Natural resistance-associated macrophage protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cadmium ion binding Source: UniProtKB
• cadmium ion transmembrane transporter activity Source: MGI
• cobalt ion binding Source: MGI
• cobalt ion transmembrane transporter activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 10942769
  • 12522007
  • 12724326
  • 16142913
  • 16905747
• copper ion binding Source: MGI
• copper ion transmembrane transporter activity Source: MGI
• ferrous iron transmembrane transporter activity Source: MGIInferred from direct assayⁱ
  • 10942769
  • 12522007
  • 15024413
• inorganic cation transmembrane transporter activity Source: MGI
• iron ion binding Source: MGI
• iron ion transmembrane transporter activity Source: MGIInferred from direct assayⁱ
  • 16142913
• lead ion transmembrane transporter activity Source: MGI
• manganese ion binding Source: MGI
• manganese ion transmembrane transporter activity Source: MGI
• nickel cation binding Source: MGI
• nickel cation transmembrane transporter activity Source: MGI
• proton transmembrane transporter activity Source: MGIInferred from direct assayⁱ
  • 15024413
• solute:proton symporter activity Source: MGI
• transition metal ion transmembrane transporter activity Source: MGI
• vanadium ion transmembrane transporter activity Source: MGI
• zinc ion binding Source: MGI

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• cadmium ion transmembrane transport Source: UniProtKB
• cellular copper ion homeostasis Source: MGI
• cellular response to oxidative stress Source: MGI
• cobalt ion transport Source: MGIInferred from direct assayⁱ
  • 10942769
  • 12522007
  • 12724326
  • 16142913
  • 16905747
• copper ion import across plasma membrane Source: MGI
• copper ion transport Source: MGI
• dendrite morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19211831
• erythrocyte development Source: MGIInferred from mutant phenotypeⁱ
  • 15849611
• ferrous iron import Source: MGIInferred from direct assayⁱ
  • 15024413
• ferrous iron transmembrane transport Source: MGI
• ferrous iron transport Source: MGIInferred from direct assayⁱ
  • 10942769
• heme biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • 11739192
• iron ion transport Source: MGIInferred from direct assayⁱ
  • 12522007
  • 16142913
• lead ion transport Source: MGI
• learning or memory Source: MGIInferred from mutant phenotypeⁱ
  • 19211831
• manganese ion transport Source: MGI
• multicellular organismal iron ion homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 18076961
  • 5070129
• nickel cation transport Source: MGI
• porphyrin-containing compound biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • 658175
• porphyrin-containing compound metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 4404581
• proton transmembrane transport Source: MGIInferred from direct assayⁱ
  • 15024413
• response to iron ion Source: Ensembl
• response to manganese ion Source: MGI
• transition metal ion transport Source: MGI
• vanadium ion transport Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 5 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY 
        60         70         80         90        100
FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA 
       110        120        130        140        150
GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 
       160        170        180        190        200
LMVELAIIGS DMQEVIGSAI AINLLSAGRV PLWGGVLITI ADTFVFLFLD 
       210        220        230        240        250
KYGLRKLEAF FGFLITIMAL TFGYEYITVK PSQSQVLRGM FVPSCPGCRT 
       260        270        280        290        300
PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 
       310        320        330        340        350
CIALFVSFII NVFVVSVFAE AFFEKTNKQV VEVCKNNSSP HADLFPSDNS 
       360        370        380        390        400
TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG 
       410        420        430        440        450
FLNLKWSRFA RVILTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL 
       460        470        480        490        500
PFALIPILTF TSLRPVMSEF SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ 
       510        520        530        540        550
ELGHVALYVV AAVVSVAYLT FVFYLGWQCL IALGLSFLDC GRSYRLGLTA 
       560 
QPELYLLNTV DADSVVSR                                    

        10         20         30         40         50
MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY 
        60         70         80         90        100
FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA 
       110        120        130        140        150
GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 
       160        170        180        190        200
LMVELAIIGS DMQEVIGSAI AINLLSAGRV PLWGGVLITI ADTFVFLFLD 
       210        220        230        240        250
KYGLRKLEAF FGFLITIMAL TFGYEYITVK PSQSQVLRGM FVPSCPGCRT 
       260        270        280        290        300
PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 
       310        320        330        340        350
CIALFVSFII NVFVVSVFAE AFFEKTNKQV VEVCKNNSSP HADLFPSDNS 
       360        370        380        390        400
TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG 
       410        420        430        440        450
FLNLKWSRFA RVILTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL 
       460        470        480        490        500
PFALIPILTF TSLRPVMSEF SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ 
       510        520        530        540        550
ELGHVALYVV AAVVSVAYLT FVFYLGWQCL IALGLSFLDC GRSVSISKVL 
       560 
LSEDTSGGNI K                                           

        10         20         30         40         50
MGKKQPRAAA AAPNCELKSY SKSTDPQVST MVLDPKEKMP DDGASGDHGD 
        60         70         80         90        100
SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL 
       110        120        130        140        150
WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 
       160        170        180        190        200
LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI 
       210        220        230        240        250
AINLLSAGRV PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL 
       260        270        280        290        300
TFGYEYITVK PSQSQVLRGM FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY 
       310        320        330        340        350
LHSALVKSRQ VNRANKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE 
       360        370        380        390        400
AFFEKTNKQV VEVCKNNSSP HADLFPSDNS TLAVDIYKGG VVLGCYFGPA 
       410        420        430        440        450
ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 
       460        470        480        490        500
IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF 
       510        520        530        540        550
SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLT 
       560        570        580        590 
FVFYLGWQCL IALGLSFLDC GRSVSISKVL LSEDTSGGNI K          

        10         20         30         40         50
MGKKQPRAAA AAPNCELKSY SKSTDPQVST MVLDPKEKMP DDGASGDHGD 
        60         70         80         90        100
SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL 
       110        120        130        140        150
WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 
       160        170        180        190        200
LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI 
       210        220        230        240        250
AINLLSAGRV PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL 
       260        270        280        290        300
TFGYEYITVK PSQSQVLRGM FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY 
       310        320        330        340        350
LHSALVKSRQ VNRANKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE 
       360        370        380        390        400
AFFEKTNKQV VEVCKNNSSP HADLFPSDNS TLAVDIYKGG VVLGCYFGPA 
       410        420        430        440        450
ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 
       460        470        480        490        500
IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF 
       510        520        530        540        550
SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLT 
       560        570        580        590 
FVFYLGWQCL IALGLSFLDC GRSYRLGLTA QPELYLLNTV DADSVVSR   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ