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Entry version 167 (31 Jul 2019)
Sequence version 3 (26 Jun 2013)
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Protein

Hydroxycarboxylic acid receptor 3

Gene

HCAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 3
Alternative name(s):
G-protein coupled receptor 109B
G-protein coupled receptor HM74
G-protein coupled receptor HM74B
Niacin receptor 2
Nicotinic acid receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCAR3
Synonyms:GPR109B, HCA3, HM74B, NIACR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16824 HCAR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606039 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P49019

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 50Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini51 – 63CytoplasmicSequence analysisAdd BLAST13
Transmembranei64 – 85Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini86 – 102ExtracellularSequence analysisAdd BLAST17
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 194ExtracellularSequence analysisAdd BLAST31
Transmembranei195 – 209Helical; Name=5Sequence analysisAdd BLAST15
Topological domaini210 – 236CytoplasmicSequence analysisAdd BLAST27
Transmembranei237 – 256Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini257 – 273ExtracellularSequence analysisAdd BLAST17
Transmembranei274 – 298Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini299 – 387CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111R → A: Abrogates completely the activation by OH-octanoid acid. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8843

Open Targets

More...
OpenTargetsi
ENSG00000255398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165512827

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4421

Drug and drug target database

More...
DrugBanki
DB00627 Niacin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
313

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HCAR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
519668680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696041 – 387Hydroxycarboxylic acid receptor 3Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P49019

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P49019

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P49019

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P49019

PeptideAtlas

More...
PeptideAtlasi
P49019

PRoteomics IDEntifications database

More...
PRIDEi
P49019

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20737
55956

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P49019

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P49019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression largely restricted to adipose tissue and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255398 Expressed in 62 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P49019 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028660

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P49019, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000436714

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P49019

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P49019

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKI5 Eukaryota
ENOG4110VUM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182614

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P49019

KEGG Orthology (KO)

More...
KOi
K08402

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWDWKFG

Database of Orthologous Groups

More...
OrthoDBi
692811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P49019

TreeFam database of animal gene trees

More...
TreeFami
TF330775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028017 HCAR2/3_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR46048:SF5 PTHR46048:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P49019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRHHLQDHF LEIDKKNCCV FRDDFIAKVL PPVLGLEFIF GLLGNGLALW
60 70 80 90 100
IFCFHLKSWK SSRIFLFNLA VADFLLIICL PFVMDYYVRR SDWKFGDIPC
110 120 130 140 150
RLVLFMFAMN RQGSIIFLTV VAVDRYFRVV HPHHALNKIS NWTAAIISCL
160 170 180 190 200
LWGITVGLTV HLLKKKLLIQ NGTANVCISF SICHTFRWHE AMFLLEFFLP
210 220 230 240 250
LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF VICFLPSVVV
260 270 280 290 300
RIHIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS
310 320 330 340 350
FPNFFSTLIN RCLQRKITGE PDNNRSTSVE LTGDPNKTRG APEALIANSG
360 370 380
EPWSPSYLGP TSNNHSKKGH CHQEPASLEK QLGCCIE
Length:387
Mass (Da):44,478
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i887BA427B6134A3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94K → N in BAA01721 (PubMed:7505609).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038715173T → P4 PublicationsCorresponds to variant dbSNP:rs1798192Ensembl.1
Natural variantiVAR_038716198F → L4 PublicationsCorresponds to variant dbSNP:rs17884481Ensembl.1
Natural variantiVAR_038717253H → R4 PublicationsCorresponds to variant dbSNP:rs118091133Ensembl.1
Natural variantiVAR_038718317I → M4 PublicationsCorresponds to variant dbSNP:rs116821988Ensembl.1
Natural variantiVAR_038719346I → M4 PublicationsCorresponds to variant dbSNP:rs1696351Ensembl.1
Natural variantiVAR_038720350G → S. Corresponds to variant dbSNP:rs201835480Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D10923 mRNA Translation: BAA01721.1
AB065865 Genomic DNA Translation: BAC06083.1
AK290930 mRNA Translation: BAF83619.1
AK313212 mRNA Translation: BAG36027.1
EU293604 Genomic DNA Translation: ABX64359.1
AC026333 Genomic DNA No translation available.
BC047891 mRNA Translation: AAH47891.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53842.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I69202

NCBI Reference Sequences

More...
RefSeqi
NP_006009.2, NM_006018.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000528880; ENSP00000436714; ENSG00000255398

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8843

UCSC genome browser

More...
UCSCi
uc001ucy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10923 mRNA Translation: BAA01721.1
AB065865 Genomic DNA Translation: BAC06083.1
AK290930 mRNA Translation: BAF83619.1
AK313212 mRNA Translation: BAG36027.1
EU293604 Genomic DNA Translation: ABX64359.1
AC026333 Genomic DNA No translation available.
BC047891 mRNA Translation: AAH47891.1
CCDSiCCDS53842.1
PIRiI69202
RefSeqiNP_006009.2, NM_006018.2

3D structure databases

SMRiP49019
ModBaseiSearch...

Protein-protein interaction databases

IntActiP49019, 1 interactor
STRINGi9606.ENSP00000436714

Chemistry databases

BindingDBiP49019
ChEMBLiCHEMBL4421
DrugBankiDB00627 Niacin
GuidetoPHARMACOLOGYi313

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP49019
PhosphoSitePlusiP49019

Polymorphism and mutation databases

BioMutaiHCAR3
DMDMi519668680

Proteomic databases

EPDiP49019
jPOSTiP49019
MaxQBiP49019
PaxDbiP49019
PeptideAtlasiP49019
PRIDEiP49019
ProteomicsDBi20737
55956

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8843
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528880; ENSP00000436714; ENSG00000255398
GeneIDi8843
KEGGihsa:8843
UCSCiuc001ucy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8843
DisGeNETi8843

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HCAR3
HGNCiHGNC:16824 HCAR3
HPAiHPA028660
MIMi606039 gene
neXtProtiNX_P49019
OpenTargetsiENSG00000255398
PharmGKBiPA165512827

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00950000182614
InParanoidiP49019
KOiK08402
OMAiKWDWKFG
OrthoDBi692811at2759
PhylomeDBiP49019
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8843

Protein Ontology

More...
PROi
PR:P49019

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000255398 Expressed in 62 organ(s), highest expression level in blood
GenevisibleiP49019 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028017 HCAR2/3_rcpt
PANTHERiPTHR46048:SF5 PTHR46048:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCAR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49019
Secondary accession number(s): A8K4G5
, B2R830, E9PI97, Q8NGE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 26, 2013
Last modified: July 31, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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