q8NFU1]3EBI-8646596,EBI-19947314
BET1 [O15155]3EBI-8646596,EBI-749204
BIK [Q13323]3EBI-8646596,EBI-700794
BNIP1 [Q12981]3EBI-8646596,EBI-4402847
CD79A [P11912]3EBI-8646596,EBI-7797864
CDIPT [O14735]3EBI-8646596,EBI-358858
CLDN9 [O95484]3EBI-8646596,EBI-18341636
CMTM2 [Q8TAZ6]3EBI-8646596,EBI-2339374
DARS2 [Q6PI48]3EBI-8646596,EBI-3917045
EBP [Q15125]3EBI-8646596,EBI-3915253
EDA [Q92838]6EBI-8646596,EBI-529425
EFNA5 [P52803]3EBI-8646596,EBI-1753674
EHHADH [Q08426]3EBI-8646596,EBI-2339219
ERG28 [Q9UKR5]3EBI-8646596,EBI-711490
ERGIC3 [Q9Y282]3EBI-8646596,EBI-781551
FKBP8 [Q14318]3EBI-8646596,EBI-724839
GGT7 [Q9UJ14]3EBI-8646596,EBI-1058791
GIMAP5 [Q96F15]3EBI-8646596,EBI-6166686
GOSR2 [O14653]3EBI-8646596,EBI-4401517
GPR152 [Q8TDT2]3EBI-8646596,EBI-13345167
GPX8 [Q8TED1]3EBI-8646596,EBI-11721746
HMOX1 [P09601]3EBI-8646596,EBI-2806151
LHFPL5 [Q8TAF8]3EBI-8646596,EBI-2820517
LPAR3 [Q9UBY5]3EBI-8646596,EBI-12033434
OPRM1 - isoform 10 [P35372-10]3EBI-8646596,EBI-12807478
ORMDL2 [Q53FV1]3EBI-8646596,EBI-11075081
PLP2 [Q04941]3EBI-8646596,EBI-608347
REEP6 - isoform 2 [Q96HR9-2]3EBI-8646596,EBI-14065960
RNF5 [Q99942]3EBI-8646596,EBI-348482
SCD [O00767]3EBI-8646596,EBI-2684237
SEC22A [Q96IW7]3EBI-8646596,EBI-8652744
SERP2 [Q8N6R1]3EBI-8646596,EBI-749270
SLC19A3 [Q9BZV2]3EBI-8646596,EBI-3923779
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-8646596,EBI-17295964
SLC38A7 [Q9NVC3]3EBI-8646596,EBI-10314552
SLC39A1 [Q9NY26]3EBI-8646596,EBI-726491
SLC39A2 [Q9NP94]3EBI-8646596,EBI-12898013
SMIM1 [B2RUZ4]3EBI-8646596,EBI-12188413
SSMEM1 [Q8WWF3]3EBI-8646596,EBI-17280858
STX3 [Q13277]3EBI-8646596,EBI-1394295
SYNJ2BP [P57105]3EBI-8646596,EBI-1049004
TM4SF18 [Q96CE8]3EBI-8646596,EBI-13351685
TMEM11 [P17152]3EBI-8646596,EBI-723946
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-8646596,EBI-10694905
TMEM14B [Q9NUH8]3EBI-8646596,EBI-8638294
TMEM179B [Q7Z7N9]3EBI-8646596,EBI-11724423
TMEM242 [Q9NWH2]3EBI-8646596,EBI-10315004
TMEM65 [Q6PI78]3EBI-8646596,EBI-6656213
TMPPE [Q6ZT21]3EBI-8646596,EBI-11724433
TREX1 - isoform 1 [Q9NSU2-1]3EBI-8646596,EBI-16746122
TSNARE1 [A0AVG3]3EBI-8646596,EBI-12003468
UBE2J1 [Q9Y385]3EBI-8646596,EBI-988826
VAPA [Q9P0L0]3EBI-8646596,EBI-1059156
VAPB [O95292]3EBI-8646596,EBI-1188298
ZDHHC7 - isoform 2 [Q9NXF8-2]3EBI-8646596,EBI-12948063

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107914, 61 interactors

Protein interaction database and analysis system

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IntActi
P49447, 59 interactors

Molecular INTeraction database

More...
MINTi
P49447

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376702

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49447, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 220Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183197

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_069712_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49447

KEGG Orthology (KO)

More...
KOi
K08360

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49447

TreeFam database of animal gene trees

More...
TreeFami
TF314222

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043205, CYB561/CYBRD1-like
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR028837, Cytochrome_b561

The PANTHER Classification System

More...
PANTHERi
PTHR10106, PTHR10106, 1 hit
PTHR10106:SF14, PTHR10106:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03188, Cytochrom_B561, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00665, B561, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49447-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF
60 70 80 90 100
NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV
110 120 130 140 150
GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF
160 170 180 190 200
SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL
210 220 230 240 250
ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS

Q
Length:251
Mass (Da):27,559
Last modified:November 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EE53AE4D2569B77
GO
Isoform 2 (identifier: P49447-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-251: WLVGFSFFLF...LTEGDSPGSQ → GQV

Show »
Length:138
Mass (Da):15,206
Checksum:iFC34B9D5326D4222
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H757F5H757_HUMAN
Cytochrome b-561
CYB561
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRH5J3QRH5_HUMAN
Cytochrome b-561
CYB561
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS47J3QS47_HUMAN
Cytochrome b-561
CYB561
222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKN3J3QKN3_HUMAN
Cytochrome b-561
CYB561 hCG_41832
194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS09J3QS09_HUMAN
Cytochrome b-561
CYB561
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSL5J3KSL5_HUMAN
Cytochrome b-561
CYB561
305Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRF9J3QRF9_HUMAN
Cytochrome b-561
CYB561
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLS0J3QLS0_HUMAN
Cytochrome b561
CYB561
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR25J3QR25_HUMAN
Cytochrome b561
CYB561
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6A → S in AAH02976 (PubMed:15489334).Curated1
Sequence conflicti171S → P in AAC50212 (PubMed:7559396).Curated1
Sequence conflicti171S → P in AAA50952 (PubMed:7980462).Curated1
Sequence conflicti243 – 244TE → RQ in AAC50212 (PubMed:7559396).Curated2
Sequence conflicti243 – 244TE → RQ in AAA50952 (PubMed:7980462).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08173044 – 251Missing in ORTHYP2. 1 PublicationAdd BLAST208
Natural variantiVAR_08173188G → R in ORTHYP2. 1 PublicationCorresponds to variant dbSNP:rs772361572EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056950136 – 251WLVGF…SPGSQ → GQV in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U29462 U29469 Genomic DNA Translation: AAC50212.1
BT007096 mRNA Translation: AAP35760.1
AK301541 mRNA Translation: BAH13511.1
AK316606 mRNA Translation: BAG38193.1
AC005828 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94322.1
CH471109 Genomic DNA Translation: EAW94323.1
CH471109 Genomic DNA Translation: EAW94326.1
BC000021 mRNA Translation: AAH00021.1
BC002976 mRNA Translation: AAH02976.1
BC091485 mRNA Translation: AAH91485.1
U06715 mRNA Translation: AAA50952.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11636.1 [P49447-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S53321

NCBI Reference Sequences

More...
RefSeqi
NP_001017916.1, NM_001017916.1 [P49447-1]
NP_001017917.1, NM_001017917.1 [P49447-1]
NP_001317350.1, NM_001330421.1
NP_001906.3, NM_001915.3 [P49447-1]
XP_005257148.1, XM_005257091.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360793; ENSP00000354028; ENSG00000008283 [P49447-1]
ENST00000392975; ENSP00000376701; ENSG00000008283 [P49447-1]
ENST00000392976; ENSP00000376702; ENSG00000008283 [P49447-1]
ENST00000448884; ENSP00000400350; ENSG00000008283 [P49447-2]
ENST00000581573; ENSP00000462325; ENSG00000008283 [P49447-1]
ENST00000584291; ENSP00000462543; ENSG00000008283 [P49447-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1534

UCSC genome browser

More...
UCSCi
uc002jap.4, human [P49447-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29462 U29469 Genomic DNA Translation: AAC50212.1
BT007096 mRNA Translation: AAP35760.1
AK301541 mRNA Translation: BAH13511.1
AK316606 mRNA Translation: BAG38193.1
AC005828 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94322.1
CH471109 Genomic DNA Translation: EAW94323.1
CH471109 Genomic DNA Translation: EAW94326.1
BC000021 mRNA Translation: AAH00021.1
BC002976 mRNA Translation: AAH02976.1
BC091485 mRNA Translation: AAH91485.1
U06715 mRNA Translation: AAA50952.1
CCDSiCCDS11636.1 [P49447-1]
PIRiS53321
RefSeqiNP_001017916.1, NM_001017916.1 [P49447-1]
NP_001017917.1, NM_001017917.1 [P49447-1]
NP_001317350.1, NM_001330421.1
NP_001906.3, NM_001915.3 [P49447-1]
XP_005257148.1, XM_005257091.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi107914, 61 interactors
IntActiP49447, 59 interactors
MINTiP49447
STRINGi9606.ENSP00000376702

Protein family/group databases

TCDBi5.B.2.1.4, the eukaryotic cytochrome b561 (cytb561) family

PTM databases

iPTMnetiP49447
PhosphoSitePlusiP49447

Polymorphism and mutation databases

BioMutaiCYB561
DMDMi25453426

Proteomic databases

EPDiP49447
jPOSTiP49447
MassIVEiP49447
MaxQBiP49447
PaxDbiP49447
PeptideAtlasiP49447
PRIDEiP49447
ProteomicsDBi56011 [P49447-1]
6840

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18653, 85 antibodies

The DNASU plasmid repository

More...
DNASUi
1534

Genome annotation databases

EnsembliENST00000360793; ENSP00000354028; ENSG00000008283 [P49447-1]
ENST00000392975; ENSP00000376701; ENSG00000008283 [P49447-1]
ENST00000392976; ENSP00000376702; ENSG00000008283 [P49447-1]
ENST00000448884; ENSP00000400350; ENSG00000008283 [P49447-2]
ENST00000581573; ENSP00000462325; ENSG00000008283 [P49447-1]
ENST00000584291; ENSP00000462543; ENSG00000008283 [P49447-1]
GeneIDi1534
KEGGihsa:1534
UCSCiuc002jap.4, human [P49447-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1534
DisGeNETi1534
EuPathDBiHostDB:ENSG00000008283.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYB561
HGNCiHGNC:2571, CYB561
HPAiENSG00000008283, Tissue enhanced (pancreas)
MalaCardsiCYB561
MIMi600019, gene
618182, phenotype
neXtProtiNX_P49447
OpenTargetsiENSG00000008283
PharmGKBiPA27069

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1619, Eukaryota
GeneTreeiENSGT00950000183197
HOGENOMiCLU_069712_3_2_1
InParanoidiP49447
KOiK08360
PhylomeDBiP49447
TreeFamiTF314222

Enzyme and pathway databases

PathwayCommonsiP49447

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1534, 9 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYB561, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYB561

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1534
PharosiP49447, Tbio

Protein Ontology

More...
PROi
PR:P49447
RNActiP49447, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008283, Expressed in adrenal gland and 222 other tissues
ExpressionAtlasiP49447, baseline and differential
GenevisibleiP49447, HS

Family and domain databases

InterProiView protein in InterPro
IPR043205, CYB561/CYBRD1-like
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR028837, Cytochrome_b561
PANTHERiPTHR10106, PTHR10106, 1 hit
PTHR10106:SF14, PTHR10106:SF14, 1 hit
PfamiView protein in Pfam
PF03188, Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665, B561, 1 hit
PROSITEiView protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCY561_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49447
Secondary accession number(s): B2RE96
, B7Z775, D3DU11, Q5BJG9, Q9BU05, Q9BWR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2002
Last modified: October 7, 2020
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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