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Protein

Protein timeless

Gene

tim

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • protein heterodimerization activity Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein timeless
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tim
ORF Names:CG3234
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014396 tim

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant flies show loss of both behavioral circadian rhythms and molecular oscillations of per RNA and protein.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000225321 – 1398Protein timelessAdd BLAST1398

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated with a circadian rhythmicity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49021

PRoteomics IDEntifications database

More...
PRIDEi
P49021

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in head, photoreceptors, lateral neurons and glial cells in the lamina and medulla of the optic lobes. Expression follows a light-dark cycle, levels show a significant decrease at the end of the night and then remain low throughout the light period (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014396 Expressed in 33 organ(s), highest expression level in capitellum (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P49021 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P49021 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with period (PER); the complex then translocates into the nucleus.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
perP07663-12EBI-266295,EBI-15718452

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
59781, 22 interactors

Database of interacting proteins

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DIPi
DIP-29425N

Protein interaction database and analysis system

More...
IntActi
P49021, 9 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0305454

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni237 – 268Necessary for normal circadian rhythmAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi550 – 560Nuclear localization signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi360 – 389Asp/Glu-rich (acidic)Add BLAST30
Compositional biasi432 – 437Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the timeless family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1974 Eukaryota
ENOG410XQM6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000015124

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P49021

KEGG Orthology (KO)

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KOi
K12074

Identification of Orthologs from Complete Genome Data

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OMAi
EFRVPHY

Database of Orthologous Groups

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OrthoDBi
EOG091G01UQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006906 Timeless

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04821 TIMELESS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform BImported (identifier: P49021-4) [UniParc]FASTAAdd to basket
Also known as: PImported

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWLLATPQL YSAFSSLGCL EGDTYVVNPN ALAILEEINY KLTYEDQTLR
60 70 80 90 100
TFRRAIGFGQ NVRSDLIPLL ENAKDDAVLE SVIRILVNLT VPVECLFSVD
110 120 130 140 150
VMYRTDVGRH TIFELNKLLY TSKEAFTEAR STKSVVEYMK HILESDPKLS
160 170 180 190 200
PHKCDQINNC LLLLRNILHI PETHAHCVMP MMQSMPHGIS MQNTILWNLF
210 220 230 240 250
IQSIDKLLLY LMTCPQRAFW GVTMVQLIAL IYKDQHVSTL QKLLSLWFEA
260 270 280 290 300
SLSESSEDNE SNTSPPKQGS GDSSPMLTSD PTSDSSDNGS NGRGMGGGMR
310 320 330 340 350
EGTAATLQEV SRKGQEYQNA MARVPADKPD GSEEASDMTG NDSEQPGSPE
360 370 380 390 400
QSQPAGESMD DGDYEDQRHR QLNEHGEEDE DEDEVEEEEY LQLGPASEPL
410 420 430 440 450
NLTQQPADKV NNTTNPTSSA PQGCLGNEPF KPPPPLPVRA STSAHAQMQK
460 470 480 490 500
FNESSYASHV SAVKLGQKSP HAGQLQLTKG KCCPQKRECP SSQSELSDCG
510 520 530 540 550
YGTQVENQES ISTSSNDDDG PQGKPQHQKP PCNTKPRNKP RTIMSPMDKK
560 570 580 590 600
ELRRKKLVKR SKSSLINMKG LVQHTPTDDD ISNLLKEFTV DFLLKGYSYL
610 620 630 640 650
VEELHMQLLS NAKVPIDTSH FFWLVTYFLK FAAQLELDME HIDTILTYDV
660 670 680 690 700
LSYLTYEGVS LCEQLELNAR QEGSDLKPYL RRMHLVVTAI REFLQAIDTY
710 720 730 740 750
NKVTHLNEDD KAHLRQLQLQ ISEMSDLRCL FVLLLRRFNP SIHSKQYLQD
760 770 780 790 800
LVVTNHILLL ILDSSAKLGG CQTIRLSEHI TQFATLEVMH YYGILLEDFN
810 820 830 840 850
NNGEFVNDCI FTMMHHIGGD LGQIGVLFQP IILKTYSRIW EADYELCDDW
860 870 880 890 900
SDLIEYVIHK FMNTPPKSPL TIPTTSLTEM TKEHNQEHTV CSWSQEEMDT
910 920 930 940 950
LYWYYVQSKK NNDIVGKIVK LFSNNGNKLK TRISIIQQLL QQDIITLLEY
960 970 980 990 1000
DDLMKFEDAE YQRTLLTTPT SATTESGIEI KECAYGKPSD DVQILLDLII
1010 1020 1030 1040 1050
KENKAQHLLW LQRILIECCF VKLTLRSGLK VPEGDHIMEP VAYHCICKQK
1060 1070 1080 1090 1100
SIPVVQWNNE QSTTMLYQPF VLLLHKLGIQ LPADAGSIFA RIPDYWTPET
1110 1120 1130 1140 1150
MYGLAKKLGP LDKLNLKFDA SELEDATASS PSRYHHTGPR NSLSSVSSLD
1160 1170 1180 1190 1200
VDLGDTEELA LIPEVDAAVE KAHAMASTPS PSEIFAVPKT KHCNSIIRYT
1210 1220 1230 1240 1250
PDPTPPVPNW LQLVMRSKCN HRTGPSGDPS DCIGSSSTTV DDEGFGKSIS
1260 1270 1280 1290 1300
AATSQAASTS MSTVNPTTTL SLNMLNTFMG SHNENSSSSG CGGTVSSLSM
1310 1320 1330 1340 1350
VALMSTGAAG GGGNTSGLEM DVDASMKSSF ERLEVNGSHF SRANNLDQEY
1360 1370 1380 1390
SAMVASVYEK EKELNSDNVS LASDLTRMYV SDEDDRLERT EIRVPHYH
Length:1,398
Mass (Da):156,382
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7974EDCF6F94A88
GO
Isoform RImported (identifier: P49021-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-268: Missing.

Note: No experimental confirmation available.
Show »
Length:1,366
Mass (Da):152,847
Checksum:i06F0104288A8703F
GO
Isoform OImported (identifier: P49021-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     891-891: C → W
     892-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:891
Mass (Da):100,623
Checksum:iAB62EC51D0F761AD
GO
Isoform NImported (identifier: P49021-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-613: Missing.
     891-891: C → W
     892-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:890
Mass (Da):100,495
Checksum:iBC8202CC37F333B3
GO
Isoform SImported (identifier: P49021-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-268: Missing.
     1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
     1132-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:1,099
Mass (Da):124,696
Checksum:i80AA3EF3AB03EF6C
GO
Isoform MImported (identifier: P49021-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
     1132-1398: Missing.

Note: No experimental confirmation available.
Show »
Length:1,131
Mass (Da):128,231
Checksum:i608FBAE2361C8271
GO
Isoform LImported (identifier: P49021-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-613: Missing.

Note: No experimental confirmation available.
Show »
Length:1,397
Mass (Da):156,253
Checksum:iCFA4573C81C95F41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W5PW00A0A1W5PW00_DROME
Timeless, isoform T
tim Dmel\CG3234, dTIM, dTim, dtim, mel_tim
1,421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC46920 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAL13507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAN71179 differs from that shown. Intron retention.Curated
The sequence AAN71179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ACX54883 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1233I → V in AAB94890 (PubMed:9365248).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004457237 – 268Missing in isoform R and isoform S. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_054859613Missing in isoform L and isoform N. 1 Publication1
Alternative sequenceiVSP_007693891C → W in isoform N and isoform O. 2 Publications1
Alternative sequenceiVSP_007694892 – 1398Missing in isoform N and isoform O. 2 PublicationsAdd BLAST507
Alternative sequenceiVSP_0548601114 – 1131LNLKF…TASSP → RELKSTTEKNNPFVIPQR in isoform S and isoform M. CuratedAdd BLAST18
Alternative sequenceiVSP_0548611132 – 1398Missing in isoform S and isoform M. CuratedAdd BLAST267

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U37018 mRNA Translation: AAC46920.1 Different initiation.
AF032401, AF032400 Genomic DNA Translation: AAB94890.1
AE014134 Genomic DNA Translation: AAF51098.4
AE014134 Genomic DNA Translation: AAN10371.3
AE014134 Genomic DNA Translation: AAN10372.3
AE014134 Genomic DNA Translation: AAX52649.2
AE014134 Genomic DNA Translation: ABC65862.2
AE014134 Genomic DNA Translation: ACL82987.2
AE014134 Genomic DNA Translation: ACL82988.2
AE014134 Genomic DNA Translation: ADV36936.2
Y09930 Genomic DNA No translation available.
Y09931 Genomic DNA No translation available.
Y09932 Genomic DNA No translation available.
Y09933 Genomic DNA No translation available.
Y09934 Genomic DNA No translation available.
Y09935 Genomic DNA No translation available.
AY058278 mRNA Translation: AAL13507.1 Different initiation.
BT001424 mRNA Translation: AAN71179.1 Sequence problems.
BT024951 mRNA Translation: ABE01181.1
BT099999 mRNA Translation: ACX54883.1 Different initiation.
AF038501 Genomic DNA Translation: AAB94929.1

Protein sequence database of the Protein Information Resource

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PIRi
A57655

NCBI Reference Sequences

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RefSeqi
NP_001014463.2, NM_001014463.4 [P49021-6]
NP_001033872.2, NM_001038783.3 [P49021-7]
NP_001137780.2, NM_001144308.3 [P49021-2]
NP_001137781.2, NM_001144309.4 [P49021-3]
NP_001188686.2, NM_001201757.2 [P49021-5]
NP_722912.3, NM_164540.4 [P49021-4]
NP_722913.3, NM_164541.6 [P49021-8]
NP_722914.3, NM_164542.5 [P49021-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.2663

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0077567; FBpp0077256; FBgn0014396 [P49021-4]
FBtr0333252; FBpp0305450; FBgn0014396 [P49021-8]
FBtr0333253; FBpp0305451; FBgn0014396 [P49021-7]
FBtr0333254; FBpp0305452; FBgn0014396 [P49021-5]
FBtr0333255; FBpp0305453; FBgn0014396 [P49021-3]
FBtr0333256; FBpp0305454; FBgn0014396 [P49021-4]
FBtr0333258; FBpp0305456; FBgn0014396 [P49021-2]
FBtr0333259; FBpp0305457; FBgn0014396 [P49021-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
33571

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3234

UCSC genome browser

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UCSCi
CG3234-RA d. melanogaster [P49021-4]
CG3234-RE d. melanogaster

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37018 mRNA Translation: AAC46920.1 Different initiation.
AF032401, AF032400 Genomic DNA Translation: AAB94890.1
AE014134 Genomic DNA Translation: AAF51098.4
AE014134 Genomic DNA Translation: AAN10371.3
AE014134 Genomic DNA Translation: AAN10372.3
AE014134 Genomic DNA Translation: AAX52649.2
AE014134 Genomic DNA Translation: ABC65862.2
AE014134 Genomic DNA Translation: ACL82987.2
AE014134 Genomic DNA Translation: ACL82988.2
AE014134 Genomic DNA Translation: ADV36936.2
Y09930 Genomic DNA No translation available.
Y09931 Genomic DNA No translation available.
Y09932 Genomic DNA No translation available.
Y09933 Genomic DNA No translation available.
Y09934 Genomic DNA No translation available.
Y09935 Genomic DNA No translation available.
AY058278 mRNA Translation: AAL13507.1 Different initiation.
BT001424 mRNA Translation: AAN71179.1 Sequence problems.
BT024951 mRNA Translation: ABE01181.1
BT099999 mRNA Translation: ACX54883.1 Different initiation.
AF038501 Genomic DNA Translation: AAB94929.1
PIRiA57655
RefSeqiNP_001014463.2, NM_001014463.4 [P49021-6]
NP_001033872.2, NM_001038783.3 [P49021-7]
NP_001137780.2, NM_001144308.3 [P49021-2]
NP_001137781.2, NM_001144309.4 [P49021-3]
NP_001188686.2, NM_001201757.2 [P49021-5]
NP_722912.3, NM_164540.4 [P49021-4]
NP_722913.3, NM_164541.6 [P49021-8]
NP_722914.3, NM_164542.5 [P49021-4]
UniGeneiDm.2663

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protein-protein interaction databases

BioGridi59781, 22 interactors
DIPiDIP-29425N
IntActiP49021, 9 interactors
STRINGi7227.FBpp0305454

Proteomic databases

PaxDbiP49021
PRIDEiP49021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077567; FBpp0077256; FBgn0014396 [P49021-4]
FBtr0333252; FBpp0305450; FBgn0014396 [P49021-8]
FBtr0333253; FBpp0305451; FBgn0014396 [P49021-7]
FBtr0333254; FBpp0305452; FBgn0014396 [P49021-5]
FBtr0333255; FBpp0305453; FBgn0014396 [P49021-3]
FBtr0333256; FBpp0305454; FBgn0014396 [P49021-4]
FBtr0333258; FBpp0305456; FBgn0014396 [P49021-2]
FBtr0333259; FBpp0305457; FBgn0014396 [P49021-6]
GeneIDi33571
KEGGidme:Dmel_CG3234
UCSCiCG3234-RA d. melanogaster [P49021-4]
CG3234-RE d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
107698
FlyBaseiFBgn0014396 tim

Phylogenomic databases

eggNOGiKOG1974 Eukaryota
ENOG410XQM6 LUCA
GeneTreeiENSGT00390000015124
InParanoidiP49021
KOiK12074
OMAiEFRVPHY
OrthoDBiEOG091G01UQ

Enzyme and pathway databases

ReactomeiR-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
tim fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33571

Protein Ontology

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PROi
PR:P49021

Gene expression databases

BgeeiFBgn0014396 Expressed in 33 organ(s), highest expression level in capitellum (Drosophila)
ExpressionAtlasiP49021 baseline and differential
GenevisibleiP49021 DM

Family and domain databases

InterProiView protein in InterPro
IPR006906 Timeless
PfamiView protein in Pfam
PF04821 TIMELESS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIM_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49021
Secondary accession number(s): A4V040
, B7Z007, B7Z008, C9QPB7, M9MRE9, O44380, Q1WWF5, Q59E16, Q8I037, Q95U67, Q9VQR6, Q9VQR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 14, 2014
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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