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Entry version 144 (11 Dec 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Secretory phospholipase A2 receptor

Gene

PLA2R1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1482788 Acyl chain remodelling of PC
R-BTA-1482801 Acyl chain remodelling of PS
R-BTA-1482839 Acyl chain remodelling of PE
R-BTA-1482922 Acyl chain remodelling of PI
R-BTA-1482925 Acyl chain remodelling of PG
R-BTA-1483166 Synthesis of PA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretory phospholipase A2 receptor
Short name:
PLA2-R
Short name:
PLA2R
Alternative name(s):
180 kDa secretory phospholipase A2 receptor
M-type receptor
Cleaved into the following chain:
Soluble secretory phospholipase A2 receptor
Short name:
Soluble PLA2-R
Short name:
Soluble PLA2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:32966 PLA2R1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1392ExtracellularSequence analysisAdd BLAST1372
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1393 – 1421HelicalSequence analysisAdd BLAST29
Topological domaini1422 – 1463CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001755021 – 1463Secretory phospholipase A2 receptorAdd BLAST1443
ChainiPRO_000031124921 – ?Soluble secretory phospholipase A2 receptorBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi178 ↔ 204By similarity
Disulfide bondi192 ↔ 219By similarity
Disulfide bondi260 ↔ 354By similarity
Disulfide bondi330 ↔ 346By similarity
Disulfide bondi406 ↔ 501By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 493By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi699 ↔ 796By similarity
Disulfide bondi774 ↔ 788By similarity
Disulfide bondi840 ↔ 938By similarity
Disulfide bondi915 ↔ 930By similarity
Disulfide bondi992 ↔ 1096By similarity
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1068 ↔ 1088By similarity
Disulfide bondi1209 ↔ 1223By similarity
Disulfide bondi1280 ↔ 1377By similarity
Disulfide bondi1354 ↔ 1369By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49259

PRoteomics IDEntifications database

More...
PRIDEi
P49259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000032515 Expressed in 8 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000043437

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49259

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 115Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST78
Domaini173 – 221Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini229 – 353C-type lectin 1PROSITE-ProRule annotationAdd BLAST125
Domaini357 – 500C-type lectin 2PROSITE-ProRule annotationAdd BLAST144
Domaini504 – 641C-type lectin 3PROSITE-ProRule annotationAdd BLAST138
Domaini646 – 795C-type lectin 4PROSITE-ProRule annotationAdd BLAST150
Domaini799 – 937C-type lectin 5PROSITE-ProRule annotationAdd BLAST139
Domaini941 – 1095C-type lectin 6PROSITE-ProRule annotationAdd BLAST155
Domaini1099 – 1230C-type lectin 7PROSITE-ProRule annotationAdd BLAST132
Domaini1235 – 1376C-type lectin 8PROSITE-ProRule annotationAdd BLAST142

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1436 – 1442Endocytosis signal7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.By similarity
The endocytosis signal probably mediates endocytosis via clathrin-coated pits.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDES Eukaryota
ENOG4111FAE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49259

KEGG Orthology (KO)

More...
KOi
K06560

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCRHFKA

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P49259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLSLSLLL LLLQVPAGSA ETAAWAVTPE RLREWQDKGI FIIQSENLEK
60 70 80 90 100
CIQASKSTLT LENCKPPNKY MLWKWVSNHR LFNIGGSGCL GLNVSSPEQP
110 120 130 140 150
LSIYECDSTH VSLKWHCNKK TITGPLQYLV QVKQDNTLVA SRKYLHKWVS
160 170 180 190 200
YMSGGGGICD YLHKDLYTIK GNAHGTPCMF PFQYNQQWHH ECTREGREDN
210 220 230 240 250
LLWCATTSRY ERDEKWGFCP DPTSTEVGCD AVWEKDLHSR ICYQFNLLSS
260 270 280 290 300
LSWSEAHSSC QMQGAALLSI ADETEENFVR KHLGSEAVEV WMGLNQLDED
310 320 330 340 350
AGWQWSDRTP LNYLNWKPEI NFEPFVEYHC GTFNAFMPKA WKSRDCESTL
360 370 380 390 400
PYVCKKYLNP TDHGVVEKDA WKYYATHCEP GWNPHNRNCY KLQKEKKTWN
410 420 430 440 450
EALQSCQSNN SVLTDITSLA EVEFLVTLLG DENASETWIG LSSHKIPVSF
460 470 480 490 500
EWSNGSSVTF TNWHTLEPHI FPNRSQLCVS AEQSEGHWKV KNCEETLFYL
510 520 530 540 550
CKKTGLVLSD TESGCQKGWE RHGKFCYKID TVLRSFDHAS SGYYCPPALI
560 570 580 590 600
TITSRFEQAF ITSLISSVVK TKDTYFWIAL QDQNNTGEYT WKTAGQQLEP
610 620 630 640 650
VKYTHWNTRQ PRYSGGCVVM RGRSHPGRWE VRDCRHFKAM SLCKQPVENR
660 670 680 690 700
EKTKQEEGWP FHPCYLDWES EPGLASCFKV FHSEKVLMKR TWRQAEEFCE
710 720 730 740 750
EFGAHLASFA HIEEENFVNE LLHSKFNRTE ERQFWIGFNK RNPLNAGSWE
760 770 780 790 800
WSDGTPVVSS FLDNSYFGED ARNCAVYKAN KTLLPSYCGS KREWICKIPR
810 820 830 840 850
DVRPKVPPWY QYDAPWLFYQ DAEYLFHISA SEWSSFEFVC GWLRSDILTI
860 870 880 890 900
HSAHEQEFIH SKIRALSKYG VNWWIGLREE RASDEFRWRD GSPVIYQNWD
910 920 930 940 950
KGKERSMGLN ESQRCGFISS ITGLWASEEC SISMPSICKR KKVWVIEKKK
960 970 980 990 1000
DIPKQHGTCP KGWLYFDYKC LLLKIPEGPS DWKNWTSAQD FCVEEGGTLV
1010 1020 1030 1040 1050
AIENEVEQAF ITMNLFGHTT NVWIGLQDDD YEKWLNGRPV SYSNWSPFDT
1060 1070 1080 1090 1100
KNIPNHNTTE VQKRIPLCGL LSNNPNFHFT GKWYFEDCRE GYGFVCEKMQ
1110 1120 1130 1140 1150
DASGHSINTS DMYPIPNTLE YGNRTYKIIN ANMTWYTALK TCLMHGAELA
1160 1170 1180 1190 1200
SITDQYHQSF LTVILNRVGY AHWIGLFTED NGLSFDWSDG TKSSFTFWKD
1210 1220 1230 1240 1250
DESSFLGDCV FADTSGRWSS TACESYLQGA ICQVPTETRL SGRLELCSET
1260 1270 1280 1290 1300
SIPWIKFKSN CYSFSTVLES TSFEAAHEFC KKKGSNLLTI KDEAENSFLL
1310 1320 1330 1340 1350
EELLAFRSSV QMIWLNAQFD GDNETIKWFD GTPTDQSNWG IRKPEVYHFK
1360 1370 1380 1390 1400
PHLCVALRIP EGVWQLSSCQ DKKGFICKME ADIHTVKKHP GKGPSHSVIP
1410 1420 1430 1440 1450
LTVALTLLVI LAISTLSFCM YKHSHIIFGR LAQFRNPYYP SANFSTVHLE
1460
ENILISDLEK NDQ
Length:1,463
Mass (Da):168,651
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4276FF206F92A397
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1M557A0A3Q1M557_BOVIN
Secretory phospholipase A2 receptor
PLA2R1
1,633Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1LVE1A0A3Q1LVE1_BOVIN
Secretory phospholipase A2 receptor
PLA2R1
1,586Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M287A0A3Q1M287_BOVIN
Secretory phospholipase A2 receptor
PLA2R1
1,605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16109 mRNA Translation: BAA03683.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A53210

NCBI Reference Sequences

More...
RefSeqi
NP_778221.1, NM_175051.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000046112; ENSBTAP00000043437; ENSBTAG00000032515

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
317777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:317777

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16109 mRNA Translation: BAA03683.1
PIRiA53210
RefSeqiNP_778221.1, NM_175051.1

3D structure databases

SMRiP49259
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043437

Proteomic databases

PaxDbiP49259
PRIDEiP49259

Genome annotation databases

EnsembliENSBTAT00000046112; ENSBTAP00000043437; ENSBTAG00000032515
GeneIDi317777
KEGGibta:317777

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22925
VGNCiVGNC:32966 PLA2R1

Phylogenomic databases

eggNOGiENOG410KDES Eukaryota
ENOG4111FAE LUCA
GeneTreeiENSGT00950000182821
HOGENOMiHOG000231191
InParanoidiP49259
KOiK06560
OMAiDCRHFKA
OrthoDBi29241at2759
TreeFamiTF316663

Enzyme and pathway databases

ReactomeiR-BTA-1482788 Acyl chain remodelling of PC
R-BTA-1482801 Acyl chain remodelling of PS
R-BTA-1482839 Acyl chain remodelling of PE
R-BTA-1482922 Acyl chain remodelling of PI
R-BTA-1482925 Acyl chain remodelling of PG
R-BTA-1483166 Synthesis of PA

Gene expression databases

BgeeiENSBTAG00000032515 Expressed in 8 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLA2R_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49259
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 11, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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