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Entry version 118 (25 May 2022)
Sequence version 2 (01 May 2007)
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Protein

Positive regulator of purine utilization

Gene

uaY

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the induction of a number of unlinked genes involved in purine utilization. Binds to the consensus sequence 5'-TCGGNNNNNNCCGA-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi67 – 94Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Positive regulator of purine utilization
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uaY
ORF Names:AN0891
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:AN0891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149851 – 1060Positive regulator of purine utilizationAdd BLAST1060

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00001766

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P49413

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49413

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni163 – 207DisorderedSequence analysisAdd BLAST45
Regioni251 – 282DisorderedSequence analysisAdd BLAST32
Regioni367 – 391DisorderedSequence analysisAdd BLAST25
Regioni811 – 862DisorderedSequence analysisAdd BLAST52
Regioni876 – 969DisorderedSequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 48Polar residuesSequence analysisAdd BLAST16
Compositional biasi172 – 207Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi367 – 382Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi811 – 852Polar residuesSequence analysisAdd BLAST42
Compositional biasi892 – 906Polar residuesSequence analysisAdd BLAST15
Compositional biasi928 – 947Polar residuesSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR1M, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004517_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49413

Identification of Orthologs from Complete Genome Data

More...
OMAi
WCVYSFD

Database of Orthologous Groups

More...
OrthoDBi
545687at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067, GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701, SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNPSTSDIH TSPTAVGNGR KRPHPIADSG SAMPSDPSAQ QLPHPANESA
60 70 80 90 100
AIPSIASSSS FRNVSACNRC RQRKNRCDQR LPRCQACEKA GVRCVGYDPI
110 120 130 140 150
TKREIPRSYV YFLESRVAYL EKVLMDNGIE YNEAVAFDEE EAVKIEAGYE
160 170 180 190 200
AYAGSANGPA AGEIAAQDGS NDKSVRIKKE KNGPLGLEKA SRYDHDPEVK
210 220 230 240 250
QDSDAEDGWR IQNLVSNIGM VSVQGTSDPR YLGSTSGISF ARVVFAAVKS
260 270 280 290 300
SVPGNSSERG PSRPKERLPH SATGTEGSTT RDSFFGLQTR PMMKCAAFPD
310 320 330 340 350
RELAERLADL YFEHANPQIP IVHRVDFMEL LDRTYSVDEK SRSPRSLYFL
360 370 380 390 400
NIVFAIGSGI IFEDKPAEDQ KEGRDHSPSA TKRQRLSSRQ YQPEEYHASA
410 420 430 440 450
IVHLESFLST SPTTDGFGAL EELQAVLLLA SFALLRPVAP GLWYIVGVAM
460 470 480 490 500
RLAVDLGLHY EDGAGIDGPE NDNMNRTNNK DGEKAKLRID DHERGRREWV
510 520 530 540 550
RDFRRRLWWC CYSFDRLVSC CVGRPFGISD QAISTEFPSI LEDKYITKSG
560 570 580 590 600
IIKAPEGAPS YKHSAFHYFK LRVLQSEIQD VLQHQQARFA RQRGPPGARS
610 620 630 640 650
FMRLDVVSPF LQGFDSFRSW RRDVDRRLLE WKNSAPMPSE NGVRFPLEFL
660 670 680 690 700
ELNYWQAVIM LYQQSLTVPA ELADELSPAE DVSSPSFSQV EEDEHDIYYK
710 720 730 740 750
VAEAGQKVIR IYRQMHRVRL VNYTYLATHH IFMAGISFLY AIWHSPYVRS
760 770 780 790 800
RLTLDEVDFT VLAATSVLRD LMHKCPPAEA CRDAFERMSK ATVEMSLSTT
810 820 830 840 850
GFGPQVELNR VQTSTSGSRQ FNATQSRSRP YSRQQAEQRQ RQSASRRQLQ
860 870 880 890 900
MRQSRPLPRF DMNLEDLFGD NRAVAERQGS GGMGKLAQPY PVSETSDPNF
910 920 930 940 950
ARPQSHRNPS MEYYGPFENP VSPQQPQPQP RYYYNNSPQQ SGSPGSVVAA
960 970 980 990 1000
SGIPPYQVTP TEQENPSGMG LDYLDYDPTG IERQLSLGSE ENSDFKFQGG
1010 1020 1030 1040 1050
AQSLGHGAGH NFGIDLGFGM AVDFQHDWSE NANYDLLEGY FFGGAGATGP
1060
GHGHGHGSGI
Length:1,060
Mass (Da):118,391
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ED64081BC4EAA8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449A → R in CAA58838 (PubMed:7729421).Curated1
Sequence conflicti476R → A in CAA58838 (PubMed:7729421).Curated1
Sequence conflicti497R → A in CAA58838 (PubMed:7729421).Curated1
Sequence conflicti984 – 985QL → HV in CAA58838 (PubMed:7729421).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X84015 Genomic DNA Translation: CAA58838.1
AACD01000014 Genomic DNA Translation: EAA65920.1
BN001308 Genomic DNA Translation: CBF88580.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54779

NCBI Reference Sequences

More...
RefSeqi
XP_658495.1, XM_653403.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF88580; CBF88580; ANIA_00891
EAA65920; EAA65920; AN0891.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2876671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN0891.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84015 Genomic DNA Translation: CAA58838.1
AACD01000014 Genomic DNA Translation: EAA65920.1
BN001308 Genomic DNA Translation: CBF88580.1
PIRiS54779
RefSeqiXP_658495.1, XM_653403.1

3D structure databases

AlphaFoldDBiP49413
SMRiP49413
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001766

Genome annotation databases

EnsemblFungiiCBF88580; CBF88580; ANIA_00891
EAA65920; EAA65920; AN0891.2
GeneIDi2876671
KEGGiani:AN0891.2

Organism-specific databases

VEuPathDBiFungiDB:AN0891

Phylogenomic databases

eggNOGiENOG502QR1M, Eukaryota
HOGENOMiCLU_004517_0_0_1
InParanoidiP49413
OMAiWCVYSFD
OrthoDBi545687at2759

Family and domain databases

CDDicd00067, GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219, Transcription_factor_dom_fun
IPR001138, Zn2-C6_fun-type_DNA-bd
IPR036864, Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082, Fungal_trans, 1 hit
PF00172, Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906, Fungal_trans, 1 hit
SM00066, GAL4, 1 hit
SUPFAMiSSF57701, SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463, ZN2_CY6_FUNGAL_1, 1 hit
PS50048, ZN2_CY6_FUNGAL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUAY_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49413
Secondary accession number(s): C8VUT2, Q5BEY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 1, 2007
Last modified: May 25, 2022
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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