Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 3, mitochondrial

Gene

ADH3

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi93Zinc 1; catalyticBy similarity1
Metal bindingi124Zinc 2By similarity1
Metal bindingi127Zinc 2By similarity1
Metal bindingi130Zinc 2By similarity1
Metal bindingi138Zinc 2By similarity1
Metal bindingi180Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei367NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 210NADBy similarity7
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.2 2825
SABIO-RKiP49384

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3, mitochondrial (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
Gene namesi
Name:ADH3
Ordered Locus Names:KLLA0B09064g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000000087727 – 374Alcohol dehydrogenase 3, mitochondrialAdd BLAST348

Proteomic databases

PRIDEiP49384

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_451932.1

Structurei

3D structure databases

ProteinModelPortaliP49384
SMRiP49384
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0023 Eukaryota
COG1064 LUCA
HOGENOMiHOG000294685
InParanoidiP49384
KOiK13953
OMAiINANHLM
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLTSARSI VSPLRKGAFG SIRTLATSVP ETQKGVIFYE NGGKLEYKDI
60 70 80 90 100
PVPKPKPNEI LINVKYSGVC HTDLHAWKGD WPLPTKLPLV GGHEGAGVVV
110 120 130 140 150
AMGENVKGWN IGDFAGIKWL NGSCMSCEYC ELSNESNCPD ADLSGYTHDG
160 170 180 190 200
SFQQYATADA VQAARIPKGT DLAEVAPILC AGVTVYKALK SANLKAGDWV
210 220 230 240 250
AISGAAGGLG SLAVQYAKAM GYRVVGIDGG EEKGKLVKQL GGEAFVDFTK
260 270 280 290 300
TKDMVAEIQE ITNGGPHGVI NVSVSEAAMN ASTQFVRPTG TVVLVGLPAG
310 320 330 340 350
AVIKSEVFSH VVKSINIKGS YVGNRADTRE AINFFANGHV HSPIKVVGLS
360 370
ELPKVYELME QGKILGRYVV DTSN
Length:374
Mass (Da):39,609
Last modified:August 31, 2004 - v2
Checksum:iB6F932FDCF4163EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → R in CAA44613 (PubMed:1872030).Curated1
Sequence conflicti178I → T in CAA44613 (PubMed:1872030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62766 Genomic DNA Translation: CAA44613.1
CR382122 Genomic DNA Translation: CAH02325.1
PIRiS17252
RefSeqiXP_451932.1, XM_451932.1

Genome annotation databases

EnsemblFungiiCAH02325; CAH02325; KLLA0_B09064g
GeneIDi2897174
KEGGikla:KLLA0B09064g

Similar proteinsi

Entry informationi

Entry nameiADH3_KLULA
AccessioniPrimary (citable) accession number: P49384
Secondary accession number(s): Q6CVV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health