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Entry version 169 (13 Nov 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Natural resistance-associated macrophage protein 1

Gene

SLC11A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-425410 Metal ion SLC transporters
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803544 Ion influx/efflux at host-pathogen interface

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49279

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.55.2.3 the metal ion (mn(2+)-iron) transporter (nramp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Natural resistance-associated macrophage protein 1
Short name:
NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC11A1
Synonyms:LSH, NRAMP, NRAMP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10907 SLC11A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600266 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 76HelicalSequence analysisAdd BLAST18
Topological domaini77 – 85ExtracellularSequence analysis9
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Topological domaini106 – 142CytoplasmicSequence analysisAdd BLAST37
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 167ExtracellularSequence analysis4
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Topological domaini188 – 196CytoplasmicSequence analysis9
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 240ExtracellularSequence analysisAdd BLAST23
Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 287CytoplasmicSequence analysisAdd BLAST28
Transmembranei288 – 307HelicalSequence analysisAdd BLAST20
Topological domaini308 – 349ExtracellularSequence analysisAdd BLAST42
Transmembranei350 – 369HelicalSequence analysisAdd BLAST20
Topological domaini370 – 400CytoplasmicSequence analysisAdd BLAST31
Transmembranei401 – 418HelicalSequence analysisAdd BLAST18
Topological domaini419 – 429ExtracellularSequence analysisAdd BLAST11
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 466CytoplasmicSequence analysisAdd BLAST16
Transmembranei467 – 488HelicalSequence analysisAdd BLAST22
Topological domaini489 – 496ExtracellularSequence analysis8
Transmembranei497 – 516HelicalSequence analysisAdd BLAST20
Topological domaini517 – 550CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6556

MalaCards human disease database

More...
MalaCardsi
SLC11A1
MIMi607948 phenotype
610446 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000018280

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3389 Tuberculosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA319

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49279

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2052040

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC11A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352521

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002125881 – 550Natural resistance-associated macrophage protein 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49279

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49279

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49279

PeptideAtlas

More...
PeptideAtlasi
P49279

PRoteomics IDEntifications database

More...
PRIDEi
P49279

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55978 [P49279-1]
7572

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In response to lymphokine or bacterial products.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000018280 Expressed in 164 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49279 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49279 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029590

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233202

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P49279

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 80Pro/Ser-richAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1291 Eukaryota
COG1914 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000152203

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49279

KEGG Orthology (KO)

More...
KOi
K12347

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYNALQD

Database of Orthologous Groups

More...
OrthoDBi
666470at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49279

TreeFam database of animal gene trees

More...
TreeFami
TF315185

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00221 NRAMP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001046 NRAMP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11706 PTHR11706, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01566 Nramp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00447 NATRESASSCMP

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01197 nramp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P49279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP
60 70 80 90 100
GTFSLRKLWA FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT
110 120 130 140 150
VLGLLCQRLA ARLGVVTGKD LGEVCHLYYP KVPRTVLWLT IELAIVGSDM
160 170 180 190 200
QEVIGTAIAF NLLSAGRIPL WGGVLITIVD TFFFLFLDNY GLRKLEAFFG
210 220 230 240 250
LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA
260 270 280 290 300
IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL
310 320 330 340 350
FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV
360 370 380 390 400
ILGCLFGPAA LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR
410 420 430 440 450
VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT
460 470 480 490 500
SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN LYFVVSYLPS LPHPAYFGLA
510 520 530 540 550
ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL EEDQKGETSG
Length:550
Mass (Da):59,872
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA670763D52EEECC
GO
Isoform 2 (identifier: P49279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MTGDKGPQRLSGS → MVRCQLTATSTSQ
     14-131: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):47,292
Checksum:i1C005994A512B944
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9HBK0Q9HBK0_HUMAN
Natural resistance-associated macro...
SLC11A1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2D6A0A087X2D6_HUMAN
Natural resistance-associated macro...
SLC11A1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X181A0A087X181_HUMAN
Natural resistance-associated macro...
SLC11A1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTL3A0A0A0MTL3_HUMAN
Natural resistance-associated macro...
SLC11A1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54S → R in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti84A → L (PubMed:8529098).Curated1
Sequence conflicti86A → P (PubMed:8529098).Curated1
Sequence conflicti275A → V in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti305V → A in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti315N → K in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti397R → S in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti441F → V in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti478A → T in CAA57541 (PubMed:8529098).Curated1
Sequence conflicti544Q → H in CAA57541 (PubMed:8529098).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIMi:610446].
Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIMi:607948].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00462930Q → R. Corresponds to variant dbSNP:rs751872662Ensembl.1
Natural variantiVAR_004630318A → V1 PublicationCorresponds to variant dbSNP:rs201565523Ensembl.1
Natural variantiVAR_004631543D → N Associated with susceptibility to infection with Mycobacterium ulcerans. 1 PublicationCorresponds to variant dbSNP:rs17235409EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0478751 – 13MTGDK…RLSGS → MVRCQLTATSTSQ in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_04787614 – 131Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L32185 mRNA Translation: AAA57521.1
L38593, L38592 Genomic DNA Translation: AAA57557.1
AF229163 Genomic DNA Translation: AAG15405.1
AC021016 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70611.1
BC071165 mRNA Translation: AAH71165.1
D50402 mRNA Translation: BAA08907.1
D50403 mRNA Translation: BAA08908.1
D38171 mRNA Translation: BAA07370.1
X82015 Genomic DNA Translation: CAA57541.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2415.1 [P49279-1]

Protein sequence database of the Protein Information Resource

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PIRi
I55679
JC4095

NCBI Reference Sequences

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RefSeqi
NP_000569.3, NM_000578.3 [P49279-1]
XP_005246850.1, XM_005246793.3
XP_005246851.1, XM_005246794.3 [P49279-2]
XP_006712772.1, XM_006712709.3 [P49279-2]
XP_006712773.1, XM_006712710.3 [P49279-2]
XP_016860255.1, XM_017004766.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233202; ENSP00000233202; ENSG00000018280 [P49279-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6556

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6556

UCSC genome browser

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UCSCi
uc002vhv.3 human [P49279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32185 mRNA Translation: AAA57521.1
L38593, L38592 Genomic DNA Translation: AAA57557.1
AF229163 Genomic DNA Translation: AAG15405.1
AC021016 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70611.1
BC071165 mRNA Translation: AAH71165.1
D50402 mRNA Translation: BAA08907.1
D50403 mRNA Translation: BAA08908.1
D38171 mRNA Translation: BAA07370.1
X82015 Genomic DNA Translation: CAA57541.1
CCDSiCCDS2415.1 [P49279-1]
PIRiI55679
JC4095
RefSeqiNP_000569.3, NM_000578.3 [P49279-1]
XP_005246850.1, XM_005246793.3
XP_005246851.1, XM_005246794.3 [P49279-2]
XP_006712772.1, XM_006712709.3 [P49279-2]
XP_006712773.1, XM_006712710.3 [P49279-2]
XP_016860255.1, XM_017004766.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000233202

Chemistry databases

BindingDBiP49279
ChEMBLiCHEMBL2052040

Protein family/group databases

TCDBi2.A.55.2.3 the metal ion (mn(2+)-iron) transporter (nramp) family

PTM databases

iPTMnetiP49279
PhosphoSitePlusiP49279

Polymorphism and mutation databases

BioMutaiSLC11A1
DMDMi1352521

Proteomic databases

jPOSTiP49279
MassIVEiP49279
PaxDbiP49279
PeptideAtlasiP49279
PRIDEiP49279
ProteomicsDBi55978 [P49279-1]
7572

Genome annotation databases

EnsembliENST00000233202; ENSP00000233202; ENSG00000018280 [P49279-1]
GeneIDi6556
KEGGihsa:6556
UCSCiuc002vhv.3 human [P49279-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6556
DisGeNETi6556

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC11A1
HGNCiHGNC:10907 SLC11A1
HPAiHPA029590
MalaCardsiSLC11A1
MIMi600266 gene
607948 phenotype
610446 phenotype
neXtProtiNX_P49279
OpenTargetsiENSG00000018280
Orphaneti3389 Tuberculosis
PharmGKBiPA319

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1291 Eukaryota
COG1914 LUCA
GeneTreeiENSGT00940000160799
HOGENOMiHOG000152203
InParanoidiP49279
KOiK12347
OMAiMYNALQD
OrthoDBi666470at2759
PhylomeDBiP49279
TreeFamiTF315185

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-425410 Metal ion SLC transporters
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803544 Ion influx/efflux at host-pathogen interface
SIGNORiP49279

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC11A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC11A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6556
PharosiP49279

Protein Ontology

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PROi
PR:P49279

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000018280 Expressed in 164 organ(s), highest expression level in blood
ExpressionAtlasiP49279 baseline and differential
GenevisibleiP49279 HS

Family and domain databases

HAMAPiMF_00221 NRAMP, 1 hit
InterProiView protein in InterPro
IPR001046 NRAMP_fam
PANTHERiPTHR11706 PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566 Nramp, 1 hit
PRINTSiPR00447 NATRESASSCMP
TIGRFAMsiTIGR01197 nramp, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRAM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49279
Secondary accession number(s): C0H5Y3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 13, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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