PXN

Functionⁱ

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

GO - Molecular functionⁱ

beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids."
  Birukova A.A., Malyukova I., Poroyko V., Birukov K.G.
  Am J Physiol Lung Cell Mol Physiol 293:L199-211(2007) [PubMed] [Europe PMC] [Abstract]
metal ion binding Source: UniProtKB-KW
neuropilin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells."
  Raimondi C., Fantin A., Lampropoulou A., Denti L., Chikh A., Ruhrberg C.
  J Exp Med 211:1167-1183(2014) [PubMed] [Europe PMC] [Abstract]
protein phosphatase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration."
  Chen Y.R., Chou H.C., Yang C.H., Chen H.Y., Liu Y.W., Lin T.Y., Yeh C.L., Chao W.T., Tsou H.H., Chuang H.C., Tan T.H.
  Oncogene 36:6509-6517(2017) [PubMed] [Europe PMC] [Abstract]
transcription coregulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
vinculin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.3
  "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins."
  Mazaki Y., Hashimoto S., Sabe H.
  J. Biol. Chem. 272:7437-7444(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA AND GAMMA), INTERACTION WITH VCL AND PTK2, VARIANT GLY-73.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	P49023
Reactomeⁱ	R-HSA-180292, GAB1 signalosome R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P49023
SIGNORⁱ	P49023

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Paxillin
Gene namesⁱ	Name:PXN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9718, PXN
MIMⁱ	602505, gene
neXtProtⁱ	NX_P49023
VEuPathDBⁱ	HostDB:ENSG00000089159

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	7 – 8	LL → RR: Loss of interaction with PDCD10. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5829
Open Targets More...OpenTargetsⁱ	ENSG00000089159
PharmGKBⁱ	PA34062

Miscellaneous databases

Pharosⁱ	P49023, Tbio

Pharosⁱ

P49023, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL5715

ChEMBLⁱ

CHEMBL5715

Genetic variation databases

BioMutaⁱ	PXN
DMDMⁱ	317373486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000075853	1 – 591	PaxillinAdd BLAST	591
Isoform 4 (identifier: P49023-4)
Initiator methionineⁱ		RemovedCombined sources

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	31	Phosphotyrosine; by PTK62 Publications	1
Modified residueⁱ	83	PhosphoserineBy similarity	1
Modified residueⁱ	85	PhosphoserineCombined sources	1
Modified residueⁱ	88	PhosphotyrosineBy similarity	1
Modified residueⁱ	106	PhosphoserineCombined sources	1
Modified residueⁱ	118	Phosphotyrosine; by PTK62 Publications	1
Modified residueⁱ	119	PhosphoserineCombined sources	1
Modified residueⁱ	126	PhosphoserineCombined sources	1
Modified residueⁱ	130	PhosphoserineCombined sources	1
Modified residueⁱ	132	PhosphothreonineBy similarity	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	140	PhosphoserineBy similarity	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	181	Phosphotyrosine1 Publication	1
Modified residueⁱ	230	PhosphoserineBy similarity	1
Modified residueⁱ	244	Phosphoserine; by CDK51 Publication	1
Modified residueⁱ	250	Phosphoserine; by SLK1 Publication	1
Modified residueⁱ	258	PhosphoserineBy similarity	1
Modified residueⁱ	261	PhosphoserineBy similarity	1
Modified residueⁱ	272	PhosphoserineCombined sources	1
Modified residueⁱ	303	PhosphoserineCombined sources	1
Modified residueⁱ	322	PhosphoserineCombined sources	1
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	340	PhosphoserineBy similarity	1
Modified residueⁱ	533	PhosphoserineCombined sources	1
Isoform 4 (identifier: P49023-4)
Modified residueⁱ	2	N-acetylserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).By similarity4 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P49023
jPOSTⁱ	P49023
MassIVEⁱ	P49023
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P49023
PaxDbⁱ	P49023
PeptideAtlas More...PeptideAtlasⁱ	P49023
PRIDEⁱ	P49023
ProteomicsDBⁱ	55957 [P49023-1] 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4]
TopDownProteomicsⁱ	P49023-2 [P49023-2] P49023-3 [P49023-3]

PTM databases

GlyGenⁱ	P49023, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetⁱ	P49023
MetOSiteⁱ	P49023
PhosphoSitePlusⁱ	P49023

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000089159, Expressed in fundus of stomach and 217 other tissues
ExpressionAtlasⁱ	P49023, baseline and differential
Genevisibleⁱ	P49023, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000089159, Low tissue specificity

HPAⁱ

ENSG00000089159, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts in vitro with VCL/vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of CRK (PubMed:7534286).

Interacts with GIT1 (PubMed:10938112).

Interacts with NUDT16L1/SDOS (By similarity).

Interacts with PTK2/FAK1 (PubMed:14527389).

Interacts with PTK2B/PYK2 (PubMed:19358827).

Interacts with ASAP2 (PubMed:10749932).

Interacts with unphosphorylated ITGA4 (PubMed:10604475).

Interacts with RNF5 (PubMed:12861019).

Interacts with PDCD10 (PubMed:20489202).

Interacts with NEK3, the interaction is prolactin-dependent (PubMed:17297458).

Interacts with PTK6 (PubMed:15572663).

Interacts with TGFB1I1 (By similarity).

Interacts with SORBS1 (PubMed:17462669).

Interacts with PARVB (PubMed:22869380).

Interacts (via LD motif 4) with PARVA/PARVIN (PubMed:15817463, PubMed:18508764, PubMed:18940607).

Interacts (via LD motif 4) with ILK (PubMed:15817463, PubMed:18508764, PubMed:18940607).

Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932).

Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988).

Interacts with CD36 (via C-terminus) (PubMed:20037584).

By similarity18 Publications

Isoform Beta:

Interacts strongly with PTK2/FAK1 and weakly with VCL/vinculin.

1 Publication

Isoform Gamma:

Interacts strongly with VCL/vinculin but only weakly with PTK2/FAK1.

1 Publication

Binary interactionsⁱ

Hide details

P49023

With	#Exp.	IntAct
CSK [P41240]	4	EBI-702209,EBI-1380630
CTNNB1 [P35222]	4	EBI-702209,EBI-491549
GAB1 [Q13480]	2	EBI-702209,EBI-517684
GIT1 [Q9Y2X7]	3	EBI-702209,EBI-466061
GIT2 [Q14161]	4	EBI-702209,EBI-1046878
ITGA4 [P13612]	4	EBI-702209,EBI-703044
ITGB1 - isoform 1 [P05556-1]	2	EBI-702209,EBI-6082935
PTK2 [Q05397]	18	EBI-702209,EBI-702142
PTPN11 [Q06124]	3	EBI-702209,EBI-297779
PTPN12 [Q05209]	2	EBI-702209,EBI-2266035
RNF5 [Q99942]	6	EBI-702209,EBI-348482
E6 [P06931] from Bovine papillomavirus type 1.	3	EBI-702209,EBI-7281937
rnf-5 [Q09463] from Caenorhabditis elegans.	2	EBI-702209,EBI-963421
Sorbs1 - isoform 2 [Q62417-2] from Mus musculus.	8	EBI-702209,EBI-7072893

Isoform Alpha [P49023-2]

With	#Exp.	IntAct
BLK [P51451]	3	EBI-11954250,EBI-2105445
DPY30 [Q9C005]	3	EBI-11954250,EBI-744973
LMO1 [P25800]	5	EBI-11954250,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]	3	EBI-11954250,EBI-11742507
NDEL1 [Q9GZM8]	5	EBI-11954250,EBI-928842
PARVA - isoform 1 [Q9NVD7-1]	3	EBI-11954250,EBI-15735104
PLEKHH2 - isoform 3 [Q8IVE3-3]	3	EBI-11954250,EBI-11954248
PLEKHN1 - isoform 3 [Q494U1-3]	3	EBI-11954250,EBI-12014286
TCEANC - isoform 2 [Q8N8B7-2]	3	EBI-11954250,EBI-11955057
WHRN [Q9P202]	3	EBI-11954250,EBI-310886
YES1 [P07947]	3	EBI-11954250,EBI-515331

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111787, 281 interactors
CORUMⁱ	P49023
Database of interacting proteins More...DIPⁱ	DIP-33851N
ELMⁱ	P49023
IntActⁱ	P49023, 128 interactors
Molecular INTeraction database More...MINTⁱ	P49023
STRINGⁱ	9606.ENSP00000267257

Miscellaneous databases

RNActⁱ	P49023, protein

RNActⁱ

P49023, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 11	Combined sources	9
Helixⁱ	144 – 154	Combined sources	11
Helixⁱ	261 – 271	Combined sources	11
Turnⁱ	536 – 538	Combined sources	3
Beta strandⁱ	547 – 551	Combined sources	5
Turnⁱ	556 – 558	Combined sources	3
Turnⁱ	562 – 564	Combined sources	3
Helixⁱ	570 – 572	Combined sources	3
Beta strandⁱ	573 – 576	Combined sources	4
Beta strandⁱ	579 – 582	Combined sources	4
Helixⁱ	583 – 589	Combined sources	7

Show more details

3D structure databases

AlphaFoldDBⁱ	P49023
SMRⁱ	P49023
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P49023

EvolutionaryTraceⁱ

P49023

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	356 – 415	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	416 – 473	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	474 – 533	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	534 – 591	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	58

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	17 – 138	DisorderedSequence analysisAdd BLAST	122
Regionⁱ	159 – 260	DisorderedSequence analysisAdd BLAST	102
Regionⁱ	262 – 315	Required for binding to PARVA and ILKBy similarityAdd BLAST	54
Regionⁱ	291 – 335	DisorderedSequence analysisAdd BLAST	45

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	3 – 15	LD motif 1Add BLAST	13
Motifⁱ	144 – 156	LD motif 2Add BLAST	13
Motifⁱ	216 – 228	LD motif 3Add BLAST	13
Motifⁱ	265 – 276	LD motif 4Add BLAST	12
Motifⁱ	333 – 345	LD motif 5Add BLAST	13

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	65 – 106	Polar residuesSequence analysisAdd BLAST	42
Compositional biasⁱ	123 – 138	Polar residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	197 – 219	Basic and acidic residuesSequence analysisAdd BLAST	23
Compositional biasⁱ	231 – 260	Polar residuesSequence analysisAdd BLAST	30

Sequence similaritiesⁱ

Belongs to the paxillin family.Curated

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1703, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158897
HOGENOMⁱ	CLU_001357_1_2_1
InParanoidⁱ	P49023
Database of Orthologous Groups More...OrthoDBⁱ	1593918at2759
PhylomeDBⁱ	P49023
TreeFamⁱ	TF314113

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904, Paxillin IPR001781, Znf_LIM
PANTHERⁱ	PTHR24216:SF11, PTHR24216:SF11, 4 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412, LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132, LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform Beta (identifier: P49023-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 
       310        320        330        340        350
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV 
       360        370        380        390        400
ATVAKGVCGA CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD 
       410        420        430        440        450
GQPYCEKDYH NLFSPRCYYC NGPILDKVVT ALDRTWHPEH FFCAQCGAFF 
       460        470        480        490        500
GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA RAILENYISA LNTLWHPECF 
       510        520        530        540        550
VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK PITGRCITAM 
       560        570        580        590 
AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C

Length:591

Mass (Da):64,505

Last modified:January 11, 2011 - v3

Checksum:ⁱABF6C0BE5939623F

GO

Isoform Alpha (identifier: P49023-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-311: Missing.

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKFMA QGKTGSSSPP GGPPKPGSQL 
       310        320        330        340        350
DSMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC 
       360        370        380        390        400
THCQEEIGSR NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR 
       410        420        430        440        450
TWHPEHFFCA QCGAFFGPEG FHEKDGKAYC RKDYFDMFAP KCGGCARAIL 
       460        470        480        490        500
ENYISALNTL WHPECFVCRE CFTPFVNGSF FEHDGQPYCE VHYHERRGSL 
       510        520        530        540        550
CSGCQKPITG RCITAMAKKF HPEHFVCAFC LKQLNKGTFK EQNDKPYCQN 

CFLKLFC

Show »

Length:557

Mass (Da):60,967

Checksum:ⁱ94A6C321E4735076

GO

Isoform Gamma (identifier: P49023-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-311: IQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG → GSWPLEEVVL...SPDQPPPCPQ

« Hide

        10         20         30         40         50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 
        60         70         80         90        100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP 
       110        120        130        140        150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 
       160        170        180        190        200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 
       210        220        230        240        250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 
       260        270        280        290        300
TQQQTRISAS SATRELDELM ASLSDFKGSW PLEEVVLLVS ISSSVQEGEK 
       310        320        330        340        350
YPHPCAARHR TPSLRSPDQP PPCPQFMAQG KTGSSSPPGG PPKPGSQLDS 
       360        370        380        390        400
MLGSLQSDLN KLGVATVAKG VCGACKKPIA GQVVTAMGKT WHPEHFVCTH 
       410        420        430        440        450
CQEEIGSRNF FERDGQPYCE KDYHNLFSPR CYYCNGPILD KVVTALDRTW 
       460        470        480        490        500
HPEHFFCAQC GAFFGPEGFH EKDGKAYCRK DYFDMFAPKC GGCARAILEN 
       510        520        530        540        550
YISALNTLWH PECFVCRECF TPFVNGSFFE HDGQPYCEVH YHERRGSLCS 
       560        570        580        590        600
GCQKPITGRC ITAMAKKFHP EHFVCAFCLK QLNKGTFKEQ NDKPYCQNCF 

LKLFC

Show »

Length:605

Mass (Da):66,212

Checksum:ⁱ0121D1C68C6F7398

GO

Isoform 4 (identifier: P49023-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-133: Missing.
278-311: Missing.

« Hide

        10         20         30         40         50
MSTSLGSNLS ELDRLLLELN AVQHNPPGFP ADEANSSPPL PGALSPLYGV 
        60         70         80         90        100
PETNSPLGGK AGPLTKEKPK RNGGRGLEDV RPSVESLLDE LESSVPSPVP 
       110        120        130        140        150
AITVNQGEMS SPQRVTSTQQ QTRISASSAT RELDELMASL SDFKFMAQGK 
       160        170        180        190        200
TGSSSPPGGP PKPGSQLDSM LGSLQSDLNK LGVATVAKGV CGACKKPIAG 
       210        220        230        240        250
QVVTAMGKTW HPEHFVCTHC QEEIGSRNFF ERDGQPYCEK DYHNLFSPRC 
       260        270        280        290        300
YYCNGPILDK VVTALDRTWH PEHFFCAQCG AFFGPEGFHE KDGKAYCRKD 
       310        320        330        340        350
YFDMFAPKCG GCARAILENY ISALNTLWHP ECFVCRECFT PFVNGSFFEH 
       360        370        380        390        400
DGQPYCEVHY HERRGSLCSG CQKPITGRCI TAMAKKFHPE HFVCAFCLKQ 
       410        420 
LNKGTFKEQN DKPYCQNCFL KLFC

Show »

Length:424

Mass (Da):46,604

Checksum:ⁱ74D536A48B653D6D

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GZ78	F5GZ78_HUMAN	Paxillin Paxillin	PXN	589	Annotation score:
A0A1B0GTU4	A0A1B0GTU4_HUMAN	Paxillin Paxillin	PXN	1,081	Annotation score:
F5H836	F5H836_HUMAN	Paxillin Paxillin	PXN	176	Annotation score:
A0A1B0GV30	A0A1B0GV30_HUMAN	Paxillin Paxillin	PXN	207	Annotation score:
A0A1B0GU60	A0A1B0GU60_HUMAN	Paxillin Paxillin	PXN	706	Annotation score:
F8W0G0	F8W0G0_HUMAN	Paxillin Paxillin	PXN	36	Annotation score:
F8W0K8	F8W0K8_HUMAN	Paxillin Paxillin	PXN	37	Annotation score:
F8W1E0	F8W1E0_HUMAN	Paxillin Paxillin	PXN	31	Annotation score:
F8VZ39	F8VZ39_HUMAN	Paxillin Paxillin	PXN	91	Annotation score:
A0A1B0GWE7	A0A1B0GWE7_HUMAN	Paxillin Paxillin	PXN	192	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	280	G → D in BAA18997 (PubMed:9054445).Curated	1
Sequence conflictⁱ	327	P → L in CAI46024 (PubMed:17974005).Curated	1
Sequence conflictⁱ	413	F → S in CAI46024 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065099	73	S → G5 PublicationsCorresponds to variant dbSNP:rs4767884Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040483	1 – 133	Missing in isoform 4. 1 PublicationAdd BLAST	133
Alternative sequenceⁱVSP_003114	278 – 311	Missing in isoform Alpha and isoform 4. 4 PublicationsAdd BLAST	34
Alternative sequenceⁱVSP_003115	278 – 311	IQGLE…QDEGG → GSWPLEEVVLLVSISSSVQE GEKYPHPCAARHRTPSLRSP DQPPPCPQ in isoform Gamma. 1 PublicationAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14588 mRNA Translation: AAC50104.1 U87946 U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3]
PIRⁱ	A55933
NCBI Reference Sequences More...RefSeqⁱ	NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4]

Genome annotation databases

Ensemblⁱ	ENST00000228307.11; ENSP00000228307.7; ENSG00000089159.17 ENST00000267257.11; ENSP00000267257.7; ENSG00000089159.17 [P49023-3] ENST00000424649.6; ENSP00000391283.2; ENSG00000089159.17 [P49023-2] ENST00000458477.6; ENSP00000395536.2; ENSG00000089159.17 [P49023-4]
GeneIDⁱ	5829
KEGGⁱ	hsa:5829
UCSC genome browser More...UCSCⁱ	uc001txt.4, human [P49023-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin		HUMAN		591	UniRef100_P49023
P49023-4	Paxillin		PANPA		563	UniRef100_A0A2R9AWG2
Paxillin		PANTR		424
Paxillin		PANTR		424

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin	)	MOUSE		591	UniRef90_P49023
Paxillin		HUMAN		591
Paxillin		MACMU		620
Paxillin		PANTR		604
Paxillin		PANPR		601
+89
P49023-3	Paxillin		RHIBE		606	UniRef90_P49023-3
Paxillin		CEBIM		605
Paxillin		CALJA		605
Paxillin		CERAT		605
Paxillin		GORGO		605
+9
P49023-4	Paxillin		PANPA		563	UniRef90_A0A2R9AWG2
Paxillin		PANTR		424
Paxillin		PANTR		424

Protein	Similar proteins		Species	Score	Length	Source
P49023	Paxillin	)	MOUSE		591	UniRef50_P49023
Paxillin		HUMAN		591
Paxillin		MACMU		620
Paxillin		PANTR		604
Paxillin		ACIJB		601
+112
P49023-2	Paxillin	)	CHICK		559	UniRef50_P49023-2
Paxillin		PANTR		555
Paxillin		PROSS		587
Paxillin (Fragment)		black-headed bulbul		580
Paxillin (Fragment)		Nicator chloris		580
+201
P49023-3	Paxillin		RAT		586	UniRef50_P49023-3
Paxillin		RHIBE		606
Paxillin		CALJA		605
Paxillin		AOTNA		605
Paxillin		CEBIM		605
+368

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14588 mRNA Translation: AAC50104.1 U87946 U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1
CCDSⁱ	CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3]
PIRⁱ	A55933
RefSeqⁱ	NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OW6	X-ray	2.35	D/F	262-274	[»]
	1OW7	X-ray	2.60	D/E/F	262-274	[»]
	1OW8	X-ray	2.85	D/F	141-153	[»]
	2K2R	NMR	-	B	3-12	[»]
	2O9V	X-ray	1.63	B	45-54	[»]
	2VZD	X-ray	2.10	C/D	1-20	[»]
	2VZG	X-ray	1.80	A	141-160	[»]
	2VZI	X-ray	2.20	A	262-277	[»]
	3GM1	X-ray	2.95	C/D/E/F	262-274	[»]
	3PY7	X-ray	2.29	A	1-10	[»]
	3RQE	X-ray	2.80	E	2-15	[»]
	3RQF	X-ray	2.70	E	141-153	[»]
	3RQG	X-ray	2.50	E	262-274	[»]
	3U3F	X-ray	3.10	E/F/G/H/I/J	261-277	[»]
	4EDN	X-ray	2.90	K/L/M/N/O/P/Q	1-20	[»]
	4R32	X-ray	3.70	B/C	139-160	[»]
	4XGZ	X-ray	2.50	a/c/e/g/h/j/m/o/q/s/u/w	141-159	[»]
	4XH2	X-ray	2.00	a/c/e/g/h/j	261-275	[»]
	5UWH	X-ray	2.26	D	264-277	[»]
	6IUI	X-ray	2.60	C/D	261-280	[»]
	6PW8	X-ray	1.95	B	141-153	[»]
	6U4M	NMR	-	A	527-591	[»]
	6U4N	NMR	-	B	527-591	[»]
AlphaFoldDBⁱ	P49023
SMRⁱ	P49023
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111787, 281 interactors
CORUMⁱ	P49023
DIPⁱ	DIP-33851N
ELMⁱ	P49023
IntActⁱ	P49023, 128 interactors
MINTⁱ	P49023
STRINGⁱ	9606.ENSP00000267257

Chemistry databases

ChEMBLⁱ	CHEMBL5715

ChEMBLⁱ

CHEMBL5715

PTM databases

GlyGenⁱ	P49023, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetⁱ	P49023
MetOSiteⁱ	P49023
PhosphoSitePlusⁱ	P49023

Genetic variation databases

BioMutaⁱ	PXN
DMDMⁱ	317373486

Proteomic databases

EPDⁱ	P49023
jPOSTⁱ	P49023
MassIVEⁱ	P49023
MaxQBⁱ	P49023
PaxDbⁱ	P49023
PeptideAtlasⁱ	P49023
PRIDEⁱ	P49023
ProteomicsDBⁱ	55957 [P49023-1] 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4]
TopDownProteomicsⁱ	P49023-2 [P49023-2] P49023-3 [P49023-3]

Protocols and materials databases

ABCDⁱ	P49023, 2 sequenced antibodies
Antibodypediaⁱ	3546, 1656 antibodies from 47 providers
The DNASU plasmid repository More...DNASUⁱ	5829

Genome annotation databases

Ensemblⁱ	ENST00000228307.11; ENSP00000228307.7; ENSG00000089159.17 ENST00000267257.11; ENSP00000267257.7; ENSG00000089159.17 [P49023-3] ENST00000424649.6; ENSP00000391283.2; ENSG00000089159.17 [P49023-2] ENST00000458477.6; ENSP00000395536.2; ENSG00000089159.17 [P49023-4]
GeneIDⁱ	5829
KEGGⁱ	hsa:5829
UCSCⁱ	uc001txt.4, human [P49023-1]

Organism-specific databases

CTDⁱ	5829
DisGeNETⁱ	5829
GeneCardsⁱ	PXN
HGNCⁱ	HGNC:9718, PXN
HPAⁱ	ENSG00000089159, Low tissue specificity
MIMⁱ	602505, gene
neXtProtⁱ	NX_P49023
OpenTargetsⁱ	ENSG00000089159
PharmGKBⁱ	PA34062
VEuPathDBⁱ	HostDB:ENSG00000089159
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1703, Eukaryota
GeneTreeⁱ	ENSGT00940000158897
HOGENOMⁱ	CLU_001357_1_2_1
InParanoidⁱ	P49023
OrthoDBⁱ	1593918at2759
PhylomeDBⁱ	P49023
TreeFamⁱ	TF314113

Enzyme and pathway databases

PathwayCommonsⁱ	P49023
Reactomeⁱ	R-HSA-180292, GAB1 signalosome R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P49023
SIGNORⁱ	P49023

Miscellaneous databases

BioGRID-ORCSⁱ	5829, 170 hits in 1080 CRISPR screens
ChiTaRSⁱ	PXN, human
EvolutionaryTraceⁱ	P49023
GeneWikiⁱ	Paxillin
GenomeRNAiⁱ	5829
Pharosⁱ	P49023, Tbio
Protein Ontology More...PROⁱ	PR:P49023
RNActⁱ	P49023, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089159, Expressed in fundus of stomach and 217 other tissues
ExpressionAtlasⁱ	P49023, baseline and differential
Genevisibleⁱ	P49023, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001904, Paxillin IPR001781, Znf_LIM
PANTHERⁱ	PTHR24216:SF11, PTHR24216:SF11, 4 hits
Pfamⁱ	View protein in Pfam PF00412, LIM, 4 hits
SMARTⁱ	View protein in SMART SM00132, LIM, 4 hits
PROSITEⁱ	View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAXI_HUMAN
Accessionⁱ	P49023Primary (citable) accession number: P49023 Secondary accession number(s): B2RAI3 , B7ZMB4, O14970, O14971, O60360, Q5HYA4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 11, 2011
	Last modified:	May 25, 2022
	This is version 226 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P49023 (PAXI_HUMAN)

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Paxillin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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P49023

Isoform Alpha [P49023-2]

GO - Molecular functioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

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GO - Molecular functionⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ