Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 186 (17 Jun 2020)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Flavin-containing monooxygenase 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).By similarity1 Publication4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 11.84 with NADPH as substrate.1 Publication
  1. KM=59 µM for NADPH1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33FADBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 14FADBy similarity5
    Nucleotide bindingi41 – 42FADBy similarity2
    Nucleotide bindingi62 – 63FADBy similarity2
    Nucleotide bindingi196 – 199NADPBy similarity4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    LigandFAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.14.13.8 2681

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P49326

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001774

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Flavin-containing monooxygenase 5
    Short name:
    FMO 5
    Alternative name(s):
    Baeyer-Villiger monooxygenase 11 Publication (EC:1.14.13.-3 Publications)
    Short name:
    hBVMO11 Publication
    Dimethylaniline monooxygenase [N-oxide-forming] 5Curated (EC:1.14.13.81 Publication)
    Dimethylaniline oxidase 5
    NAPDH oxidase1 Publication (EC:1.6.3.11 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FMO5Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000131781.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:3773 FMO5

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603957 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P49326

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei513 – 533HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2330

    Open Targets

    More...
    OpenTargetsi
    ENSG00000131781

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA28189

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P49326 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3430871

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    FMO5

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    1346021

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476651 – 533Flavin-containing monooxygenase 5Add BLAST533

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5Dimethylated arginine; alternateBy similarity1
    Modified residuei5Omega-N-methylated arginine; alternateBy similarity1
    Modified residuei54PhosphoserineCombined sources1
    Modified residuei56PhosphotyrosineCombined sources1
    Modified residuei58PhosphoserineCombined sources1
    Modified residuei280PhosphoserineCombined sources1
    Modified residuei284PhosphothreonineCombined sources1
    Modified residuei401PhosphoserineBy similarity1

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P49326

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P49326

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P49326

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P49326

    PeptideAtlas

    More...
    PeptideAtlasi
    P49326

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P49326

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    10453
    55987 [P49326-1]
    55988 [P49326-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P49326

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P49326

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in fetal and adult liver.1 Publication1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000131781 Expressed in body of stomach and 144 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P49326 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P49326 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000131781 Group enriched (intestine, liver, stomach)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108617, 6 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P49326, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000254090

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P49326 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P49326

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FMO family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1399 Eukaryota
    COG2072 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160493

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_006909_8_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P49326

    KEGG Orthology (KO)

    More...
    KOi
    K00485

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HHWDPRY

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P49326

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105285

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.50.50.60, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR000960 Flavin_mOase
    IPR020946 Flavin_mOase-like
    IPR002257 Flavin_mOase_5

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00743 FMO-like, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000332 FMO, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00370 FMOXYGENASE
    PR01125 FMOXYGENASE5

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51905 SSF51905, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE
    60 70 80 90 100
    GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD
    110 120 130 140 150
    LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH
    160 170 180 190 200
    HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL
    210 220 230 240 250
    AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ
    260 270 280 290 300
    SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV
    310 320 330 340 350
    KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI
    360 370 380 390 400
    SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP
    410 420 430 440 450
    SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL
    460 470 480 490 500
    SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM
    510 520 530
    TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF
    Length:533
    Mass (Da):60,221
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9D9F092F1DD71DA
    GO
    Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-285: ALSQHPTL → SKDIALTE
         286-533: Missing.

    Show »
    Length:285
    Mass (Da):32,480
    Checksum:i4DE507F329B99046
    GO
    Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
         465-533: Missing.

    Show »
    Length:464
    Mass (Da):52,477
    Checksum:i1989AA851C48E893
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PJF3E9PJF3_HUMAN
    Flavin-containing monooxygenase
    FMO5
    278Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PP51E9PP51_HUMAN
    Dimethylaniline monooxygenase [N-ox...
    FMO5
    192Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PQ84E9PQ84_HUMAN
    Dimethylaniline monooxygenase [N-ox...
    FMO5
    145Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti351S → P in CAA87633 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022308400P → A1 PublicationCorresponds to variant dbSNP:rs28381218Ensembl.1
    Natural variantiVAR_015370457P → L1 PublicationCorresponds to variant dbSNP:rs72549314Ensembl.1
    Natural variantiVAR_022309506R → S1 PublicationCorresponds to variant dbSNP:rs28381223Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042729278 – 285ALSQHPTL → SKDIALTE in isoform 2. 1 Publication8
    Alternative sequenceiVSP_042730286 – 533Missing in isoform 2. 1 PublicationAdd BLAST248
    Alternative sequenceiVSP_045616419 – 464RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationAdd BLAST46
    Alternative sequenceiVSP_045617465 – 533Missing in isoform 3. 1 PublicationAdd BLAST69

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L37080 mRNA Translation: AAA67849.1
    Z47553 mRNA Translation: CAA87633.1
    AY902236 Genomic DNA Translation: AAW69390.1
    AK314647 mRNA Translation: BAG37208.1
    AK225739 mRNA No translation available.
    AL356378 Genomic DNA Translation: CAH72648.1
    AL356378 Genomic DNA Translation: CAH72649.1
    CH471223 Genomic DNA Translation: EAW50939.1
    CH471223 Genomic DNA Translation: EAW50940.1
    BC035687 mRNA Translation: AAH35687.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS44209.1 [P49326-3]
    CCDS44210.1 [P49326-2]
    CCDS926.1 [P49326-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S51131
    S71618

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001138301.1, NM_001144829.2 [P49326-3]
    NP_001138302.1, NM_001144830.2 [P49326-2]
    NP_001452.2, NM_001461.3 [P49326-1]
    XP_005273003.1, XM_005272946.4 [P49326-1]
    XP_005273004.1, XM_005272947.4 [P49326-1]
    XP_005273005.1, XM_005272948.4 [P49326-1]
    XP_006711308.1, XM_006711245.3 [P49326-2]
    XP_011507652.1, XM_011509350.2 [P49326-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000254090; ENSP00000254090; ENSG00000131781 [P49326-1]
    ENST00000369272; ENSP00000358277; ENSG00000131781 [P49326-2]
    ENST00000441068; ENSP00000416011; ENSG00000131781 [P49326-3]
    ENST00000578284; ENSP00000462062; ENSG00000131781 [P49326-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2330

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2330

    UCSC genome browser

    More...
    UCSCi
    uc001eph.5 human [P49326-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L37080 mRNA Translation: AAA67849.1
    Z47553 mRNA Translation: CAA87633.1
    AY902236 Genomic DNA Translation: AAW69390.1
    AK314647 mRNA Translation: BAG37208.1
    AK225739 mRNA No translation available.
    AL356378 Genomic DNA Translation: CAH72648.1
    AL356378 Genomic DNA Translation: CAH72649.1
    CH471223 Genomic DNA Translation: EAW50939.1
    CH471223 Genomic DNA Translation: EAW50940.1
    BC035687 mRNA Translation: AAH35687.1
    CCDSiCCDS44209.1 [P49326-3]
    CCDS44210.1 [P49326-2]
    CCDS926.1 [P49326-1]
    PIRiS51131
    S71618
    RefSeqiNP_001138301.1, NM_001144829.2 [P49326-3]
    NP_001138302.1, NM_001144830.2 [P49326-2]
    NP_001452.2, NM_001461.3 [P49326-1]
    XP_005273003.1, XM_005272946.4 [P49326-1]
    XP_005273004.1, XM_005272947.4 [P49326-1]
    XP_005273005.1, XM_005272948.4 [P49326-1]
    XP_006711308.1, XM_006711245.3 [P49326-2]
    XP_011507652.1, XM_011509350.2 [P49326-1]

    3D structure databases

    SMRiP49326
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi108617, 6 interactors
    IntActiP49326, 5 interactors
    STRINGi9606.ENSP00000254090

    Chemistry databases

    ChEMBLiCHEMBL3430871
    SwissLipidsiSLP:000001774

    PTM databases

    iPTMnetiP49326
    PhosphoSitePlusiP49326

    Polymorphism and mutation databases

    BioMutaiFMO5
    DMDMi1346021

    Proteomic databases

    jPOSTiP49326
    MassIVEiP49326
    MaxQBiP49326
    PaxDbiP49326
    PeptideAtlasiP49326
    PRIDEiP49326
    ProteomicsDBi10453
    55987 [P49326-1]
    55988 [P49326-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    2436 198 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    2330

    Genome annotation databases

    EnsembliENST00000254090; ENSP00000254090; ENSG00000131781 [P49326-1]
    ENST00000369272; ENSP00000358277; ENSG00000131781 [P49326-2]
    ENST00000441068; ENSP00000416011; ENSG00000131781 [P49326-3]
    ENST00000578284; ENSP00000462062; ENSG00000131781 [P49326-3]
    GeneIDi2330
    KEGGihsa:2330
    UCSCiuc001eph.5 human [P49326-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2330
    DisGeNETi2330
    EuPathDBiHostDB:ENSG00000131781.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    FMO5
    HGNCiHGNC:3773 FMO5
    HPAiENSG00000131781 Group enriched (intestine, liver, stomach)
    MIMi603957 gene
    neXtProtiNX_P49326
    OpenTargetsiENSG00000131781
    PharmGKBiPA28189

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1399 Eukaryota
    COG2072 LUCA
    GeneTreeiENSGT00940000160493
    HOGENOMiCLU_006909_8_0_1
    InParanoidiP49326
    KOiK00485
    OMAiHHWDPRY
    PhylomeDBiP49326
    TreeFamiTF105285

    Enzyme and pathway databases

    BRENDAi1.14.13.8 2681
    SABIO-RKiP49326

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    2330 1 hit in 786 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    FMO5 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    FMO5

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2330
    PharosiP49326 Tbio

    Protein Ontology

    More...
    PROi
    PR:P49326
    RNActiP49326 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000131781 Expressed in body of stomach and 144 other tissues
    ExpressionAtlasiP49326 baseline and differential
    GenevisibleiP49326 HS

    Family and domain databases

    Gene3Di3.50.50.60, 2 hits
    InterProiView protein in InterPro
    IPR036188 FAD/NAD-bd_sf
    IPR000960 Flavin_mOase
    IPR020946 Flavin_mOase-like
    IPR002257 Flavin_mOase_5
    PfamiView protein in Pfam
    PF00743 FMO-like, 1 hit
    PIRSFiPIRSF000332 FMO, 1 hit
    PRINTSiPR00370 FMOXYGENASE
    PR01125 FMOXYGENASE5
    SUPFAMiSSF51905 SSF51905, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMO5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49326
    Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: June 17, 2020
    This is version 186 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again