UniProtKB - P49146 (NPY2R_HUMAN)
Protein
Neuropeptide Y receptor type 2
Gene
NPY2R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
GO - Molecular functioni
- calcium channel regulator activity Source: ProtInc
- neuropeptide Y receptor activity Source: ProtInc
- peptide YY receptor activity Source: Ensembl
- signaling receptor activity Source: ProtInc
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtInc
- aging Source: Ensembl
- behavioral fear response Source: Ensembl
- cardiac left ventricle morphogenesis Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- locomotory behavior Source: ProtInc
- negative regulation of cAMP-mediated signaling Source: Ensembl
- negative regulation of excitatory postsynaptic potential Source: Ensembl
- negative regulation of feeding behavior Source: Ensembl
- negative regulation of nervous system process Source: Ensembl
- negative regulation of secretion Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: Ensembl
- nitric oxide mediated signal transduction Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- positive regulation of cell-substrate adhesion Source: Ensembl
- positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of dopamine secretion Source: Ensembl
- positive regulation of peptide secretion Source: Ensembl
- positive regulation of smooth muscle contraction Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- secretion Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P49146 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P49146 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide Y receptor type 2Short name: NPY2-R Alternative name(s): NPY-Y2 receptor Short name: Y2 receptor |
Gene namesi | Name:NPY2R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7957, NPY2R |
MIMi | 162642, gene |
neXtProti | NX_P49146 |
VEuPathDBi | HostDB:ENSG00000185149.5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cilium Source: MGI
- non-motile cilium Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 86 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 87 – 107 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 124 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 125 – 145 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 165 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 216 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 217 – 237 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 268 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 269 – 289 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 304 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 305 – 325 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 381 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4887 |
OpenTargetsi | ENSG00000185149 |
PharmGKBi | PA31741 |
Miscellaneous databases
Pharosi | P49146, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4018 |
DrugBanki | DB00847, Cysteamine DB05045, Obinepitide DB05004, Peptide YY (3-36) |
DrugCentrali | P49146 |
GuidetoPHARMACOLOGYi | 306 |
Genetic variation databases
BioMutai | NPY2R |
DMDMi | 1352610 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069928 | 1 – 381 | Neuropeptide Y receptor type 2Add BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 203 | PROSITE-ProRule annotation | ||
Lipidationi | 342 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
EPDi | P49146 |
jPOSTi | P49146 |
PaxDbi | P49146 |
PeptideAtlasi | P49146 |
PRIDEi | P49146 |
ProteomicsDBi | 55966 |
PTM databases
GlyGeni | P49146, 1 site |
iPTMneti | P49146 |
PhosphoSitePlusi | P49146 |
Expressioni
Tissue specificityi
High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.
Gene expression databases
Bgeei | ENSG00000185149, Expressed in Ammon's horn and 97 other tissues |
Genevisiblei | P49146, HS |
Organism-specific databases
HPAi | ENSG00000185149, Tissue enhanced (brain, breast) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 110947, 65 interactors |
IntActi | P49146, 57 interactors |
STRINGi | 9606.ENSP00000332591 |
Chemistry databases
BindingDBi | P49146 |
Miscellaneous databases
RNActi | P49146, protein |
Structurei
3D structure databases
BMRBi | P49146 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155973 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P49146 |
OMAi | AYTRIWT |
OrthoDBi | 746515at2759 |
PhylomeDBi | P49146 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001358, NPY2_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01014, NRPEPTIDEY2R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P49146-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ
60 70 80 90 100
VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV
260 270 280 290 300
SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 | V → A in AAA93170 (PubMed:7559383).Curated | 1 | |
Sequence conflicti | 172 | A → G (PubMed:8643460).Curated | 1 | |
Sequence conflicti | 174 | G → R (PubMed:8643460).Curated | 1 | |
Sequence conflicti | 202 | A → P in AAB07760 (PubMed:8643460).Curated | 1 | |
Sequence conflicti | 209 | G → A in AAB07760 (PubMed:8643460).Curated | 1 | |
Sequence conflicti | 248 | N → S in AAD00248 (Ref. 6) Curated | 1 | |
Sequence conflicti | 311 | H → Y in AAD00248 (Ref. 6) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36269 mRNA Translation: AAC50281.1 U42766 mRNA Translation: AAB04120.1 U32500 mRNA Translation: AAA93170.1 U42389 mRNA Translation: AAB07760.1 U50146 Genomic DNA Translation: AAC51115.1 U76254 Genomic DNA Translation: AAD00248.1 AY236540 Genomic DNA Translation: AAO92062.1 AC104407 Genomic DNA Translation: AAY40940.1 CH471056 Genomic DNA Translation: EAX04901.1 BC075053 mRNA Translation: AAH75053.2 BC075052 mRNA Translation: AAH75052.2 |
CCDSi | CCDS3791.1 |
PIRi | I39187 |
RefSeqi | NP_000901.1, NM_000910.3 XP_005263090.1, XM_005263033.4 XP_005263091.1, XM_005263034.4 |
Genome annotation databases
Ensembli | ENST00000329476; ENSP00000332591; ENSG00000185149 ENST00000506608; ENSP00000426366; ENSG00000185149 |
GeneIDi | 4887 |
KEGGi | hsa:4887 |
UCSCi | uc003ioq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36269 mRNA Translation: AAC50281.1 U42766 mRNA Translation: AAB04120.1 U32500 mRNA Translation: AAA93170.1 U42389 mRNA Translation: AAB07760.1 U50146 Genomic DNA Translation: AAC51115.1 U76254 Genomic DNA Translation: AAD00248.1 AY236540 Genomic DNA Translation: AAO92062.1 AC104407 Genomic DNA Translation: AAY40940.1 CH471056 Genomic DNA Translation: EAX04901.1 BC075053 mRNA Translation: AAH75053.2 BC075052 mRNA Translation: AAH75052.2 |
CCDSi | CCDS3791.1 |
PIRi | I39187 |
RefSeqi | NP_000901.1, NM_000910.3 XP_005263090.1, XM_005263033.4 XP_005263091.1, XM_005263034.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IK3 | model | - | @ | 1-381 | [»] | |
BMRBi | P49146 | |||||
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110947, 65 interactors |
IntActi | P49146, 57 interactors |
STRINGi | 9606.ENSP00000332591 |
Chemistry databases
BindingDBi | P49146 |
ChEMBLi | CHEMBL4018 |
DrugBanki | DB00847, Cysteamine DB05045, Obinepitide DB05004, Peptide YY (3-36) |
DrugCentrali | P49146 |
GuidetoPHARMACOLOGYi | 306 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P49146, 1 site |
iPTMneti | P49146 |
PhosphoSitePlusi | P49146 |
Genetic variation databases
BioMutai | NPY2R |
DMDMi | 1352610 |
Proteomic databases
EPDi | P49146 |
jPOSTi | P49146 |
PaxDbi | P49146 |
PeptideAtlasi | P49146 |
PRIDEi | P49146 |
ProteomicsDBi | 55966 |
Protocols and materials databases
Antibodypediai | 2964, 308 antibodies |
Genome annotation databases
Ensembli | ENST00000329476; ENSP00000332591; ENSG00000185149 ENST00000506608; ENSP00000426366; ENSG00000185149 |
GeneIDi | 4887 |
KEGGi | hsa:4887 |
UCSCi | uc003ioq.3, human |
Organism-specific databases
CTDi | 4887 |
DisGeNETi | 4887 |
GeneCardsi | NPY2R |
HGNCi | HGNC:7957, NPY2R |
HPAi | ENSG00000185149, Tissue enhanced (brain, breast) |
MIMi | 162642, gene |
neXtProti | NX_P49146 |
OpenTargetsi | ENSG00000185149 |
PharmGKBi | PA31741 |
VEuPathDBi | HostDB:ENSG00000185149.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155973 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P49146 |
OMAi | AYTRIWT |
OrthoDBi | 746515at2759 |
PhylomeDBi | P49146 |
TreeFami | TF315303 |
Enzyme and pathway databases
PathwayCommonsi | P49146 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P49146 |
Miscellaneous databases
BioGRID-ORCSi | 4887, 2 hits in 874 CRISPR screens |
ChiTaRSi | NPY2R, human |
GeneWikii | Neuropeptide_Y_receptor_Y2 |
GenomeRNAii | 4887 |
Pharosi | P49146, Tchem |
PROi | PR:P49146 |
RNActi | P49146, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185149, Expressed in Ammon's horn and 97 other tissues |
Genevisiblei | P49146, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001358, NPY2_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01014, NRPEPTIDEY2R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPY2R_HUMAN | |
Accessioni | P49146Primary (citable) accession number: P49146 Secondary accession number(s): Q13281 Q9UE67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families