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Protein

Hydroxycarboxylic acid receptor 3

Gene

HCAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.2 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 3
Alternative name(s):
G-protein coupled receptor 109B
G-protein coupled receptor HM74
G-protein coupled receptor HM74B
Niacin receptor 2
Nicotinic acid receptor 2
Gene namesi
Name:HCAR3
Synonyms:GPR109B, HCA3, HM74B, NIACR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000255398.2
HGNCiHGNC:16824 HCAR3
MIMi606039 gene
neXtProtiNX_P49019

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 50Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini51 – 63CytoplasmicSequence analysisAdd BLAST13
Transmembranei64 – 85Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini86 – 102ExtracellularSequence analysisAdd BLAST17
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 194ExtracellularSequence analysisAdd BLAST31
Transmembranei195 – 209Helical; Name=5Sequence analysisAdd BLAST15
Topological domaini210 – 236CytoplasmicSequence analysisAdd BLAST27
Transmembranei237 – 256Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini257 – 273ExtracellularSequence analysisAdd BLAST17
Transmembranei274 – 298Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini299 – 387CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111R → A: Abrogates completely the activation by OH-octanoid acid. 1 Publication1

Organism-specific databases

DisGeNETi8843
OpenTargetsiENSG00000255398
PharmGKBiPA165512827

Chemistry databases

ChEMBLiCHEMBL4421
DrugBankiDB00627 Niacin
GuidetoPHARMACOLOGYi313

Polymorphism and mutation databases

BioMutaiHCAR3
DMDMi519668680

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696041 – 387Hydroxycarboxylic acid receptor 3Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP49019
MaxQBiP49019
PaxDbiP49019
PeptideAtlasiP49019
PRIDEiP49019
ProteomicsDBi55956

PTM databases

iPTMnetiP49019
PhosphoSitePlusiP49019

Expressioni

Tissue specificityi

Expression largely restricted to adipose tissue and spleen.1 Publication

Gene expression databases

BgeeiENSG00000255398 Expressed in 62 organ(s), highest expression level in blood
CleanExiHS_GPR109B
GenevisibleiP49019 HS

Organism-specific databases

HPAiHPA028660

Interactioni

Protein-protein interaction databases

IntActiP49019, 1 interactor
STRINGi9606.ENSP00000436714

Chemistry databases

BindingDBiP49019

Structurei

3D structure databases

ProteinModelPortaliP49019
SMRiP49019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00510000046798
HOVERGENiHBG051680
InParanoidiP49019
KOiK08402
OMAiKWDWKFG
OrthoDBiEOG091G0AN6
PhylomeDBiP49019
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028017 HCAR2/3_rcpt
PANTHERiPTHR24231:SF0 PTHR24231:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRHHLQDHF LEIDKKNCCV FRDDFIAKVL PPVLGLEFIF GLLGNGLALW
60 70 80 90 100
IFCFHLKSWK SSRIFLFNLA VADFLLIICL PFVMDYYVRR SDWKFGDIPC
110 120 130 140 150
RLVLFMFAMN RQGSIIFLTV VAVDRYFRVV HPHHALNKIS NWTAAIISCL
160 170 180 190 200
LWGITVGLTV HLLKKKLLIQ NGTANVCISF SICHTFRWHE AMFLLEFFLP
210 220 230 240 250
LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF VICFLPSVVV
260 270 280 290 300
RIHIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS
310 320 330 340 350
FPNFFSTLIN RCLQRKITGE PDNNRSTSVE LTGDPNKTRG APEALIANSG
360 370 380
EPWSPSYLGP TSNNHSKKGH CHQEPASLEK QLGCCIE
Length:387
Mass (Da):44,478
Last modified:June 26, 2013 - v3
Checksum:i887BA427B6134A3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94K → N in BAA01721 (PubMed:7505609).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038715173T → P4 PublicationsCorresponds to variant dbSNP:rs1798192Ensembl.1
Natural variantiVAR_038716198F → L4 PublicationsCorresponds to variant dbSNP:rs17884481Ensembl.1
Natural variantiVAR_038717253H → R4 PublicationsCorresponds to variant dbSNP:rs118091133Ensembl.1
Natural variantiVAR_038718317I → M4 PublicationsCorresponds to variant dbSNP:rs116821988Ensembl.1
Natural variantiVAR_038719346I → M4 PublicationsCorresponds to variant dbSNP:rs1696351Ensembl.1
Natural variantiVAR_038720350G → S. Corresponds to variant dbSNP:rs201835480Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10923 mRNA Translation: BAA01721.1
AB065865 Genomic DNA Translation: BAC06083.1
AK290930 mRNA Translation: BAF83619.1
AK313212 mRNA Translation: BAG36027.1
EU293604 Genomic DNA Translation: ABX64359.1
AC026333 Genomic DNA No translation available.
BC047891 mRNA Translation: AAH47891.1
CCDSiCCDS53842.1
PIRiI69202
RefSeqiNP_006009.2, NM_006018.2
UniGeneiHs.458425

Genome annotation databases

EnsembliENST00000528880; ENSP00000436714; ENSG00000255398
GeneIDi8843
KEGGihsa:8843
UCSCiuc001ucy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10923 mRNA Translation: BAA01721.1
AB065865 Genomic DNA Translation: BAC06083.1
AK290930 mRNA Translation: BAF83619.1
AK313212 mRNA Translation: BAG36027.1
EU293604 Genomic DNA Translation: ABX64359.1
AC026333 Genomic DNA No translation available.
BC047891 mRNA Translation: AAH47891.1
CCDSiCCDS53842.1
PIRiI69202
RefSeqiNP_006009.2, NM_006018.2
UniGeneiHs.458425

3D structure databases

ProteinModelPortaliP49019
SMRiP49019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49019, 1 interactor
STRINGi9606.ENSP00000436714

Chemistry databases

BindingDBiP49019
ChEMBLiCHEMBL4421
DrugBankiDB00627 Niacin
GuidetoPHARMACOLOGYi313

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP49019
PhosphoSitePlusiP49019

Polymorphism and mutation databases

BioMutaiHCAR3
DMDMi519668680

Proteomic databases

EPDiP49019
MaxQBiP49019
PaxDbiP49019
PeptideAtlasiP49019
PRIDEiP49019
ProteomicsDBi55956

Protocols and materials databases

DNASUi8843
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528880; ENSP00000436714; ENSG00000255398
GeneIDi8843
KEGGihsa:8843
UCSCiuc001ucy.4 human

Organism-specific databases

CTDi8843
DisGeNETi8843
EuPathDBiHostDB:ENSG00000255398.2
GeneCardsiHCAR3
H-InvDBiHIX0036803
HGNCiHGNC:16824 HCAR3
HPAiHPA028660
MIMi606039 gene
neXtProtiNX_P49019
OpenTargetsiENSG00000255398
PharmGKBiPA165512827
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00510000046798
HOVERGENiHBG051680
InParanoidiP49019
KOiK08402
OMAiKWDWKFG
OrthoDBiEOG091G0AN6
PhylomeDBiP49019
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GenomeRNAii8843
PROiPR:P49019
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255398 Expressed in 62 organ(s), highest expression level in blood
CleanExiHS_GPR109B
GenevisibleiP49019 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028017 HCAR2/3_rcpt
PANTHERiPTHR24231:SF0 PTHR24231:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHCAR3_HUMAN
AccessioniPrimary (citable) accession number: P49019
Secondary accession number(s): A8K4G5
, B2R830, E9PI97, Q8NGE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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