UniProtKB - P49346 (QCR8_KLULA)
Cytochrome b-c1 complex subunit 8
QCR8
Functioni
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
By similarityGO - Biological processi
- mitochondrial electron transport, ubiquinol to cytochrome c Source: EnsemblFungi
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 8Alternative name(s): Complex III subunit 8 Complex III subunit VII Ubiquinol-cytochrome c reductase complex 11 kDa protein Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
Gene namesi | Name:QCR8 Ordered Locus Names:KLLA0A06754g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex III Source: EnsemblFungi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | Mitochondrial matrixBy similarityAdd BLAST | 49 | |
Transmembranei | 50 – 80 | HelicalBy similarityAdd BLAST | 31 | |
Topological domaini | 81 – 94 | Mitochondrial intermembraneBy similarityAdd BLAST | 14 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193549 | 1 – 94 | Cytochrome b-c1 complex subunit 8Add BLAST | 94 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
By similarityProtein-protein interaction databases
STRINGi | 28985.XP_451301.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4116, Eukaryota |
HOGENOMi | CLU_156007_0_1_1 |
InParanoidi | P49346 |
OMAi | KTTWHIG |
Family and domain databases
Gene3Di | 1.20.5.210, 1 hit |
InterProi | View protein in InterPro IPR004205, Cyt_bc1_su8 IPR036642, Cyt_bc1_su8_sf |
PANTHERi | PTHR12119, PTHR12119, 1 hit |
Pfami | View protein in Pfam PF02939, UcrQ, 1 hit |
SUPFAMi | SSF81508, SSF81508, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MGGPHAKAYM GWWGSIGSPA QKGITTYTVS PYAQKPLNNI FHNAVFNTFR
60 70 80 90
RVKSQILYMA LPAALYWAWW VNCRDYNAYL YTKAGREELE RVNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76026 Genomic DNA Translation: CAA53615.1 CR382121 Genomic DNA Translation: CAH02889.1 |
PIRi | S50215 |
RefSeqi | XP_451301.1, XM_451301.1 |
Genome annotation databases
EnsemblFungii | CAH02889; CAH02889; KLLA0_A06754g |
GeneIDi | 2896709 |
KEGGi | kla:KLLA0_A06754g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76026 Genomic DNA Translation: CAA53615.1 CR382121 Genomic DNA Translation: CAH02889.1 |
PIRi | S50215 |
RefSeqi | XP_451301.1, XM_451301.1 |
3D structure databases
AlphaFoldDBi | P49346 |
SMRi | P49346 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28985.XP_451301.1 |
Genome annotation databases
EnsemblFungii | CAH02889; CAH02889; KLLA0_A06754g |
GeneIDi | 2896709 |
KEGGi | kla:KLLA0_A06754g |
Phylogenomic databases
eggNOGi | KOG4116, Eukaryota |
HOGENOMi | CLU_156007_0_1_1 |
InParanoidi | P49346 |
OMAi | KTTWHIG |
Family and domain databases
Gene3Di | 1.20.5.210, 1 hit |
InterProi | View protein in InterPro IPR004205, Cyt_bc1_su8 IPR036642, Cyt_bc1_su8_sf |
PANTHERi | PTHR12119, PTHR12119, 1 hit |
Pfami | View protein in Pfam PF02939, UcrQ, 1 hit |
SUPFAMi | SSF81508, SSF81508, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR8_KLULA | |
Accessioni | P49346Primary (citable) accession number: P49346 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families