Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-type lectin domain family 10 member A

Gene

Clec10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • connective tissue replacement involved in inflammatory response wound healing Source: MGI

Keywordsi

LigandCalcium, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 10 member A
Alternative name(s):
MMGL
Macrophage asialoglycoprotein-binding protein 1
Short name:
M-ASGP-BP-1
Macrophage galactose/N-acetylgalactosamine-specific lectin
Gene namesi
Name:Clec10a
Synonyms:Mgl, Mgl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96975 Clec10a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 304ExtracellularSequence analysisAdd BLAST248

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466571 – 304C-type lectin domain family 10 member AAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 184PROSITE-ProRule annotation
Disulfide bondi201 ↔ 296PROSITE-ProRule annotation
Disulfide bondi274 ↔ 288PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49300
PRIDEiP49300

PTM databases

iPTMnetiP49300
PhosphoSitePlusiP49300

Expressioni

Tissue specificityi

Detected in lymph node in the subcapsular sinus, interfollicular regions, T and B-cell boundary and in the areas surrounding high endothelial venules (at protein level). Expressed on the surface of activated macrophages. Expressed in heart, lung, testis, skeletal muscle, spleen, brain, kidney and thymus. Expressed in P388, RAW 264.7 and M1 cell lines.2 Publications

Developmental stagei

Detected in E7, E11, E15 and E17 embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000000318 Expressed in 113 organ(s), highest expression level in zone of skin
ExpressionAtlasiP49300 baseline and differential
GenevisibleiP49300 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with SIGLEC1, which may act as a counter-receptor for CLEC10A in lymph node.1 Publication

Protein-protein interaction databases

IntActiP49300, 1 interactor
MINTiP49300
STRINGi10090.ENSMUSP00000000327

Structurei

3D structure databases

ProteinModelPortaliP49300
SMRiP49300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 298C-type lectinPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP49300
KOiK06721
PhylomeDBiP49300

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P49300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYENLQNSR IEEKTQEPGK APSQSFLWRI LSWTHLLLFS LGLSLLLLVV
60 70 80 90 100
VSVIGSQNSQ LRRDLGTLRA TLDNTTSKIK AEFQSLDSRA DSFEKGISSL
110 120 130 140 150
KVDVEDHRQE LQAGRDLSQK VTSLESTVEK REQALKTDLS DLTDHVQQLR
160 170 180 190 200
KDLKALTCQL ANLKNNGSEV ACCPLHWTEH EGSCYWFSES EKSWPEADKY
210 220 230 240 250
CRLENSHLVV VNSLEEQNFL QNRLANVVSW IGLTDQNGPW RWVDGTDFEK
260 270 280 290 300
GFKNWAPLQP DNWFGHGLGG GEDCAHITTG GPWNDDVCQR TFRWICEMKL

AKES
Length:304
Mass (Da):34,596
Last modified:February 1, 1996 - v1
Checksum:i3F79CD12C34F5BCC
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHB7F8WHB7_MOUSE
C-type lectin domain family 10 memb...
Clec10a
305Annotation score:
J3QPR7J3QPR7_MOUSE
C-type lectin domain family 10 memb...
Clec10a
308Annotation score:
A2CF63A2CF63_MOUSE
C-type lectin domain family 10 memb...
Clec10a
57Annotation score:
A2CF65A2CF65_MOUSE
C-type lectin domain family 10 memb...
Clec10a
214Annotation score:
B1AU03B1AU03_MOUSE
C-type lectin domain family 10 memb...
Clec10a
103Annotation score:
B1AU01B1AU01_MOUSE
C-type lectin domain family 10 memb...
Clec10a
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71T → I in AAH14811 (PubMed:15489334).Curated1
Sequence conflicti128V → L in AAH14811 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S36676 mRNA Translation: AAB22171.1
AF132744 Genomic DNA Translation: AAD31028.1
CH466596 Genomic DNA Translation: EDL12536.1
AL669869 Genomic DNA Translation: CAI35217.1
CR933731 Genomic DNA Translation: CAM28085.1
BC014811 mRNA Translation: AAH14811.1
CCDSiCCDS24936.1
PIRiJX0209
RefSeqiNP_034926.1, NM_010796.3
UniGeneiMm.252405

Genome annotation databases

EnsembliENSMUST00000102571; ENSMUSP00000099631; ENSMUSG00000000318
GeneIDi17312
KEGGimmu:17312
UCSCiuc007jtx.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

MGL1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S36676 mRNA Translation: AAB22171.1
AF132744 Genomic DNA Translation: AAD31028.1
CH466596 Genomic DNA Translation: EDL12536.1
AL669869 Genomic DNA Translation: CAI35217.1
CR933731 Genomic DNA Translation: CAM28085.1
BC014811 mRNA Translation: AAH14811.1
CCDSiCCDS24936.1
PIRiJX0209
RefSeqiNP_034926.1, NM_010796.3
UniGeneiMm.252405

3D structure databases

ProteinModelPortaliP49300
SMRiP49300
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49300, 1 interactor
MINTiP49300
STRINGi10090.ENSMUSP00000000327

PTM databases

iPTMnetiP49300
PhosphoSitePlusiP49300

Proteomic databases

PaxDbiP49300
PRIDEiP49300

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102571; ENSMUSP00000099631; ENSMUSG00000000318
GeneIDi17312
KEGGimmu:17312
UCSCiuc007jtx.2 mouse

Organism-specific databases

CTDi10462
MGIiMGI:96975 Clec10a

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP49300
KOiK06721
PhylomeDBiP49300

Miscellaneous databases

PROiPR:P49300
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000318 Expressed in 113 organ(s), highest expression level in zone of skin
ExpressionAtlasiP49300 baseline and differential
GenevisibleiP49300 MM

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC10_MOUSE
AccessioniPrimary (citable) accession number: P49300
Secondary accession number(s): Q549F6, Q91YT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again