Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P49184 (DNSL1_HUMAN)

Entry version 184 (02 Jun 2021)
Sequence version 1 (01 Feb 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Deoxyribonuclease-1-like 1

Gene

DNASE1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei97By similarity1
Active sitei148By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49184

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyribonuclease-1-like 1 (EC:3.1.21.-)
Alternative name(s):
DNase X
Deoxyribonuclease I-like 1
Short name:
DNase I-like 1
Muscle-specific DNase I-like
XIB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNASE1L1
Synonyms:DNAS1L1, DNL1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2957, DNASE1L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300081, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49184

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000013563.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1774

Open Targets

More...OpenTargetsi		ENSG00000013563

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27428

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49184, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNASE1L1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1352319

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000728419 – 302Deoxyribonuclease-1-like 1Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi187 ↔ 224Essential for enzymatic activityBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49184

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49184

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49184

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49184

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49184

PeptideAtlas

More...PeptideAtlasi		P49184

PRoteomics IDEntifications database

More...PRIDEi		P49184

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55967

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49184, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49184

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49184

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in skeletal and cardiac muscles. Detectable in all other tissues tested except brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000013563, Expressed in quadriceps femoris and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49184, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49184, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000013563, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108113, 11 interactors

Protein interaction database and analysis system

More...IntActi		P49184, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358824

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49184, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49184

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPNY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043335_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49184

Identification of Orthologs from Complete Genome Data

More...OMAi		FHWAIAD

Database of Orthologous Groups

More...OrthoDBi		1282784at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49184

TreeFam database of animal gene trees

More...TreeFami		TF329541

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018057, Deoxyribonuclease-1_AS
IPR016202, DNase_I
IPR033125, DNASE_I_2
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03372, Exo_endo_phos, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000988, DNase_I_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00130, DNASEI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00476, DNaseIc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56219, SSF56219, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00919, DNASE_I_1, 1 hit
PS00918, DNASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P49184-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHYPTALLFL ILANGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC 
        60         70         80         90        100
DIMVLQEVVD SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV 
       110        120        130        140        150
YFYRSHKTQV LSSYVYNDED DVFAREPFVA QFSLPSNVLP SLVLVPLHTT 
       160        170        180        190        200
PKAVEKELNA LYDVFLEVSQ HWQSKDVILL GDFNADCASL TKKRLDKLEL 
       210        220        230        240        250
RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL HTAAAFDFPT 
       260        270        280        290        300
SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP 

AA
Length:302
Mass (Da):33,893
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD10CE8B470173727
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6QRJ0A6QRJ0_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5HY40Q5HY40_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESG1E7ESG1_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUJ0E7EUJ0_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KQT1A3KQT1_HUMAN
Deoxyribonuclease-1-like 1
DNASE1L1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73L → I in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti78G → D in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti205G → S in AAB00496 (PubMed:8541839).Curated1
Sequence conflicti227D → A in AAB00495 (PubMed:8541839).Curated1
Sequence conflicti227D → A in AAA92647 (PubMed:8733135).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048869122V → I. Corresponds to variant dbSNP:rs34952165Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X90392 mRNA Translation: CAA62037.1
L40817 Genomic DNA Translation: AAB00495.1
L40823 mRNA Translation: AAB00496.1
L44140 Genomic DNA Translation: AAA92647.1
U06846 mRNA Translation: AAB17022.1
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72731.1
CH471172 Genomic DNA Translation: EAW72732.1
CH471172 Genomic DNA Translation: EAW72733.1
CH471172 Genomic DNA Translation: EAW72734.1
CH471172 Genomic DNA Translation: EAW72735.1
BC001561 mRNA Translation: AAH01561.1
BC028092 mRNA Translation: AAH28092.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14747.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC4633

NCBI Reference Sequences

More...RefSeqi		NP_001009932.1, NM_001009932.2
NP_001009933.1, NM_001009933.2
NP_001009934.1, NM_001009934.2
NP_001290549.1, NM_001303620.1
NP_006721.1, NM_006730.3
XP_005277886.1, XM_005277829.4
XP_011529424.1, XM_011531122.2
XP_016884821.1, XM_017029332.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000014935; ENSP00000014935; ENSG00000013563
ENST00000309585; ENSP00000309168; ENSG00000013563
ENST00000369807; ENSP00000358822; ENSG00000013563
ENST00000369808; ENSP00000358823; ENSG00000013563
ENST00000369809; ENSP00000358824; ENSG00000013563
ENST00000393638; ENSP00000377255; ENSG00000013563

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1774

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1774

UCSC genome browser

More...UCSCi		uc033fbh.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90392 mRNA Translation: CAA62037.1
L40817 Genomic DNA Translation: AAB00495.1
L40823 mRNA Translation: AAB00496.1
L44140 Genomic DNA Translation: AAA92647.1
U06846 mRNA Translation: AAB17022.1
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72731.1
CH471172 Genomic DNA Translation: EAW72732.1
CH471172 Genomic DNA Translation: EAW72733.1
CH471172 Genomic DNA Translation: EAW72734.1
CH471172 Genomic DNA Translation: EAW72735.1
BC001561 mRNA Translation: AAH01561.1
BC028092 mRNA Translation: AAH28092.1
CCDSiCCDS14747.1
PIRiJC4633
RefSeqiNP_001009932.1, NM_001009932.2
NP_001009933.1, NM_001009933.2
NP_001009934.1, NM_001009934.2
NP_001290549.1, NM_001303620.1
NP_006721.1, NM_006730.3
XP_005277886.1, XM_005277829.4
XP_011529424.1, XM_011531122.2
XP_016884821.1, XM_017029332.1

3D structure databases

SMRiP49184
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108113, 11 interactors
IntActiP49184, 18 interactors
STRINGi9606.ENSP00000358824

PTM databases

GlyGeniP49184, 1 site
iPTMnetiP49184
PhosphoSitePlusiP49184

Genetic variation databases

BioMutaiDNASE1L1
DMDMi1352319

Proteomic databases

EPDiP49184
jPOSTiP49184
MassIVEiP49184
MaxQBiP49184
PaxDbiP49184
PeptideAtlasiP49184
PRIDEiP49184
ProteomicsDBi55967

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31202, 165 antibodies

The DNASU plasmid repository

More...DNASUi		1774

Genome annotation databases

EnsembliENST00000014935; ENSP00000014935; ENSG00000013563
ENST00000309585; ENSP00000309168; ENSG00000013563
ENST00000369807; ENSP00000358822; ENSG00000013563
ENST00000369808; ENSP00000358823; ENSG00000013563
ENST00000369809; ENSP00000358824; ENSG00000013563
ENST00000393638; ENSP00000377255; ENSG00000013563
GeneIDi1774
KEGGihsa:1774
UCSCiuc033fbh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1774
DisGeNETi1774

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNASE1L1
HGNCiHGNC:2957, DNASE1L1
HPAiENSG00000013563, Tissue enhanced (skeletal)
MIMi300081, gene
neXtProtiNX_P49184
OpenTargetsiENSG00000013563
PharmGKBiPA27428
VEuPathDBiHostDB:ENSG00000013563.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPNY, Eukaryota
GeneTreeiENSGT00950000182846
HOGENOMiCLU_043335_1_0_1
InParanoidiP49184
OMAiFHWAIAD
OrthoDBi1282784at2759
PhylomeDBiP49184
TreeFamiTF329541

Enzyme and pathway databases

PathwayCommonsiP49184
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1774, 13 hits in 626 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNASE1L1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNASE1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1774
PharosiP49184, Tbio

Protein Ontology

More...PROi		PR:P49184
RNActiP49184, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000013563, Expressed in quadriceps femoris and 226 other tissues
ExpressionAtlasiP49184, baseline and differential
GenevisibleiP49184, HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057, Deoxyribonuclease-1_AS
IPR016202, DNase_I
IPR033125, DNASE_I_2
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372, Exo_endo_phos, 1 hit
PIRSFiPIRSF000988, DNase_I_euk, 1 hit
PRINTSiPR00130, DNASEI
SMARTiView protein in SMART
SM00476, DNaseIc, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919, DNASE_I_1, 1 hit
PS00918, DNASE_I_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNSL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49184
Secondary accession number(s): D3DWW7, Q5HY41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again