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UniProtKB - P49023 (PAXI_HUMAN)

Protein

Paxillin

Gene

PXN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell-matrix adhesion Source: InterPro
  • cellular response to reactive oxygen species Source: BHF-UCL
  • endothelial cell migration Source: BHF-UCL
  • growth hormone receptor signaling pathway Source: BHF-UCL
  • muscle contraction Source: Reactome
  • positive regulation of stress fiber assembly Source: BHF-UCL
  • signal complex assembly Source: ProtInc
  • signal transduction Source: ProtInc
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • vascular endothelial growth factor receptor signaling pathway Source: Reactome
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-180292 GAB1 signalosome
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445355 Smooth Muscle Contraction
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49023

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49023

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paxillin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PXN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000089159.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:9718 PXN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602505 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7 – 8LL → RR: Loss of interaction with PDCD10. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		5829

Open Targets

More...OpenTargetsi		ENSG00000089159

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34062

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5715

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PXN

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373486

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758531 – 591PaxillinAdd BLAST591
Isoform 4 (identifier: P49023-4)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei31Phosphotyrosine; by PTK62 Publications1
Modified residuei83PhosphoserineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Modified residuei88PhosphotyrosineBy similarity1
Modified residuei106PhosphoserineCombined sources1
Modified residuei118Phosphotyrosine; by PTK62 Publications1
Modified residuei119PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphothreonineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei143PhosphoserineCombined sources1
Modified residuei181Phosphotyrosine1 Publication1
Modified residuei230PhosphoserineBy similarity1
Modified residuei244Phosphoserine; by CDK51 Publication1
Modified residuei250Phosphoserine; by SLK1 Publication1
Modified residuei258PhosphoserineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei533PhosphoserineCombined sources1
Isoform 4 (identifier: P49023-4)
Modified residuei2N-acetylserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).By similarity4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49023

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49023

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49023

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49023

PeptideAtlas

More...PeptideAtlasi		P49023

PRoteomics IDEntifications database

More...PRIDEi		P49023

ProteomicsDB human proteome resource

More...ProteomicsDBi		55957
55958 [P49023-2]
55959 [P49023-3]
55960 [P49023-4]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P49023-2 [P49023-2]
P49023-3 [P49023-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49023

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P49023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089159 Expressed in 202 organ(s), highest expression level in fundus of stomach

CleanEx database of gene expression profiles

More...CleanExi		HS_PXN

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49023 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49023 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB003841
HPA051309

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB. Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988).16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111787, 97 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P49023

Database of interacting proteins

More...DIPi		DIP-33851N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P49023

Protein interaction database and analysis system

More...IntActi		P49023, 74 interactors

Molecular INTeraction database

More...MINTi		P49023

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000228307

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKYmodel-A142-157[»]
1KL0model-B142-157[»]
1OW6X-ray2.35D/F262-274[»]
1OW7X-ray2.60D/E/F262-274[»]
1OW8X-ray2.85D/F141-153[»]
2K2RNMR-B3-12[»]
2O9VX-ray1.63B45-54[»]
2VZDX-ray2.10C/D1-20[»]
2VZGX-ray1.80A141-160[»]
2VZIX-ray2.20A262-277[»]
3GM1X-ray2.95C/D/E/F262-274[»]
3PY7X-ray2.29A1-10[»]
3RQEX-ray2.80E2-15[»]
3RQFX-ray2.70E141-153[»]
3RQGX-ray2.50E262-274[»]
3U3FX-ray3.10E/F/G/H/I/J261-277[»]
4EDNX-ray2.90K/L/M/N/O/P/Q1-20[»]
4R32X-ray3.70B/C139-160[»]
4XGZX-ray2.50a/c/e/g/h/j/m/o/q/s/u/w141-159[»]
4XH2X-ray2.00a/c/e/g/h/j261-275[»]
5UWHX-ray2.26D264-277[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P49023

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49023

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49023

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini356 – 415LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini416 – 473LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini474 – 533LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini534 – 591LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 15LD motif 1Add BLAST13
Motifi144 – 156LD motif 2Add BLAST13
Motifi216 – 228LD motif 3Add BLAST13
Motifi265 – 276LD motif 4Add BLAST12
Motifi333 – 345LD motif 5Add BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 53Pro-rich8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paxillin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1703 Eukaryota
ENOG410XRD4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158897

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG001512

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49023

KEGG Orthology (KO)

More...KOi		K05760

Database of Orthologous Groups

More...OrthoDBi		1593918at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49023

TreeFam database of animal gene trees

More...TreeFami		TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001904 Paxillin
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM

The PANTHER Classification System

More...PANTHERi		PTHR24216:SF11 PTHR24216:SF11, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00412 LIM, 4 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037881 Leupaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132 LIM, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta (identifier: P49023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 
       310        320        330        340        350
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV 
       360        370        380        390        400
ATVAKGVCGA CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD 
       410        420        430        440        450
GQPYCEKDYH NLFSPRCYYC NGPILDKVVT ALDRTWHPEH FFCAQCGAFF 
       460        470        480        490        500
GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA RAILENYISA LNTLWHPECF 
       510        520        530        540        550
VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK PITGRCITAM 
       560        570        580        590 
AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C
Length:591
Mass (Da):64,505
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABF6C0BE5939623F
GO
Isoform Alpha (identifier: P49023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-311: Missing.

Show »
Length:557
Mass (Da):60,967
Checksum:i94A6C321E4735076
GO
Isoform Gamma (identifier: P49023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-311: IQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG → GSWPLEEVVL...SPDQPPPCPQ

Show »
Length:605
Mass (Da):66,212
Checksum:i0121D1C68C6F7398
GO
Isoform 4 (identifier: P49023-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     278-311: Missing.

Show »
Length:424
Mass (Da):46,604
Checksum:i74D536A48B653D6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZ78F5GZ78_HUMAN
Paxillin
PXN
589Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTU4A0A1B0GTU4_HUMAN
Paxillin
PXN
1,081Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H836F5H836_HUMAN
Paxillin
PXN
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0K8F8W0K8_HUMAN
Paxillin
PXN
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1E0F8W1E0_HUMAN
Paxillin
PXN
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0G0F8W0G0_HUMAN
Paxillin
PXN
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZ39F8VZ39_HUMAN
Paxillin
PXN
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU60A0A1B0GU60_HUMAN
Paxillin
PXN
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV30A0A1B0GV30_HUMAN
Paxillin
PXN
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWE7A0A1B0GWE7_HUMAN
Paxillin
PXN
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti280G → D in BAA18997 (PubMed:9054445).Curated1
Sequence conflicti327P → L in CAI46024 (PubMed:17974005).Curated1
Sequence conflicti413F → S in CAI46024 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06509973S → G5 PublicationsCorresponds to variant dbSNP:rs4767884Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0404831 – 133Missing in isoform 4. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_003114278 – 311Missing in isoform Alpha and isoform 4. 4 PublicationsAdd BLAST34
Alternative sequenceiVSP_003115278 – 311IQGLE…QDEGG → GSWPLEEVVLLVSISSSVQE GEKYPHPCAARHRTPSLRSP DQPPPCPQ in isoform Gamma. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U14588 mRNA Translation: AAC50104.1
U87946
, U87941, U87942, U87943, U87944, U87945 Genomic DNA Translation: AAD00648.1
D86862 mRNA Translation: BAA18997.1
D86863 mRNA Translation: BAA18998.1
AK314204 mRNA Translation: BAG36880.1
BX648777 mRNA Translation: CAI46024.1
AC004263 Genomic DNA Translation: AAC05175.1
BC136787 mRNA Translation: AAI36788.1
BC136794 mRNA Translation: AAI36795.1
BC144410 mRNA Translation: AAI44411.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44996.1 [P49023-2]
CCDS44997.1 [P49023-1]
CCDS44998.1 [P49023-4]
CCDS58281.1 [P49023-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A55933

NCBI Reference Sequences

More...RefSeqi		NP_001074324.1, NM_001080855.2 [P49023-1]
NP_001230685.1, NM_001243756.1 [P49023-3]
NP_002850.2, NM_002859.3 [P49023-2]
NP_079433.3, NM_025157.4 [P49023-4]
XP_016875232.1, XM_017019743.1 [P49023-4]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.446336

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1]
ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3]
ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2]
ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5829

UCSC genome browser

More...UCSCi		uc001txt.4 human [P49023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14588 mRNA Translation: AAC50104.1
U87946
, U87941, U87942, U87943, U87944, U87945 Genomic DNA Translation: AAD00648.1
D86862 mRNA Translation: BAA18997.1
D86863 mRNA Translation: BAA18998.1
AK314204 mRNA Translation: BAG36880.1
BX648777 mRNA Translation: CAI46024.1
AC004263 Genomic DNA Translation: AAC05175.1
BC136787 mRNA Translation: AAI36788.1
BC136794 mRNA Translation: AAI36795.1
BC144410 mRNA Translation: AAI44411.1
CCDSiCCDS44996.1 [P49023-2]
CCDS44997.1 [P49023-1]
CCDS44998.1 [P49023-4]
CCDS58281.1 [P49023-3]
PIRiA55933
RefSeqiNP_001074324.1, NM_001080855.2 [P49023-1]
NP_001230685.1, NM_001243756.1 [P49023-3]
NP_002850.2, NM_002859.3 [P49023-2]
NP_079433.3, NM_025157.4 [P49023-4]
XP_016875232.1, XM_017019743.1 [P49023-4]
UniGeneiHs.446336

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKYmodel-A142-157[»]
1KL0model-B142-157[»]
1OW6X-ray2.35D/F262-274[»]
1OW7X-ray2.60D/E/F262-274[»]
1OW8X-ray2.85D/F141-153[»]
2K2RNMR-B3-12[»]
2O9VX-ray1.63B45-54[»]
2VZDX-ray2.10C/D1-20[»]
2VZGX-ray1.80A141-160[»]
2VZIX-ray2.20A262-277[»]
3GM1X-ray2.95C/D/E/F262-274[»]
3PY7X-ray2.29A1-10[»]
3RQEX-ray2.80E2-15[»]
3RQFX-ray2.70E141-153[»]
3RQGX-ray2.50E262-274[»]
3U3FX-ray3.10E/F/G/H/I/J261-277[»]
4EDNX-ray2.90K/L/M/N/O/P/Q1-20[»]
4R32X-ray3.70B/C139-160[»]
4XGZX-ray2.50a/c/e/g/h/j/m/o/q/s/u/w141-159[»]
4XH2X-ray2.00a/c/e/g/h/j261-275[»]
5UWHX-ray2.26D264-277[»]
ProteinModelPortaliP49023
SMRiP49023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111787, 97 interactors
CORUMiP49023
DIPiDIP-33851N
ELMiP49023
IntActiP49023, 74 interactors
MINTiP49023
STRINGi9606.ENSP00000228307

Chemistry databases

ChEMBLiCHEMBL5715

PTM databases

iPTMnetiP49023
PhosphoSitePlusiP49023

Polymorphism and mutation databases

BioMutaiPXN
DMDMi317373486

Proteomic databases

EPDiP49023
jPOSTiP49023
MaxQBiP49023
PaxDbiP49023
PeptideAtlasiP49023
PRIDEiP49023
ProteomicsDBi55957
55958 [P49023-2]
55959 [P49023-3]
55960 [P49023-4]
TopDownProteomicsiP49023-2 [P49023-2]
P49023-3 [P49023-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1]
ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3]
ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2]
ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4]
GeneIDi5829
KEGGihsa:5829
UCSCiuc001txt.4 human [P49023-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5829
DisGeNETi5829
EuPathDBiHostDB:ENSG00000089159.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		PXN
HGNCiHGNC:9718 PXN
HPAiCAB003841
HPA051309
MIMi602505 gene
neXtProtiNX_P49023
OpenTargetsiENSG00000089159
PharmGKBiPA34062

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00940000158897
HOVERGENiHBG001512
InParanoidiP49023
KOiK05760
OrthoDBi1593918at2759
PhylomeDBiP49023
TreeFamiTF314113

Enzyme and pathway databases

ReactomeiR-HSA-180292 GAB1 signalosome
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445355 Smooth Muscle Contraction
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkiP49023
SIGNORiP49023

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PXN human
EvolutionaryTraceiP49023

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Paxillin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5829
PMAP-CutDBiP49023

Protein Ontology

More...PROi		PR:P49023

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000089159 Expressed in 202 organ(s), highest expression level in fundus of stomach
CleanExiHS_PXN
ExpressionAtlasiP49023 baseline and differential
GenevisibleiP49023 HS

Family and domain databases

InterProiView protein in InterPro
IPR001904 Paxillin
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM
PANTHERiPTHR24216:SF11 PTHR24216:SF11, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF037881 Leupaxin, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAXI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49023
Secondary accession number(s): B2RAI3
, B7ZMB4, O14970, O14971, O60360, Q5HYA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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