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Protein

60S ribosomal protein L34

Gene

RPL34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication3 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L34
Alternative name(s):
Large ribosomal subunit protein eL341 Publication
Gene namesi
Name:RPL34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109475.16
HGNCiHGNC:10340 RPL34
MIMi616862 gene
neXtProtiNX_P49207

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6164
OpenTargetsiENSG00000109475
PharmGKBiPA34723

Polymorphism and mutation databases

BioMutaiRPL34

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001318312 – 11760S ribosomal protein L34Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei36N6-acetyllysineCombined sources1
Modified residuei43N6-acetyllysineBy similarity1
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP49207
MaxQBiP49207
PaxDbiP49207
PeptideAtlasiP49207
PRIDEiP49207
ProteomicsDBi55970
TopDownProteomicsiP49207

PTM databases

iPTMnetiP49207
PhosphoSitePlusiP49207
SwissPalmiP49207

Expressioni

Gene expression databases

BgeeiENSG00000109475
CleanExiHS_RPL34
ExpressionAtlasiP49207 baseline and differential
GenevisibleiP49207 HS

Organism-specific databases

HPAiHPA035139

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112083, 92 interactors
CORUMiP49207
IntActiP49207, 18 interactors
MINTiP49207
STRINGi9606.ENSP00000378160

Structurei

3D structure databases

ProteinModelPortaliP49207
SMRiP49207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1790 Eukaryota
COG2174 LUCA
GeneTreeiENSGT00390000008294
HOGENOMiHOG000216922
HOVERGENiHBG024280
InParanoidiP49207
KOiK02915
OMAiRCGDCVK
OrthoDBiEOG091G0WY7
PhylomeDBiP49207
TreeFamiTF314326

Family and domain databases

Gene3Di3.40.1800.40, 1 hit
InterProiView protein in InterPro
IPR008195 Ribosomal_L34Ae
IPR038562 Ribosomal_L34Ae_sf
IPR018065 Ribosomal_L34e_CS
PANTHERiPTHR10759 PTHR10759, 1 hit
PfamiView protein in Pfam
PF01199 Ribosomal_L34e, 1 hit
PRINTSiPR01250 RIBOSOMALL34
PROSITEiView protein in PROSITE
PS01145 RIBOSOMAL_L34E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP
60 70 80 90 100
GRLRGVRAVR PKVLMRLSKT KKHVSRAYGG SMCAKCVRDR IKRAFLIEEQ
110
KIVVKVLKAQ AQSQKAK
Length:117
Mass (Da):13,293
Last modified:January 23, 2007 - v3
Checksum:iFC09D00B98CB770C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → K in AAC41916 (PubMed:7490091).Curated1
Sequence conflicti58A → P in AAC41916 (PubMed:7490091).Curated1
Sequence conflicti103V → I in AAC41916 (PubMed:7490091).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38941 mRNA Translation: AAC41916.1
AB061832 Genomic DNA Translation: BAB79470.1
CR542232 mRNA Translation: CAG47028.1
CR542242 mRNA Translation: CAG47038.1
BC001773 mRNA Translation: AAH01773.1
BC070208 mRNA Translation: AAH70208.1
BC106009 mRNA Translation: AAI06010.1
AB007181 Genomic DNA Translation: BAA25840.1
CCDSiCCDS3680.1
PIRiI68524
RefSeqiNP_000986.2, NM_000995.4
NP_001306161.1, NM_001319232.1
NP_001306163.1, NM_001319234.1
NP_001306164.1, NM_001319235.1
NP_001306165.1, NM_001319236.1
NP_296374.1, NM_033625.3
UniGeneiHs.438227

Genome annotation databases

EnsembliENST00000394665; ENSP00000378160; ENSG00000109475
ENST00000394667; ENSP00000378162; ENSG00000109475
ENST00000394668; ENSP00000378163; ENSG00000109475
ENST00000502534; ENSP00000423983; ENSG00000109475
ENST00000506397; ENSP00000423316; ENSG00000109475
GeneIDi6164
KEGGihsa:6164
UCSCiuc003hza.4 human

Similar proteinsi

Entry informationi

Entry nameiRL34_HUMAN
AccessioniPrimary (citable) accession number: P49207
Secondary accession number(s): Q6FG66, Q9BUZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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