Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Paxillin

Gene

PXN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • vinculin binding Source: AgBase

GO - Biological processi

  • cell-matrix adhesion Source: InterPro
  • response to muscle stretch Source: AgBase

Keywordsi

Biological processCell adhesion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Paxillin
Gene namesi
Name:PXN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758571 – 559PaxillinAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei118Phosphotyrosine; by FAK11 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49024
PRIDEiP49024

PTM databases

iPTMnetiP49024

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676106, 4 interactors
ELMiP49024
IntActiP49024, 12 interactors
MINTiP49024
STRINGi9031.ENSGALP00000011713

Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP49024
SMRiP49024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 376LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST51
Domaini385 – 435LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST51
Domaini444 – 494LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini503 – 553LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Pro-rich8

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
HOGENOMiHOG000018764
HOVERGENiHBG001512
InParanoidiP49024
KOiK05760
PhylomeDBiP49024

Family and domain databases

InterProiView protein in InterPro
IPR001904 Paxillin
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM
PANTHERiPTHR24216:SF11 PTHR24216:SF11, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF037881 Leupaxin, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P49024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLTEETP YSYPTGNHTY QEIAVPPPVP
60 70 80 90 100
PPPSSEALNG TVIDPLDQWQ PSVSRYGHQQ PQSQSPIYSS SAKSSSASVP
110 120 130 140 150
RDGLSSPSPR ASEEEHVYSF PNKQKSAEPS PTMTSTSLGS NLSELDRLLL
160 170 180 190 200
ELNAVQHNPP SGFSADEVSR SPSLPNVTGP HYVIPESSSS AGGKAAPPTK
210 220 230 240 250
EKPKRNGGRG IEDVRPSVES LLDELESSVP SPVPAITVSQ GEVSSPQRVN
260 270 280 290 300
ASQQQTRISA SSATRELDEL MASLSDFKFM AQGKAGGSSS PPSTTPKPGS
310 320 330 340 350
QLDTMLGSLQ SDLNKLGVAT VAKGVCGACK KPIAGQVVTA MGKTWHPEHF
360 370 380 390 400
VCTHCQEEIG SRNFFERDGQ PYCEKDYHNL FSPRCYYCNG PILDKVVTAL
410 420 430 440 450
DRTWHPEHFF CAQCGVFFGP EGFHEKDGKA YCRKDYFDMF APKCGGCARA
460 470 480 490 500
ILENYISALN TLWHPECFVC RECFTPFING SFFEHDGQPY CEVHYHERRG
510 520 530 540 550
SLCSGCQKPI TGRCITAMGK KFHPEHFVCA FCLKQLNKGT FKEQNDKPYC

QNCFLKLFC
Length:559
Mass (Da):61,243
Last modified:February 1, 1996 - v1
Checksum:i6450270D90B2DE84
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1NB68F1NB68_CHICK
Paxillin
PXN
559Annotation score:
A0A1D5PGG4A0A1D5PGG4_CHICK
Paxillin
PXN
563Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14589 mRNA Translation: AAC59665.1
L30099 mRNA Translation: AAC38018.1
PIRiB55933
RefSeqiNP_990315.1, NM_204984.1
UniGeneiGga.4056

Genome annotation databases

GeneIDi395832
KEGGigga:395832

Similar proteinsi

Entry informationi

Entry nameiPAXI_CHICK
AccessioniPrimary (citable) accession number: P49024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again