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Entry version 196 (07 Oct 2020)
Sequence version 1 (01 Feb 1996)
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Protein

Deoxyhypusine synthase

Gene

DHPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei137NAD1 Publication1
Binding sitei238NAD1 Publication1
Binding sitei243SpermidineCurated1
Binding sitei283NAD; via amide nitrogen1 Publication1
Binding sitei288SpermidineCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei329Nucleophile1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi105 – 109NAD1 Publication5
Nucleotide bindingi131 – 133NAD1 Publication3
Nucleotide bindingi308 – 309NAD1 Publication2
Nucleotide bindingi342 – 343NAD1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHypusine biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS01810-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.46, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P49366

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204626, Hypusine synthesis from eIF5A-lysine

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P49366

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00354

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyhypusine synthase (EC:2.5.1.461 Publication)
Short name:
DHS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHPS
Synonyms:DS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000095059.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2869, DHPS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600944, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49366

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with seizures and speech and walking impairment (NEDSSWI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by global developmental delay with intellectual disability and poor speech acquisition, and walking difficulties due to hypotonia, hypertonia, spasticity, or poor coordination. Additional features include seizures, mild dysmorphic features, and variable short stature.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082649173N → S in NEDSSWI; decreased deoxyhypusine synthase activity. 1 PublicationCorresponds to variant dbSNP:rs758100382EnsemblClinVar.1
Natural variantiVAR_082650305 – 306Missing in NEDSSWI; loss of deoxyhypusine synthase activity. 1 Publication2

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106N → A: Strongly reduced NAD and spermidine binding. Reduced activity. 1 Publication1
Mutagenesisi109S → A: Strongly reduced spermidine binding. Reduced activity. 1 Publication1
Mutagenesisi137E → A: Strongly reduced NAD binding. Strongly reduced formation of covalent intermediate. 1 Publication1
Mutagenesisi238D → A: Strongly reduced NAD binding. Strongly reduced formation of covalent intermediate. 1 Publication1
Mutagenesisi243D → A: Reduces spermidine binding by 98%. Strongly reduced formation of covalent intermediate. 1 Publication1
Mutagenesisi287K → A: Reduces covalent intermediate formation and deoxyhypusine synthesis by 99.5%. Retains low spermidine cleavage activity. 1 Publication1
Mutagenesisi288H → A: Reduces spermidine binding by 98%. Strongly reduced NAD binding. Strongly reduced formation of covalent intermediate. 1 Publication1
Mutagenesisi305Y → A: Strongly reduced NAD binding. No effect on enzyme activity. 1 Publication1
Mutagenesisi313D → A: Strongly reduced NAD binding. 1 Publication1
Mutagenesisi316D → A: Reduces spermidine binding by 98%. Loss of covalent intermediate formation and deoxyhypusine synthesis. 1 Publication1
Mutagenesisi317S → A: Strongly reduced NAD binding. No effect on enzyme activity. 1 Publication1
Mutagenesisi323E → A: Reduces spermidine binding by 98%. Strongly reduced formation of covalent intermediate. 1 Publication1
Mutagenesisi327W → A: Reduces spermidine binding by 98%. Loss of covalent intermediate formation and deoxyhypusine synthesis. 1 Publication1
Mutagenesisi329K → A or R: Loss of covalent intermediate formation and deoxyhypusine synthesis. 1 Publication1
Mutagenesisi342D → A: Strongly reduced NAD binding. Strongly reduced activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1725

MalaCards human disease database

More...
MalaCardsi
DHPS
MIMi618480, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000095059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27329

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49366, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4415

Drug and drug target database

More...
DrugBanki
DB03639, 1-Guanidinium-7-Aminoheptane

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DHPS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352267

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001344691 – 369Deoxyhypusine synthaseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P49366

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P49366

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P49366

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49366

PeptideAtlas

More...
PeptideAtlasi
P49366

PRoteomics IDEntifications database

More...
PRIDEi
P49366

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55996 [P49366-1]
55997 [P49366-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49366

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P49366

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49366

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095059, Expressed in right hemisphere of cerebellum and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49366, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49366, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000095059, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer formed by a dimer of dimers.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108070, 67 interactors

Protein interaction database and analysis system

More...
IntActi
P49366, 36 interactors

Molecular INTeraction database

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MINTi
P49366

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000210060

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49366, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49366

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P49366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni136 – 137Spermidine bindingCurated2
Regioni314 – 316Spermidine bindingCurated3
Regioni323 – 329Spermidine bindingCurated7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2924, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039781_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49366

KEGG Orthology (KO)

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KOi
K00809

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49366

TreeFam database of animal gene trees

More...
TreeFami
TF300625

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.910.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002773, Deoxyhypusine_synthase
IPR036982, Deoxyhypusine_synthase_sf
IPR029035, DHS-like_NAD/FAD-binding_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11703, PTHR11703, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01916, DS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52467, SSF52467, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00321, dhys, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P49366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG
60 70 80 90 100
TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF
110 120 130 140 150
LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE
160 170 180 190 200
FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK
210 220 230 240 250
WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY
260 270 280 290 300
KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA
310 320 330 340 350
DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL
360
VAETFAQKMD AFMHEKNED
Length:369
Mass (Da):40,971
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5314FED620AC9EE7
GO
Isoform Short (identifier: P49366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-308: Missing.

Note: Inactive.Curated
Show »
Length:322
Mass (Da):35,916
Checksum:i1F44CC2AB89F7A2E
GO
Isoform 3 (identifier: P49366-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MEGSLEREAP...FGRAVQQVNA → MPIIPAFWEAEAGGSREEEFETSLAN

Show »
Length:327
Mass (Da):36,583
Checksum:i313374BBDB63A758
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0J4M0R0J4_HUMAN
Deoxyhypusine synthase
DHPS
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZK0A0A087WZK0_HUMAN
Deoxyhypusine synthase
DHPS
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R264M0R264_HUMAN
Deoxyhypusine synthase
DHPS
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0V2M0R0V2_HUMAN
Deoxyhypusine synthase
DHPS
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1T2M0R1T2_HUMAN
Deoxyhypusine synthase
DHPS
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1T4M0R1T4_HUMAN
Deoxyhypusine synthase
DHPS
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R253M0R253_HUMAN
Deoxyhypusine synthase
DHPS
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX43M0QX43_HUMAN
Deoxyhypusine synthase
DHPS
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYZ7M0QYZ7_HUMAN
Deoxyhypusine synthase
DHPS
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5J8M5Q5J8M5_HUMAN
Deoxyhypusine synthase
DHPS
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AL520040 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11A → R in AAB02175 (PubMed:8615810).Curated1
Sequence conflicti11A → R in AAB02179 (PubMed:8615810).Curated1
Sequence conflicti13 – 14AL → R in AAB02175 (PubMed:8615810).Curated2
Sequence conflicti13 – 14AL → R in AAB02179 (PubMed:8615810).Curated2
Sequence conflicti85A → G in AAB02175 (PubMed:8615810).Curated1
Sequence conflicti85A → G in AAB02179 (PubMed:8615810).Curated1
Sequence conflicti196T → I in AAB02175 (PubMed:8615810).Curated1
Sequence conflicti196T → I in AAB02179 (PubMed:8615810).Curated1
Sequence conflicti199V → A in AAB02175 (PubMed:8615810).Curated1
Sequence conflicti199V → A in AAB02179 (PubMed:8615810).Curated1
Sequence conflicti220V → A in AAB02175 (PubMed:8615810).Curated1
Sequence conflicti220V → A in AAB02179 (PubMed:8615810).Curated1
Sequence conflicti228H → K AA sequence (PubMed:7750572).Curated1
Sequence conflicti296 – 297MR → SG in AAB02179 (PubMed:8615810).Curated2
Sequence conflicti311E → EE in AAB02179 (PubMed:8615810).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082649173N → S in NEDSSWI; decreased deoxyhypusine synthase activity. 1 PublicationCorresponds to variant dbSNP:rs758100382EnsemblClinVar.1
Natural variantiVAR_043005174E → D. Corresponds to variant dbSNP:rs10425108Ensembl.1
Natural variantiVAR_082650305 – 306Missing in NEDSSWI; loss of deoxyhypusine synthase activity. 1 Publication2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475641 – 68MEGSL…QQVNA → MPIIPAFWEAEAGGSREEEF ETSLAN in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_001351262 – 308Missing in isoform Short. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39068 mRNA Translation: AAA86282.1
U40579 mRNA Translation: AAA96151.1
U32178 mRNA Translation: AAB02179.1
U26266 mRNA Translation: AAB02175.1
AJ001701 AJ001704 Genomic DNA Translation: CAA04940.1
U79262 mRNA Translation: AAB50208.1
AL520040 mRNA No translation available.
AK291553 mRNA Translation: BAF84242.1
AC010422 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84288.1
BC000333 mRNA Translation: AAH00333.1
BC014016 mRNA Translation: AAH14016.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12276.1 [P49366-1]
CCDS12277.1 [P49366-2]
CCDS59354.1 [P49366-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68692

NCBI Reference Sequences

More...
RefSeqi
NP_001193903.1, NM_001206974.1 [P49366-3]
NP_001921.1, NM_001930.3 [P49366-1]
NP_037538.1, NM_013406.2 [P49366-2]
XP_011526072.1, XM_011527770.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000210060; ENSP00000210060; ENSG00000095059 [P49366-1]
ENST00000351660; ENSP00000221303; ENSG00000095059 [P49366-2]
ENST00000594424; ENSP00000471886; ENSG00000095059 [P49366-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1725

UCSC genome browser

More...
UCSCi
uc002mug.3, human [P49366-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39068 mRNA Translation: AAA86282.1
U40579 mRNA Translation: AAA96151.1
U32178 mRNA Translation: AAB02179.1
U26266 mRNA Translation: AAB02175.1
AJ001701 AJ001704 Genomic DNA Translation: CAA04940.1
U79262 mRNA Translation: AAB50208.1
AL520040 mRNA No translation available.
AK291553 mRNA Translation: BAF84242.1
AC010422 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84288.1
BC000333 mRNA Translation: AAH00333.1
BC014016 mRNA Translation: AAH14016.1
CCDSiCCDS12276.1 [P49366-1]
CCDS12277.1 [P49366-2]
CCDS59354.1 [P49366-3]
PIRiS68692
RefSeqiNP_001193903.1, NM_001206974.1 [P49366-3]
NP_001921.1, NM_001930.3 [P49366-1]
NP_037538.1, NM_013406.2 [P49366-2]
XP_011526072.1, XM_011527770.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DHSX-ray2.20A9-369[»]
1RLZX-ray2.15A1-369[»]
1ROZX-ray2.21A/B1-369[»]
1RQDX-ray3.00A/B1-369[»]
6P4VX-ray1.65A/B1-369[»]
6PGRX-ray1.95A/B1-369[»]
6XXHX-ray1.52A/B1-369[»]
6XXIX-ray1.68A/B1-369[»]
6XXJX-ray1.41A/B1-369[»]
6XXKX-ray1.65A/B1-369[»]
6XXLX-ray1.69A/B1-369[»]
6XXMX-ray1.67A/B1-369[»]
SMRiP49366
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108070, 67 interactors
IntActiP49366, 36 interactors
MINTiP49366
STRINGi9606.ENSP00000210060

Chemistry databases

ChEMBLiCHEMBL4415
DrugBankiDB03639, 1-Guanidinium-7-Aminoheptane

PTM databases

iPTMnetiP49366
MetOSiteiP49366
PhosphoSitePlusiP49366

Polymorphism and mutation databases

BioMutaiDHPS
DMDMi1352267

Proteomic databases

EPDiP49366
jPOSTiP49366
MassIVEiP49366
MaxQBiP49366
PaxDbiP49366
PeptideAtlasiP49366
PRIDEiP49366
ProteomicsDBi55996 [P49366-1]
55997 [P49366-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1964, 299 antibodies

The DNASU plasmid repository

More...
DNASUi
1725

Genome annotation databases

EnsembliENST00000210060; ENSP00000210060; ENSG00000095059 [P49366-1]
ENST00000351660; ENSP00000221303; ENSG00000095059 [P49366-2]
ENST00000594424; ENSP00000471886; ENSG00000095059 [P49366-3]
GeneIDi1725
KEGGihsa:1725
UCSCiuc002mug.3, human [P49366-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1725
DisGeNETi1725
EuPathDBiHostDB:ENSG00000095059.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DHPS
HGNCiHGNC:2869, DHPS
HPAiENSG00000095059, Low tissue specificity
MalaCardsiDHPS
MIMi600944, gene
618480, phenotype
neXtProtiNX_P49366
OpenTargetsiENSG00000095059
PharmGKBiPA27329

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2924, Eukaryota
GeneTreeiENSGT00390000008063
HOGENOMiCLU_039781_0_0_1
InParanoidiP49366
KOiK00809
PhylomeDBiP49366
TreeFamiTF300625

Enzyme and pathway databases

UniPathwayiUPA00354
BioCyciMetaCyc:HS01810-MONOMER
BRENDAi2.5.1.46, 2681
PathwayCommonsiP49366
ReactomeiR-HSA-204626, Hypusine synthesis from eIF5A-lysine
SABIO-RKiP49366

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1725, 553 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DHPS, human
EvolutionaryTraceiP49366

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DHPS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1725
PharosiP49366, Tbio

Protein Ontology

More...
PROi
PR:P49366
RNActiP49366, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095059, Expressed in right hemisphere of cerebellum and 237 other tissues
ExpressionAtlasiP49366, baseline and differential
GenevisibleiP49366, HS

Family and domain databases

Gene3Di3.40.910.10, 1 hit
InterProiView protein in InterPro
IPR002773, Deoxyhypusine_synthase
IPR036982, Deoxyhypusine_synthase_sf
IPR029035, DHS-like_NAD/FAD-binding_dom
PANTHERiPTHR11703, PTHR11703, 1 hit
PfamiView protein in Pfam
PF01916, DS, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
TIGRFAMsiTIGR00321, dhys, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHYS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49366
Secondary accession number(s): A8K688
, M0R1I5, Q13184, Q13276, Q9UDG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 7, 2020
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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