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Protein

Fatty acid synthase

Gene

FASN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.

Miscellaneous

The relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein.

Catalytic activityi

Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.1 Publication
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].1 Publication
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].1 Publication
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].1 Publication
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.1 Publication
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.1 Publication
An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.1 Publication
Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei161For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei581For malonyltransferase activityPROSITE-ProRule annotation1
Active sitei878For beta-hydroxyacyl dehydratase activityPROSITE-ProRule annotation1
Active sitei2308For thioesterase activityPROSITE-ProRule annotation1 Publication1
Active sitei2481For thioesterase activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1671 – 1688NADP (ER)By similarityAdd BLAST18
Nucleotide bindingi1886 – 1901NADP (KR)By similarityAdd BLAST16

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNAD, NADP, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS09992-MONOMER
BRENDAi2.3.1.85 2681
ReactomeiR-HSA-163765 ChREBP activates metabolic gene expression
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-75105 Fatty acyl-CoA biosynthesis
SABIO-RKiP49327
SIGNORiP49327

Protein family/group databases

ESTHERihuman-FASN Thioesterase

Chemistry databases

SwissLipidsiSLP:000000765

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid synthase (EC:2.3.1.85)
Including the following 7 domains:
[Acyl-carrier-protein] S-acetyltransferase (EC:2.3.1.38)
[Acyl-carrier-protein] S-malonyltransferase (EC:2.3.1.39)
3-oxoacyl-[acyl-carrier-protein] synthase (EC:2.3.1.41)
3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.100)
3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Enoyl-[acyl-carrier-protein] reductase (EC:1.3.1.39)
Oleoyl-[acyl-carrier-protein] hydrolase (EC:3.1.2.14)
Gene namesi
Name:FASN
Synonyms:FAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000169710.7
HGNCiHGNC:3594 FASN
MIMi600212 gene
neXtProtiNX_P49327

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2194
OpenTargetsiENSG00000169710
PharmGKBiPA28006

Chemistry databases

ChEMBLiCHEMBL4158
DrugBankiDB01034 Cerulenin
DB01083 Orlistat
GuidetoPHARMACOLOGYi2608

Polymorphism and mutation databases

BioMutaiFASN
DMDMi269849686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001802761 – 2511Fatty acid synthaseAdd BLAST2511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei63PhosphoserineCombined sources1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei298N6-acetyllysineCombined sources1
Modified residuei436N6-acetyllysineCombined sources1
Modified residuei528N6-acetyllysineCombined sources1
Modified residuei673N6-acetyllysineCombined sources1
Modified residuei725PhosphoserineBy similarity1
Modified residuei992N6-acetyllysineBy similarity1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1411PhosphoserineCombined sources1
Modified residuei1584PhosphoserineCombined sources1
Modified residuei1594PhosphoserineBy similarity1
Modified residuei1704N6-(pyridoxal phosphate)lysine; alternateBy similarity1
Modified residuei1704N6-acetyllysine; alternateCombined sources1
Modified residuei1771N6-acetyllysineCombined sources1
Modified residuei1847N6-acetyllysineCombined sources1
Modified residuei1995N6-acetyllysineCombined sources1
Modified residuei2156O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotation1 Publication1
Modified residuei2156Phosphoserine; alternateBy similarity1
Modified residuei2198PhosphoserineCombined sources1
Modified residuei2204PhosphothreonineCombined sources1
Modified residuei2215PhosphothreonineCombined sources1
Modified residuei2236PhosphoserineCombined sources1
Modified residuei2391N6-acetyllysineBy similarity1
Cross-linki2449Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphopantetheine, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP49327
MaxQBiP49327
PaxDbiP49327
PeptideAtlasiP49327
PRIDEiP49327
ProteomicsDBi55989

PTM databases

CarbonylDBiP49327
iPTMnetiP49327
PhosphoSitePlusiP49327
SwissPalmiP49327

Expressioni

Tissue specificityi

Ubiquitous. Prominent expression in brain, lung, and liver.2 Publications

Gene expression databases

BgeeiENSG00000169710 Expressed in 215 organ(s), highest expression level in liver
CleanExiHS_FAS
HS_FASN
ExpressionAtlasiP49327 baseline and differential
GenevisibleiP49327 HS

Organism-specific databases

HPAiCAB005192
CAB015417
HPA006461
HPA056108

Interactioni

Subunit structurei

Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref. 28). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108488, 111 interactors
DIPiDIP-33681N
IntActiP49327, 60 interactors
MINTiP49327
STRINGi9606.ENSP00000304592

Chemistry databases

BindingDBiP49327

Structurei

Secondary structure

12511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49327
SMRiP49327
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49327

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2121 – 2198CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 414Beta-ketoacyl synthaseBy similarityAdd BLAST414
Regioni429 – 817Acyl and malonyl transferasesBy similarityAdd BLAST389
Regioni1635 – 1863Enoyl reductaseBy similarityAdd BLAST229
Regioni1864 – 2118Beta-ketoacyl reductaseBy similarityAdd BLAST255
Regioni2207 – 2511ThioesteraseBy similarityAdd BLAST305

Phylogenomic databases

eggNOGiKOG1202 Eukaryota
COG3321 LUCA
GeneTreeiENSGT00530000063309
HOVERGENiHBG005640
InParanoidiP49327
KOiK00665
OMAiTEALCAF
OrthoDBiEOG091G003K
PhylomeDBiP49327
TreeFamiTF300549

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR023102 Fatty_acid_synthase_dom_2
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR001031 Thioesterase
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
PF00975 Thioesterase, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53474 SSF53474, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P49327-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEVVIAGMS GKLPESENLQ EFWDNLIGGV DMVTDDDRRW KAGLYGLPRR
60 70 80 90 100
SGKLKDLSRF DASFFGVHPK QAHTMDPQLR LLLEVTYEAI VDGGINPDSL
110 120 130 140 150
RGTHTGVWVG VSGSETSEAL SRDPETLVGY SMVGCQRAMM ANRLSFFFDF
160 170 180 190 200
RGPSIALDTA CSSSLMALQN AYQAIHSGQC PAAIVGGINV LLKPNTSVQF
210 220 230 240 250
LRLGMLSPEG TCKAFDTAGN GYCRSEGVVA VLLTKKSLAR RVYATILNAG
260 270 280 290 300
TNTDGFKEQG VTFPSGDIQE QLIRSLYQSA GVAPESFEYI EAHGTGTKVG
310 320 330 340 350
DPQELNGITR ALCATRQEPL LIGSTKSNMG HPEPASGLAA LAKVLLSLEH
360 370 380 390 400
GLWAPNLHFH SPNPEIPALL DGRLQVVDQP LPVRGGNVGI NSFGFGGSNV
410 420 430 440 450
HIILRPNTQP PPAPAPHATL PRLLRASGRT PEAVQKLLEQ GLRHSQDLAF
460 470 480 490 500
LSMLNDIAAV PATAMPFRGY AVLGGERGGP EVQQVPAGER PLWFICSGMG
510 520 530 540 550
TQWRGMGLSL MRLDRFRDSI LRSDEAVKPF GLKVSQLLLS TDESTFDDIV
560 570 580 590 600
HSFVSLTAIQ IGLIDLLSCM GLRPDGIVGH SLGEVACGYA DGCLSQEEAV
610 620 630 640 650
LAAYWRGQCI KEAHLPPGAM AAVGLSWEEC KQRCPPGVVP ACHNSKDTVT
660 670 680 690 700
ISGPQAPVFE FVEQLRKEGV FAKEVRTGGM AFHSYFMEAI APPLLQELKK
710 720 730 740 750
VIREPKPRSA RWLSTSIPEA QWHSSLARTS SAEYNVNNLV SPVLFQEALW
760 770 780 790 800
HVPEHAVVLE IAPHALLQAV LKRGLKPSCT IIPLMKKDHR DNLEFFLAGI
810 820 830 840 850
GRLHLSGIDA NPNALFPPVE FPAPRGTPLI SPLIKWDHSL AWDVPAAEDF
860 870 880 890 900
PNGSGSPSAA IYNIDTSSES PDHYLVDHTL DGRVLFPATG YLSIVWKTLA
910 920 930 940 950
RALGLGVEQL PVVFEDVVLH QATILPKTGT VSLEVRLLEA SRAFEVSENG
960 970 980 990 1000
NLVVSGKVYQ WDDPDPRLFD HPESPTPNPT EPLFLAQAEV YKELRLRGYD
1010 1020 1030 1040 1050
YGPHFQGILE ASLEGDSGRL LWKDNWVSFM DTMLQMSILG SAKHGLYLPT
1060 1070 1080 1090 1100
RVTAIHIDPA THRQKLYTLQ DKAQVADVVV SRWLRVTVAG GVHISGLHTE
1110 1120 1130 1140 1150
SAPRRQQEQQ VPILEKFCFT PHTEEGCLSE RAALQEELQL CKGLVQALQT
1160 1170 1180 1190 1200
KVTQQGLKMV VPGLDGAQIP RDPSQQELPR LLSAACRLQL NGNLQLELAQ
1210 1220 1230 1240 1250
VLAQERPKLP EDPLLSGLLD SPALKACLDT AVENMPSLKM KVVEVLAGHG
1260 1270 1280 1290 1300
HLYSRIPGLL SPHPLLQLSY TATDRHPQAL EAAQAELQQH DVAQGQWDPA
1310 1320 1330 1340 1350
DPAPSALGSA DLLVCNCAVA ALGDPASALS NMVAALREGG FLLLHTLLRG
1360 1370 1380 1390 1400
HPLGDIVAFL TSTEPQYGQG ILSQDAWESL FSRVSLRLVG LKKSFYGSTL
1410 1420 1430 1440 1450
FLCRRPTPQD SPIFLPVDDT SFRWVESLKG ILADEDSSRP VWLKAINCAT
1460 1470 1480 1490 1500
SGVVGLVNCL RREPGGNRLR CVLLSNLSST SHVPEVDPGS AELQKVLQGD
1510 1520 1530 1540 1550
LVMNVYRDGA WGAFRHFLLE EDKPEEPTAH AFVSTLTRGD LSSIRWVCSS
1560 1570 1580 1590 1600
LRHAQPTCPG AQLCTVYYAS LNFRDIMLAT GKLSPDAIPG KWTSQDSLLG
1610 1620 1630 1640 1650
MEFSGRDASG KRVMGLVPAK GLATSVLLSP DFLWDVPSNW TLEEAASVPV
1660 1670 1680 1690 1700
VYSTAYYALV VRGRVRPGET LLIHSGSGGV GQAAIAIALS LGCRVFTTVG
1710 1720 1730 1740 1750
SAEKRAYLQA RFPQLDSTSF ANSRDTSFEQ HVLWHTGGKG VDLVLNSLAE
1760 1770 1780 1790 1800
EKLQASVRCL ATHGRFLEIG KFDLSQNHPL GMAIFLKNVT FHGVLLDAFF
1810 1820 1830 1840 1850
NESSADWREV WALVQAGIRD GVVRPLKCTV FHGAQVEDAF RYMAQGKHIG
1860 1870 1880 1890 1900
KVVVQVLAEE PEAVLKGAKP KLMSAISKTF CPAHKSYIIA GGLGGFGLEL
1910 1920 1930 1940 1950
AQWLIQRGVQ KLVLTSRSGI RTGYQAKQVR RWRRQGVQVQ VSTSNISSLE
1960 1970 1980 1990 2000
GARGLIAEAA QLGPVGGVFN LAVVLRDGLL ENQTPEFFQD VCKPKYSGTL
2010 2020 2030 2040 2050
NLDRVTREAC PELDYFVVFS SVSCGRGNAG QSNYGFANSA MERICEKRRH
2060 2070 2080 2090 2100
EGLPGLAVQW GAIGDVGILV ETMSTNDTIV SGTLPQRMAS CLEVLDLFLN
2110 2120 2130 2140 2150
QPHMVLSSFV LAEKAAAYRD RDSQRDLVEA VAHILGIRDL AAVNLDSSLA
2160 2170 2180 2190 2200
DLGLDSLMSV EVRQTLEREL NLVLSVREVR QLTLRKLQEL SSKADEASEL
2210 2220 2230 2240 2250
ACPTPKEDGL AQQQTQLNLR SLLVNPEGPT LMRLNSVQSS ERPLFLVHPI
2260 2270 2280 2290 2300
EGSTTVFHSL ASRLSIPTYG LQCTRAAPLD SIHSLAAYYI DCIRQVQPEG
2310 2320 2330 2340 2350
PYRVAGYSYG ACVAFEMCSQ LQAQQSPAPT HNSLFLFDGS PTYVLAYTQS
2360 2370 2380 2390 2400
YRAKLTPGCE AEAETEAICF FVQQFTDMEH NRVLEALLPL KGLEERVAAA
2410 2420 2430 2440 2450
VDLIIKSHQG LDRQELSFAA RSFYYKLRAA EQYTPKAKYH GNVMLLRAKT
2460 2470 2480 2490 2500
GGAYGEDLGA DYNLSQVCDG KVSVHVIEGD HRTLLEGSGL ESIISIIHSS
2510
LAEPRVSVRE G
Length:2,511
Mass (Da):273,427
Last modified:November 24, 2009 - v3
Checksum:i7A07171FEFA3287B
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQF0A0A0U1RQF0_HUMAN
Fatty acid synthase
FASN
2,509Annotation score:
A0A0U1RRG3A0A0U1RRG3_HUMAN
Fatty acid synthase
FASN
150Annotation score:
J3KTF0J3KTF0_HUMAN
Fatty acid synthase
FASN
78Annotation score:
A0A1B0GVK4A0A1B0GVK4_HUMAN
Fatty acid synthase
FASN
10Annotation score:
A0A1B0GTR5A0A1B0GTR5_HUMAN
Fatty acid synthase
FASN
18Annotation score:
A0A1B0GWG8A0A1B0GWG8_HUMAN
Fatty acid synthase
FASN
27Annotation score:

Sequence cautioni

The sequence AAB35516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC50259 differs from that shown. Several sequencing errors.Curated
The sequence BAE06070 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459 – 462AVPA → LSPT in AAA73576 (Ref. 2) Curated4
Sequence conflicti528 – 529KP → NR in AAA73576 (Ref. 2) Curated2
Sequence conflicti637G → A in AAA73576 (Ref. 2) Curated1
Sequence conflicti801G → R in AAA73576 (Ref. 2) Curated1
Sequence conflicti902A → P in AAA73576 (Ref. 2) Curated1
Sequence conflicti958V → M in AAS09886 (Ref. 3) Curated1
Sequence conflicti1121P → S in AAA73576 (Ref. 2) Curated1
Sequence conflicti1121P → S in AAS09886 (Ref. 3) Curated1
Sequence conflicti1151K → T in AAH63242 (PubMed:15489334).Curated1
Sequence conflicti1353 – 1356LGDI → SGH in AAA73576 (Ref. 2) Curated4
Sequence conflicti1386L → V in AAA73576 (Ref. 2) Curated1
Sequence conflicti1467 – 1468NR → T in AAA73576 (Ref. 2) Curated2
Sequence conflicti1827K → E in AAS09886 (Ref. 3) Curated1
Sequence conflicti1934R → A in AAA73576 (Ref. 2) Curated1
Sequence conflicti2065D → H in AAB35516 (PubMed:7595075).Curated1
Sequence conflicti2087R → A in AAA73576 (Ref. 2) Curated1
Sequence conflicti2363A → P in AAB35516 (PubMed:7595075).Curated1
Sequence conflicti2428R → G in AAA73576 (Ref. 2) Curated1
Sequence conflicti2453A → T in AAB35516 (PubMed:7595075).Curated1
Sequence conflicti2456E → Q in AAB35516 (PubMed:7595075).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079534477R → H1 PublicationCorresponds to variant dbSNP:rs113931914Ensembl.1
Natural variantiVAR_0554791483V → I. Corresponds to variant dbSNP:rs2228305Ensembl.1
Natural variantiVAR_0554801694R → H. Corresponds to variant dbSNP:rs561903908Ensembl.1
Natural variantiVAR_0554811888I → V. Corresponds to variant dbSNP:rs2228307EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26644 mRNA Translation: AAC50259.1 Sequence problems.
U29344 mRNA Translation: AAA73576.1
AY451392 mRNA Translation: AAS09886.1
AB209988 mRNA Translation: BAE06070.1 Different initiation.
AC135056 Genomic DNA No translation available.
BC007267 mRNA Translation: AAH07267.1
BC007909 mRNA Translation: AAH07909.1
BC014634 mRNA Translation: AAH14634.2
BC063242 mRNA Translation: AAH63242.1
S80437 mRNA Translation: AAB35516.1 Different initiation.
CCDSiCCDS11801.1
PIRiA57788
G01880
RefSeqiNP_004095.4, NM_004104.4
XP_011521840.1, XM_011523538.2
UniGeneiHs.83190

Genome annotation databases

EnsembliENST00000306749; ENSP00000304592; ENSG00000169710
GeneIDi2194
KEGGihsa:2194
UCSCiuc002kdu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26644 mRNA Translation: AAC50259.1 Sequence problems.
U29344 mRNA Translation: AAA73576.1
AY451392 mRNA Translation: AAS09886.1
AB209988 mRNA Translation: BAE06070.1 Different initiation.
AC135056 Genomic DNA No translation available.
BC007267 mRNA Translation: AAH07267.1
BC007909 mRNA Translation: AAH07909.1
BC014634 mRNA Translation: AAH14634.2
BC063242 mRNA Translation: AAH63242.1
S80437 mRNA Translation: AAB35516.1 Different initiation.
CCDSiCCDS11801.1
PIRiA57788
G01880
RefSeqiNP_004095.4, NM_004104.4
XP_011521840.1, XM_011523538.2
UniGeneiHs.83190

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKTX-ray2.60A/B2218-2502[»]
2CG5X-ray2.70B2119-2207[»]
2JFDX-ray2.81A/B/C/D422-823[»]
2JFKX-ray2.40A/B/C/D422-831[»]
2PX6X-ray2.30A/B2200-2511[»]
3HHDX-ray2.15A/B/C/D2-963[»]
3TJMX-ray1.48A2218-2500[»]
4PIVX-ray2.30A/B1110-2114[»]
4W82X-ray1.70A/B1529-1867[»]
4W9NX-ray1.84A/B/C/D1529-1867[»]
4Z49X-ray1.70A/B2221-2502[»]
5C37X-ray2.30A/C1108-1523[»]
A/C1877-2122[»]
ProteinModelPortaliP49327
SMRiP49327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108488, 111 interactors
DIPiDIP-33681N
IntActiP49327, 60 interactors
MINTiP49327
STRINGi9606.ENSP00000304592

Chemistry databases

BindingDBiP49327
ChEMBLiCHEMBL4158
DrugBankiDB01034 Cerulenin
DB01083 Orlistat
GuidetoPHARMACOLOGYi2608
SwissLipidsiSLP:000000765

Protein family/group databases

ESTHERihuman-FASN Thioesterase

PTM databases

CarbonylDBiP49327
iPTMnetiP49327
PhosphoSitePlusiP49327
SwissPalmiP49327

Polymorphism and mutation databases

BioMutaiFASN
DMDMi269849686

Proteomic databases

EPDiP49327
MaxQBiP49327
PaxDbiP49327
PeptideAtlasiP49327
PRIDEiP49327
ProteomicsDBi55989

Protocols and materials databases

DNASUi2194
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306749; ENSP00000304592; ENSG00000169710
GeneIDi2194
KEGGihsa:2194
UCSCiuc002kdu.4 human

Organism-specific databases

CTDi2194
DisGeNETi2194
EuPathDBiHostDB:ENSG00000169710.7
GeneCardsiFASN
H-InvDBiHIX0014269
HGNCiHGNC:3594 FASN
HPAiCAB005192
CAB015417
HPA006461
HPA056108
MIMi600212 gene
neXtProtiNX_P49327
OpenTargetsiENSG00000169710
PharmGKBiPA28006
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1202 Eukaryota
COG3321 LUCA
GeneTreeiENSGT00530000063309
HOVERGENiHBG005640
InParanoidiP49327
KOiK00665
OMAiTEALCAF
OrthoDBiEOG091G003K
PhylomeDBiP49327
TreeFamiTF300549

Enzyme and pathway databases

BioCyciMetaCyc:HS09992-MONOMER
BRENDAi2.3.1.85 2681
ReactomeiR-HSA-163765 ChREBP activates metabolic gene expression
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-75105 Fatty acyl-CoA biosynthesis
SABIO-RKiP49327
SIGNORiP49327

Miscellaneous databases

ChiTaRSiFASN human
EvolutionaryTraceiP49327
GeneWikiiFatty_acid_synthase
GenomeRNAii2194
PROiPR:P49327
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169710 Expressed in 215 organ(s), highest expression level in liver
CleanExiHS_FAS
HS_FASN
ExpressionAtlasiP49327 baseline and differential
GenevisibleiP49327 HS

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH_C
IPR023102 Fatty_acid_synthase_dom_2
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
IPR001031 Thioesterase
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00107 ADH_zinc_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
PF00975 Thioesterase, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53474 SSF53474, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAS_HUMAN
AccessioniPrimary (citable) accession number: P49327
Secondary accession number(s): Q13479
, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 210 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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