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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 14FADBy similarity5
Nucleotide bindingi41 – 42FADBy similarity2
Nucleotide bindingi62 – 63FADBy similarity2
Nucleotide bindingi196 – 199NADPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.13.8 2681

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P49326

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001774

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 5
Hepatic flavin-containing monooxygenase 5
Short name:
FMO 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FMO5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131781.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3773 FMO5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603957 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49326

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei513 – 533HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2330

Open Targets

More...
OpenTargetsi
ENSG00000131781

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28189

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430871

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FMO5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476651 – 533Dimethylaniline monooxygenase [N-oxide-forming] 5Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5Dimethylated arginine; alternateBy similarity1
Modified residuei5Omega-N-methylated arginine; alternateBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei56PhosphotyrosineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P49326

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49326

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P49326

PeptideAtlas

More...
PeptideAtlasi
P49326

PRoteomics IDEntifications database

More...
PRIDEi
P49326

ProteomicsDB human proteome resource

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ProteomicsDBi
55987
55988 [P49326-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P49326

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49326

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal and adult liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131781 Expressed in 145 organ(s), highest expression level in body of stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_FMO5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49326 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49326 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012373

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108617, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254090

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P49326

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P49326

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1399 Eukaryota
COG2072 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000076537

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002037

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49326

KEGG Orthology (KO)

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KOi
K00485

Identification of Orthologs from Complete Genome Data

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OMAi
MHNSHVL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0465

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49326

TreeFam database of animal gene trees

More...
TreeFami
TF105285

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002257 Flavin_mOase_5

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00743 FMO-like, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000332 FMO, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00370 FMOXYGENASE
PR01125 FMOXYGENASE5

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE
60 70 80 90 100
GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD
110 120 130 140 150
LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH
160 170 180 190 200
HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL
210 220 230 240 250
AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ
260 270 280 290 300
SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV
310 320 330 340 350
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI
360 370 380 390 400
SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP
410 420 430 440 450
SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL
460 470 480 490 500
SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM
510 520 530
TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF
Length:533
Mass (Da):60,221
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9D9F092F1DD71DA
GO
Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-285: ALSQHPTL → SKDIALTE
     286-533: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):32,480
Checksum:i4DE507F329B99046
GO
Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
     465-533: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,477
Checksum:i1989AA851C48E893
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJF3E9PJF3_HUMAN
Flavin-containing monooxygenase
FMO5
278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP51E9PP51_HUMAN
Dimethylaniline monooxygenase [N-ox...
FMO5
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ84E9PQ84_HUMAN
Dimethylaniline monooxygenase [N-ox...
FMO5
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti351S → P in CAA87633 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022308400P → A1 PublicationCorresponds to variant dbSNP:rs28381218Ensembl.1
Natural variantiVAR_015370457P → L1 PublicationCorresponds to variant dbSNP:rs72549314Ensembl.1
Natural variantiVAR_022309506R → S1 PublicationCorresponds to variant dbSNP:rs28381223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042729278 – 285ALSQHPTL → SKDIALTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_042730286 – 533Missing in isoform 2. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_045616419 – 464RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_045617465 – 533Missing in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L37080 mRNA Translation: AAA67849.1
Z47553 mRNA Translation: CAA87633.1
AY902236 Genomic DNA Translation: AAW69390.1
AK314647 mRNA Translation: BAG37208.1
AK225739 mRNA No translation available.
AL356378 Genomic DNA Translation: CAH72648.1
AL356378 Genomic DNA Translation: CAH72649.1
CH471223 Genomic DNA Translation: EAW50939.1
CH471223 Genomic DNA Translation: EAW50940.1
BC035687 mRNA Translation: AAH35687.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44209.1 [P49326-3]
CCDS44210.1 [P49326-2]
CCDS926.1 [P49326-1]

Protein sequence database of the Protein Information Resource

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PIRi
S51131
S71618

NCBI Reference Sequences

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RefSeqi
NP_001138301.1, NM_001144829.2 [P49326-3]
NP_001138302.1, NM_001144830.2 [P49326-2]
NP_001452.2, NM_001461.3 [P49326-1]
XP_005273003.1, XM_005272946.4 [P49326-1]
XP_005273004.1, XM_005272947.4 [P49326-1]
XP_005273005.1, XM_005272948.4 [P49326-1]
XP_006711308.1, XM_006711245.3 [P49326-2]
XP_011507652.1, XM_011509350.2 [P49326-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.642706

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254090; ENSP00000254090; ENSG00000131781 [P49326-1]
ENST00000369272; ENSP00000358277; ENSG00000131781 [P49326-2]
ENST00000441068; ENSP00000416011; ENSG00000131781 [P49326-3]
ENST00000578284; ENSP00000462062; ENSG00000131781 [P49326-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2330

UCSC genome browser

More...
UCSCi
uc001eph.5 human [P49326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37080 mRNA Translation: AAA67849.1
Z47553 mRNA Translation: CAA87633.1
AY902236 Genomic DNA Translation: AAW69390.1
AK314647 mRNA Translation: BAG37208.1
AK225739 mRNA No translation available.
AL356378 Genomic DNA Translation: CAH72648.1
AL356378 Genomic DNA Translation: CAH72649.1
CH471223 Genomic DNA Translation: EAW50939.1
CH471223 Genomic DNA Translation: EAW50940.1
BC035687 mRNA Translation: AAH35687.1
CCDSiCCDS44209.1 [P49326-3]
CCDS44210.1 [P49326-2]
CCDS926.1 [P49326-1]
PIRiS51131
S71618
RefSeqiNP_001138301.1, NM_001144829.2 [P49326-3]
NP_001138302.1, NM_001144830.2 [P49326-2]
NP_001452.2, NM_001461.3 [P49326-1]
XP_005273003.1, XM_005272946.4 [P49326-1]
XP_005273004.1, XM_005272947.4 [P49326-1]
XP_005273005.1, XM_005272948.4 [P49326-1]
XP_006711308.1, XM_006711245.3 [P49326-2]
XP_011507652.1, XM_011509350.2 [P49326-1]
UniGeneiHs.642706

3D structure databases

ProteinModelPortaliP49326
SMRiP49326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108617, 6 interactors
STRINGi9606.ENSP00000254090

Chemistry databases

ChEMBLiCHEMBL3430871
SwissLipidsiSLP:000001774

PTM databases

iPTMnetiP49326
PhosphoSitePlusiP49326

Polymorphism and mutation databases

BioMutaiFMO5
DMDMi1346021

Proteomic databases

EPDiP49326
MaxQBiP49326
PaxDbiP49326
PeptideAtlasiP49326
PRIDEiP49326
ProteomicsDBi55987
55988 [P49326-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2330
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254090; ENSP00000254090; ENSG00000131781 [P49326-1]
ENST00000369272; ENSP00000358277; ENSG00000131781 [P49326-2]
ENST00000441068; ENSP00000416011; ENSG00000131781 [P49326-3]
ENST00000578284; ENSP00000462062; ENSG00000131781 [P49326-3]
GeneIDi2330
KEGGihsa:2330
UCSCiuc001eph.5 human [P49326-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2330
DisGeNETi2330
EuPathDBiHostDB:ENSG00000131781.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FMO5
HGNCiHGNC:3773 FMO5
HPAiHPA012373
MIMi603957 gene
neXtProtiNX_P49326
OpenTargetsiENSG00000131781
PharmGKBiPA28189

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00940000160493
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiP49326
KOiK00485
OMAiMHNSHVL
OrthoDBiEOG091G0465
PhylomeDBiP49326
TreeFamiTF105285

Enzyme and pathway databases

BRENDAi1.14.13.8 2681
SABIO-RKiP49326

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FMO5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FMO5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2330

Protein Ontology

More...
PROi
PR:P49326

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131781 Expressed in 145 organ(s), highest expression level in body of stomach
CleanExiHS_FMO5
ExpressionAtlasiP49326 baseline and differential
GenevisibleiP49326 HS

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002257 Flavin_mOase_5
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01125 FMOXYGENASE5
SUPFAMiSSF51905 SSF51905, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMO5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49326
Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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