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Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited in cells after FCER1A triggering.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei290Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei334SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name:
HEPTP
Protein-tyrosine phosphatase LC-PTP
Gene namesi
Name:Ptpn7
Synonyms:Lcptp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi708516 Ptpn7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947631 – 359Tyrosine-protein phosphatase non-receptor type 7Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei66PhosphothreonineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei290Cysteine sulfenic acid (-SOH)1 Publication1

Post-translational modificationi

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

PaxDbiP49445
PRIDEiP49445

PTM databases

iPTMnetiP49445
PhosphoSitePlusiP49445

Expressioni

Gene expression databases

BgeeiENSRNOG00000005807
GenevisibleiP49445 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007833

Structurei

3D structure databases

ProteinModelPortaliP49445
SMRiP49445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 349Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 51Interaction with MAP kinasesBy similarityAdd BLAST14
Regioni290 – 296Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiP49445
KOiK18019
OMAiSEQYQFL
OrthoDBiEOG091G0HLB
PhylomeDBiP49445
TreeFamiTF331016

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P49445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQACEGRSR AQLPTLSLGA DMTQPPPAKA PAKKHVRLQE RRGSSVALML
60 70 80 90 100
DVRSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE
110 120 130 140 150
FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AHSQEDSDYI
160 170 180 190 200
NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG
210 220 230 240 250
KEKCVHYWPT EEEAYGPFQI RIQGMKEHPE YTVRHLTIQH QQECRSVKHI
260 270 280 290 300
LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF
310 320 330 340 350
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA

AQLPPETDP
Length:359
Mass (Da):40,314
Last modified:February 1, 1996 - v1
Checksum:i5B98E196DB633677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28356 mRNA Translation: AAA84443.1
RefSeqiNP_663716.1, NM_145683.1
XP_006249883.1, XM_006249821.3
UniGeneiRn.10160

Genome annotation databases

EnsembliENSRNOT00000007833; ENSRNOP00000007833; ENSRNOG00000005807
GeneIDi246781
KEGGirno:246781
UCSCiRGD:708516 rat

Similar proteinsi

Entry informationi

Entry nameiPTN7_RAT
AccessioniPrimary (citable) accession number: P49445
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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