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UniProtKB - P49441 (INPP_HUMAN)

Entry version 178 (07 Apr 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Inositol polyphosphate 1-phosphatase

Gene

INPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Li+.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Magnesium 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119SubstrateBy similarity1
Metal bindingi153Magnesium 1By similarity1
Metal bindingi153Magnesium 2By similarity1
Metal bindingi155Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi156Magnesium 2By similarity1
Metal bindingi316Magnesium 2By similarity1
Binding sitei316SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS07761-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.57, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49441

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00944

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6071, INPP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147263, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49441

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151689.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3628

Open Targets

More...OpenTargetsi		ENSG00000151689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29880

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49441, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INPP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1352464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001425101 – 399Inositol polyphosphate 1-phosphataseAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49441

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49441

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49441

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49441

PeptideAtlas

More...PeptideAtlasi		P49441

PRoteomics IDEntifications database

More...PRIDEi		P49441

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56010

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P49441

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		INPP1

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49441

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49441

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in pancreas and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151689, Expressed in sperm and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49441, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49441, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151689, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109840, 23 interactors

Protein interaction database and analysis system

More...IntActi		P49441, 4 interactors

Molecular INTeraction database

More...MINTi		P49441

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376142

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49441, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni155 – 158Substrate bindingBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inositol monophosphatase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3099, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043868_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49441

Identification of Orthologs from Complete Genome Data

More...OMAi		TIKHEVG

Database of Orthologous Groups

More...OrthoDBi		1096950at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49441

TreeFam database of animal gene trees

More...TreeFami		TF314300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020583, Inositol_monoP_metal-BS
IPR000760, Inositol_monophosphatase-like
IPR020550, Inositol_monophosphatase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00459, Inositol_P, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00629, IMP_1, 1 hit
PS00630, IMP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P49441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK 
        60         70         80         90        100
TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE 
       110        120        130        140        150
EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI 
       160        170        180        190        200
WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV 
       210        220        230        240        250
INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT 
       260        270        280        290        300
GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 
       310        320        330        340        350
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ 
       360        370        380        390 
LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
Length:399
Mass (Da):43,998
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEFD592199A40C6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENF2E7ENF2_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET59E7ET59_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUX4E7EUX4_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZF6B8ZZF6_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J128C9J128_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2N5C9J2N5_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2Z6C9J2Z6_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J173C9J173_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMQ4A0A1D5RMQ4_HUMAN
Inositol polyphosphate 1-phosphatas...
INPP1
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019669228T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. 1 PublicationCorresponds to variant dbSNP:rs7592352Ensembl.1
Natural variantiVAR_049599355V → M. Corresponds to variant dbSNP:rs35616200Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L08488 mRNA Translation: AAA36117.1
AF141325 Genomic DNA Translation: AAD46766.1
BC015496 mRNA Translation: AAH15496.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2305.1

NCBI Reference Sequences

More...RefSeqi		NP_001122400.1, NM_001128928.1
NP_002185.1, NM_002194.3
XP_005246589.1, XM_005246532.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322522; ENSP00000325423; ENSG00000151689
ENST00000392329; ENSP00000376142; ENSG00000151689

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3628

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08488 mRNA Translation: AAA36117.1
AF141325 Genomic DNA Translation: AAD46766.1
BC015496 mRNA Translation: AAH15496.1
CCDSiCCDS2305.1
RefSeqiNP_001122400.1, NM_001128928.1
NP_002185.1, NM_002194.3
XP_005246589.1, XM_005246532.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109840, 23 interactors
IntActiP49441, 4 interactors
MINTiP49441
STRINGi9606.ENSP00000376142

PTM databases

DEPODiINPP1
iPTMnetiP49441
PhosphoSitePlusiP49441

Genetic variation databases

BioMutaiINPP1
DMDMi1352464

Proteomic databases

EPDiP49441
jPOSTiP49441
MassIVEiP49441
PaxDbiP49441
PeptideAtlasiP49441
PRIDEiP49441
ProteomicsDBi56010
TopDownProteomicsiP49441

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34038, 145 antibodies

The DNASU plasmid repository

More...DNASUi		3628

Genome annotation databases

EnsembliENST00000322522; ENSP00000325423; ENSG00000151689
ENST00000392329; ENSP00000376142; ENSG00000151689
GeneIDi3628
KEGGihsa:3628

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3628
DisGeNETi3628

GeneCards: human genes, protein and diseases

More...GeneCardsi		INPP1
HGNCiHGNC:6071, INPP1
HPAiENSG00000151689, Low tissue specificity
MIMi147263, gene
neXtProtiNX_P49441
OpenTargetsiENSG00000151689
PharmGKBiPA29880
VEuPathDBiHostDB:ENSG00000151689.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3099, Eukaryota
GeneTreeiENSGT00940000156785
HOGENOMiCLU_043868_2_0_1
InParanoidiP49441
OMAiTIKHEVG
OrthoDBi1096950at2759
PhylomeDBiP49441
TreeFamiTF314300

Enzyme and pathway databases

UniPathwayiUPA00944
BioCyciMetaCyc:HS07761-MONOMER
BRENDAi3.1.3.57, 2681
PathwayCommonsiP49441
ReactomeiR-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3628, 5 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INPP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		INPP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3628
PharosiP49441, Tbio

Protein Ontology

More...PROi		PR:P49441
RNActiP49441, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151689, Expressed in sperm and 245 other tissues
ExpressionAtlasiP49441, baseline and differential
GenevisibleiP49441, HS

Family and domain databases

InterProiView protein in InterPro
IPR020583, Inositol_monoP_metal-BS
IPR000760, Inositol_monophosphatase-like
IPR020550, Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459, Inositol_P, 1 hit
PROSITEiView protein in PROSITE
PS00629, IMP_1, 1 hit
PS00630, IMP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINPP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49441
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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