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Protein

Amphiphysin

Gene

AMPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.

Miscellaneous

Antibodies against AMPH are detected in patients with stiff-man syndrome, a rare disease of the central nervous system characterized by progressive rigidity of the body musculature with superimposed painful spasms.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phospholipid binding Source: FlyBase

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • endocytosis Source: ProtInc
  • membrane organization Source: Reactome
  • synaptic vesicle endocytosis Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

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SIGNORi
P49418

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amphiphysin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMPH
Synonyms:AMPH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078053.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:471 AMPH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600418 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49418

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
273

Open Targets

More...
OpenTargetsi
ENSG00000078053

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24779

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMPH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351924

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001929471 – 695AmphiphysinAdd BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei252PhosphoserineBy similarity1
Modified residuei260PhosphothreonineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei280PhosphothreonineBy similarity1
Modified residuei506PhosphoserineBy similarity1
Modified residuei638PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49418

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49418

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49418

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49418

PeptideAtlas

More...
PeptideAtlasi
P49418

PRoteomics IDEntifications database

More...
PRIDEi
P49418

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56004
56005 [P49418-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49418

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49418

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P49418

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neurons, certain endocrine cell types and spermatocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078053 Expressed in 159 organ(s), highest expression level in middle temporal gyrus

CleanEx database of gene expression profiles

More...
CleanExi
HS_AMPH

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49418 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49418 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008559
HPA019828
HPA019829

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with BIN1 (By similarity). Binds SH3GLB1 (By similarity). Interacts with REPS1 and SGIP1(PubMed:20946875). Binds AP2A2 (PubMed:12057195). Interacts with AP2B1 (PubMed:16903783). Interacts with DNM1 AND SYNJ1 (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106770, 50 interactors

Database of interacting proteins

More...
DIPi
DIP-40729N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P49418

Protein interaction database and analysis system

More...
IntActi
P49418, 14 interactors

Molecular INTeraction database

More...
MINTi
P49418

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KY7X-ray2.15P322-330[»]
1UTCX-ray2.30P/Q379-387[»]
3SOGX-ray2.30A34-236[»]
4ATMX-ray1.78A1-242[»]
5M5SX-ray1.88E/F/G/H349-358[»]
5M61X-ray1.84E/F/G/H349-360[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P49418

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49418

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49418

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 240BARPROSITE-ProRule annotationAdd BLAST217
Domaini622 – 695SH3PROSITE-ProRule annotationAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili10 – 83Sequence analysisAdd BLAST74
Coiled coili144 – 191Sequence analysisAdd BLAST48

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3771 Eukaryota
ENOG410ZBW1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153828

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004224

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49418

KEGG Orthology (KO)

More...
KOi
K12562

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFAETQG

Database of Orthologous Groups

More...
OrthoDBi
1366218at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49418

TreeFam database of animal gene trees

More...
TreeFami
TF313542

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12140 SH3_Amphiphysin_I, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR003017 Amphiphysin_1
IPR035470 Amphiphysin_I_SH3
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR44669 PTHR44669, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01251 AMPHIPHYSIN
PR01252 AMPHIPHYSIN1
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49418-1) [UniParc]FASTAAdd to basket
Also known as: 128 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE
60 70 80 90 100
AEGTRLQREL RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE
110 120 130 140 150
KCDVLWEDFH QKLVDGSLLT LDTYLGQFPD IKNRIAKRSR KLVDYDSARH
160 170 180 190 200
HLEALQSSKR KDESRISKAE EEFQKAQKVF EEFNVDLQEE LPSLWSRRVG
210 220 230 240 250
FYVNTFKNVS SLEAKFHKEI AVLCHKLYEV MTKLGDQHAD KAFTIQGAPS
260 270 280 290 300
DSGPLRIAKT PSPPEEPSPL PSPTASPNHT LAPASPAPAR PRSPSQTRKG
310 320 330 340 350
PPVPPLPKVT PTKELQQENI ISFFEDNFVP EISVTTPSQN EVPEVKKEET
360 370 380 390 400
LLDLDFDPFK PEVTPAGSAG VTHSPMSQTL PWDLWTTSTD LVQPASGGSF
410 420 430 440 450
NGFTQPQDTS LFTMQTDQSM ICNLAESEQA PPTEPKAEEP LAAVTPAVGL
460 470 480 490 500
DLGMDTRAEE PVEEAVIIPG ADADAAVGTL VSAAEGAPGE EAEAEKATVP
510 520 530 540 550
AGEGVSLEEA KIGTETTEGA ESAQPEAEEL EATVPQEKVI PSVVIEPASN
560 570 580 590 600
HEEEGENEIT IGAEPKETTE DAAPPGPTSE TPELATEQKP IQDPQPTPSA
610 620 630 640 650
PAMGAADQLA SAREASQELP PGFLYKVETL HDFEAANSDE LTLQRGDVVL
660 670 680 690
VVPSDSEADQ DAGWLVGVKE SDWLQYRDLA TYKGLFPENF TRRLD
Length:695
Mass (Da):76,257
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78B4F75AB75BA357
GO
Isoform 2 (identifier: P49418-2) [UniParc]FASTAAdd to basket
Also known as: 108 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     425-466: Missing.

Show »
Length:653
Mass (Da):71,929
Checksum:i44C1115E3E70B6A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7T8H0Y7T8_HUMAN
Amphiphysin
AMPH
578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5S4H0Y5S4_HUMAN
Amphiphysin
AMPH
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053004218K → E. Corresponds to variant dbSNP:rs35166354Ensembl.1
Natural variantiVAR_053005376M → I. Corresponds to variant dbSNP:rs17171345Ensembl.1
Natural variantiVAR_053006496K → T1 PublicationCorresponds to variant dbSNP:rs35024632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000245425 – 466Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07616 mRNA Translation: AAA21865.1
X81438 mRNA Translation: CAA57197.1
AF034996 mRNA Translation: AAC02977.1
AC011309 Genomic DNA Translation: AAS07391.1
AC012490 Genomic DNA Translation: AAS07563.1
AC007245 Genomic DNA Translation: AAS07541.1
CH236951 Genomic DNA Translation: EAL23989.1
CH236951 Genomic DNA Translation: EAL23990.1
CH471073 Genomic DNA Translation: EAW94110.1
CH471073 Genomic DNA Translation: EAW94111.1
BC034376 mRNA Translation: AAH34376.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47574.1 [P49418-2]
CCDS5456.1 [P49418-1]

Protein sequence database of the Protein Information Resource

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PIRi
S62400

NCBI Reference Sequences

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RefSeqi
NP_001626.1, NM_001635.3 [P49418-1]
NP_647477.1, NM_139316.2 [P49418-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.592182

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325590; ENSP00000317441; ENSG00000078053 [P49418-2]
ENST00000356264; ENSP00000348602; ENSG00000078053 [P49418-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:273

UCSC genome browser

More...
UCSCi
uc003tgu.4 human [P49418-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07616 mRNA Translation: AAA21865.1
X81438 mRNA Translation: CAA57197.1
AF034996 mRNA Translation: AAC02977.1
AC011309 Genomic DNA Translation: AAS07391.1
AC012490 Genomic DNA Translation: AAS07563.1
AC007245 Genomic DNA Translation: AAS07541.1
CH236951 Genomic DNA Translation: EAL23989.1
CH236951 Genomic DNA Translation: EAL23990.1
CH471073 Genomic DNA Translation: EAW94110.1
CH471073 Genomic DNA Translation: EAW94111.1
BC034376 mRNA Translation: AAH34376.1
CCDSiCCDS47574.1 [P49418-2]
CCDS5456.1 [P49418-1]
PIRiS62400
RefSeqiNP_001626.1, NM_001635.3 [P49418-1]
NP_647477.1, NM_139316.2 [P49418-2]
UniGeneiHs.592182

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KY7X-ray2.15P322-330[»]
1UTCX-ray2.30P/Q379-387[»]
3SOGX-ray2.30A34-236[»]
4ATMX-ray1.78A1-242[»]
5M5SX-ray1.88E/F/G/H349-358[»]
5M61X-ray1.84E/F/G/H349-360[»]
ProteinModelPortaliP49418
SMRiP49418
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106770, 50 interactors
DIPiDIP-40729N
ELMiP49418
IntActiP49418, 14 interactors
MINTiP49418
STRINGi9606.ENSP00000348602

PTM databases

iPTMnetiP49418
PhosphoSitePlusiP49418

Polymorphism and mutation databases

BioMutaiAMPH
DMDMi1351924

Proteomic databases

EPDiP49418
jPOSTiP49418
MaxQBiP49418
PaxDbiP49418
PeptideAtlasiP49418
PRIDEiP49418
ProteomicsDBi56004
56005 [P49418-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
273
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325590; ENSP00000317441; ENSG00000078053 [P49418-2]
ENST00000356264; ENSP00000348602; ENSG00000078053 [P49418-1]
GeneIDi273
KEGGihsa:273
UCSCiuc003tgu.4 human [P49418-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
273
DisGeNETi273
EuPathDBiHostDB:ENSG00000078053.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMPH
HGNCiHGNC:471 AMPH
HPAiCAB008559
HPA019828
HPA019829
MIMi600418 gene
neXtProtiNX_P49418
OpenTargetsiENSG00000078053
PharmGKBiPA24779

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3771 Eukaryota
ENOG410ZBW1 LUCA
GeneTreeiENSGT00940000153828
HOVERGENiHBG004224
InParanoidiP49418
KOiK12562
OMAiPFAETQG
OrthoDBi1366218at2759
PhylomeDBiP49418
TreeFamiTF313542

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiP49418

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AMPH human
EvolutionaryTraceiP49418

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Amphiphysin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
273
PMAP-CutDBiP49418

Protein Ontology

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PROi
PR:P49418

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078053 Expressed in 159 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_AMPH
ExpressionAtlasiP49418 baseline and differential
GenevisibleiP49418 HS

Family and domain databases

CDDicd12140 SH3_Amphiphysin_I, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR003017 Amphiphysin_1
IPR035470 Amphiphysin_I_SH3
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR44669 PTHR44669, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR01251 AMPHIPHYSIN
PR01252 AMPHIPHYSIN1
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49418
Secondary accession number(s): A4D1X8
, A4D1X9, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 16, 2019
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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