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Protein

Alpha-aminoadipic semialdehyde dehydrogenase

Gene

ALDH7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.2 Publications

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Kineticsi

  1. KM=28.5 µM for nonanal1 Publication
  2. KM=5.3 µM for trans-2-nonenal1 Publication
  3. KM=39.1 µM for hexanal1 Publication
  4. KM=17.5 µM for octanal1 Publication
  5. KM=41.1 µM for betaine aldehyde1 Publication
  6. KM=169 µM for L-2-aminoadipate 6-semialdehyde1 Publication
  7. KM=530.2 µM for benzaldehyde1 Publication
  8. KM=647.4 µM for propanal1 Publication
  9. KM=7374.3 µM for glyceraldehyde1 Publication
  1. Vmax=364.9 nmol/min/mg enzyme toward nonanal1 Publication
  2. Vmax=34.9 nmol/min/mg enzyme toward trans-2-nonenal1 Publication
  3. Vmax=243.3 nmol/min/mg enzyme toward hexanal1 Publication
  4. Vmax=72.3 nmol/min/mg enzyme toward octanal1 Publication
  5. Vmax=101.4 nmol/min/mg enzyme toward betaine aldehyde1 Publication
  6. Vmax=276.2 nmol/min/mg enzyme toward L-2-aminoadipate 6-semialdehyde1 Publication
  7. Vmax=125.2 nmol/min/mg enzyme toward benzaldehyde1 Publication
  8. Vmax=69.9 nmol/min/mg enzyme toward propanal1 Publication
  9. Vmax=174 nmol/min/mg enzyme toward glyceraldehyde1 Publication

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei195Transition state stabilizerBy similarity1
Active sitei296Proton acceptorPROSITE-ProRule annotation1
Active sitei330Nucleophile1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi274 – 279NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:HS09157-MONOMER
BRENDAi1.2.1.31 2681
ReactomeiR-HSA-6798163 Choline catabolism
R-HSA-71064 Lysine catabolism
SABIO-RKiP49419
UniPathwayi
UPA00529;UER00386

Protein family/group databases

UniLectiniP49419

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-aminoadipic semialdehyde dehydrogenase (EC:1.2.1.31)
Short name:
Alpha-AASA dehydrogenase
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
Antiquitin-1
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Delta1-piperideine-6-carboxylate dehydrogenase
Short name:
P6c dehydrogenase
Gene namesi
Name:ALDH7A1
Synonyms:ATQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164904.15
HGNCiHGNC:877 ALDH7A1
MIMi107323 gene
neXtProtiNX_P49419

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Involvement in diseasei

Pyridoxine-dependent epilepsy (PDE)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride.
See also OMIM:266100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031718199A → V in PDE. 1 PublicationCorresponds to variant dbSNP:rs121912709EnsemblClinVar.1
Natural variantiVAR_069184202G → V in PDE. 1 Publication1
Natural variantiVAR_069185291G → E in PDE. 1 Publication1
Natural variantiVAR_069186301N → I in PDE. 1 PublicationCorresponds to variant dbSNP:rs121912711EnsemblClinVar.1
Natural variantiVAR_069187335R → Q in PDE. 1 PublicationCorresponds to variant dbSNP:rs754449549EnsemblClinVar.1
Natural variantiVAR_069188395V → G in PDE. 1 Publication1
Natural variantiVAR_031719427E → Q in PDE. 2 PublicationsCorresponds to variant dbSNP:rs121912707EnsemblClinVar.1
Natural variantiVAR_069189458S → N in PDE. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi501
GeneReviewsiALDH7A1
MalaCardsiALDH7A1
MIMi266100 phenotype
OpenTargetsiENSG00000164904
Orphaneti3006 Pyridoxine-dependent epilepsy
PharmGKBiPA24704

Chemistry databases

DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiALDH7A1
DMDMi294862544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000005649027 – 539Alpha-aminoadipic semialdehyde dehydrogenaseAdd BLAST513
Isoform 2 (identifier: P49419-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei462N6-acetyllysineBy similarity1
Modified residuei500N6-acetyllysineBy similarity1
Modified residuei537N6-succinyllysineBy similarity1
Isoform 2 (identifier: P49419-2)
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP49419
MaxQBiP49419
PaxDbiP49419
PeptideAtlasiP49419
PRIDEiP49419
ProteomicsDBi56006
56007 [P49419-2]

2D gel databases

UCD-2DPAGEiP49419

PTM databases

iPTMnetiP49419
PhosphoSitePlusiP49419
SwissPalmiP49419

Expressioni

Tissue specificityi

Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.2 Publications

Gene expression databases

BgeeiENSG00000164904 Expressed in 210 organ(s), highest expression level in right ovary
CleanExiHS_ALDH7A1
ExpressionAtlasiP49419 baseline and differential
GenevisibleiP49419 HS

Organism-specific databases

HPAiHPA023296

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EPS8Q129292EBI-726842,EBI-375576

Protein-protein interaction databases

BioGridi106990, 41 interactors
IntActiP49419, 15 interactors
MINTiP49419
STRINGi9606.ENSP00000387123

Structurei

Secondary structure

1539
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49419
SMRiP49419
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49419

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2453 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271511
HOVERGENiHBG050485
InParanoidiP49419
KOiK14085
OrthoDBiEOG091G058Y
PhylomeDBiP49419
TreeFamiTF300388

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 17 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P49419-1) [UniParc]FASTAAdd to basket
Also known as: hALDH7A1_v11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE
60 70 80 90 100
NEGVYNGSWG GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK
110 120 130 140 150
IWADIPAPKR GEIVRQIGDA LREKIQVLGS LVSLEMGKIL VEGVGEVQEY
160 170 180 190 200
VDICDYAVGL SRMIGGPILP SERSGHALIE QWNPVGLVGI ITAFNFPVAV
210 220 230 240 250
YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED NKLPGAICSL
260 270 280 290 300
TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN
310 320 330 340 350
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL
360 370 380 390 400
KKAYAQIRVG NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK
410 420 430 440 450
VMDRPGNYVE PTIVTGLGHD ASIAHTETFA PILYVFKFKN EEEVFAWNNE
460 470 480 490 500
VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI VNVNIPTSGA EIGGAFGGEK
510 520 530
HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ
Length:539
Mass (Da):58,487
Last modified:April 20, 2010 - v5
Checksum:i05385562F71312B6
GO
Isoform 2 (identifier: P49419-2) [UniParc]FASTAAdd to basket
Also known as: hALDH7A1_v21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:511
Mass (Da):55,366
Checksum:i08F6F7672C948E2C
GO
Isoform 4 (identifier: P49419-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-400: Missing.

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):51,411
Checksum:i6CE7B327556B0A90
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GW77A0A1B0GW77_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
554Annotation score:
A0A1B0GTJ4A0A1B0GTJ4_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
499Annotation score:
A0A1B0GW82A0A1B0GW82_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
545Annotation score:
A0A1B0GUA1A0A1B0GUA1_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
521Annotation score:
A0A1B0GV49A0A1B0GV49_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
472Annotation score:
A0A1B0GTG2A0A1B0GTG2_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
536Annotation score:
A0A1B0GUY0A0A1B0GUY0_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
348Annotation score:
F8WDY6F8WDY6_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
136Annotation score:
H0YHM6H0YHM6_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
239Annotation score:
F8VVF2F8VVF2_HUMAN
Alpha-aminoadipic semialdehyde dehy...
ALDH7A1
193Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAC51935 differs from that shown. Reason: Frameshift at positions 233 and 268.Curated
The sequence AAH02515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH71712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH73174 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG35366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58439 differs from that shown. Aberrant splicing.Curated
The sequence BAG59812 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236K → R in BAG59812 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031718199A → V in PDE. 1 PublicationCorresponds to variant dbSNP:rs121912709EnsemblClinVar.1
Natural variantiVAR_069184202G → V in PDE. 1 Publication1
Natural variantiVAR_069185291G → E in PDE. 1 Publication1
Natural variantiVAR_069186301N → I in PDE. 1 PublicationCorresponds to variant dbSNP:rs121912711EnsemblClinVar.1
Natural variantiVAR_069187335R → Q in PDE. 1 PublicationCorresponds to variant dbSNP:rs754449549EnsemblClinVar.1
Natural variantiVAR_069188395V → G in PDE. 1 Publication1
Natural variantiVAR_028202412T → A. Corresponds to variant dbSNP:rs2306618EnsemblClinVar.1
Natural variantiVAR_031719427E → Q in PDE. 2 PublicationsCorresponds to variant dbSNP:rs121912707EnsemblClinVar.1
Natural variantiVAR_028203439K → Q1 PublicationCorresponds to variant dbSNP:rs12514417EnsemblClinVar.1
Natural variantiVAR_069189458S → N in PDE. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0389871 – 28Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_045905337 – 400Missing in isoform 4. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74728 mRNA Translation: AAB31966.1
AK312459 mRNA Translation: BAG35366.1 Different initiation.
AK295526 mRNA Translation: BAG58439.1 Sequence problems.
AK297365 mRNA Translation: BAG59812.1 Different initiation.
AC093535 Genomic DNA No translation available.
AC099513 Genomic DNA No translation available.
BC002515 mRNA Translation: AAH02515.3 Different initiation.
BC071712 mRNA Translation: AAH71712.1 Different initiation.
BC073174 mRNA Translation: AAH73174.1 Different initiation.
AF002696 Genomic DNA Translation: AAC51935.1 Sequence problems.
CCDSiCCDS4137.2 [P49419-1]
CCDS56380.2 [P49419-4]
PIRiA54676
RefSeqiNP_001173.2, NM_001182.4 [P49419-1]
NP_001188306.1, NM_001201377.1 [P49419-2]
NP_001189333.2, NM_001202404.1 [P49419-4]
UniGeneiHs.483239

Genome annotation databases

EnsembliENST00000409134; ENSP00000387123; ENSG00000164904 [P49419-1]
ENST00000553117; ENSP00000448593; ENSG00000164904 [P49419-4]
GeneIDi501
KEGGihsa:501
UCSCiuc003ktx.5 human [P49419-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74728 mRNA Translation: AAB31966.1
AK312459 mRNA Translation: BAG35366.1 Different initiation.
AK295526 mRNA Translation: BAG58439.1 Sequence problems.
AK297365 mRNA Translation: BAG59812.1 Different initiation.
AC093535 Genomic DNA No translation available.
AC099513 Genomic DNA No translation available.
BC002515 mRNA Translation: AAH02515.3 Different initiation.
BC071712 mRNA Translation: AAH71712.1 Different initiation.
BC073174 mRNA Translation: AAH73174.1 Different initiation.
AF002696 Genomic DNA Translation: AAC51935.1 Sequence problems.
CCDSiCCDS4137.2 [P49419-1]
CCDS56380.2 [P49419-4]
PIRiA54676
RefSeqiNP_001173.2, NM_001182.4 [P49419-1]
NP_001188306.1, NM_001201377.1 [P49419-2]
NP_001189333.2, NM_001202404.1 [P49419-4]
UniGeneiHs.483239

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J6LX-ray1.30A/B/C/D/E/F/G/H30-527[»]
4X0TX-ray2.40A/B/C/D29-539[»]
4X0UX-ray1.95A/B/C/D29-539[»]
4ZUKX-ray2.00A/B/C/D/E/F/G/H29-539[»]
4ZULX-ray1.76A/B/C/D/E/F/G/H29-539[»]
4ZVWX-ray2.40A/B/C/D/E/F/G/H29-539[»]
4ZVXX-ray1.90A/B29-539[»]
4ZVYX-ray1.90A/B29-539[»]
ProteinModelPortaliP49419
SMRiP49419
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106990, 41 interactors
IntActiP49419, 15 interactors
MINTiP49419
STRINGi9606.ENSP00000387123

Chemistry databases

DrugBankiDB00157 NADH

Protein family/group databases

UniLectiniP49419

PTM databases

iPTMnetiP49419
PhosphoSitePlusiP49419
SwissPalmiP49419

Polymorphism and mutation databases

BioMutaiALDH7A1
DMDMi294862544

2D gel databases

UCD-2DPAGEiP49419

Proteomic databases

EPDiP49419
MaxQBiP49419
PaxDbiP49419
PeptideAtlasiP49419
PRIDEiP49419
ProteomicsDBi56006
56007 [P49419-2]

Protocols and materials databases

DNASUi501
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409134; ENSP00000387123; ENSG00000164904 [P49419-1]
ENST00000553117; ENSP00000448593; ENSG00000164904 [P49419-4]
GeneIDi501
KEGGihsa:501
UCSCiuc003ktx.5 human [P49419-1]

Organism-specific databases

CTDi501
DisGeNETi501
EuPathDBiHostDB:ENSG00000164904.15
GeneCardsiALDH7A1
GeneReviewsiALDH7A1
HGNCiHGNC:877 ALDH7A1
HPAiHPA023296
MalaCardsiALDH7A1
MIMi107323 gene
266100 phenotype
neXtProtiNX_P49419
OpenTargetsiENSG00000164904
Orphaneti3006 Pyridoxine-dependent epilepsy
PharmGKBiPA24704
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2453 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271511
HOVERGENiHBG050485
InParanoidiP49419
KOiK14085
OrthoDBiEOG091G058Y
PhylomeDBiP49419
TreeFamiTF300388

Enzyme and pathway databases

UniPathwayi
UPA00529;UER00386

BioCyciMetaCyc:HS09157-MONOMER
BRENDAi1.2.1.31 2681
ReactomeiR-HSA-6798163 Choline catabolism
R-HSA-71064 Lysine catabolism
SABIO-RKiP49419

Miscellaneous databases

ChiTaRSiALDH7A1 human
EvolutionaryTraceiP49419
GeneWikiiALDH7A1
GenomeRNAii501
PROiPR:P49419
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164904 Expressed in 210 organ(s), highest expression level in right ovary
CleanExiHS_ALDH7A1
ExpressionAtlasiP49419 baseline and differential
GenevisibleiP49419 HS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAL7A1_HUMAN
AccessioniPrimary (citable) accession number: P49419
Secondary accession number(s): B2R669
, B4DIC7, B4DMA0, E7EPT3, O14619, Q6IPU8, Q9BUL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 187 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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