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Protein

Protein-glutamine gamma-glutamyltransferase 4

Gene

TGM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei268PROSITE-ProRule annotation1
Active sitei327PROSITE-ProRule annotation1
Active sitei350PROSITE-ProRule annotation1
Metal bindingi390CalciumBy similarity1
Metal bindingi392CalciumBy similarity1
Metal bindingi442CalciumBy similarity1
Metal bindingi447CalciumBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 4 (EC:2.3.2.13)
Alternative name(s):
Fibrinoligase
Prostate transglutaminase
Prostate-specific transglutaminase
Transglutaminase P
Short name:
TG(P)
Short name:
TGP
Short name:
TGase P
Transglutaminase-4
Short name:
TGase-4
Gene namesi
Name:TGM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163810.11
HGNCiHGNC:11780 TGM4
MIMi600585 gene
neXtProtiNX_P49221

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7047
OpenTargetsiENSG00000163810
PharmGKBiPA36493

Chemistry databases

DrugBankiDB00130 L-Glutamine

Polymorphism and mutation databases

BioMutaiTGM4
DMDMi3915892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137111 – 684Protein-glutamine gamma-glutamyltransferase 4Add BLAST684

Proteomic databases

MaxQBiP49221
PaxDbiP49221
PeptideAtlasiP49221
PRIDEiP49221
ProteomicsDBi55971

PTM databases

iPTMnetiP49221
PhosphoSitePlusiP49221

Expressioni

Tissue specificityi

Prostate.

Gene expression databases

BgeeiENSG00000163810 Expressed in 73 organ(s), highest expression level in sperm
CleanExiHS_TGM4
ExpressionAtlasiP49221 baseline and differential
GenevisibleiP49221 HS

Organism-specific databases

HPAiCAB033571
HPA032072

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi112905, 2 interactors
IntActiP49221, 2 interactors
STRINGi9606.ENSP00000296125

Structurei

3D structure databases

ProteinModelPortaliP49221
SMRiP49221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP49221
KOiK05621
OMAiTAFDSAH
OrthoDBiEOG091G030K
PhylomeDBiP49221
TreeFamiTF324278

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 1 hit
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ
60 70 80 90 100
PLQSYHQLKL EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE
110 120 130 140 150
VTVAVTSSPN AILGKYQLNV KTGNHILKSE ENILYLLFNP WCKEDMVFMP
160 170 180 190 200
DEDERKEYIL NDTGCHYVGA ARSIKCKPWN FGQFEKNVLD CCISLLTESS
210 220 230 240 250
LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG TAPYKWTGSA
260 270 280 290 300
PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER
310 320 330 340 350
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD
360 370 380 390 400
ATPQERSQGV FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM
410 420 430 440 450
VNGQEELHVI SMETTSIGKN ISTKAVGQDR RRDITYEYKY PEGSSEERQV
460 470 480 490 500
MDHAFLLLSS EREHRRPVKE NFLHMSVQSD DVLLGNSVNF TVILKRKTAA
510 520 530 540 550
LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT LTLDSKTYIN
560 570 580 590 600
SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG
610 620 630 640 650
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI
660 670 680
KCTPIKTGPK KFIVKLSSKQ VKEINAQKIV LITK
Length:684
Mass (Da):77,145
Last modified:December 15, 1998 - v2
Checksum:i64A3E754EA46BFEC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCU8F8WCU8_HUMAN
Protein-glutamine gamma-glutamyltra...
TGM4
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353P → S in AAH07003 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052555100E → D. Corresponds to variant dbSNP:rs2271087Ensembl.1
Natural variantiVAR_052556244Y → H. Corresponds to variant dbSNP:rs9818345Ensembl.1
Natural variantiVAR_052557249S → T. Corresponds to variant dbSNP:rs937838Ensembl.1
Natural variantiVAR_052558313E → K1 PublicationCorresponds to variant dbSNP:rs1995641Ensembl.1
Natural variantiVAR_052559372R → C. Corresponds to variant dbSNP:rs3749195Ensembl.1
Natural variantiVAR_052560372R → H. Corresponds to variant dbSNP:rs13326552Ensembl.1
Natural variantiVAR_052561376I → V. Corresponds to variant dbSNP:rs17077022Ensembl.1
Natural variantiVAR_052562409V → I. Corresponds to variant dbSNP:rs9876921Ensembl.1
Natural variantiVAR_052563437E → Q. Corresponds to variant dbSNP:rs1395388Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34840 mRNA Translation: AAB95430.1
U31905 mRNA Translation: AAC50516.1
BC007003 mRNA Translation: AAH07003.1
CCDSiCCDS2723.1
PIRiS71105
RefSeqiNP_003232.2, NM_003241.3
UniGeneiHs.438265

Genome annotation databases

EnsembliENST00000296125; ENSP00000296125; ENSG00000163810
ENST00000628744; ENSP00000487307; ENSG00000281886
GeneIDi7047
KEGGihsa:7047
UCSCiuc003coc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34840 mRNA Translation: AAB95430.1
U31905 mRNA Translation: AAC50516.1
BC007003 mRNA Translation: AAH07003.1
CCDSiCCDS2723.1
PIRiS71105
RefSeqiNP_003232.2, NM_003241.3
UniGeneiHs.438265

3D structure databases

ProteinModelPortaliP49221
SMRiP49221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112905, 2 interactors
IntActiP49221, 2 interactors
STRINGi9606.ENSP00000296125

Chemistry databases

DrugBankiDB00130 L-Glutamine

PTM databases

iPTMnetiP49221
PhosphoSitePlusiP49221

Polymorphism and mutation databases

BioMutaiTGM4
DMDMi3915892

Proteomic databases

MaxQBiP49221
PaxDbiP49221
PeptideAtlasiP49221
PRIDEiP49221
ProteomicsDBi55971

Protocols and materials databases

DNASUi7047
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296125; ENSP00000296125; ENSG00000163810
ENST00000628744; ENSP00000487307; ENSG00000281886
GeneIDi7047
KEGGihsa:7047
UCSCiuc003coc.5 human

Organism-specific databases

CTDi7047
DisGeNETi7047
EuPathDBiHostDB:ENSG00000163810.11
GeneCardsiTGM4
HGNCiHGNC:11780 TGM4
HPAiCAB033571
HPA032072
MIMi600585 gene
neXtProtiNX_P49221
OpenTargetsiENSG00000163810
PharmGKBiPA36493
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00760000119108
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiP49221
KOiK05621
OMAiTAFDSAH
OrthoDBiEOG091G030K
PhylomeDBiP49221
TreeFamiTF324278

Miscellaneous databases

GeneWikiiTGM4
GenomeRNAii7047
PROiPR:P49221
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163810 Expressed in 73 organ(s), highest expression level in sperm
CleanExiHS_TGM4
ExpressionAtlasiP49221 baseline and differential
GenevisibleiP49221 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 1 hit
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGM4_HUMAN
AccessioniPrimary (citable) accession number: P49221
Secondary accession number(s): Q16707, Q96QN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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