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Protein

Calcium signal-modulating cyclophilin ligand

Gene

CAMLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Protein family/group databases

TCDBi3.A.19.1.1 the tms recognition/insertion complex (trc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name:
CAML
Gene namesi
Name:CAMLG
Synonyms:CAML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164615.4
HGNCiHGNC:1471 CAMLG
MIMi601118 gene
neXtProtiNX_P49069

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189CytoplasmicSequence analysisAdd BLAST189
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 240ExtracellularSequence analysisAdd BLAST30
Transmembranei241 – 257HelicalSequence analysisAdd BLAST17
Topological domaini258 – 296CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi819
OpenTargetsiENSG00000164615
PharmGKBiPA26053

Chemistry databases

DrugBankiDB00091 Cyclosporine

Polymorphism and mutation databases

BioMutaiCAMLG
DMDMi1345662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892911 – 296Calcium signal-modulating cyclophilin ligandAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49069
MaxQBiP49069
PaxDbiP49069
PeptideAtlasiP49069
PRIDEiP49069
ProteomicsDBi55961

PTM databases

iPTMnetiP49069
PhosphoSitePlusiP49069

Miscellaneous databases

PMAP-CutDBiP49069

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in brain, testis and ovary.

Gene expression databases

BgeeiENSG00000164615 Expressed in 237 organ(s), highest expression level in secondary oocyte
CleanExiHS_CAMLG
ExpressionAtlasiP49069 baseline and differential
GenevisibleiP49069 HS

Organism-specific databases

HPAiHPA052636
HPA056472

Interactioni

Subunit structurei

The N-terminal domain binds to TNFRSF13B/TACI.
(Microbial infection) Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi107269, 17 interactors
CORUMiP49069
IntActiP49069, 32 interactors
STRINGi9606.ENSP00000297156

Structurei

3D structure databases

ProteinModelPortaliP49069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEK3 Eukaryota
ENOG4111HUY LUCA
GeneTreeiENSGT00390000015996
HOGENOMiHOG000220891
HOVERGENiHBG050786
InParanoidiP49069
KOiK22385
OMAiHHGLEQY
OrthoDBiEOG091G0HL4
PhylomeDBiP49069
TreeFamiTF331902

Family and domain databases

InterProiView protein in InterPro
IPR016719 Ca_signal-mod_cyclophilin_lig
PANTHERiPTHR15026 PTHR15026, 1 hit
PfamiView protein in Pfam
PF14963 CAML, 1 hit
PIRSFiPIRSF018259 CAML, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P49069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF
60 70 80 90 100
HRPGSGAEEE SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG
110 120 130 140 150
GVAEVKGTQL GDKLDSFIKP PECSSDVNLE LRQRNRGDLT ADSVQRGSRH
160 170 180 190 200
GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN TTEEFDSFRI FRLVGCALLA
210 220 230 240 250
LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT TVLTAALLLS
260 270 280 290
GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP
Length:296
Mass (Da):32,953
Last modified:February 1, 1996 - v1
Checksum:i22DCD8CF022FEF09
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIW3D6RIW3_HUMAN
Calcium signal-modulating cyclophil...
CAMLG
80Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02429778V → I. Corresponds to variant dbSNP:rs12657663Ensembl.1
Natural variantiVAR_050710100G → S. Corresponds to variant dbSNP:rs11552197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA Translation: AAA59420.1
AK313156 mRNA Translation: BAG35974.1
CH471062 Genomic DNA Translation: EAW62243.1
CH471062 Genomic DNA Translation: EAW62244.1
BC130325 mRNA Translation: AAI30326.1
AF068179 mRNA Translation: AAC23596.1
CCDSiCCDS4178.1
PIRiS47594
RefSeqiNP_001736.1, NM_001745.3
UniGeneiHs.529846

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615
GeneIDi819
KEGGihsa:819
UCSCiuc003kzt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA Translation: AAA59420.1
AK313156 mRNA Translation: BAG35974.1
CH471062 Genomic DNA Translation: EAW62243.1
CH471062 Genomic DNA Translation: EAW62244.1
BC130325 mRNA Translation: AAI30326.1
AF068179 mRNA Translation: AAC23596.1
CCDSiCCDS4178.1
PIRiS47594
RefSeqiNP_001736.1, NM_001745.3
UniGeneiHs.529846

3D structure databases

ProteinModelPortaliP49069
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107269, 17 interactors
CORUMiP49069
IntActiP49069, 32 interactors
STRINGi9606.ENSP00000297156

Chemistry databases

DrugBankiDB00091 Cyclosporine

Protein family/group databases

TCDBi3.A.19.1.1 the tms recognition/insertion complex (trc) family

PTM databases

iPTMnetiP49069
PhosphoSitePlusiP49069

Polymorphism and mutation databases

BioMutaiCAMLG
DMDMi1345662

Proteomic databases

EPDiP49069
MaxQBiP49069
PaxDbiP49069
PeptideAtlasiP49069
PRIDEiP49069
ProteomicsDBi55961

Protocols and materials databases

DNASUi819
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615
GeneIDi819
KEGGihsa:819
UCSCiuc003kzt.4 human

Organism-specific databases

CTDi819
DisGeNETi819
EuPathDBiHostDB:ENSG00000164615.4
GeneCardsiCAMLG
H-InvDBiHIX0164331
HGNCiHGNC:1471 CAMLG
HPAiHPA052636
HPA056472
MIMi601118 gene
neXtProtiNX_P49069
OpenTargetsiENSG00000164615
PharmGKBiPA26053
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK3 Eukaryota
ENOG4111HUY LUCA
GeneTreeiENSGT00390000015996
HOGENOMiHOG000220891
HOVERGENiHBG050786
InParanoidiP49069
KOiK22385
OMAiHHGLEQY
OrthoDBiEOG091G0HL4
PhylomeDBiP49069
TreeFamiTF331902

Miscellaneous databases

ChiTaRSiCAMLG human
GeneWikiiCAMLG
GenomeRNAii819
PMAP-CutDBiP49069
PROiPR:P49069
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164615 Expressed in 237 organ(s), highest expression level in secondary oocyte
CleanExiHS_CAMLG
ExpressionAtlasiP49069 baseline and differential
GenevisibleiP49069 HS

Family and domain databases

InterProiView protein in InterPro
IPR016719 Ca_signal-mod_cyclophilin_lig
PANTHERiPTHR15026 PTHR15026, 1 hit
PfamiView protein in Pfam
PF14963 CAML, 1 hit
PIRSFiPIRSF018259 CAML, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAMLG_HUMAN
AccessioniPrimary (citable) accession number: P49069
Secondary accession number(s): A1L3Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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