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UniProtKB - P49335 (PO3F4_HUMAN)

Entry version 197 (25 May 2022)
Sequence version 2 (11 Oct 2005)
Previous versions | rss
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Protein

POU domain, class 3, transcription factor 4

Gene

POU3F4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi278 – 337HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49335

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49335

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49335

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 3, transcription factor 4
Alternative name(s):
Brain-specific homeobox/POU domain protein 4
Short name:
Brain-4
Short name:
Brn-4
Octamer-binding protein 9
Short name:
Oct-9
Octamer-binding transcription factor 9
Short name:
OTF-9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU3F4
Synonyms:BRN4, OTF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9217, POU3F4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300039, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, X-linked, 2 (DFNX2)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation, and progressive sensorineural deafness.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015261201 – 202Missing in DFNX2. 1 Publication2
Natural variantiVAR_003782312A → V in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs387906502EnsemblClinVar.1
Natural variantiVAR_003783317L → W in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894921EnsemblClinVar.1
Natural variantiVAR_003784323R → G in DFNX2; somatic mosaicism in 50% of the peripheral blood lymphocytes. 1 PublicationCorresponds to variant dbSNP:rs104894924EnsemblClinVar.1
Natural variantiVAR_003785330R → S in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894923EnsemblClinVar.1
Natural variantiVAR_003786334K → E in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894922EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease variant, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		5456

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		POU3F4

MalaCards human disease database

More...MalaCardsi		POU3F4
MIMi304400, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90641, Mitochondrial non-syndromic sensorineural deafness
1435, Xq21 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33541

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49335, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POU3F4

Domain mapping of disease mutations (DMDM)

More...DMDMi		77416874

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007321 – 361POU domain, class 3, transcription factor 4Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei265PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49335

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49335

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49335

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49335

PeptideAtlas

More...PeptideAtlasi		P49335

PRoteomics IDEntifications database

More...PRIDEi		P49335

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55990

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49335

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49335

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196767, Expressed in subventricular zone (inner) (primate) and 36 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49335, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HNRNPU.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111452, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362296

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49335, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P49335

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49335

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 260POU-specificPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni99 – 131DisorderedSequence analysisAdd BLAST33
Regioni144 – 192DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 131Polar residuesSequence analysisAdd BLAST22
Compositional biasi167 – 192Basic and acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3802, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013065_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49335

Database of Orthologous Groups

More...OrthoDBi		752252at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49335

TreeFam database of animal gene trees

More...TreeFami		TF316413

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR016362, TF_POU_3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002629, Transcription_factor_POU, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00028, POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49335-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG 
        60         70         80         90        100
HPLGHHWVTS LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH 
       110        120        130        140        150
VAHHSPHTNH PNAWGASPAP NPSITSSGQP LNVYSQPGFT VSGMLEHGGL 
       160        170        180        190        200
TPPPAAASAQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ 
       210        220        230        240        250
FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEGLQL SFKNMCKLKP 
       260        270        280        290        300
LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 
       310        320        330        340        350
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH 
       360 
TVKTDTSCHD L
Length:361
Mass (Da):39,427
Last modified:October 11, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE30602CFAC4683A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y739A0A2R8Y739_HUMAN
POU domain protein
POU3F4
361Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015261201 – 202Missing in DFNX2. 1 Publication2
Natural variantiVAR_067431237G → A2 PublicationsCorresponds to variant dbSNP:rs5921979Ensembl.1
Natural variantiVAR_003782312A → V in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs387906502EnsemblClinVar.1
Natural variantiVAR_003783317L → W in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894921EnsemblClinVar.1
Natural variantiVAR_003784323R → G in DFNX2; somatic mosaicism in 50% of the peripheral blood lymphocytes. 1 PublicationCorresponds to variant dbSNP:rs104894924EnsemblClinVar.1
Natural variantiVAR_003785330R → S in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894923EnsemblClinVar.1
Natural variantiVAR_003786334K → E in DFNX2. 1 PublicationCorresponds to variant dbSNP:rs104894922EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82324 mRNA Translation: CAA57767.1
AK314967 mRNA Translation: BAG37468.1
Z82170 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98577.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14450.1

Protein sequence database of the Protein Information Resource

More...PIRi		A55557

NCBI Reference Sequences

More...RefSeqi		NP_000298.3, NM_000307.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5456

UCSC genome browser

More...UCSCi		uc004eeg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Hereditary hearing loss homepage

Gene page

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82324 mRNA Translation: CAA57767.1
AK314967 mRNA Translation: BAG37468.1
Z82170 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98577.1
CCDSiCCDS14450.1
PIRiA55557
RefSeqiNP_000298.3, NM_000307.4

3D structure databases

AlphaFoldDBiP49335
SMRiP49335
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111452, 11 interactors
STRINGi9606.ENSP00000362296

PTM databases

iPTMnetiP49335
PhosphoSitePlusiP49335

Genetic variation databases

BioMutaiPOU3F4
DMDMi77416874

Proteomic databases

jPOSTiP49335
MassIVEiP49335
MaxQBiP49335
PaxDbiP49335
PeptideAtlasiP49335
PRIDEiP49335
ProteomicsDBi55990

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5456

Genome annotation databases

GeneIDi5456
KEGGihsa:5456
UCSCiuc004eeg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5456
DisGeNETi5456

GeneCards: human genes, protein and diseases

More...GeneCardsi		POU3F4
GeneReviewsiPOU3F4
HGNCiHGNC:9217, POU3F4
MalaCardsiPOU3F4
MIMi300039, gene
304400, phenotype
neXtProtiNX_P49335
Orphaneti90641, Mitochondrial non-syndromic sensorineural deafness
1435, Xq21 microdeletion syndrome
PharmGKBiPA33541

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
HOGENOMiCLU_013065_1_2_1
InParanoidiP49335
OrthoDBi752252at2759
PhylomeDBiP49335
TreeFamiTF316413

Enzyme and pathway databases

PathwayCommonsiP49335
SignaLinkiP49335
SIGNORiP49335

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5456, 12 hits in 715 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POU3F4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POU3F4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5456
PharosiP49335, Tbio

Protein Ontology

More...PROi		PR:P49335
RNActiP49335, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196767, Expressed in subventricular zone (inner) (primate) and 36 other tissues
GenevisibleiP49335, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR016362, TF_POU_3
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit
PIRSFiPIRSF002629, Transcription_factor_POU, 1 hit
PRINTSiPR00028, POUDOMAIN
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO3F4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49335
Secondary accession number(s): B2RC71, Q5H9G9, Q99410
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 11, 2005
Last modified: May 25, 2022
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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