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Protein

Neuropeptide Y receptor type 2

Gene

NPY2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP49146

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 2
Short name:
NPY2-R
Alternative name(s):
NPY-Y2 receptor
Short name:
Y2 receptor
Gene namesi
Name:NPY2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000185149.5
HGNCiHGNC:7957 NPY2R
MIMi162642 gene
neXtProtiNX_P49146

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51ExtracellularSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 86CytoplasmicSequence analysisAdd BLAST14
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 124ExtracellularSequence analysisAdd BLAST17
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 216ExtracellularSequence analysisAdd BLAST30
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 268CytoplasmicSequence analysisAdd BLAST31
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 304ExtracellularSequence analysisAdd BLAST15
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 381CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4887
OpenTargetsiENSG00000185149
PharmGKBiPA31741

Chemistry databases

ChEMBLiCHEMBL4018
DrugBankiDB05004 AC162352
DB00847 Cysteamine
DB05045 TM30338
GuidetoPHARMACOLOGYi306

Polymorphism and mutation databases

BioMutaiNPY2R
DMDMi1352610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699281 – 381Neuropeptide Y receptor type 2Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 203PROSITE-ProRule annotation
Lipidationi342S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiP49146
PaxDbiP49146
PeptideAtlasiP49146
PRIDEiP49146
ProteomicsDBi55966

PTM databases

iPTMnetiP49146
PhosphoSitePlusiP49146

Expressioni

Tissue specificityi

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Gene expression databases

BgeeiENSG00000185149 Expressed in 83 organ(s), highest expression level in Ammon's horn
CleanExiHS_NPY2R
GenevisibleiP49146 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-6655721,EBI-6655667

Protein-protein interaction databases

BioGridi110947, 62 interactors
IntActiP49146, 3 interactors
STRINGi9606.ENSP00000332591

Chemistry databases

BindingDBiP49146

Structurei

3D structure databases

ProteinModelPortaliP49146
SMRiP49146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG105675
InParanoidiP49146
KOiK04205
OMAiAFQCEQR
OrthoDBiEOG091G0C6Q
PhylomeDBiP49146
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001358 NPY2_rcpt
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01014 NRPEPTIDEY2R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ
60 70 80 90 100
VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV
260 270 280 290 300
SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V
Length:381
Mass (Da):42,731
Last modified:February 1, 1996 - v1
Checksum:i7D018C0169597BC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134V → A in AAA93170 (PubMed:7559383).Curated1
Sequence conflicti172A → G (PubMed:8643460).Curated1
Sequence conflicti174G → R (PubMed:8643460).Curated1
Sequence conflicti202A → P in AAB07760 (PubMed:8643460).Curated1
Sequence conflicti209G → A in AAB07760 (PubMed:8643460).Curated1
Sequence conflicti248N → S in AAD00248 (Ref. 6) Curated1
Sequence conflicti311H → Y in AAD00248 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36269 mRNA Translation: AAC50281.1
U42766 mRNA Translation: AAB04120.1
U32500 mRNA Translation: AAA93170.1
U42389 mRNA Translation: AAB07760.1
U50146 Genomic DNA Translation: AAC51115.1
U76254 Genomic DNA Translation: AAD00248.1
AY236540 Genomic DNA Translation: AAO92062.1
AC104407 Genomic DNA Translation: AAY40940.1
CH471056 Genomic DNA Translation: EAX04901.1
BC075053 mRNA Translation: AAH75053.2
BC075052 mRNA Translation: AAH75052.2
CCDSiCCDS3791.1
PIRiI39187
RefSeqiNP_000901.1, NM_000910.3
XP_005263090.1, XM_005263033.4
XP_005263091.1, XM_005263034.4
UniGeneiHs.37125

Genome annotation databases

EnsembliENST00000329476; ENSP00000332591; ENSG00000185149
ENST00000506608; ENSP00000426366; ENSG00000185149
GeneIDi4887
KEGGihsa:4887
UCSCiuc003ioq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36269 mRNA Translation: AAC50281.1
U42766 mRNA Translation: AAB04120.1
U32500 mRNA Translation: AAA93170.1
U42389 mRNA Translation: AAB07760.1
U50146 Genomic DNA Translation: AAC51115.1
U76254 Genomic DNA Translation: AAD00248.1
AY236540 Genomic DNA Translation: AAO92062.1
AC104407 Genomic DNA Translation: AAY40940.1
CH471056 Genomic DNA Translation: EAX04901.1
BC075053 mRNA Translation: AAH75053.2
BC075052 mRNA Translation: AAH75052.2
CCDSiCCDS3791.1
PIRiI39187
RefSeqiNP_000901.1, NM_000910.3
XP_005263090.1, XM_005263033.4
XP_005263091.1, XM_005263034.4
UniGeneiHs.37125

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK3model-@1-381[»]
ProteinModelPortaliP49146
SMRiP49146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110947, 62 interactors
IntActiP49146, 3 interactors
STRINGi9606.ENSP00000332591

Chemistry databases

BindingDBiP49146
ChEMBLiCHEMBL4018
DrugBankiDB05004 AC162352
DB00847 Cysteamine
DB05045 TM30338
GuidetoPHARMACOLOGYi306

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP49146
PhosphoSitePlusiP49146

Polymorphism and mutation databases

BioMutaiNPY2R
DMDMi1352610

Proteomic databases

EPDiP49146
PaxDbiP49146
PeptideAtlasiP49146
PRIDEiP49146
ProteomicsDBi55966

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329476; ENSP00000332591; ENSG00000185149
ENST00000506608; ENSP00000426366; ENSG00000185149
GeneIDi4887
KEGGihsa:4887
UCSCiuc003ioq.3 human

Organism-specific databases

CTDi4887
DisGeNETi4887
EuPathDBiHostDB:ENSG00000185149.5
GeneCardsiNPY2R
HGNCiHGNC:7957 NPY2R
MIMi162642 gene
neXtProtiNX_P49146
OpenTargetsiENSG00000185149
PharmGKBiPA31741
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG105675
InParanoidiP49146
KOiK04205
OMAiAFQCEQR
OrthoDBiEOG091G0C6Q
PhylomeDBiP49146
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP49146

Miscellaneous databases

GeneWikiiNeuropeptide_Y_receptor_Y2
GenomeRNAii4887
PROiPR:P49146
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185149 Expressed in 83 organ(s), highest expression level in Ammon's horn
CleanExiHS_NPY2R
GenevisibleiP49146 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001358 NPY2_rcpt
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01014 NRPEPTIDEY2R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPY2R_HUMAN
AccessioniPrimary (citable) accession number: P49146
Secondary accession number(s): Q13281
, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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