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Entry version 172 (29 Sep 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Parathyroid hormone 2 receptor

Gene

PTH2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P49190

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373080, Class B/2 (Secretin family receptors)
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P49190

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTH2R
Synonyms:PTHR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9609, PTH2R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601469, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49190

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000144407

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 145ExtracellularSequence analysisAdd BLAST119
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei146 – 169Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini170 – 176CytoplasmicSequence analysis7
Transmembranei177 – 196Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini197 – 237ExtracellularSequence analysisAdd BLAST41
Transmembranei238 – 260Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini261 – 275CytoplasmicSequence analysisAdd BLAST15
Transmembranei276 – 297Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini298 – 316ExtracellularSequence analysisAdd BLAST19
Transmembranei317 – 337Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini338 – 364CytoplasmicSequence analysisAdd BLAST27
Transmembranei365 – 383Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini384 – 394ExtracellularSequence analysisAdd BLAST11
Transmembranei395 – 417Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini418 – 550CytoplasmicSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5746

Open Targets

More...
OpenTargetsi
ENSG00000144407

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400333

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P49190, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105836

Drug and drug target database

More...
DrugBanki
DB05829, Parathyroid hormone

DrugCentral

More...
DrugCentrali
P49190

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
332

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTH2R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001284925 – 550Parathyroid hormone 2 receptorAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P49190

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49190

PeptideAtlas

More...
PeptideAtlasi
P49190

PRoteomics IDEntifications database

More...
PRIDEi
P49190

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55969

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P49190

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P49190, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49190

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49190

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in brain and pancreas. Also expressed in the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144407, Expressed in adult mammalian kidney and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P49190, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49190, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144407, Tissue enhanced (bone marrow, brain, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to TIPF39/TIP39.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111718, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P49190, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272847

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P49190, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49190

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni511 – 550DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi511 – 529Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4564, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49190

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVRMHCE

Database of Orthologous Groups

More...
OrthoDBi
651627at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49190

TreeFam database of animal gene trees

More...
TreeFami
TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P49190-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF
110 120 130 140 150
RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV
160 170 180 190 200
GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV
210 220 230 240 250
VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN
260 270 280 290 300
YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT
310 320 330 340 350
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV
360 370 380 390 400
GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF
410 420 430 440 450
FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS
460 470 480 490 500
VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS
510 520 530 540 550
EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL
Length:550
Mass (Da):62,236
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ADD14DBA68A9BF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DFN8B4DFN8_HUMAN
Parathyroid hormone 2 receptor
PTH2R
439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0B0H7C0B0_HUMAN
Parathyroid hormone 2 receptor
PTH2R
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25128 mRNA Translation: AAC50157.1
AY497546 mRNA Translation: AAR90849.1
BC036811 mRNA Translation: AAH36811.2
U47124 Genomic DNA Translation: AAA96796.1
AH006647 Genomic DNA Translation: AAC50767.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2383.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57519

NCBI Reference Sequences

More...
RefSeqi
NP_001296445.1, NM_001309516.1
NP_005039.1, NM_005048.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272847; ENSP00000272847; ENSG00000144407

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5746

UCSC genome browser

More...
UCSCi
uc002vdb.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25128 mRNA Translation: AAC50157.1
AY497546 mRNA Translation: AAR90849.1
BC036811 mRNA Translation: AAH36811.2
U47124 Genomic DNA Translation: AAA96796.1
AH006647 Genomic DNA Translation: AAC50767.1
CCDSiCCDS2383.1
PIRiA57519
RefSeqiNP_001296445.1, NM_001309516.1
NP_005039.1, NM_005048.3

3D structure databases

SMRiP49190
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111718, 4 interactors
IntActiP49190, 3 interactors
STRINGi9606.ENSP00000272847

Chemistry databases

ChEMBLiCHEMBL4105836
DrugBankiDB05829, Parathyroid hormone
DrugCentraliP49190
GuidetoPHARMACOLOGYi332

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniP49190, 4 sites
iPTMnetiP49190
PhosphoSitePlusiP49190

Genetic variation databases

BioMutaiPTH2R
DMDMi1346906

Proteomic databases

MassIVEiP49190
PaxDbiP49190
PeptideAtlasiP49190
PRIDEiP49190
ProteomicsDBi55969
TopDownProteomicsiP49190

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20012, 228 antibodies

The DNASU plasmid repository

More...
DNASUi
5746

Genome annotation databases

EnsembliENST00000272847; ENSP00000272847; ENSG00000144407
GeneIDi5746
KEGGihsa:5746
UCSCiuc002vdb.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5746
DisGeNETi5746

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTH2R
HGNCiHGNC:9609, PTH2R
HPAiENSG00000144407, Tissue enhanced (bone marrow, brain, salivary gland)
MIMi601469, gene
neXtProtiNX_P49190
OpenTargetsiENSG00000144407
PharmGKBiPA162400333
VEuPathDBiHostDB:ENSG00000144407

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00940000159094
InParanoidiP49190
OMAiEVRMHCE
OrthoDBi651627at2759
PhylomeDBiP49190
TreeFamiTF315710

Enzyme and pathway databases

PathwayCommonsiP49190
ReactomeiR-HSA-373080, Class B/2 (Secretin family receptors)
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SIGNORiP49190

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5746, 3 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTH2R, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Parathyroid_hormone_2_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5746
PharosiP49190, Tchem

Protein Ontology

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PROi
PR:P49190
RNActiP49190, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144407, Expressed in adult mammalian kidney and 112 other tissues
ExpressionAtlasiP49190, baseline and differential
GenevisibleiP49190, HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTH2R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49190
Secondary accession number(s): Q8N429
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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