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Protein

Deoxyribonuclease-1-like 1

Gene

DNASE1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97By similarity1
Active sitei148By similarity1

GO - Molecular functioni

  • deoxyribonuclease activity Source: GO_Central
  • deoxyribonuclease I activity Source: GO_Central
  • DNA binding Source: GO_Central

GO - Biological processi

  • DNA catabolic process Source: GO_Central
  • DNA catabolic process, endonucleolytic Source: GO_Central
  • DNA metabolic process Source: ProtInc
  • neutrophil degranulation Source: Reactome

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-1-like 1 (EC:3.1.21.-)
Alternative name(s):
DNase X
Deoxyribonuclease I-like 1
Short name:
DNase I-like 1
Muscle-specific DNase I-like
XIB
Gene namesi
Name:DNASE1L1
Synonyms:DNAS1L1, DNL1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000013563.13
HGNCiHGNC:2957 DNASE1L1
MIMi300081 gene
neXtProtiNX_P49184

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000013563
PharmGKBiPA27428

Polymorphism and mutation databases

BioMutaiDNASE1L1
DMDMi1352319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000728419 – 302Deoxyribonuclease-1-like 1Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi187 ↔ 224Essential for enzymatic activityBy similarity
Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP49184
MaxQBiP49184
PaxDbiP49184
PeptideAtlasiP49184
PRIDEiP49184
ProteomicsDBi55967

PTM databases

iPTMnetiP49184
PhosphoSitePlusiP49184

Expressioni

Tissue specificityi

Highest levels in skeletal and cardiac muscles. Detectable in all other tissues tested except brain.1 Publication

Gene expression databases

BgeeiENSG00000013563 Expressed in 212 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DNASE1L1
ExpressionAtlasiP49184 baseline and differential
GenevisibleiP49184 HS

Organism-specific databases

HPAiHPA072635

Interactioni

Protein-protein interaction databases

BioGridi108113, 6 interactors
STRINGi9606.ENSP00000014935

Structurei

3D structure databases

ProteinModelPortaliP49184
SMRiP49184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH3K Eukaryota
ENOG410Z4MV LUCA
GeneTreeiENSGT00390000013146
HOGENOMiHOG000059570
HOVERGENiHBG051368
InParanoidiP49184
KOiK11995
OMAiLHGERCQ
OrthoDBiEOG091G0I0B
PhylomeDBiP49184
TreeFamiTF329541

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P49184-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHYPTALLFL ILANGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC
60 70 80 90 100
DIMVLQEVVD SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV
110 120 130 140 150
YFYRSHKTQV LSSYVYNDED DVFAREPFVA QFSLPSNVLP SLVLVPLHTT
160 170 180 190 200
PKAVEKELNA LYDVFLEVSQ HWQSKDVILL GDFNADCASL TKKRLDKLEL
210 220 230 240 250
RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL HTAAAFDFPT
260 270 280 290 300
SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP

AA
Length:302
Mass (Da):33,893
Last modified:February 1, 1996 - v1
Checksum:iD10CE8B470173727
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6QRJ0A6QRJ0_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
208Annotation score:
Q5HY40Q5HY40_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
103Annotation score:
E7ESG1E7ESG1_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
62Annotation score:
E7EUJ0E7EUJ0_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
85Annotation score:
A3KQT1A3KQT1_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73L → I in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti78G → D in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti205G → S in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti227D → A in AAB00495 (PubMed:8541839).Curated1
Sequence conflicti227D → A in AAA92647 (PubMed:8733135).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048869122V → I. Corresponds to variant dbSNP:rs34952165Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90392 mRNA Translation: CAA62037.1
L40817 Genomic DNA Translation: AAB00495.1
L40823 mRNA Translation: AAB00496.1
L44140 Genomic DNA Translation: AAA92647.1
U06846 mRNA Translation: AAB17022.1
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72731.1
CH471172 Genomic DNA Translation: EAW72732.1
CH471172 Genomic DNA Translation: EAW72733.1
CH471172 Genomic DNA Translation: EAW72734.1
CH471172 Genomic DNA Translation: EAW72735.1
BC001561 mRNA Translation: AAH01561.1
BC028092 mRNA Translation: AAH28092.1
CCDSiCCDS14747.1
PIRiJC4633
RefSeqiNP_001009932.1, NM_001009932.2
NP_001009933.1, NM_001009933.2
NP_001009934.1, NM_001009934.2
NP_001290549.1, NM_001303620.1
NP_006721.1, NM_006730.3
XP_005277886.1, XM_005277829.4
XP_011529424.1, XM_011531122.2
XP_016884821.1, XM_017029332.1
UniGeneiHs.401929
Hs.534404

Genome annotation databases

EnsembliENST00000014935; ENSP00000014935; ENSG00000013563
ENST00000309585; ENSP00000309168; ENSG00000013563
ENST00000369807; ENSP00000358822; ENSG00000013563
ENST00000369808; ENSP00000358823; ENSG00000013563
ENST00000369809; ENSP00000358824; ENSG00000013563
ENST00000393638; ENSP00000377255; ENSG00000013563
GeneIDi1774
KEGGihsa:1774
UCSCiuc033fbh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90392 mRNA Translation: CAA62037.1
L40817 Genomic DNA Translation: AAB00495.1
L40823 mRNA Translation: AAB00496.1
L44140 Genomic DNA Translation: AAA92647.1
U06846 mRNA Translation: AAB17022.1
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72731.1
CH471172 Genomic DNA Translation: EAW72732.1
CH471172 Genomic DNA Translation: EAW72733.1
CH471172 Genomic DNA Translation: EAW72734.1
CH471172 Genomic DNA Translation: EAW72735.1
BC001561 mRNA Translation: AAH01561.1
BC028092 mRNA Translation: AAH28092.1
CCDSiCCDS14747.1
PIRiJC4633
RefSeqiNP_001009932.1, NM_001009932.2
NP_001009933.1, NM_001009933.2
NP_001009934.1, NM_001009934.2
NP_001290549.1, NM_001303620.1
NP_006721.1, NM_006730.3
XP_005277886.1, XM_005277829.4
XP_011529424.1, XM_011531122.2
XP_016884821.1, XM_017029332.1
UniGeneiHs.401929
Hs.534404

3D structure databases

ProteinModelPortaliP49184
SMRiP49184
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108113, 6 interactors
STRINGi9606.ENSP00000014935

PTM databases

iPTMnetiP49184
PhosphoSitePlusiP49184

Polymorphism and mutation databases

BioMutaiDNASE1L1
DMDMi1352319

Proteomic databases

EPDiP49184
MaxQBiP49184
PaxDbiP49184
PeptideAtlasiP49184
PRIDEiP49184
ProteomicsDBi55967

Protocols and materials databases

DNASUi1774
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000014935; ENSP00000014935; ENSG00000013563
ENST00000309585; ENSP00000309168; ENSG00000013563
ENST00000369807; ENSP00000358822; ENSG00000013563
ENST00000369808; ENSP00000358823; ENSG00000013563
ENST00000369809; ENSP00000358824; ENSG00000013563
ENST00000393638; ENSP00000377255; ENSG00000013563
GeneIDi1774
KEGGihsa:1774
UCSCiuc033fbh.2 human

Organism-specific databases

CTDi1774
EuPathDBiHostDB:ENSG00000013563.13
GeneCardsiDNASE1L1
HGNCiHGNC:2957 DNASE1L1
HPAiHPA072635
MIMi300081 gene
neXtProtiNX_P49184
OpenTargetsiENSG00000013563
PharmGKBiPA27428
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3K Eukaryota
ENOG410Z4MV LUCA
GeneTreeiENSGT00390000013146
HOGENOMiHOG000059570
HOVERGENiHBG051368
InParanoidiP49184
KOiK11995
OMAiLHGERCQ
OrthoDBiEOG091G0I0B
PhylomeDBiP49184
TreeFamiTF329541

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GeneWikiiDNASE1L1
GenomeRNAii1774
PROiPR:P49184
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013563 Expressed in 212 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DNASE1L1
ExpressionAtlasiP49184 baseline and differential
GenevisibleiP49184 HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNSL1_HUMAN
AccessioniPrimary (citable) accession number: P49184
Secondary accession number(s): D3DWW7, Q5HY41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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