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UniProtKB - P49223 (SPIT3_HUMAN)

Entry version 148 (10 Feb 2021)
Sequence version 3 (10 Jul 2007)
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Protein

Kunitz-type protease inhibitor 3

Gene

SPINT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49223

Protein family/group databases

MEROPS protease database

More...MEROPSi		I02.969

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kunitz-type protease inhibitor 3
Alternative name(s):
HKIB9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPINT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11248, SPINT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613941, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49223

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101446.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10816

Open Targets

More...OpenTargetsi		ENSG00000101446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36078

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49223, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPINT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		152031689

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001688725 – 89Kunitz-type protease inhibitor 3Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 86PROSITE-ProRule annotation
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49223

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49223

PeptideAtlas

More...PeptideAtlasi		P49223

PRoteomics IDEntifications database

More...PRIDEi		P49223

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101446, Expressed in cauda epididymis and 30 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49223, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101446, Tissue enriched (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116029, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000217428

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49223, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49223

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 86BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4295, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163688

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_164133_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49223

Identification of Orthologs from Complete Genome Data

More...OMAi		VCAFPME

Database of Orthologous Groups

More...OrthoDBi		1564520at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49223

TreeFam database of animal gene trees

More...TreeFami		TF327278

Family and domain databases

Conserved Domains Database

More...CDDi		cd00109, KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR020901, Prtase_inh_Kunz-CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00014, Kunitz_BPTI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00131, KU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57362, SSF57362, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P49223-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLQASLSFL LILTLCLELR SELARDTIKD LLPNVCAFPM EKGPCQTYMT 
        60         70         80 
RWFFNFETGE CELFAYGGCG GNSNNFLRKE KCEKFCKFT
Length:89
Mass (Da):10,252
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C471371CD77A9F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05944377L → S. Corresponds to variant dbSNP:rs6032259Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY372172 mRNA Translation: AAR17081.2
AL031663 Genomic DNA No translation available.
X77166 Genomic DNA Translation: CAA54410.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46608.1

Protein sequence database of the Protein Information Resource

More...PIRi		S41399

NCBI Reference Sequences

More...RefSeqi		NP_006643.1, NM_006652.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000217428; ENSP00000217428; ENSG00000101446

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10816

UCSC genome browser

More...UCSCi		uc010ghg.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372172 mRNA Translation: AAR17081.2
AL031663 Genomic DNA No translation available.
X77166 Genomic DNA Translation: CAA54410.1
CCDSiCCDS46608.1
PIRiS41399
RefSeqiNP_006643.1, NM_006652.1

3D structure databases

SMRiP49223
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116029, 1 interactor
STRINGi9606.ENSP00000217428

Protein family/group databases

MEROPSiI02.969

Genetic variation databases

BioMutaiSPINT3
DMDMi152031689

Proteomic databases

MassIVEiP49223
PaxDbiP49223
PeptideAtlasiP49223
PRIDEiP49223
ProteomicsDBi55972

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72138, 7 antibodies

Genome annotation databases

EnsembliENST00000217428; ENSP00000217428; ENSG00000101446
GeneIDi10816
KEGGihsa:10816
UCSCiuc010ghg.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10816
DisGeNETi10816

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPINT3
HGNCiHGNC:11248, SPINT3
HPAiENSG00000101446, Tissue enriched (epididymis)
MIMi613941, gene
neXtProtiNX_P49223
OpenTargetsiENSG00000101446
PharmGKBiPA36078
VEuPathDBiHostDB:ENSG00000101446.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4295, Eukaryota
GeneTreeiENSGT00940000163688
HOGENOMiCLU_164133_0_3_1
InParanoidiP49223
OMAiVCAFPME
OrthoDBi1564520at2759
PhylomeDBiP49223
TreeFamiTF327278

Enzyme and pathway databases

PathwayCommonsiP49223

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10816, 2 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPINT3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10816
PharosiP49223, Tdark

Protein Ontology

More...PROi		PR:P49223
RNActiP49223, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101446, Expressed in cauda epididymis and 30 other tissues
GenevisibleiP49223, HS

Family and domain databases

CDDicd00109, KU, 1 hit
Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR020901, Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014, Kunitz_BPTI, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00131, KU, 1 hit
SUPFAMiSSF57362, SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49223
Secondary accession number(s): A6NCQ6, Q6UDR8, Q96KK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 10, 2007
Last modified: February 10, 2021
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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