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UniProtKB - P49146 (NPY2R_HUMAN)

Entry version 163 (13 Feb 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Neuropeptide Y receptor type 2

Gene

NPY2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49146

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropeptide Y receptor type 2
Short name:
NPY2-R
Alternative name(s):
NPY-Y2 receptor
Short name:
Y2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPY2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000185149.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:7957 NPY2R

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		162642 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49146

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51ExtracellularSequence analysisAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 86CytoplasmicSequence analysisAdd BLAST14
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 124ExtracellularSequence analysisAdd BLAST17
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 216ExtracellularSequence analysisAdd BLAST30
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 268CytoplasmicSequence analysisAdd BLAST31
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 304ExtracellularSequence analysisAdd BLAST15
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 381CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4887

Open Targets

More...OpenTargetsi		ENSG00000185149

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31741

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4018

Drug and drug target database

More...DrugBanki		DB05004 AC162352
DB00847 Cysteamine
DB05045 TM30338

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		306

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NPY2R

Domain mapping of disease mutations (DMDM)

More...DMDMi		1352610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000699281 – 381Neuropeptide Y receptor type 2Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi123 ↔ 203PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi342S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49146

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49146

PeptideAtlas

More...PeptideAtlasi		P49146

PRoteomics IDEntifications database

More...PRIDEi		P49146

ProteomicsDB human proteome resource

More...ProteomicsDBi		55966

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49146

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49146

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185149 Expressed in 83 organ(s), highest expression level in Ammon's horn

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49146 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-6655721,EBI-6655667

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110947, 62 interactors

Protein interaction database and analysis system

More...IntActi		P49146, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332591

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P49146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK3model-@1-381[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P49146

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49146

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155973

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000050229

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG105675

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49146

KEGG Orthology (KO)

More...KOi		K04205

Identification of Orthologs from Complete Genome Data

More...OMAi		AFQCEQR

Database of Orthologous Groups

More...OrthoDBi		746515at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49146

TreeFam database of animal gene trees

More...TreeFami		TF315303

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001358 NPY2_rcpt
IPR000611 NPY_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237 GPCRRHODOPSN
PR01014 NRPEPTIDEY2R
PR01012 NRPEPTIDEYR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ 
        60         70         80         90        100
VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN 
       110        120        130        140        150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR 
       160        170        180        190        200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI 
       210        220        230        240        250
VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV 
       260        270        280        290        300
SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL 
       310        320        330        340        350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH 
       360        370        380 
SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V
Length:381
Mass (Da):42,731
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D018C0169597BC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134V → A in AAA93170 (PubMed:7559383).Curated1
Sequence conflicti172A → G (PubMed:8643460).Curated1
Sequence conflicti174G → R (PubMed:8643460).Curated1
Sequence conflicti202A → P in AAB07760 (PubMed:8643460).Curated1
Sequence conflicti209G → A in AAB07760 (PubMed:8643460).Curated1
Sequence conflicti248N → S in AAD00248 (Ref. 6) Curated1
Sequence conflicti311H → Y in AAD00248 (Ref. 6) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U36269 mRNA Translation: AAC50281.1
U42766 mRNA Translation: AAB04120.1
U32500 mRNA Translation: AAA93170.1
U42389 mRNA Translation: AAB07760.1
U50146 Genomic DNA Translation: AAC51115.1
U76254 Genomic DNA Translation: AAD00248.1
AY236540 Genomic DNA Translation: AAO92062.1
AC104407 Genomic DNA Translation: AAY40940.1
CH471056 Genomic DNA Translation: EAX04901.1
BC075053 mRNA Translation: AAH75053.2
BC075052 mRNA Translation: AAH75052.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3791.1

Protein sequence database of the Protein Information Resource

More...PIRi		I39187

NCBI Reference Sequences

More...RefSeqi		NP_000901.1, NM_000910.3
XP_005263090.1, XM_005263033.4
XP_005263091.1, XM_005263034.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.37125

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329476; ENSP00000332591; ENSG00000185149
ENST00000506608; ENSP00000426366; ENSG00000185149

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4887

UCSC genome browser

More...UCSCi		uc003ioq.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36269 mRNA Translation: AAC50281.1
U42766 mRNA Translation: AAB04120.1
U32500 mRNA Translation: AAA93170.1
U42389 mRNA Translation: AAB07760.1
U50146 Genomic DNA Translation: AAC51115.1
U76254 Genomic DNA Translation: AAD00248.1
AY236540 Genomic DNA Translation: AAO92062.1
AC104407 Genomic DNA Translation: AAY40940.1
CH471056 Genomic DNA Translation: EAX04901.1
BC075053 mRNA Translation: AAH75053.2
BC075052 mRNA Translation: AAH75052.2
CCDSiCCDS3791.1
PIRiI39187
RefSeqiNP_000901.1, NM_000910.3
XP_005263090.1, XM_005263033.4
XP_005263091.1, XM_005263034.4
UniGeneiHs.37125

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK3model-@1-381[»]
ProteinModelPortaliP49146
SMRiP49146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110947, 62 interactors
IntActiP49146, 5 interactors
STRINGi9606.ENSP00000332591

Chemistry databases

BindingDBiP49146
ChEMBLiCHEMBL4018
DrugBankiDB05004 AC162352
DB00847 Cysteamine
DB05045 TM30338
GuidetoPHARMACOLOGYi306

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP49146
PhosphoSitePlusiP49146

Polymorphism and mutation databases

BioMutaiNPY2R
DMDMi1352610

Proteomic databases

EPDiP49146
PaxDbiP49146
PeptideAtlasiP49146
PRIDEiP49146
ProteomicsDBi55966

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329476; ENSP00000332591; ENSG00000185149
ENST00000506608; ENSP00000426366; ENSG00000185149
GeneIDi4887
KEGGihsa:4887
UCSCiuc003ioq.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4887
DisGeNETi4887
EuPathDBiHostDB:ENSG00000185149.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		NPY2R
HGNCiHGNC:7957 NPY2R
MIMi162642 gene
neXtProtiNX_P49146
OpenTargetsiENSG00000185149
PharmGKBiPA31741

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000155973
HOGENOMiHOG000050229
HOVERGENiHBG105675
InParanoidiP49146
KOiK04205
OMAiAFQCEQR
OrthoDBi746515at2759
PhylomeDBiP49146
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP49146

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Neuropeptide_Y_receptor_Y2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4887

Protein Ontology

More...PROi		PR:P49146

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185149 Expressed in 83 organ(s), highest expression level in Ammon's horn
GenevisibleiP49146 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001358 NPY2_rcpt
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01014 NRPEPTIDEY2R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPY2R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49146
Secondary accession number(s): Q13281
, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 13, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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