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UniProtKB - P49441 (INPP_HUMAN)
Protein
Inositol polyphosphate 1-phosphatase
Gene
INPP1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.57
Cofactori
Activity regulationi
Inhibited by Li+.
: phosphatidylinositol signaling pathway Pathwayi
This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 79 | Magnesium 1By similarity | 1 | |
Binding sitei | 119 | SubstrateBy similarity | 1 | |
Metal bindingi | 153 | Magnesium 1By similarity | 1 | |
Metal bindingi | 153 | Magnesium 2By similarity | 1 | |
Metal bindingi | 155 | Magnesium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 156 | Magnesium 2By similarity | 1 | |
Metal bindingi | 316 | Magnesium 2By similarity | 1 | |
Binding sitei | 316 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- inositol-1,4-bisphosphate 1-phosphatase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- inositol phosphate dephosphorylation Source: GO_Central
- phosphate-containing compound metabolic process Source: ProtInc
- phosphatidylinositol phosphate biosynthetic process Source: InterPro
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Hydrolase |
Ligand | Lithium, Magnesium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.3.57, 2681 |
PathwayCommonsi | P49441 |
Reactomei | R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
SignaLinki | P49441 |
UniPathwayi | UPA00944 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)Short name: IPP Short name: IPPase |
Gene namesi | Name:INPP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6071, INPP1 |
MIMi | 147263, gene |
neXtProti | NX_P49441 |
VEuPathDBi | HostDB:ENSG00000151689 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3628 |
OpenTargetsi | ENSG00000151689 |
PharmGKBi | PA29880 |
Miscellaneous databases
Pharosi | P49441, Tbio |
Genetic variation databases
BioMutai | INPP1 |
DMDMi | 1352464 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142510 | 1 – 399 | Inositol polyphosphate 1-phosphataseAdd BLAST | 399 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 317 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P49441 |
jPOSTi | P49441 |
MassIVEi | P49441 |
PaxDbi | P49441 |
PeptideAtlasi | P49441 |
PRIDEi | P49441 |
ProteomicsDBi | 56010 |
TopDownProteomicsi | P49441 |
PTM databases
DEPODi | INPP1 |
GlyGeni | P49441, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P49441 |
PhosphoSitePlusi | P49441 |
Expressioni
Tissue specificityi
Ubiquitously expressed, with highest levels in pancreas and kidney.
Gene expression databases
Bgeei | ENSG00000151689, Expressed in sperm and 245 other tissues |
ExpressionAtlasi | P49441, baseline and differential |
Genevisiblei | P49441, HS |
Organism-specific databases
HPAi | ENSG00000151689, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
By similarityBinary interactionsi
P49441
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-725432,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 109840, 26 interactors |
IntActi | P49441, 4 interactors |
MINTi | P49441 |
STRINGi | 9606.ENSP00000376142 |
Miscellaneous databases
RNActi | P49441, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 155 – 158 | Substrate bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the inositol monophosphatase superfamily.Curated
Phylogenomic databases
eggNOGi | KOG3099, Eukaryota |
GeneTreei | ENSGT00940000156785 |
HOGENOMi | CLU_043868_2_0_1 |
InParanoidi | P49441 |
OMAi | ANIARVC |
OrthoDBi | 1096950at2759 |
PhylomeDBi | P49441 |
TreeFami | TF314300 |
Family and domain databases
Gene3Di | 4.10.460.10, 1 hit |
InterProi | View protein in InterPro IPR020583, Inositol_monoP_metal-BS IPR000760, Inositol_monophosphatase-like IPR020550, Inositol_monophosphatase_CS IPR044897, INPP1_dom_1 |
Pfami | View protein in Pfam PF00459, Inositol_P, 1 hit |
PROSITEi | View protein in PROSITE PS00629, IMP_1, 1 hit PS00630, IMP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P49441-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK
60 70 80 90 100
TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE
110 120 130 140 150
EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI
160 170 180 190 200
WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV
210 220 230 240 250
INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT
260 270 280 290 300
GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG
310 320 330 340 350
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ
360 370 380 390
LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ENF2 | E7ENF2_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 213 | Annotation score: | ||
E7ET59 | E7ET59_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 190 | Annotation score: | ||
E7EUX4 | E7EUX4_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 212 | Annotation score: | ||
B8ZZF6 | B8ZZF6_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 155 | Annotation score: | ||
C9J128 | C9J128_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 68 | Annotation score: | ||
C9J2N5 | C9J2N5_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 30 | Annotation score: | ||
C9J2Z6 | C9J2Z6_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 88 | Annotation score: | ||
C9J173 | C9J173_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 143 | Annotation score: | ||
A0A1D5RMQ4 | A0A1D5RMQ4_HUMAN | Inositol polyphosphate 1-phosphatas... | INPP1 | 9 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019669 | 228 | T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. 1 PublicationCorresponds to variant dbSNP:rs7592352Ensembl. | 1 | |
Natural variantiVAR_049599 | 355 | V → M. Corresponds to variant dbSNP:rs35616200Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08488 mRNA Translation: AAA36117.1 AF141325 Genomic DNA Translation: AAD46766.1 BC015496 mRNA Translation: AAH15496.1 |
CCDSi | CCDS2305.1 |
RefSeqi | NP_001122400.1, NM_001128928.1 NP_002185.1, NM_002194.3 XP_005246589.1, XM_005246532.1 |
Genome annotation databases
Ensembli | ENST00000322522; ENSP00000325423; ENSG00000151689 ENST00000392329; ENSP00000376142; ENSG00000151689 |
GeneIDi | 3628 |
KEGGi | hsa:3628 |
MANE-Selecti | ENST00000392329.7; ENSP00000376142.2; NM_001128928.2; NP_001122400.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08488 mRNA Translation: AAA36117.1 AF141325 Genomic DNA Translation: AAD46766.1 BC015496 mRNA Translation: AAH15496.1 |
CCDSi | CCDS2305.1 |
RefSeqi | NP_001122400.1, NM_001128928.1 NP_002185.1, NM_002194.3 XP_005246589.1, XM_005246532.1 |
3D structure databases
SMRi | P49441 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109840, 26 interactors |
IntActi | P49441, 4 interactors |
MINTi | P49441 |
STRINGi | 9606.ENSP00000376142 |
PTM databases
DEPODi | INPP1 |
GlyGeni | P49441, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P49441 |
PhosphoSitePlusi | P49441 |
Genetic variation databases
BioMutai | INPP1 |
DMDMi | 1352464 |
Proteomic databases
EPDi | P49441 |
jPOSTi | P49441 |
MassIVEi | P49441 |
PaxDbi | P49441 |
PeptideAtlasi | P49441 |
PRIDEi | P49441 |
ProteomicsDBi | 56010 |
TopDownProteomicsi | P49441 |
Protocols and materials databases
Antibodypediai | 34038, 149 antibodies from 21 providers |
DNASUi | 3628 |
Genome annotation databases
Ensembli | ENST00000322522; ENSP00000325423; ENSG00000151689 ENST00000392329; ENSP00000376142; ENSG00000151689 |
GeneIDi | 3628 |
KEGGi | hsa:3628 |
MANE-Selecti | ENST00000392329.7; ENSP00000376142.2; NM_001128928.2; NP_001122400.1 |
Organism-specific databases
CTDi | 3628 |
DisGeNETi | 3628 |
GeneCardsi | INPP1 |
HGNCi | HGNC:6071, INPP1 |
HPAi | ENSG00000151689, Low tissue specificity |
MIMi | 147263, gene |
neXtProti | NX_P49441 |
OpenTargetsi | ENSG00000151689 |
PharmGKBi | PA29880 |
VEuPathDBi | HostDB:ENSG00000151689 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3099, Eukaryota |
GeneTreei | ENSGT00940000156785 |
HOGENOMi | CLU_043868_2_0_1 |
InParanoidi | P49441 |
OMAi | ANIARVC |
OrthoDBi | 1096950at2759 |
PhylomeDBi | P49441 |
TreeFami | TF314300 |
Enzyme and pathway databases
UniPathwayi | UPA00944 |
BRENDAi | 3.1.3.57, 2681 |
PathwayCommonsi | P49441 |
Reactomei | R-HSA-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
SignaLinki | P49441 |
Miscellaneous databases
BioGRID-ORCSi | 3628, 5 hits in 1044 CRISPR screens |
ChiTaRSi | INPP1, human |
GeneWikii | INPP1 |
GenomeRNAii | 3628 |
Pharosi | P49441, Tbio |
PROi | PR:P49441 |
RNActi | P49441, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151689, Expressed in sperm and 245 other tissues |
ExpressionAtlasi | P49441, baseline and differential |
Genevisiblei | P49441, HS |
Family and domain databases
Gene3Di | 4.10.460.10, 1 hit |
InterProi | View protein in InterPro IPR020583, Inositol_monoP_metal-BS IPR000760, Inositol_monophosphatase-like IPR020550, Inositol_monophosphatase_CS IPR044897, INPP1_dom_1 |
Pfami | View protein in Pfam PF00459, Inositol_P, 1 hit |
PROSITEi | View protein in PROSITE PS00629, IMP_1, 1 hit PS00630, IMP_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INPP_HUMAN | |
Accessioni | P49441Primary (citable) accession number: P49441 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families