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Protein

MARCKS-related protein

Gene

MARCKSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MARCKS-related protein
Alternative name(s):
MARCKS-like protein 1
Macrophage myristoylated alanine-rich C kinase substrate
Short name:
Mac-MARCKS
Short name:
MacMARCKS
Gene namesi
Name:MARCKSL1
Synonyms:MLP, MRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175130.6
HGNCiHGNC:7142 MARCKSL1
MIMi602940 gene
neXtProtiNX_P49006

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi65108
OpenTargetsiENSG00000175130
PharmGKBiPA30857

Polymorphism and mutation databases

BioMutaiMARCKSL1
DMDMi1346576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001571522 – 195MARCKS-related proteinAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei14PhosphothreonineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei48PhosphoserineBy similarity1
Modified residuei71PhosphoserineCombined sources1
Modified residuei85PhosphothreonineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei119PhosphoserineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei135PhosphoserineBy similarity1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei162PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei178PhosphothreonineCombined sources1
Modified residuei187PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP49006
MaxQBiP49006
PaxDbiP49006
PeptideAtlasiP49006
PRIDEiP49006
ProteomicsDBi55955
TopDownProteomicsiP49006

PTM databases

iPTMnetiP49006
PhosphoSitePlusiP49006
SwissPalmiP49006

Miscellaneous databases

PMAP-CutDBiP49006

Expressioni

Gene expression databases

BgeeiENSG00000175130 Expressed in 233 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_MARCKSL1
GenevisibleiP49006 HS

Organism-specific databases

HPAiCAB020787
HPA030528

Interactioni

Subunit structurei

Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LOXL2Q9Y4K04EBI-4289961,EBI-7172227

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122395, 43 interactors
IntActiP49006, 14 interactors
MINTiP49006
STRINGi9606.ENSP00000362638

Structurei

3D structure databases

ProteinModelPortaliP49006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 110Effector domain involved in lipid-binding and calmodulin-bindingBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 91Poly-Lys5

Sequence similaritiesi

Belongs to the MARCKS family.Curated

Phylogenomic databases

eggNOGiENOG410IDYZ Eukaryota
ENOG410Z8K4 LUCA
GeneTreeiENSGT00730000111349
HOGENOMiHOG000059262
HOVERGENiHBG003515
InParanoidiP49006
KOiK13536
OMAiEIGACGE
OrthoDBiEOG091G0ULD
PhylomeDBiP49006
TreeFamiTF332815

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 2 hits
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49006-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVKSNGDL SPKGEGESPP
60 70 80 90 100
VNGTDEAAGA TGDAIEPAPP SQGAEAKGEV PPKETPKKKK KFSFKKPFKL
110 120 130 140 150
SGLSFKRNRK EGGGDSSASS PTEEEQEQGE IGACSDEGTA QEGKAAATPE
160 170 180 190
SQEPQAKGAE ASAASEEEAG PQATEPSTPS GPESGPTPAS AEQNE
Length:195
Mass (Da):19,529
Last modified:January 23, 2007 - v2
Checksum:i8B997FAA8D20E34B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70P → T in AAH66915 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70326 mRNA Translation: CAA49793.1
AL109945 Genomic DNA No translation available.
AY293577 Genomic DNA Translation: AAP37955.1
AL713653 mRNA Translation: CAD28462.1
CH471059 Genomic DNA Translation: EAX07538.1
CH471059 Genomic DNA Translation: EAX07539.1
BC007904 mRNA Translation: AAH07904.1
BC066915 mRNA Translation: AAH66915.1
CCDSiCCDS361.1
PIRiS31861
RefSeqiNP_075385.1, NM_023009.6
UniGeneiHs.75061

Genome annotation databases

EnsembliENST00000329421; ENSP00000362638; ENSG00000175130
GeneIDi65108
KEGGihsa:65108
UCSCiuc001bvd.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70326 mRNA Translation: CAA49793.1
AL109945 Genomic DNA No translation available.
AY293577 Genomic DNA Translation: AAP37955.1
AL713653 mRNA Translation: CAD28462.1
CH471059 Genomic DNA Translation: EAX07538.1
CH471059 Genomic DNA Translation: EAX07539.1
BC007904 mRNA Translation: AAH07904.1
BC066915 mRNA Translation: AAH66915.1
CCDSiCCDS361.1
PIRiS31861
RefSeqiNP_075385.1, NM_023009.6
UniGeneiHs.75061

3D structure databases

ProteinModelPortaliP49006
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122395, 43 interactors
IntActiP49006, 14 interactors
MINTiP49006
STRINGi9606.ENSP00000362638

PTM databases

iPTMnetiP49006
PhosphoSitePlusiP49006
SwissPalmiP49006

Polymorphism and mutation databases

BioMutaiMARCKSL1
DMDMi1346576

Proteomic databases

EPDiP49006
MaxQBiP49006
PaxDbiP49006
PeptideAtlasiP49006
PRIDEiP49006
ProteomicsDBi55955
TopDownProteomicsiP49006

Protocols and materials databases

DNASUi65108
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329421; ENSP00000362638; ENSG00000175130
GeneIDi65108
KEGGihsa:65108
UCSCiuc001bvd.5 human

Organism-specific databases

CTDi65108
DisGeNETi65108
EuPathDBiHostDB:ENSG00000175130.6
GeneCardsiMARCKSL1
HGNCiHGNC:7142 MARCKSL1
HPAiCAB020787
HPA030528
MIMi602940 gene
neXtProtiNX_P49006
OpenTargetsiENSG00000175130
PharmGKBiPA30857
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYZ Eukaryota
ENOG410Z8K4 LUCA
GeneTreeiENSGT00730000111349
HOGENOMiHOG000059262
HOVERGENiHBG003515
InParanoidiP49006
KOiK13536
OMAiEIGACGE
OrthoDBiEOG091G0ULD
PhylomeDBiP49006
TreeFamiTF332815

Miscellaneous databases

ChiTaRSiMARCKSL1 human
GeneWikiiMARCKSL1
GenomeRNAii65108
PMAP-CutDBiP49006
PROiPR:P49006
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175130 Expressed in 233 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_MARCKSL1
GenevisibleiP49006 HS

Family and domain databases

InterProiView protein in InterPro
IPR002101 MARCKS
PANTHERiPTHR14353 PTHR14353, 1 hit
PfamiView protein in Pfam
PF02063 MARCKS, 2 hits
PRINTSiPR00963 MARCKS
PROSITEiView protein in PROSITE
PS00826 MARCKS_1, 1 hit
PS00827 MARCKS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRP_HUMAN
AccessioniPrimary (citable) accession number: P49006
Secondary accession number(s): D3DPQ0, Q5TEE6, Q6NXS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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