UniProtKB - P49184 (DNSL1_HUMAN)
Protein
Deoxyribonuclease-1-like 1
Gene
DNASE1L1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 97 | By similarity | 1 | |
Active sitei | 148 | By similarity | 1 |
GO - Molecular functioni
- deoxyribonuclease activity Source: GO_Central
- deoxyribonuclease I activity Source: GO_Central
- DNA binding Source: GO_Central
GO - Biological processi
- DNA catabolic process Source: GO_Central
- DNA catabolic process, endonucleolytic Source: GO_Central
- DNA metabolic process Source: ProtInc
- neutrophil degranulation Source: Reactome
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Enzyme and pathway databases
PathwayCommonsi | P49184 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Deoxyribonuclease-1-like 1 (EC:3.1.21.-)Alternative name(s): DNase X Deoxyribonuclease I-like 1 Short name: DNase I-like 1 Muscle-specific DNase I-like XIB |
Gene namesi | Name:DNASE1L1 Synonyms:DNAS1L1, DNL1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2957, DNASE1L1 |
MIMi | 300081, gene |
neXtProti | NX_P49184 |
VEuPathDBi | HostDB:ENSG00000013563.13 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleus Source: GO_Central
Other locations
- specific granule lumen Source: Reactome
Keywords - Cellular componenti
Endoplasmic reticulumPathology & Biotechi
Organism-specific databases
DisGeNETi | 1774 |
OpenTargetsi | ENSG00000013563 |
PharmGKBi | PA27428 |
Miscellaneous databases
Pharosi | P49184, Tbio |
Genetic variation databases
BioMutai | DNASE1L1 |
DMDMi | 1352319 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000007284 | 19 – 302 | Deoxyribonuclease-1-like 1Add BLAST | 284 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 187 ↔ 224 | Essential for enzymatic activityBy similarity | ||
Glycosylationi | 261 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P49184 |
jPOSTi | P49184 |
MassIVEi | P49184 |
MaxQBi | P49184 |
PaxDbi | P49184 |
PeptideAtlasi | P49184 |
PRIDEi | P49184 |
ProteomicsDBi | 55967 |
PTM databases
GlyGeni | P49184, 1 site |
iPTMneti | P49184 |
PhosphoSitePlusi | P49184 |
Expressioni
Tissue specificityi
Highest levels in skeletal and cardiac muscles. Detectable in all other tissues tested except brain.1 Publication
Gene expression databases
Bgeei | ENSG00000013563, Expressed in quadriceps femoris and 225 other tissues |
ExpressionAtlasi | P49184, baseline and differential |
Genevisiblei | P49184, HS |
Organism-specific databases
HPAi | ENSG00000013563, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
Hide detailsP49184
Protein-protein interaction databases
BioGRIDi | 108113, 9 interactors |
IntActi | P49184, 18 interactors |
STRINGi | 9606.ENSP00000358824 |
Miscellaneous databases
RNActi | P49184, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DNase I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QPNY, Eukaryota |
GeneTreei | ENSGT00950000182846 |
HOGENOMi | CLU_043335_1_0_1 |
InParanoidi | P49184 |
OMAi | FHWAIAD |
OrthoDBi | 1282784at2759 |
PhylomeDBi | P49184 |
TreeFami | TF329541 |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR018057, Deoxyribonuclease-1_AS IPR016202, DNase_I IPR033125, DNASE_I_2 IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
PIRSFi | PIRSF000988, DNase_I_euk, 1 hit |
PRINTSi | PR00130, DNASEI |
SMARTi | View protein in SMART SM00476, DNaseIc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS00919, DNASE_I_1, 1 hit PS00918, DNASE_I_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P49184-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHYPTALLFL ILANGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC
60 70 80 90 100
DIMVLQEVVD SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV
110 120 130 140 150
YFYRSHKTQV LSSYVYNDED DVFAREPFVA QFSLPSNVLP SLVLVPLHTT
160 170 180 190 200
PKAVEKELNA LYDVFLEVSQ HWQSKDVILL GDFNADCASL TKKRLDKLEL
210 220 230 240 250
RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL HTAAAFDFPT
260 270 280 290 300
SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP
AA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6QRJ0 | A6QRJ0_HUMAN | Deoxyribonuclease-1-like 1 | DNASE1L1 | 208 | Annotation score: | ||
Q5HY40 | Q5HY40_HUMAN | Deoxyribonuclease-1-like 1 | DNASE1L1 | 103 | Annotation score: | ||
E7ESG1 | E7ESG1_HUMAN | Deoxyribonuclease-1-like 1 | DNASE1L1 | 62 | Annotation score: | ||
E7EUJ0 | E7EUJ0_HUMAN | Deoxyribonuclease-1-like 1 | DNASE1L1 | 85 | Annotation score: | ||
A3KQT1 | A3KQT1_HUMAN | Deoxyribonuclease-1-like 1 | DNASE1L1 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 73 | L → I in AAB00496 (PubMed:8541839).Curated | 1 | |
Sequence conflicti | 78 | G → D in AAB00496 (PubMed:8541839).Curated | 1 | |
Sequence conflicti | 205 | G → S in AAB00496 (PubMed:8541839).Curated | 1 | |
Sequence conflicti | 227 | D → A in AAB00495 (PubMed:8541839).Curated | 1 | |
Sequence conflicti | 227 | D → A in AAA92647 (PubMed:8733135).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048869 | 122 | V → I. Corresponds to variant dbSNP:rs34952165Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X90392 mRNA Translation: CAA62037.1 L40817 Genomic DNA Translation: AAB00495.1 L40823 mRNA Translation: AAB00496.1 L44140 Genomic DNA Translation: AAA92647.1 U06846 mRNA Translation: AAB17022.1 BX936347 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72731.1 CH471172 Genomic DNA Translation: EAW72732.1 CH471172 Genomic DNA Translation: EAW72733.1 CH471172 Genomic DNA Translation: EAW72734.1 CH471172 Genomic DNA Translation: EAW72735.1 BC001561 mRNA Translation: AAH01561.1 BC028092 mRNA Translation: AAH28092.1 |
CCDSi | CCDS14747.1 |
PIRi | JC4633 |
RefSeqi | NP_001009932.1, NM_001009932.2 NP_001009933.1, NM_001009933.2 NP_001009934.1, NM_001009934.2 NP_001290549.1, NM_001303620.1 NP_006721.1, NM_006730.3 XP_005277886.1, XM_005277829.4 XP_011529424.1, XM_011531122.2 XP_016884821.1, XM_017029332.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X90392 mRNA Translation: CAA62037.1 L40817 Genomic DNA Translation: AAB00495.1 L40823 mRNA Translation: AAB00496.1 L44140 Genomic DNA Translation: AAA92647.1 U06846 mRNA Translation: AAB17022.1 BX936347 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72731.1 CH471172 Genomic DNA Translation: EAW72732.1 CH471172 Genomic DNA Translation: EAW72733.1 CH471172 Genomic DNA Translation: EAW72734.1 CH471172 Genomic DNA Translation: EAW72735.1 BC001561 mRNA Translation: AAH01561.1 BC028092 mRNA Translation: AAH28092.1 |
CCDSi | CCDS14747.1 |
PIRi | JC4633 |
RefSeqi | NP_001009932.1, NM_001009932.2 NP_001009933.1, NM_001009933.2 NP_001009934.1, NM_001009934.2 NP_001290549.1, NM_001303620.1 NP_006721.1, NM_006730.3 XP_005277886.1, XM_005277829.4 XP_011529424.1, XM_011531122.2 XP_016884821.1, XM_017029332.1 |
3D structure databases
SMRi | P49184 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108113, 9 interactors |
IntActi | P49184, 18 interactors |
STRINGi | 9606.ENSP00000358824 |
PTM databases
GlyGeni | P49184, 1 site |
iPTMneti | P49184 |
PhosphoSitePlusi | P49184 |
Genetic variation databases
BioMutai | DNASE1L1 |
DMDMi | 1352319 |
Proteomic databases
EPDi | P49184 |
jPOSTi | P49184 |
MassIVEi | P49184 |
MaxQBi | P49184 |
PaxDbi | P49184 |
PeptideAtlasi | P49184 |
PRIDEi | P49184 |
ProteomicsDBi | 55967 |
Protocols and materials databases
Antibodypediai | 31202, 162 antibodies |
DNASUi | 1774 |
Genome annotation databases
Organism-specific databases
CTDi | 1774 |
DisGeNETi | 1774 |
GeneCardsi | DNASE1L1 |
HGNCi | HGNC:2957, DNASE1L1 |
HPAi | ENSG00000013563, Tissue enhanced (skeletal) |
MIMi | 300081, gene |
neXtProti | NX_P49184 |
OpenTargetsi | ENSG00000013563 |
PharmGKBi | PA27428 |
VEuPathDBi | HostDB:ENSG00000013563.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPNY, Eukaryota |
GeneTreei | ENSGT00950000182846 |
HOGENOMi | CLU_043335_1_0_1 |
InParanoidi | P49184 |
OMAi | FHWAIAD |
OrthoDBi | 1282784at2759 |
PhylomeDBi | P49184 |
TreeFami | TF329541 |
Enzyme and pathway databases
PathwayCommonsi | P49184 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 1774, 11 hits in 506 CRISPR screens |
ChiTaRSi | DNASE1L1, human |
GeneWikii | DNASE1L1 |
GenomeRNAii | 1774 |
Pharosi | P49184, Tbio |
PROi | PR:P49184 |
RNActi | P49184, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000013563, Expressed in quadriceps femoris and 225 other tissues |
ExpressionAtlasi | P49184, baseline and differential |
Genevisiblei | P49184, HS |
Family and domain databases
Gene3Di | 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR018057, Deoxyribonuclease-1_AS IPR016202, DNase_I IPR033125, DNASE_I_2 IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
PIRSFi | PIRSF000988, DNase_I_euk, 1 hit |
PRINTSi | PR00130, DNASEI |
SMARTi | View protein in SMART SM00476, DNaseIc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS00919, DNASE_I_1, 1 hit PS00918, DNASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNSL1_HUMAN | |
Accessioni | P49184Primary (citable) accession number: P49184 Secondary accession number(s): D3DWW7, Q5HY41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families