Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear autoantigenic sperm protein

Gene

NASP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: UniProtKB
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA replication, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear autoantigenic sperm protein
Short name:
NASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132780.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7644 NASP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603185 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49321

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000132780

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31448

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NASP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23503077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062992 – 788Nuclear autoantigenic sperm proteinAdd BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei123PhosphothreonineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei243N6-acetyllysineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineBy similarity1
Modified residuei299PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei390PhosphothreonineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Modified residuei464PhosphothreonineCombined sources1
Modified residuei477PhosphothreonineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei490PhosphothreonineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei683PhosphothreonineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei726PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki736Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei745PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Isoform 2 (identifier: P49321-2)
Modified residuei138PhosphothreonineCombined sources1
Modified residuei141PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49321

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49321

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49321

PeptideAtlas

More...
PeptideAtlasi
P49321

PRoteomics IDEntifications database

More...
PRIDEi
P49321

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55984
55985 [P49321-2]
55986 [P49321-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49321

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49321

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P49321

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P49321

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is testis- and sperm-specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132780 Expressed in 236 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_NASP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49321 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49321 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028136
HPA030518
HPA030520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (PubMed:8724350, PubMed:27618665). Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110759, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P49321

Database of interacting proteins

More...
DIPi
DIP-47269N

Protein interaction database and analysis system

More...
IntActi
P49321, 29 interactors

Molecular INTeraction database

More...
MINTi
P49321

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P49321

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49321

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 76TPR 1Add BLAST34
Repeati542 – 575TPR 2Add BLAST34
Repeati584 – 617TPR 3Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni116 – 127Histone-binding1 PublicationAdd BLAST12
Regioni211 – 244Histone-binding1 PublicationAdd BLAST34
Regioni469 – 512Histone-binding1 PublicationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili136 – 164Sequence analysisAdd BLAST29
Coiled coili460 – 487Sequence analysisAdd BLAST28
Coiled coili597 – 665Sequence analysisAdd BLAST69
Coiled coili753 – 778Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi716 – 722Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 658Glu-rich (acidic)Add BLAST548

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NASP family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4563 Eukaryota
ENOG4110P5E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013120

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002186

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49321

KEGG Orthology (KO)

More...
KOi
K11291

Identification of Orthologs from Complete Genome Data

More...
OMAi
THYHVAT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PN0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49321

TreeFam database of animal gene trees

More...
TreeFami
TF317297

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019544 Tetratricopeptide_SHNi-TPR_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10516 SHNi-TPR, 1 hit
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49321-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMESTATAA VAAELVSADK IEDVPAPSTS ADKVESLDVD SEAKKLLGLG
60 70 80 90 100
QKHLVMGDIP AAVNAFQEAA SLLGKKYGET ANECGEAFFF YGKSLLELAR
110 120 130 140 150
MENGVLGNAL EGVHVEEEEG EKTEDESLVE NNDNIDEEAR EELREQVYDA
160 170 180 190 200
MGEKEEAKKT EDKSLAKPET DKEQDSEMEK GGREDMDISK SAEEPQEKVD
210 220 230 240 250
LTLDWLTETS EEAKGGAAPE GPNEAEVTSG KPEQEVPDAE EEKSVSGTDV
260 270 280 290 300
QEECREKGGQ EKQGEVIVSI EEKPKEVSEE QPVVTLEKQG TAVEVEAESL
310 320 330 340 350
DPTVKPVDVG GDEPEEKVVT SENEAGKAVL EQLVGQEVPP AEESPEVTTE
360 370 380 390 400
AAEASAVEAG SEVSEKPGQE APVLPKDGAV NGPSVVGDQT PIEPQTSIER
410 420 430 440 450
LTETKDGSGL EEKVRAKLVP SQEETKLSVE ESEAAGDGVD TKVAQGATEK
460 470 480 490 500
SPEDKVQIAA NEETQEREEQ MKEGEETEGS EEDDKENDKT EEMPNDSVLE
510 520 530 540 550
NKSLQENEEE EIGNLELAWD MLDLAKIIFK RQETKEAQLY AAQAHLKLGE
560 570 580 590 600
VSVESENYVQ AVEEFQSCLN LQEQYLEAHD RLLAETHYQL GLAYGYNSQY
610 620 630 640 650
DEAVAQFSKS IEVIENRMAV LNEQVKEAEG SSAEYKKEIE ELKELLPEIR
660 670 680 690 700
EKIEDAKESQ RSGNVAELAL KATLVESSTS GFTPGGGGSS VSMIASRKPT
710 720 730 740 750
DGASSSNCVT DISHLVRKKR KPEEESPRKD DAKKAKQEPE VNGGSGDAVP
760 770 780
SGNEVSENME EEAENQAESR AAVEGTVEAG ATVESTAC
Length:788
Mass (Da):85,238
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F4EB2BBE71534E8
GO
Isoform 2 (identifier: P49321-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-476: Missing.

Show »
Length:449
Mass (Da):48,804
Checksum:iA69B7FE13AAA3433
GO
Isoform 3 (identifier: P49321-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAMESTATAAVAAELVSADKIEDVPAPSTSADKVES → MFLLLLHLQIKWRATINLLSVTEDGLHFVEYYLNRIIH

Show »
Length:790
Mass (Da):86,268
Checksum:i6C7299FFBC62B4B2
GO
Isoform 4 (identifier: P49321-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-99: Missing.

Note: No experimental confirmation available.
Show »
Length:724
Mass (Da):78,450
Checksum:iB1917C4EF7BAE070
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T624Q5T624_HUMAN
Nuclear autoantigenic sperm protein
NASP
422Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI86E9PI86_HUMAN
Nuclear autoantigenic sperm protein
NASP
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPR5E9PPR5_HUMAN
Nuclear autoantigenic sperm protein
NASP
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRH9E9PRH9_HUMAN
Nuclear autoantigenic sperm protein
NASP
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF33H0YF33_HUMAN
Nuclear autoantigenic sperm protein
NASP
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDS9H0YDS9_HUMAN
Nuclear autoantigenic sperm protein
NASP
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPQ8E9PPQ8_HUMAN
Nuclear autoantigenic sperm protein
NASP
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNB5E9PNB5_HUMAN
Nuclear autoantigenic sperm protein
NASP
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQG5E9PQG5_HUMAN
Nuclear autoantigenic sperm protein
NASP
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PAU3E9PAU3_HUMAN
Nuclear autoantigenic sperm protein
NASP
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14 – 15EL → DV in AAA36027 (PubMed:1426632).Curated2
Sequence conflicti159K → T in BAD96536 (Ref. 3) Curated1
Sequence conflicti183R → G in BAG61005 (PubMed:14702039).Curated1
Sequence conflicti348T → Q in AAA36027 (PubMed:1426632).Curated1
Sequence conflicti633Missing in AAA36027 (PubMed:1426632).Curated1
Sequence conflicti767 – 770AESR → LKRG in AAA36027 (PubMed:1426632).Curated4
Sequence conflicti777V → L in AAA36027 (PubMed:1426632).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052619620V → G. Corresponds to variant dbSNP:rs34618000Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0366161 – 36MAMES…DKVES → MFLLLLHLQIKWRATINLLS VTEDGLHFVEYYLNRIIH in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_04702836 – 99Missing in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_006551138 – 476Missing in isoform 2. 1 PublicationAdd BLAST339

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M97856 mRNA Translation: AAA36027.1
AK056161 mRNA No translation available.
AK291637 mRNA Translation: BAF84326.1
AK298893 mRNA Translation: BAG61005.1
AK222816 mRNA Translation: BAD96536.1
AL355480 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06968.1
CH471059 Genomic DNA Translation: EAX06969.1
BC003113 mRNA Translation: AAH03113.1
BC053608 mRNA Translation: AAH53608.1
BC010105 mRNA Translation: AAH10105.1
BC011580 mRNA Translation: AAH11580.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS524.1 [P49321-1]
CCDS525.1 [P49321-2]
CCDS55597.1 [P49321-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A48819

NCBI Reference Sequences

More...
RefSeqi
NP_001182122.1, NM_001195193.1 [P49321-4]
NP_002473.2, NM_002482.3 [P49321-1]
NP_689511.2, NM_152298.3 [P49321-2]
XP_005270945.1, XM_005270888.2 [P49321-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.319334

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000350030; ENSP00000255120; ENSG00000132780 [P49321-1]
ENST00000351223; ENSP00000255121; ENSG00000132780 [P49321-2]
ENST00000537798; ENSP00000438871; ENSG00000132780 [P49321-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4678

UCSC genome browser

More...
UCSCi
uc001coi.3 human [P49321-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97856 mRNA Translation: AAA36027.1
AK056161 mRNA No translation available.
AK291637 mRNA Translation: BAF84326.1
AK298893 mRNA Translation: BAG61005.1
AK222816 mRNA Translation: BAD96536.1
AL355480 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06968.1
CH471059 Genomic DNA Translation: EAX06969.1
BC003113 mRNA Translation: AAH03113.1
BC053608 mRNA Translation: AAH53608.1
BC010105 mRNA Translation: AAH10105.1
BC011580 mRNA Translation: AAH11580.1
CCDSiCCDS524.1 [P49321-1]
CCDS525.1 [P49321-2]
CCDS55597.1 [P49321-4]
PIRiA48819
RefSeqiNP_001182122.1, NM_001195193.1 [P49321-4]
NP_002473.2, NM_002482.3 [P49321-1]
NP_689511.2, NM_152298.3 [P49321-2]
XP_005270945.1, XM_005270888.2 [P49321-3]
UniGeneiHs.319334

3D structure databases

ProteinModelPortaliP49321
SMRiP49321
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110759, 60 interactors
CORUMiP49321
DIPiDIP-47269N
IntActiP49321, 29 interactors
MINTiP49321
STRINGi9606.ENSP00000255120

PTM databases

iPTMnetiP49321
PhosphoSitePlusiP49321
SwissPalmiP49321

Polymorphism and mutation databases

BioMutaiNASP
DMDMi23503077

Proteomic databases

EPDiP49321
MaxQBiP49321
PaxDbiP49321
PeptideAtlasiP49321
PRIDEiP49321
ProteomicsDBi55984
55985 [P49321-2]
55986 [P49321-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4678
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350030; ENSP00000255120; ENSG00000132780 [P49321-1]
ENST00000351223; ENSP00000255121; ENSG00000132780 [P49321-2]
ENST00000537798; ENSP00000438871; ENSG00000132780 [P49321-4]
GeneIDi4678
KEGGihsa:4678
UCSCiuc001coi.3 human [P49321-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4678
EuPathDBiHostDB:ENSG00000132780.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NASP
HGNCiHGNC:7644 NASP
HPAiHPA028136
HPA030518
HPA030520
MIMi603185 gene
neXtProtiNX_P49321
OpenTargetsiENSG00000132780
PharmGKBiPA31448

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4563 Eukaryota
ENOG4110P5E LUCA
GeneTreeiENSGT00390000016650
HOGENOMiHOG000013120
HOVERGENiHBG002186
InParanoidiP49321
KOiK11291
OMAiTHYHVAT
OrthoDBiEOG091G0PN0
PhylomeDBiP49321
TreeFamiTF317297

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NASP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NASP_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4678
PMAP-CutDBiP49321

Protein Ontology

More...
PROi
PR:P49321

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132780 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_NASP
ExpressionAtlasiP49321 baseline and differential
GenevisibleiP49321 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019544 Tetratricopeptide_SHNi-TPR_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF10516 SHNi-TPR, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNASP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49321
Secondary accession number(s): A8K6H2
, B4DQP3, D3DQ07, F5H3J2, Q53GW5, Q5T622, Q5T625, Q96A69, Q9BTW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 19, 2002
Last modified: December 5, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again