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UniProtKB - P49411 (EFTU_HUMAN)

Entry version 220 (29 Sep 2021)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
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Protein

Elongation factor Tu, mitochondrial

Gene

TUFM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi64 – 71GTPBy similarity8
Nucleotide bindingi126 – 130GTPBy similarity5
Nucleotide bindingi181 – 184GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor
Biological processHost-virus interaction, Protein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49411

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5389840, Mitochondrial translation elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49411

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation factor Tu, mitochondrial
Short name:
EF-Tu
Alternative name(s):
P43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUFM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12420, TUFM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602389, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49411

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 4 (COXPD4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031902336R → Q in COXPD4. 1 Publication1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		7284

MalaCards human disease database

More...MalaCardsi		TUFM
MIMi610678, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		254925, Combined oxidative phosphorylation defect type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37082

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49411, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105970

Drug and drug target database

More...DrugBanki		DB04315, Guanosine-5'-Diphosphate
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TUFM

Domain mapping of disease mutations (DMDM)

More...DMDMi		1706611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 43Mitochondrion2 PublicationsAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000746244 – 452Elongation factor Tu, mitochondrialAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79N6-acetyllysineCombined sources1
Modified residuei88N6-acetyllysine; alternateCombined sources1
Modified residuei88N6-succinyllysine; alternateBy similarity1
Modified residuei234N6-succinyllysineBy similarity1
Modified residuei256N6-acetyllysineCombined sources1
Modified residuei278PhosphothreonineCombined sources1
Modified residuei286N6-succinyllysineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei361N6-acetyllysineBy similarity1
Modified residuei418N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49411

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49411

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49411

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49411

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49411

PeptideAtlas

More...PeptideAtlasi		P49411

PRoteomics IDEntifications database

More...PRIDEi		P49411

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56003

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P49411

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P49411

USC-OGP 2-DE database

More...OGPi		P49411

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00027107

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P49411

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P49411

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P49411

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49411, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49411

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P49411

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49411

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P49411

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178952, Expressed in testis and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49411, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49411, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178952, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NLRX1 (PubMed:22749352).

Interacts with ATG16L1 (PubMed:22749352).

1 Publication

(Microbial infection) Interacts with human parainfluenza virus 3 matrix protein; this interaction inhibits RLR-mediated type I interferon production while promoting autophagy.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113135, 537 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P49411

Protein interaction database and analysis system

More...IntActi		P49411, 111 interactors

Molecular INTeraction database

More...MINTi		P49411

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000322439

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49411, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49411

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 251tr-type GPROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 71G1PROSITE-ProRule annotation8
Regioni105 – 109G2PROSITE-ProRule annotation5
Regioni126 – 129G3PROSITE-ProRule annotation4
Regioni181 – 184G4PROSITE-ProRule annotation4
Regioni219 – 221G5PROSITE-ProRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0460, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007265_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49411

Database of Orthologous Groups

More...OrthoDBi		491836at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49411

TreeFam database of animal gene trees

More...TreeFami		TF300432

Family and domain databases

Conserved Domains Database

More...CDDi		cd01884, EF_Tu, 1 hit
cd03697, EFTU_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041709, EF-Tu_GTP-bd
IPR004161, EFTu-like_2
IPR033720, EFTU_2
IPR031157, G_TR_CS
IPR027417, P-loop_NTPase
IPR000795, T_Tr_GTP-bd_dom
IPR009000, Transl_B-barrel_sf
IPR009001, Transl_elong_EF1A/Init_IF2_C
IPR004541, Transl_elong_EFTu/EF1A_bac/org
IPR004160, Transl_elong_EFTu/EF1A_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF03144, GTP_EFTU_D2, 1 hit
PF03143, GTP_EFTU_D3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00315, ELONGATNFCT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50447, SSF50447, 1 hit
SSF50465, SSF50465, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00485, EF-Tu, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00301, G_TR_1, 1 hit
PS51722, G_TR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49411-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATLLRAT PHFSGLAAGR TFLLQGLLRL LKAPALPLLC RGLAVEAKKT 
        60         70         80         90        100
YVRDKPHVNV GTIGHVDHGK TTLTAAITKI LAEGGGAKFK KYEEIDNAPE 
       110        120        130        140        150
ERARGITINA AHVEYSTAAR HYAHTDCPGH ADYVKNMITG TAPLDGCILV 
       160        170        180        190        200
VAANDGPMPQ TREHLLLARQ IGVEHVVVYV NKADAVQDSE MVELVELEIR 
       210        220        230        240        250
ELLTEFGYKG EETPVIVGSA LCALEGRDPE LGLKSVQKLL DAVDTYIPVP 
       260        270        280        290        300
ARDLEKPFLL PVEAVYSVPG RGTVVTGTLE RGILKKGDEC ELLGHSKNIR 
       310        320        330        340        350
TVVTGIEMFH KSLERAEAGD NLGALVRGLK REDLRRGLVM VKPGSIKPHQ 
       360        370        380        390        400
KVEAQVYILS KEEGGRHKPF VSHFMPVMFS LTWDMACRII LPPEKELAMP 
       410        420        430        440        450
GEDLKFNLIL RQPMILEKGQ RFTLRDGNRT IGTGLVTNTL AMTEEEKNIK 

WG
Length:452
Mass (Da):49,542
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE37274ABFFDB5FC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNU3H3BNU3_HUMAN
Elongation factor Tu, mitochondrial
TUFM
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC60647 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01633 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10041 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195 – 197Missing in AAC60647 (PubMed:7828719).Curated3
Sequence conflicti384D → N in AAB00499 (PubMed:8547323).Curated1
Sequence conflicti384D → N in CAA72493 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031902336R → Q in COXPD4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L38995 mRNA Translation: AAB00499.1
S75463 mRNA Translation: AAC60647.1 Different initiation.
X84694 mRNA Translation: CAA59169.1
AC133550 Genomic DNA No translation available.
BC001633 mRNA Translation: AAH01633.2 Different initiation.
BC010041 mRNA Translation: AAH10041.2 Different initiation.
Y11797 Genomic DNA Translation: CAA72493.1

Protein sequence database of the Protein Information Resource

More...PIRi		S62767
S68466

NCBI Reference Sequences

More...RefSeqi		NP_003312.3, NM_003321.4
XP_016879108.1, XM_017023619.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313511; ENSP00000322439; ENSG00000178952

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7284

UCSC genome browser

More...UCSCi		uc002drh.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38995 mRNA Translation: AAB00499.1
S75463 mRNA Translation: AAC60647.1 Different initiation.
X84694 mRNA Translation: CAA59169.1
AC133550 Genomic DNA No translation available.
BC001633 mRNA Translation: AAH01633.2 Different initiation.
BC010041 mRNA Translation: AAH10041.2 Different initiation.
Y11797 Genomic DNA Translation: CAA72493.1
PIRiS62767
S68466
RefSeqiNP_003312.3, NM_003321.4
XP_016879108.1, XM_017023619.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7A5Gelectron microscopy4.33Z1-452[»]
7O9Kelectron microscopy3.10t1-452[»]
SMRiP49411
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113135, 537 interactors
CORUMiP49411
IntActiP49411, 111 interactors
MINTiP49411
STRINGi9606.ENSP00000322439

Chemistry databases

ChEMBLiCHEMBL4105970
DrugBankiDB04315, Guanosine-5'-Diphosphate
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

PTM databases

CarbonylDBiP49411
GlyGeniP49411, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiP49411
MetOSiteiP49411
PhosphoSitePlusiP49411
SwissPalmiP49411

Genetic variation databases

BioMutaiTUFM
DMDMi1706611

2D gel databases

DOSAC-COBS-2DPAGEiP49411
OGPiP49411
REPRODUCTION-2DPAGEiIPI00027107
SWISS-2DPAGEiP49411
UCD-2DPAGEiP49411

Proteomic databases

EPDiP49411
jPOSTiP49411
MassIVEiP49411
MaxQBiP49411
PaxDbiP49411
PeptideAtlasiP49411
PRIDEiP49411
ProteomicsDBi56003
TopDownProteomicsiP49411

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P49411, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13151, 315 antibodies

The DNASU plasmid repository

More...DNASUi		7284

Genome annotation databases

EnsembliENST00000313511; ENSP00000322439; ENSG00000178952
GeneIDi7284
KEGGihsa:7284
UCSCiuc002drh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7284
DisGeNETi7284

GeneCards: human genes, protein and diseases

More...GeneCardsi		TUFM
HGNCiHGNC:12420, TUFM
HPAiENSG00000178952, Low tissue specificity
MalaCardsiTUFM
MIMi602389, gene
610678, phenotype
neXtProtiNX_P49411
Orphaneti254925, Combined oxidative phosphorylation defect type 4
PharmGKBiPA37082
VEuPathDBiHostDB:ENSG00000178952

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0460, Eukaryota
HOGENOMiCLU_007265_0_0_1
InParanoidiP49411
OrthoDBi491836at2759
PhylomeDBiP49411
TreeFamiTF300432

Enzyme and pathway databases

PathwayCommonsiP49411
ReactomeiR-HSA-5389840, Mitochondrial translation elongation
SignaLinkiP49411

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7284, 238 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TUFM, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TUFM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7284
PharosiP49411, Tbio

Protein Ontology

More...PROi		PR:P49411
RNActiP49411, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000178952, Expressed in testis and 135 other tissues
ExpressionAtlasiP49411, baseline and differential
GenevisibleiP49411, HS

Family and domain databases

CDDicd01884, EF_Tu, 1 hit
cd03697, EFTU_II, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR041709, EF-Tu_GTP-bd
IPR004161, EFTu-like_2
IPR033720, EFTU_2
IPR031157, G_TR_CS
IPR027417, P-loop_NTPase
IPR000795, T_Tr_GTP-bd_dom
IPR009000, Transl_B-barrel_sf
IPR009001, Transl_elong_EF1A/Init_IF2_C
IPR004541, Transl_elong_EFTu/EF1A_bac/org
IPR004160, Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009, GTP_EFTU, 1 hit
PF03144, GTP_EFTU_D2, 1 hit
PF03143, GTP_EFTU_D3, 1 hit
PRINTSiPR00315, ELONGATNFCT
SUPFAMiSSF50447, SSF50447, 1 hit
SSF50465, SSF50465, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00485, EF-Tu, 1 hit
PROSITEiView protein in PROSITE
PS00301, G_TR_1, 1 hit
PS51722, G_TR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFTU_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49411
Secondary accession number(s): O15276
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 220 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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