PXN

Functionⁱ

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

GO - Molecular functionⁱ

beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17513457
integrin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
neuropilin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 24863063
protein kinase binding Source: Ensembl
protein phosphatase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 28759036
ubiquitin protein ligase binding Source: Ensembl
vinculin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9054445

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: ProtInc
Non-traceable author statementⁱ
- 10840040
cell-matrix adhesion Source: InterPro
cellular response to reactive oxygen species
Source: BHF-UCL
Inferred from expression patternⁱ
- 12686598
endothelial cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24863063
growth hormone receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10925297
muscle contraction Source: Reactome
positive regulation of stress fiber assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24863063
signal complex assembly
Source: ProtInc
Traceable author statementⁱ
- 9054445
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7534286
transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 24036928
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-180292 GAB1 signalosome R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-445355 Smooth Muscle Contraction R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P49023
SIGNORⁱ	P49023

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Paxillin
Gene namesⁱ	Name:PXN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089159.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9718 PXN
MIMⁱ	602505 gene
neXtProtⁱ	NX_P49023

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	7 – 8	LL → RR: Loss of interaction with PDCD10. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5829
Open Targets More...OpenTargetsⁱ	ENSG00000089159
PharmGKBⁱ	PA34062

Chemistry databases

ChEMBLⁱ	CHEMBL5715

ChEMBLⁱ

CHEMBL5715

Polymorphism and mutation databases

BioMutaⁱ	PXN
DMDMⁱ	317373486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000075853	1 – 591	PaxillinAdd BLAST	591
Isoform 4 (identifier: P49023-4)
Initiator methionineⁱ		RemovedCombined sources

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	31	Phosphotyrosine; by PTK62 Publications	1
Modified residueⁱ	83	PhosphoserineBy similarity	1
Modified residueⁱ	85	PhosphoserineCombined sources	1
Modified residueⁱ	88	PhosphotyrosineBy similarity	1
Modified residueⁱ	106	PhosphoserineCombined sources	1
Modified residueⁱ	118	Phosphotyrosine; by PTK62 Publications	1
Modified residueⁱ	119	PhosphoserineCombined sources	1
Modified residueⁱ	126	PhosphoserineCombined sources	1
Modified residueⁱ	130	PhosphoserineCombined sources	1
Modified residueⁱ	132	PhosphothreonineBy similarity	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	140	PhosphoserineBy similarity	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	181	Phosphotyrosine1 Publication	1
Modified residueⁱ	230	PhosphoserineBy similarity	1
Modified residueⁱ	244	Phosphoserine; by CDK51 Publication	1
Modified residueⁱ	250	Phosphoserine; by SLK1 Publication	1
Modified residueⁱ	258	PhosphoserineBy similarity	1
Modified residueⁱ	261	PhosphoserineBy similarity	1
Modified residueⁱ	272	PhosphoserineCombined sources	1
Modified residueⁱ	303	PhosphoserineCombined sources	1
Modified residueⁱ	322	PhosphoserineCombined sources	1
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	340	PhosphoserineBy similarity	1
Modified residueⁱ	533	PhosphoserineCombined sources	1
Isoform 4 (identifier: P49023-4)
Modified residueⁱ	2	N-acetylserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).By similarity4 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P49023
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49023
PaxDbⁱ	P49023
PeptideAtlas More...PeptideAtlasⁱ	P49023
PRIDEⁱ	P49023
ProteomicsDBⁱ	55957 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4]
TopDownProteomicsⁱ	P49023-2 [P49023-2] P49023-3 [P49023-3]

PTM databases

iPTMnetⁱ	P49023
PhosphoSitePlusⁱ	P49023

Miscellaneous databases

PMAP-CutDBⁱ	P49023

PMAP-CutDBⁱ

P49023

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000089159 Expressed in 202 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_PXN
ExpressionAtlasⁱ	P49023 baseline and differential
Genevisibleⁱ	P49023 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003841 HPA051309

HPAⁱ

CAB003841
HPA051309

Interactionⁱ

Subunit structureⁱ

Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB. Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988).16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CSK	P41240	2	EBI-702209,EBI-1380630
CTNNB1	P35222	4	EBI-702209,EBI-491549
E6	P06931	3	EBI-702209,EBI-7281937	From Bovine papillomavirus type 1.
GAB1	Q13480	2	EBI-702209,EBI-517684
GIT2	Q14161	2	EBI-702209,EBI-1046878
ITGA4	P13612	4	EBI-702209,EBI-703044
ITGB1	P05556-1	2	EBI-702209,EBI-6082935
NDEL1	Q9GZM8	5	EBI-11954250,EBI-928842
PARVA	Q9NVD7-1	3	EBI-11954250,EBI-15735104
PIK3R1	P27986	2	EBI-702209,EBI-79464
PTK2	Q05397	15	EBI-702209,EBI-702142
PTPN11	Q06124	3	EBI-702209,EBI-297779
rnf-5	Q09463	2	EBI-702209,EBI-963421	From Caenorhabditis elegans.
RNF5	Q99942	6	EBI-702209,EBI-348482
Sorbs1	Q62417-2	8	EBI-702209,EBI-7072893	From a different organism.
Src	P05480	2	EBI-702209,EBI-298680	From Mus musculus.

GO - Molecular functionⁱ

beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17513457
integrin binding Source: Ensembl
neuropilin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 24863063
protein kinase binding Source: Ensembl
protein phosphatase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 28759036
ubiquitin protein ligase binding Source: Ensembl
vinculin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9054445

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111787, 92 interactors
CORUMⁱ	P49023
Database of interacting proteins More...DIPⁱ	DIP-33851N
ELMⁱ	P49023
IntActⁱ	P49023, 74 interactors
Molecular INTeraction database More...MINTⁱ	P49023
STRINGⁱ	9606.ENSP00000228307

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 11	Combined sources	9
Helixⁱ	144 – 154	Combined sources	11
Helixⁱ	261 – 271	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P49023
SMRⁱ	P49023
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49023

EvolutionaryTraceⁱ

P49023

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	356 – 415	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	416 – 473	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	474 – 533	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	534 – 591	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	58

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	3 – 15	LD motif 1Add BLAST	13
Motifⁱ	144 – 156	LD motif 2Add BLAST	13
Motifⁱ	216 – 228	LD motif 3Add BLAST	13
Motifⁱ	265 – 276	LD motif 4Add BLAST	12
Motifⁱ	333 – 345	LD motif 5Add BLAST	13

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	46 – 53	Pro-rich		8

Sequence similaritiesⁱ

Belongs to the paxillin family.Curated

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOVERGENⁱ	HBG001512
InParanoidⁱ	P49023
KEGG Orthology (KO) More...KOⁱ	K05760
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05AW
PhylomeDBⁱ	P49023
TreeFamⁱ	TF314113

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904 Paxillin IPR017305 Tgfb1i1/Leupaxin/TGFB1I1 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24216:SF11 PTHR24216:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
PIRSFⁱ	PIRSF037881 Leupaxin, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform Beta (identifier: P49023-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 
       310        320        330        340        350
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV 
       360        370        380        390        400
ATVAKGVCGA CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD 
       410        420        430        440        450
GQPYCEKDYH NLFSPRCYYC NGPILDKVVT ALDRTWHPEH FFCAQCGAFF 
       460        470        480        490        500
GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA RAILENYISA LNTLWHPECF 
       510        520        530        540        550
VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK PITGRCITAM 
       560        570        580        590 
AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C

Length:591

Mass (Da):64,505

Last modified:January 11, 2011 - v3

Checksum:ⁱABF6C0BE5939623F

GO

Isoform Alpha (identifier: P49023-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-311: Missing.

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKFMA QGKTGSSSPP GGPPKPGSQL 
       310        320        330        340        350
DSMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC 
       360        370        380        390        400
THCQEEIGSR NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR 
       410        420        430        440        450
TWHPEHFFCA QCGAFFGPEG FHEKDGKAYC RKDYFDMFAP KCGGCARAIL 
       460        470        480        490        500
ENYISALNTL WHPECFVCRE CFTPFVNGSF FEHDGQPYCE VHYHERRGSL 
       510        520        530        540        550
CSGCQKPITG RCITAMAKKF HPEHFVCAFC LKQLNKGTFK EQNDKPYCQN 

CFLKLFC

Show »

Length:557

Mass (Da):60,967

Checksum:ⁱ94A6C321E4735076

GO

Isoform Gamma (identifier: P49023-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-311: IQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG → GSWPLEEVVL...SPDQPPPCPQ

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKGSW PLEEVVLLVS ISSSVQEGEK 
       310        320        330        340        350
YPHPCAARHR TPSLRSPDQP PPCPQFMAQG KTGSSSPPGG PPKPGSQLDS 
       360        370        380        390        400
MLGSLQSDLN KLGVATVAKG VCGACKKPIA GQVVTAMGKT WHPEHFVCTH 
       410        420        430        440        450
CQEEIGSRNF FERDGQPYCE KDYHNLFSPR CYYCNGPILD KVVTALDRTW 
       460        470        480        490        500
HPEHFFCAQC GAFFGPEGFH EKDGKAYCRK DYFDMFAPKC GGCARAILEN 
       510        520        530        540        550
YISALNTLWH PECFVCRECF TPFVNGSFFE HDGQPYCEVH YHERRGSLCS 
       560        570        580        590        600
GCQKPITGRC ITAMAKKFHP EHFVCAFCLK QLNKGTFKEQ NDKPYCQNCF 

LKLFC

Show »

Length:605

Mass (Da):66,212

Checksum:ⁱ0121D1C68C6F7398

GO

Isoform 4 (identifier: P49023-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-133: Missing.
278-311: Missing.

« Hide

        10         20         30         40         50
MSTSLGSNLS ELDRLLLELN AVQHNPPGFP ADEANSSPPL PGALSPLYGV 
        60         70         80         90        100
PETNSPLGGK AGPLTKEKPK RNGGRGLEDV RPSVESLLDE LESSVPSPVP 
       110        120        130        140        150
AITVNQGEMS SPQRVTSTQQ QTRISASSAT RELDELMASL SDFKFMAQGK 
       160        170        180        190        200
TGSSSPPGGP PKPGSQLDSM LGSLQSDLNK LGVATVAKGV CGACKKPIAG 
       210        220        230        240        250
QVVTAMGKTW HPEHFVCTHC QEEIGSRNFF ERDGQPYCEK DYHNLFSPRC 
       260        270        280        290        300
YYCNGPILDK VVTALDRTWH PEHFFCAQCG AFFGPEGFHE KDGKAYCRKD 
       310        320        330        340        350
YFDMFAPKCG GCARAILENY ISALNTLWHP ECFVCRECFT PFVNGSFFEH 
       360        370        380        390        400
DGQPYCEVHY HERRGSLCSG CQKPITGRCI TAMAKKFHPE HFVCAFCLKQ 
       410        420 
LNKGTFKEQN DKPYCQNCFL KLFC

Show »

Length:424

Mass (Da):46,604

Checksum:ⁱ74D536A48B653D6D

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GZ78	F5GZ78_HUMAN	Paxillin Paxillin	PXN	589	Annotation score:
A0A1B0GTU4	A0A1B0GTU4_HUMAN	Paxillin Paxillin	PXN	1,081	Annotation score:
F5H836	F5H836_HUMAN	Paxillin Paxillin	PXN	176	Annotation score:
F8W0K8	F8W0K8_HUMAN	Paxillin Paxillin	PXN	37	Annotation score:
F8W1E0	F8W1E0_HUMAN	Paxillin Paxillin	PXN	31	Annotation score:
F8W0G0	F8W0G0_HUMAN	Paxillin Paxillin	PXN	36	Annotation score:
F8VZ39	F8VZ39_HUMAN	Paxillin Paxillin	PXN	91	Annotation score:
A0A1B0GU60	A0A1B0GU60_HUMAN	Paxillin Paxillin	PXN	706	Annotation score:
A0A1B0GWE7	A0A1B0GWE7_HUMAN	Paxillin Paxillin	PXN	192	Annotation score:
A0A1B0GV30	A0A1B0GV30_HUMAN	Paxillin Paxillin	PXN	207	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	280	G → D in BAA18997 (PubMed:9054445).Curated	1
Sequence conflictⁱ	327	P → L in CAI46024 (PubMed:17974005).Curated	1
Sequence conflictⁱ	413	F → S in CAI46024 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065099	73	S → G5 PublicationsCorresponds to variant dbSNP:rs4767884Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040483	1 – 133	Missing in isoform 4. 1 PublicationAdd BLAST	133
Alternative sequenceⁱVSP_003114	278 – 311	Missing in isoform Alpha and isoform 4. 4 PublicationsAdd BLAST	34
Alternative sequenceⁱVSP_003115	278 – 311	IQGLE…QDEGG → GSWPLEEVVLLVSISSSVQE GEKYPHPCAARHRTPSLRSP DQPPPCPQ in isoform Gamma. 1 PublicationAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14588 mRNA Translation: AAC50104.1 U87946 U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3]
PIRⁱ	A55933
NCBI Reference Sequences More...RefSeqⁱ	NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4]
UniGeneⁱ	Hs.446336

Genome annotation databases

Ensemblⁱ	ENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1] ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3] ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2] ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4]
GeneIDⁱ	5829
KEGGⁱ	hsa:5829
UCSC genome browser More...UCSCⁱ	uc001txt.4 human [P49023-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin, isoform CRA_e		HUMAN		591	UniRef100_P49023
P49023-4	PXN isoform 10		PANTR		424	UniRef100_A0A2J8MDT8
UPI000D4FFDBF		PANPA		567

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin	)	MOUSE		591	UniRef90_P49023
Paxillin, isoform CRA_e		HUMAN		591
Paxillin		MYOBR		669
Uncharacterized protein		PANPA		597
Paxillin isoform 2		CALJA		591
+24
P49023-2	paxillin isoform X5		DELLE		583	UniRef90_P49023-2
paxillin isoform X1		PHYCD		582
paxillin isoform X2		NEOSC		566
Uncharacterized protein		PANPA		563
Uncharacterized protein		RHIBE		558
+62
P49023-3	Uncharacterized protein		RHIBE		606	UniRef90_P49023-3
Uncharacterized protein		Cebus capucinus imitator		605
Paxillin		PANTR		605
Uncharacterized protein		PANPA		600
Uncharacterized protein		CERAT		605
+9
P49023-4	Isoform Alpha of Paxillin		HUMAN		557	UniRef90_P49023-2
paxillin isoform X5		DELLE		583
paxillin isoform X1		PHYCD		582
paxillin isoform X2		NEOSC		566
Uncharacterized protein		PANPA		563
+62

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin	)	MOUSE		591	UniRef50_P49023
Paxillin		PONAB		591
Paxillin, isoform CRA_e		HUMAN		591
Paxillin		MYOBR		669
Uncharacterized protein		PANPA		597
+123
P49023-2	Isoform Gamma of Paxillin		HUMAN		605	UniRef50_P49023-3
Uncharacterized protein		RHIBE		606
Uncharacterized protein		CALJA		605
Uncharacterized protein		Cebus capucinus imitator		605
Paxillin		PANTR		605
+198
P49023-3	Uncharacterized protein		RHIBE		606	UniRef50_P49023-3
Uncharacterized protein		CALJA		605
Uncharacterized protein		Cebus capucinus imitator		605
Paxillin		PANTR		605
Uncharacterized protein		PANPA		600
+198
P49023-4	Isoform Gamma of Paxillin		HUMAN		605	UniRef50_P49023-3
Uncharacterized protein		RHIBE		606
Uncharacterized protein		CALJA		605
Uncharacterized protein		Cebus capucinus imitator		605
Paxillin		PANTR		605
+198

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14588 mRNA Translation: AAC50104.1 U87946 U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1
CCDSⁱ	CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3]
PIRⁱ	A55933
RefSeqⁱ	NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4]
UniGeneⁱ	Hs.446336

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KKY	model	-	A	142-157	[»]
	1KL0	model	-	B	142-157	[»]
	1OW6	X-ray	2.35	D/F	262-274	[»]
	1OW7	X-ray	2.60	D/E/F	262-274	[»]
	1OW8	X-ray	2.85	D/F	141-153	[»]
	2K2R	NMR	-	B	3-12	[»]
	2O9V	X-ray	1.63	B	45-54	[»]
	2VZD	X-ray	2.10	C/D	1-20	[»]
	2VZG	X-ray	1.80	A	141-160	[»]
	2VZI	X-ray	2.20	A	262-277	[»]
	3GM1	X-ray	2.95	C/D/E/F	262-274	[»]
	3PY7	X-ray	2.29	A	1-10	[»]
	3RQE	X-ray	2.80	E	2-15	[»]
	3RQF	X-ray	2.70	E	141-153	[»]
	3RQG	X-ray	2.50	E	262-274	[»]
	3U3F	X-ray	3.10	E/F/G/H/I/J	261-277	[»]
	4EDN	X-ray	2.90	K/L/M/N/O/P/Q	1-20	[»]
	4R32	X-ray	3.70	B/C	139-160	[»]
	4XGZ	X-ray	2.50	a/c/e/g/h/j/m/o/q/s/u/w	141-159	[»]
	4XH2	X-ray	2.00	a/c/e/g/h/j	261-275	[»]
	5UWH	X-ray	2.26	D	264-277	[»]
ProteinModelPortalⁱ	P49023
SMRⁱ	P49023
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111787, 92 interactors
CORUMⁱ	P49023
DIPⁱ	DIP-33851N
ELMⁱ	P49023
IntActⁱ	P49023, 74 interactors
MINTⁱ	P49023
STRINGⁱ	9606.ENSP00000228307

Chemistry databases

ChEMBLⁱ	CHEMBL5715

ChEMBLⁱ

CHEMBL5715

PTM databases

iPTMnetⁱ	P49023
PhosphoSitePlusⁱ	P49023

Polymorphism and mutation databases

BioMutaⁱ	PXN
DMDMⁱ	317373486

Proteomic databases

EPDⁱ	P49023
MaxQBⁱ	P49023
PaxDbⁱ	P49023
PeptideAtlasⁱ	P49023
PRIDEⁱ	P49023
ProteomicsDBⁱ	55957 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4]
TopDownProteomicsⁱ	P49023-2 [P49023-2] P49023-3 [P49023-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1] ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3] ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2] ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4]
GeneIDⁱ	5829
KEGGⁱ	hsa:5829
UCSCⁱ	uc001txt.4 human [P49023-1]

Organism-specific databases

CTDⁱ	5829
DisGeNETⁱ	5829
EuPathDBⁱ	HostDB:ENSG00000089159.15
GeneCardsⁱ	PXN
HGNCⁱ	HGNC:9718 PXN
HPAⁱ	CAB003841 HPA051309
MIMⁱ	602505 gene
neXtProtⁱ	NX_P49023
OpenTargetsⁱ	ENSG00000089159
PharmGKBⁱ	PA34062
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
GeneTreeⁱ	ENSGT00760000118910
HOVERGENⁱ	HBG001512
InParanoidⁱ	P49023
KOⁱ	K05760
OrthoDBⁱ	EOG091G05AW
PhylomeDBⁱ	P49023
TreeFamⁱ	TF314113

Enzyme and pathway databases

Reactomeⁱ	R-HSA-180292 GAB1 signalosome R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-445355 Smooth Muscle Contraction R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P49023
SIGNORⁱ	P49023

Miscellaneous databases

ChiTaRSⁱ	PXN human
EvolutionaryTraceⁱ	P49023
GeneWikiⁱ	Paxillin
GenomeRNAiⁱ	5829
PMAP-CutDBⁱ	P49023
Protein Ontology More...PROⁱ	PR:P49023
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089159 Expressed in 202 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_PXN
ExpressionAtlasⁱ	P49023 baseline and differential
Genevisibleⁱ	P49023 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904 Paxillin IPR017305 Tgfb1i1/Leupaxin/TGFB1I1 IPR001781 Znf_LIM
PANTHERⁱ	PTHR24216:SF11 PTHR24216:SF11, 1 hit
Pfamⁱ	View protein in Pfam PF00412 LIM, 4 hits
PIRSFⁱ	PIRSF037881 Leupaxin, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAXI_HUMAN
Accessionⁱ	P49023Primary (citable) accession number: P49023 Secondary accession number(s): B2RAI3 , B7ZMB4, O14970, O14971, O60360, Q5HYA4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 11, 2011
	Last modified:	October 10, 2018
	This is version 202 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P49023 (PAXI_HUMAN)

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Paxillin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ