UniProtKB - P49029 (MGN_CAEEL)
Protein mago nashi homolog
mag-1
Functioni
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (Probable). Positively regulates the nuclear export of spliced mRNAs including the sex determination gene tra-2 (PubMed:23149939).
Promotes oogenesis and represses germline masculinization and spermatogenesis (PubMed:10656761, PubMed:14706697, PubMed:23149939).
Required for embryonic development, possibly through positively regulating the expression of pie-1 (PubMed:30279189).
Not required for the spatial patterning of pie-1 in embryos (PubMed:30279189).
1 Publication4 PublicationsGO - Biological processi
- feminization of hermaphroditic germ-line Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- mRNA transport Source: UniProtKB-KW
- nuclear mRNA surveillance Source: UniProtKB
- oogenesis Source: UniProtKB-KW
- positive regulation of oogenesis Source: UniProtKB
- positive regulation of oviposition Source: UniProtKB
- RNA splicing Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, mRNA processing, mRNA splicing, mRNA transport, Oogenesis, Transport |
Enzyme and pathway databases
Reactomei | R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72187, mRNA 3'-end processing R-CEL-73856, RNA Polymerase II Transcription Termination R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: Protein mago nashi homologAlternative name(s): Ce-mago |
Gene namesi | Name:mag-1Imported ORF Names:R09B3.5Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R09B3.5 ; CE16310 ; WBGene00003123 ; mag-1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- catalytic step 2 spliceosome Source: GO_Central
- exon-exon junction complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174151 | 1 – 152 | Protein mago nashi homologAdd BLAST | 152 |
Proteomic databases
EPDi | P49029 |
PaxDbi | P49029 |
PeptideAtlasi | P49029 |
PTM databases
iPTMneti | P49029 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | WBGene00003123, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Heterodimer with rnp-4/RBM8A (PubMed:14706697). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, mag-1/MAGOH and rnp-4/RBM8A (Probable).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 38476, 6 interactors |
DIPi | DIP-26241N |
IntActi | P49029, 1 interactor |
STRINGi | 6239.R09B3.5 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3392, Eukaryota |
GeneTreei | ENSGT00390000003156 |
HOGENOMi | CLU_109497_1_1_1 |
InParanoidi | P49029 |
OMAi | IRKEMWI |
OrthoDBi | 1373136at2759 |
PhylomeDBi | P49029 |
Family and domain databases
CDDi | cd11295, Mago_nashi, 1 hit |
Gene3Di | 3.30.1560.10, 1 hit |
InterProi | View protein in InterPro IPR004023, Mago_nashi IPR036605, Mago_nashi_sf |
PANTHERi | PTHR12638, PTHR12638, 1 hit |
Pfami | View protein in Pfam PF02792, Mago_nashi, 1 hit |
SUPFAMi | SSF89817, SSF89817, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSGEEEKAAD FYVRYYVGHK GKFGHEFLEF EFRPNGSLRY ANNSNYKNDT
60 70 80 90 100
MIRKEATVSE SVLSELKRII EDSEIMQEDD DNWPEPDKIG RQELEILYKN
110 120 130 140 150
EHISFTTGKI GALADVNNSK DPDGLRSFYY LVQDLKCLVF SLIGLHFKIK
PI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | A → G in AAB66721 (PubMed:9272960).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KF051002 mRNA Translation: AHX83788.1 BX284601 Genomic DNA Translation: CAB03239.1 AF007861 mRNA Translation: AAB66721.1 |
PIRi | T24070 T37461 |
RefSeqi | NP_493025.1, NM_060624.6 |
Genome annotation databases
EnsemblMetazoai | R09B3.5.1; R09B3.5.1; WBGene00003123 |
GeneIDi | 173073 |
KEGGi | cel:CELE_R09B3.5 |
UCSCi | R09B3.5.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KF051002 mRNA Translation: AHX83788.1 BX284601 Genomic DNA Translation: CAB03239.1 AF007861 mRNA Translation: AAB66721.1 |
PIRi | T24070 T37461 |
RefSeqi | NP_493025.1, NM_060624.6 |
3D structure databases
AlphaFoldDBi | P49029 |
SMRi | P49029 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 38476, 6 interactors |
DIPi | DIP-26241N |
IntActi | P49029, 1 interactor |
STRINGi | 6239.R09B3.5 |
PTM databases
iPTMneti | P49029 |
Proteomic databases
EPDi | P49029 |
PaxDbi | P49029 |
PeptideAtlasi | P49029 |
Genome annotation databases
EnsemblMetazoai | R09B3.5.1; R09B3.5.1; WBGene00003123 |
GeneIDi | 173073 |
KEGGi | cel:CELE_R09B3.5 |
UCSCi | R09B3.5.2, c. elegans |
Organism-specific databases
CTDi | 173073 |
WormBasei | R09B3.5 ; CE16310 ; WBGene00003123 ; mag-1 |
Phylogenomic databases
eggNOGi | KOG3392, Eukaryota |
GeneTreei | ENSGT00390000003156 |
HOGENOMi | CLU_109497_1_1_1 |
InParanoidi | P49029 |
OMAi | IRKEMWI |
OrthoDBi | 1373136at2759 |
PhylomeDBi | P49029 |
Enzyme and pathway databases
Reactomei | R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-CEL-72163, mRNA Splicing - Major Pathway R-CEL-72187, mRNA 3'-end processing R-CEL-73856, RNA Polymerase II Transcription Termination R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:P49029 |
Gene expression databases
Bgeei | WBGene00003123, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
CDDi | cd11295, Mago_nashi, 1 hit |
Gene3Di | 3.30.1560.10, 1 hit |
InterProi | View protein in InterPro IPR004023, Mago_nashi IPR036605, Mago_nashi_sf |
PANTHERi | PTHR12638, PTHR12638, 1 hit |
Pfami | View protein in Pfam PF02792, Mago_nashi, 1 hit |
SUPFAMi | SSF89817, SSF89817, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MGN_CAEEL | |
Accessioni | P49029Primary (citable) accession number: P49029 Secondary accession number(s): A0A023T4K3, O16104, O45714 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 15, 1999 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families