Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribose-5-phosphate isomerase

Gene

RPIA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase (RPIA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • D-ribose metabolic process Source: GO_Central
  • pentose-phosphate shunt Source: Reactome
  • pentose-phosphate shunt, non-oxidative branch Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5659996 RPIA deficiency: failed conversion of R5P to RU5P
R-HSA-6791461 RPIA deficiency: failed conversion of RU5P to R5P
R-HSA-71336 Pentose phosphate pathway

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00115;UER00412

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribose-5-phosphate isomerase (EC:5.3.1.6)
Alternative name(s):
Phosphoriboisomerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPIA
Synonyms:RPI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000153574.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10297 RPIA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180430 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49247

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ribose 5-phosphate isomerase deficiency (RPID)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts.
See also OMIM:608611
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019122135A → V in RPID. 1 PublicationCorresponds to variant dbSNP:rs121918591EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
22934

MalaCards human disease database

More...
MalaCardsi
RPIA
MIMi608611 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000153574

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
440706 Ribose-5-P isomerase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34659

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01756 D-4-Phosphoerythronic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPIA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156637353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001585211 – 311Ribose-5-phosphate isomeraseAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52Omega-N-methylarginineCombined sources1
Modified residuei106PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49247

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49247

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49247

PeptideAtlas

More...
PeptideAtlasi
P49247

PRoteomics IDEntifications database

More...
PRIDEi
P49247

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55976

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49247

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49247

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153574 Expressed in 222 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_RPIA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49247 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042620

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116594, 35 interactors

Protein interaction database and analysis system

More...
IntActi
P49247, 21 interactors

Molecular INTeraction database

More...
MINTi
P49247

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283646

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P49247

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49247

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3075 Eukaryota
COG0120 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276369

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017746

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49247

KEGG Orthology (KO)

More...
KOi
K01807

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAPMAYV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0FQ2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49247

TreeFam database of animal gene trees

More...
TreeFami
TF105758

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01398 RPI_A, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00170 Rib_5P_isom_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR11934 PTHR11934, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00021 rpiA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49247-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRPGPFSTL YGRVLAPLPG RAGGAASGGG GNSWDLPGSH VRLPGRAQSG
60 70 80 90 100
TRGGAGNTST SCGDSNSICP APSTMSKAEE AKKLAGRAAV ENHVRNNQVL
110 120 130 140 150
GIGSGSTIVH AVQRIAERVK QENLNLVCIP TSFQARQLIL QYGLTLSDLD
160 170 180 190 200
RHPEIDLAID GADEVDADLN LIKGGGGCLT QEKIVAGYAS RFIVIADFRK
210 220 230 240 250
DSKNLGDQWH KGIPIEVIPM AYVPVSRAVS QKFGGVVELR MAVNKAGPVV
260 270 280 290 300
TDNGNFILDW KFDRVHKWSE VNTAIKMIPG VVDTGLFINM AERVYFGMQD
310
GSVNMREKPF C
Length:311
Mass (Da):33,269
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ED587A40F10223D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK95569 differs from that shown. Reason: Frameshift at position 24.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207D → V in L35035 (PubMed:7758956).Curated1
Sequence conflicti239L → V in L35035 (PubMed:7758956).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019122135A → V in RPID. 1 PublicationCorresponds to variant dbSNP:rs121918591EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY050633 mRNA Translation: AAK95569.1 Frameshift.
BC015529 mRNA Translation: AAH15529.2
L35035 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2004.2

NCBI Reference Sequences

More...
RefSeqi
NP_653164.2, NM_144563.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.469264

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283646; ENSP00000283646; ENSG00000153574

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22934

UCSC genome browser

More...
UCSCi
uc002ste.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050633 mRNA Translation: AAK95569.1 Frameshift.
BC015529 mRNA Translation: AAH15529.2
L35035 mRNA No translation available.
CCDSiCCDS2004.2
RefSeqiNP_653164.2, NM_144563.2
UniGeneiHs.469264

3D structure databases

ProteinModelPortaliP49247
SMRiP49247
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116594, 35 interactors
IntActiP49247, 21 interactors
MINTiP49247
STRINGi9606.ENSP00000283646

Chemistry databases

DrugBankiDB01756 D-4-Phosphoerythronic Acid

PTM databases

iPTMnetiP49247
PhosphoSitePlusiP49247

Polymorphism and mutation databases

BioMutaiRPIA
DMDMi156637353

Proteomic databases

EPDiP49247
MaxQBiP49247
PaxDbiP49247
PeptideAtlasiP49247
PRIDEiP49247
ProteomicsDBi55976

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283646; ENSP00000283646; ENSG00000153574
GeneIDi22934
KEGGihsa:22934
UCSCiuc002ste.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22934
DisGeNETi22934
EuPathDBiHostDB:ENSG00000153574.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPIA

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002249
HGNCiHGNC:10297 RPIA
HPAiHPA042620
MalaCardsiRPIA
MIMi180430 gene
608611 phenotype
neXtProtiNX_P49247
OpenTargetsiENSG00000153574
Orphaneti440706 Ribose-5-P isomerase deficiency
PharmGKBiPA34659

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3075 Eukaryota
COG0120 LUCA
GeneTreeiENSGT00390000004352
HOGENOMiHOG000276369
HOVERGENiHBG017746
InParanoidiP49247
KOiK01807
OMAiVAPMAYV
OrthoDBiEOG091G0FQ2
PhylomeDBiP49247
TreeFamiTF105758

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00412

ReactomeiR-HSA-5659996 RPIA deficiency: failed conversion of R5P to RU5P
R-HSA-6791461 RPIA deficiency: failed conversion of RU5P to R5P
R-HSA-71336 Pentose phosphate pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22934

Protein Ontology

More...
PROi
PR:P49247

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153574 Expressed in 222 organ(s), highest expression level in bone marrow
CleanExiHS_RPIA
GenevisibleiP49247 HS

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PANTHERiPTHR11934 PTHR11934, 1 hit
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPIA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49247
Secondary accession number(s): Q541P9, Q96BJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 24, 2007
Last modified: December 5, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again