UniProtKB - P49023 (PAXI_HUMAN)
Paxillin
PXN
Functioni
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- integrin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- neuropilin binding Source: BHF-UCL
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: BHF-UCL
- transcription coregulator activity Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
- vinculin binding Source: UniProtKB
GO - Biological processi
- cell adhesion Source: ProtInc
- cellular response to reactive oxygen species Source: BHF-UCL
- endothelial cell migration Source: BHF-UCL
- growth hormone receptor signaling pathway Source: BHF-UCL
- muscle contraction Source: Reactome
- positive regulation of stress fiber assembly Source: BHF-UCL
- signal complex assembly Source: ProtInc
- signal transduction Source: ProtInc
- substrate adhesion-dependent cell spreading Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Cell adhesion |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P49023 |
Reactomei | R-HSA-180292, GAB1 signalosome R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
SignaLinki | P49023 |
SIGNORi | P49023 |
Names & Taxonomyi
Protein namesi | Recommended name: Paxillin |
Gene namesi | Name:PXN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000089159.15 |
HGNCi | HGNC:9718, PXN |
MIMi | 602505, gene |
neXtProti | NX_P49023 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- focal adhesion 2 Publications
- cell cortex By similarity
Note: Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389).By similarity1 Publication
Cytoskeleton
- microtubule associated complex Source: ProtInc
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell cortex Source: UniProtKB-SubCell
- cell-cell junction Source: ARUK-UCL
- focal adhesion Source: UniProtKB
- lamellipodium Source: BHF-UCL
Keywords - Cellular componenti
Cell junction, Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 – 8 | LL → RR: Loss of interaction with PDCD10. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 5829 |
OpenTargetsi | ENSG00000089159 |
PharmGKBi | PA34062 |
Miscellaneous databases
Pharosi | P49023, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5715 |
Polymorphism and mutation databases
BioMutai | PXN |
DMDMi | 317373486 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000075853 | 1 – 591 | PaxillinAdd BLAST | 591 | ||
Isoform 4 (identifier: P49023-4) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 31 | Phosphotyrosine; by PTK62 Publications | 1 | ||
Modified residuei | 83 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 85 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 88 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 106 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 118 | Phosphotyrosine; by PTK62 Publications | 1 | ||
Modified residuei | 119 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 126 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 130 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 132 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 137 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 140 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 143 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 181 | Phosphotyrosine1 Publication | 1 | ||
Modified residuei | 230 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 244 | Phosphoserine; by CDK51 Publication | 1 | ||
Modified residuei | 250 | Phosphoserine; by SLK1 Publication | 1 | ||
Modified residuei | 258 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 261 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 272 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 303 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 322 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 332 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 340 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 533 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: P49023-4) | |||||
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P49023 |
jPOSTi | P49023 |
MassIVEi | P49023 |
MaxQBi | P49023 |
PaxDbi | P49023 |
PeptideAtlasi | P49023 |
PRIDEi | P49023 |
ProteomicsDBi | 55957 [P49023-1] 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4] |
TopDownProteomicsi | P49023-2 [P49023-2] P49023-3 [P49023-3] |
PTM databases
iPTMneti | P49023 |
MetOSitei | P49023 |
PhosphoSitePlusi | P49023 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089159, Expressed in fundus of stomach and 216 other tissues |
ExpressionAtlasi | P49023, baseline and differential |
Genevisiblei | P49023, HS |
Organism-specific databases
HPAi | ENSG00000089159, Low tissue specificity |
Interactioni
Subunit structurei
Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1.
Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1.
Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1.
Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2.
Interacts with unphosphorylated ITGA4.
Interacts with RNF5 and PDCD10.
Interacts with NEK3 and this interaction is prolactin-dependent.
Interacts with PTK6.
Interacts with SORBS1, PARVA and PARVB.
Interacts (via cytoplasmic domain) with CEACAM1; the interaction is phosphotyrosyl-dependent (PubMed:11035932).
Interacts with LIMA1; this complex stabilizes actin dynamics (PubMed:24694988).
16 PublicationsBinary interactionsi
Hide detailsP49023
Isoform Alpha [P49023-2]
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- integrin binding Source: Ensembl
- neuropilin binding Source: BHF-UCL
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: Ensembl
- vinculin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111787, 122 interactors |
CORUMi | P49023 |
DIPi | DIP-33851N |
ELMi | P49023 |
IntActi | P49023, 128 interactors |
MINTi | P49023 |
STRINGi | 9606.ENSP00000267257 |
Miscellaneous databases
RNActi | P49023, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P49023 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P49023 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 415 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 416 – 473 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 474 – 533 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 534 – 591 | LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST | 58 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 3 – 15 | LD motif 1Add BLAST | 13 | |
Motifi | 144 – 156 | LD motif 2Add BLAST | 13 | |
Motifi | 216 – 228 | LD motif 3Add BLAST | 13 | |
Motifi | 265 – 276 | LD motif 4Add BLAST | 12 | |
Motifi | 333 – 345 | LD motif 5Add BLAST | 13 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 46 – 53 | Pro-rich | 8 |
Sequence similaritiesi
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000158897 |
HOGENOMi | CLU_001357_1_2_1 |
InParanoidi | P49023 |
OrthoDBi | 1593918at2759 |
PhylomeDBi | P49023 |
TreeFami | TF314113 |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP
60 70 80 90 100
PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP
110 120 130 140 150
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL
160 170 180 190 200
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE
210 220 230 240 250
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS
260 270 280 290 300
TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG
310 320 330 340 350
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV
360 370 380 390 400
ATVAKGVCGA CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD
410 420 430 440 450
GQPYCEKDYH NLFSPRCYYC NGPILDKVVT ALDRTWHPEH FFCAQCGAFF
460 470 480 490 500
GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA RAILENYISA LNTLWHPECF
510 520 530 540 550
VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK PITGRCITAM
560 570 580 590
AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C
The sequence of this isoform differs from the canonical sequence as follows:
278-311: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
278-311: IQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG → GSWPLEEVVL...SPDQPPPCPQ
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZ78 | F5GZ78_HUMAN | Paxillin | PXN | 589 | Annotation score: | ||
A0A1B0GTU4 | A0A1B0GTU4_HUMAN | Paxillin | PXN | 1,081 | Annotation score: | ||
F5H836 | F5H836_HUMAN | Paxillin | PXN | 176 | Annotation score: | ||
F8VZ39 | F8VZ39_HUMAN | Paxillin | PXN | 91 | Annotation score: | ||
A0A1B0GV30 | A0A1B0GV30_HUMAN | Paxillin | PXN | 207 | Annotation score: | ||
A0A1B0GU60 | A0A1B0GU60_HUMAN | Paxillin | PXN | 706 | Annotation score: | ||
A0A1B0GWE7 | A0A1B0GWE7_HUMAN | Paxillin | PXN | 192 | Annotation score: | ||
F8W0G0 | F8W0G0_HUMAN | Paxillin | PXN | 36 | Annotation score: | ||
F8W0K8 | F8W0K8_HUMAN | Paxillin | PXN | 37 | Annotation score: | ||
F8W1E0 | F8W1E0_HUMAN | Paxillin | PXN | 31 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 280 | G → D in BAA18997 (PubMed:9054445).Curated | 1 | |
Sequence conflicti | 327 | P → L in CAI46024 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 413 | F → S in CAI46024 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065099 | 73 | S → G5 PublicationsCorresponds to variant dbSNP:rs4767884Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040483 | 1 – 133 | Missing in isoform 4. 1 PublicationAdd BLAST | 133 | |
Alternative sequenceiVSP_003114 | 278 – 311 | Missing in isoform Alpha and isoform 4. 4 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_003115 | 278 – 311 | IQGLE…QDEGG → GSWPLEEVVLLVSISSSVQE GEKYPHPCAARHRTPSLRSP DQPPPCPQ in isoform Gamma. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14588 mRNA Translation: AAC50104.1 U87946 , U87941, U87942, U87943, U87944, U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1 |
CCDSi | CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3] |
PIRi | A55933 |
RefSeqi | NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4] |
Genome annotation databases
Ensembli | ENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1] ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3] ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2] ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4] |
GeneIDi | 5829 |
KEGGi | hsa:5829 |
UCSCi | uc001txt.4, human [P49023-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14588 mRNA Translation: AAC50104.1 U87946 , U87941, U87942, U87943, U87944, U87945 Genomic DNA Translation: AAD00648.1 D86862 mRNA Translation: BAA18997.1 D86863 mRNA Translation: BAA18998.1 AK314204 mRNA Translation: BAG36880.1 BX648777 mRNA Translation: CAI46024.1 AC004263 Genomic DNA Translation: AAC05175.1 BC136787 mRNA Translation: AAI36788.1 BC136794 mRNA Translation: AAI36795.1 BC144410 mRNA Translation: AAI44411.1 |
CCDSi | CCDS44996.1 [P49023-2] CCDS44997.1 [P49023-1] CCDS44998.1 [P49023-4] CCDS58281.1 [P49023-3] |
PIRi | A55933 |
RefSeqi | NP_001074324.1, NM_001080855.2 [P49023-1] NP_001230685.1, NM_001243756.1 [P49023-3] NP_002850.2, NM_002859.3 [P49023-2] NP_079433.3, NM_025157.4 [P49023-4] XP_016875232.1, XM_017019743.1 [P49023-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KKY | model | - | A | 142-157 | [»] | |
1KL0 | model | - | B | 142-157 | [»] | |
1OW6 | X-ray | 2.35 | D/F | 262-274 | [»] | |
1OW7 | X-ray | 2.60 | D/E/F | 262-274 | [»] | |
1OW8 | X-ray | 2.85 | D/F | 141-153 | [»] | |
2K2R | NMR | - | B | 3-12 | [»] | |
2O9V | X-ray | 1.63 | B | 45-54 | [»] | |
2VZD | X-ray | 2.10 | C/D | 1-20 | [»] | |
2VZG | X-ray | 1.80 | A | 141-160 | [»] | |
2VZI | X-ray | 2.20 | A | 262-277 | [»] | |
3GM1 | X-ray | 2.95 | C/D/E/F | 262-274 | [»] | |
3PY7 | X-ray | 2.29 | A | 1-10 | [»] | |
3RQE | X-ray | 2.80 | E | 2-15 | [»] | |
3RQF | X-ray | 2.70 | E | 141-153 | [»] | |
3RQG | X-ray | 2.50 | E | 262-274 | [»] | |
3U3F | X-ray | 3.10 | E/F/G/H/I/J | 261-277 | [»] | |
4EDN | X-ray | 2.90 | K/L/M/N/O/P/Q | 1-20 | [»] | |
4R32 | X-ray | 3.70 | B/C | 139-160 | [»] | |
4XGZ | X-ray | 2.50 | a/c/e/g/h/j/m/o/q/s/u/w | 141-159 | [»] | |
4XH2 | X-ray | 2.00 | a/c/e/g/h/j | 261-275 | [»] | |
5UWH | X-ray | 2.26 | D | 264-277 | [»] | |
6IUI | X-ray | 2.60 | C/D | 261-280 | [»] | |
6U4M | NMR | - | A | 527-591 | [»] | |
6U4N | NMR | - | B | 527-591 | [»] | |
SMRi | P49023 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111787, 122 interactors |
CORUMi | P49023 |
DIPi | DIP-33851N |
ELMi | P49023 |
IntActi | P49023, 128 interactors |
MINTi | P49023 |
STRINGi | 9606.ENSP00000267257 |
Chemistry databases
ChEMBLi | CHEMBL5715 |
PTM databases
iPTMneti | P49023 |
MetOSitei | P49023 |
PhosphoSitePlusi | P49023 |
Polymorphism and mutation databases
BioMutai | PXN |
DMDMi | 317373486 |
Proteomic databases
EPDi | P49023 |
jPOSTi | P49023 |
MassIVEi | P49023 |
MaxQBi | P49023 |
PaxDbi | P49023 |
PeptideAtlasi | P49023 |
PRIDEi | P49023 |
ProteomicsDBi | 55957 [P49023-1] 55958 [P49023-2] 55959 [P49023-3] 55960 [P49023-4] |
TopDownProteomicsi | P49023-2 [P49023-2] P49023-3 [P49023-3] |
Protocols and materials databases
ABCDi | P49023, 2 sequenced antibodies |
Antibodypediai | 3546, 1575 antibodies |
Genome annotation databases
Ensembli | ENST00000228307; ENSP00000228307; ENSG00000089159 [P49023-1] ENST00000267257; ENSP00000267257; ENSG00000089159 [P49023-3] ENST00000424649; ENSP00000391283; ENSG00000089159 [P49023-2] ENST00000458477; ENSP00000395536; ENSG00000089159 [P49023-4] |
GeneIDi | 5829 |
KEGGi | hsa:5829 |
UCSCi | uc001txt.4, human [P49023-1] |
Organism-specific databases
CTDi | 5829 |
DisGeNETi | 5829 |
EuPathDBi | HostDB:ENSG00000089159.15 |
GeneCardsi | PXN |
HGNCi | HGNC:9718, PXN |
HPAi | ENSG00000089159, Low tissue specificity |
MIMi | 602505, gene |
neXtProti | NX_P49023 |
OpenTargetsi | ENSG00000089159 |
PharmGKBi | PA34062 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000158897 |
HOGENOMi | CLU_001357_1_2_1 |
InParanoidi | P49023 |
OrthoDBi | 1593918at2759 |
PhylomeDBi | P49023 |
TreeFami | TF314113 |
Enzyme and pathway databases
PathwayCommonsi | P49023 |
Reactomei | R-HSA-180292, GAB1 signalosome R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-446343, Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446388, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
SignaLinki | P49023 |
SIGNORi | P49023 |
Miscellaneous databases
BioGRID-ORCSi | 5829, 162 hits in 846 CRISPR screens |
ChiTaRSi | PXN, human |
EvolutionaryTracei | P49023 |
GeneWikii | Paxillin |
GenomeRNAii | 5829 |
Pharosi | P49023, Tbio |
PROi | PR:P49023 |
RNActi | P49023, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089159, Expressed in fundus of stomach and 216 other tissues |
ExpressionAtlasi | P49023, baseline and differential |
Genevisiblei | P49023, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 4 hits |
SMARTi | View protein in SMART SM00132, LIM, 4 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 4 hits PS50023, LIM_DOMAIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAXI_HUMAN | |
Accessioni | P49023Primary (citable) accession number: P49023 Secondary accession number(s): B2RAI3 Q5HYA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 220 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations