Neuropeptide Y receptor type 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium channel regulator activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line."
    Lynch J.W., Lemos V.S., Bucher B., Stoclet J.C., Takeda K.
    J. Biol. Chem. 269:8226-8233(1994) [PubMed] [Europe PMC] [Abstract]
• neuropeptide Y receptor activity Source: ProtIncTraceable author statementⁱ
  • Ref.3

    "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor."
    Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R.
    J. Biol. Chem. 270:22661-22664(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• peptide YY receptor activity Source: Ensembl
• signaling receptor activity Source: ProtIncTraceable author statementⁱ
  • "Cloned human neuropeptide Y receptor couples to two different second messenger systems."
    Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A.
    Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtIncTraceable author statementⁱ
  • Ref.3

    "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor."
    Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R.
    J. Biol. Chem. 270:22661-22664(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• aging Source: Ensembl
• behavioral fear response Source: Ensembl
• cardiac left ventricle morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study."
    Arnett D.K., Devereux R.B., Rao D.C., Li N., Tang W., Kraemer R., Claas S.A., Leon J.M., Broeckel U.
    J. Hypertens. 27:1585-1593(2009) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: Reactome
• locomotory behavior Source: ProtIncTraceable author statementⁱ
  • "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain."
    Caberlotto L., Fuxe K., Rimland J.M., Sedvall G., Hurd Y.L.
    Neuroscience 86:167-178(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cAMP-mediated signaling Source: Ensembl
• negative regulation of excitatory postsynaptic potential Source: Ensembl
• negative regulation of feeding behavior Source: Ensembl
• negative regulation of secretion Source: Ensembl
• negative regulation of synaptic transmission, glutamatergic Source: Ensembl
• nitric oxide mediated signal transduction Source: Ensembl
• outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study."
    Arnett D.K., Devereux R.B., Rao D.C., Li N., Tang W., Kraemer R., Claas S.A., Leon J.M., Broeckel U.
    J. Hypertens. 27:1585-1593(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-substrate adhesion Source: Ensembl
• positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
• positive regulation of cytosolic calcium ion concentration Source: Ensembl
• positive regulation of dopamine secretion Source: Ensembl
• positive regulation of peptide secretion Source: Ensembl
• positive regulation of smooth muscle contraction Source: Ensembl
• regulation of sensory perception of pain Source: Ensembl
• secretion Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ 
        60         70         80         90        100
VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN 
       110        120        130        140        150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR 
       160        170        180        190        200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI 
       210        220        230        240        250
VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV 
       260        270        280        290        300
SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL 
       310        320        330        340        350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH 
       360        370        380 
SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V                     

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human chromosome 4
   Human chromosome 4: entries, gene names and cross-references to MIM
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries