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Protein

Mite group 2 allergen Der p 2

Gene

DERP2

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Der p 2
Alternative name(s):
Allergen Der p II
DPX
Allergen: Der p 2
Gene namesi
Name:DERP2
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei316 Der p 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001986118 – 146Mite group 2 allergen Der p 2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 136
Disulfide bondi38 ↔ 44
Disulfide bondi90 ↔ 95

Keywords - PTMi

Disulfide bond

Interactioni

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-59729N
IntActiP49278, 3 interactors

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49278
SMRiP49278
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49278

Family & Domainsi

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR003172 ML_dom
IPR039670 NPC2-like
PANTHERiPTHR11306 PTHR11306, 1 hit
PfamiView protein in Pfam
PF02221 E1_DerP2_DerF2, 1 hit
SMARTiView protein in SMART
SM00737 ML, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMYKILCLSL LVAAVARDQV DVKDCANHEI KKVLVPGCHG SEPCIIHRGK
60 70 80 90 100
PFQLEAVFEA NQNTKTAKIE IKASIDGLEV DVPGIDPNAC HYMKCPLVKG
110 120 130 140
QQYDIKYTWN VPKIAPKSEN VVVTVKVMGD DGVLACAIAT HAKIRD
Length:146
Mass (Da):15,999
Last modified:February 1, 1996 - v1
Checksum:i591B2FA7FD26D3AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39H → A. 1
Natural varianti40G → L. 1
Natural varianti44C → N. 1
Natural varianti47H → S. 1
Natural varianti49G → T. 1
Natural varianti56A → Y. 1
Natural varianti57V → L. 1
Natural varianti61N → L. 1
Natural varianti64T → S. 1
Natural varianti75I → Y. 1
Natural varianti78L → C. 1
Natural varianti81D → V. 1
Natural varianti95C → P. 1
Natural varianti98V → T. 1
Natural varianti108T → V. 1
Natural varianti111V → L. 1
Natural varianti114I → N. 1
Natural varianti115A → T. 1
Natural varianti116P → A. 1
Natural varianti118S → A. 1
Natural varianti127V → L. 1
Natural varianti128M → L. 1
Natural varianti131D → N. 1
Natural varianti133V → A. 1
Natural varianti144I → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA Translation: AAF86462.1
PIRiA60381

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA Translation: AAF86462.1
PIRiA60381

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9VNMR-A19-146[»]
1KTJX-ray2.15A/B18-146[»]
ProteinModelPortaliP49278
SMRiP49278
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59729N
IntActiP49278, 3 interactors

Protein family/group databases

Allergomei316 Der p 2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49278

Family and domain databases

InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR003172 ML_dom
IPR039670 NPC2-like
PANTHERiPTHR11306 PTHR11306, 1 hit
PfamiView protein in Pfam
PF02221 E1_DerP2_DerF2, 1 hit
SMARTiView protein in SMART
SM00737 ML, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_DERPT
AccessioniPrimary (citable) accession number: P49278
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Allergens
    Nomenclature of allergens and list of entries
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