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UniProtKB - P49005 (DPOD2_HUMAN)

Entry version 197 (25 May 2022)
Sequence version 1 (01 Feb 1996)
Previous versions | rss
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Protein

DNA polymerase delta subunit 2

Gene

POLD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:22801543, PubMed:17317665, PubMed:24449906).

As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200).

Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433).

Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200).

Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374).

Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611).

Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906).

Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA excision, DNA repair, DNA replication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P49005

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-174411, Polymerase switching on the C-strand of the telomere
R-HSA-174414, Processive synthesis on the C-strand of the telomere
R-HSA-174417, Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174437, Removal of the Flap Intermediate from the C-strand
R-HSA-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5656169, Termination of translesion DNA synthesis
R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400, Dual Incision in GG-NER
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-69091, Polymerase switching
R-HSA-69166, Removal of the Flap Intermediate
R-HSA-69183, Processive synthesis on the lagging strand

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P49005

SIGNOR Signaling Network Open Resource

More...SIGNORi		P49005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase delta subunit 2
Alternative name(s):
DNA polymerase delta subunit p50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9176, POLD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600815, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P49005

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106628

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi217L → W: Loss of POLD3-binding in a yeast two-hybrid assay. 1 Publication1
Mutagenesisi224G → W: Loss of POLD3-binding in a yeast two-hybrid assay. 1 Publication1
Mutagenesisi231E → W: Loss of POLD3-binding in a yeast two-hybrid assay. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5425

Open Targets

More...OpenTargetsi		ENSG00000106628

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33497

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P49005, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363042

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1352307

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000961661 – 469DNA polymerase delta subunit 2Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P49005

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P49005

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P49005

MaxQB - The MaxQuant DataBase

More...MaxQBi		P49005

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P49005

PeptideAtlas

More...PeptideAtlasi		P49005

PRoteomics IDEntifications database

More...PRIDEi		P49005

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55954

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P49005, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P49005

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P49005

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is cell cycle-dependent, with highest levels in G2/M phase and lowest in S.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106628, Expressed in heart left ventricle and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P49005, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P49005, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106628, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of both the DNA polymerase delta and DNA polymerase zeta complexes (PubMed:22801543, PubMed:17317665, PubMed:24449906).

Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3' to 5' proofreading exonuclease activities (PubMed:22801543, PubMed:17317665). Within Pol-delta4, directly interacts with POLD1, POLD3 and POLD4 (PubMed:11328591, PubMed:16510448). Following stress caused by DNA damaging agents or by replication stress, POLD4 is degraded and Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3), which consists of POLD1, POLD2 and POLD3. Pol-delta3 is the major form occurring at S phase replication sites, as well as DNA damage sites (PubMed:22801543, PubMed:17317665). Also observed as a dimeric complex with POLD2 (Pol-delta2 complex). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold (PubMed:12403614). Contrary to the other components of Pol-delta4, does not directly interact with PCNA (PubMed:12403614, PubMed:16510448). As POLD1 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity (PubMed:15670210). Directly interacts with POLDIP2 and POLDIP3 (PubMed:12522211). Directly interacts with KCTD13/PDIP1; in the presence of PCNA, this interaction may stimulate DNA polymerase activity (PubMed:11593007).

Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3, with REV3L bearing DNA polymerase catalytic activity (PubMed:24449906).

Interacts with KCTD10 (By similarity).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111421, 55 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2097, DNA polymerase delta complex
CPX-994, DNA polymerase zeta complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P49005

Protein interaction database and analysis system

More...IntActi		P49005, 28 interactors

Molecular INTeraction database

More...MINTi		P49005

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480186

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P49005, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P49005

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P49005

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P49005

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase delta/II small subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2732, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021763_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P49005

Identification of Orthologs from Complete Genome Data

More...OMAi		DPANFML

Database of Orthologous Groups

More...OrthoDBi		736068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P49005

TreeFam database of animal gene trees

More...TreeFami		TF101073

Family and domain databases

Conserved Domains Database

More...CDDi		cd07387, MPP_PolD2_C, 1 hit

Database of protein disorder

More...DisProti		DP01807

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00051

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007185, DNA_pol_a/d/e_bsu
IPR040663, DNA_pol_D_N
IPR024826, DNA_pol_delta/II_ssu
IPR041863, PolD2_C

The PANTHER Classification System

More...PANTHERi		PTHR10416, PTHR10416, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18018, DNA_pol_D_N, 1 hit
PF04042, DNA_pol_E_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P49005-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSEQAAQRA HTLLSPPSAN NATFARVPVA TYTNSSQPFR LGERSFSRQY 
        60         70         80         90        100
AHIYATRLIQ MRPFLENRAQ QHWGSGVGVK KLCELQPEEK CCVVGTLFKA 
       110        120        130        140        150
MPLQPSILRE VSEEHNLLPQ PPRSKYIHPD DELVLEDELQ RIKLKGTIDV 
       160        170        180        190        200
SKLVTGTVLA VFGSVRDDGK FLVEDYCFAD LAPQKPAPPL DTDRFVLLVS 
       210        220        230        240        250
GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR VILAGNLLSH 
       260        270        280        290        300
STQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD 
       310        320        330        340        350
PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS 
       360        370        380        390        400
DIFRYSSMED HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH 
       410        420        430        440        450
VYFCGNTPSF GSKIIRGPED QTVLLVTVPD FSATQTACLV NLRSLACQPI 
       460 
SFSGFGAEDD DLGGLGLGP
Length:469
Mass (Da):51,289
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i389EF730999755AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWF6A0A087WWF6_HUMAN
DNA polymerase delta subunit 2
POLD2
504Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8R3F8W8R3_HUMAN
DNA polymerase delta subunit 2
POLD2
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHC7C9JHC7_HUMAN
DNA polymerase delta subunit 2
POLD2
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1B3H7C1B3_HUMAN
DNA polymerase delta subunit 2
POLD2
83Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLE1C9JLE1_HUMAN
DNA polymerase delta subunit 2
POLD2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8Z7C9J8Z7_HUMAN
DNA polymerase delta subunit 2
POLD2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZD2C9IZD2_HUMAN
DNA polymerase delta subunit 2
POLD2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271A → T in BAG35221 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014885303N → S1 PublicationCorresponds to variant dbSNP:rs3087366Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U21090 mRNA Translation: AAC50216.1
AF239710 Genomic DNA Translation: AAG09763.1
AY116646 Genomic DNA Translation: AAM51148.1
AK292347 mRNA Translation: BAF85036.1
AK312294 mRNA Translation: BAG35221.1
CH236960 Genomic DNA Translation: EAL23767.1
CH471128 Genomic DNA Translation: EAW61118.1
BC000459 mRNA Translation: AAH00459.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5477.1
CCDS75586.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38950

NCBI Reference Sequences

More...RefSeqi		NP_001120690.1, NM_001127218.2
NP_001243808.1, NM_001256879.1
NP_006221.2, NM_006230.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000406581.6; ENSP00000386105.2; ENSG00000106628.12
ENST00000452185.5; ENSP00000395231.1; ENSG00000106628.12
ENST00000610533.6; ENSP00000480186.2; ENSG00000106628.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5425

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5425

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000610533.6; ENSP00000480186.2; NM_006230.4; NP_006221.3

UCSC genome browser

More...UCSCi		uc010kxz.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21090 mRNA Translation: AAC50216.1
AF239710 Genomic DNA Translation: AAG09763.1
AY116646 Genomic DNA Translation: AAM51148.1
AK292347 mRNA Translation: BAF85036.1
AK312294 mRNA Translation: BAG35221.1
CH236960 Genomic DNA Translation: EAL23767.1
CH471128 Genomic DNA Translation: EAW61118.1
BC000459 mRNA Translation: AAH00459.1
CCDSiCCDS5477.1
CCDS75586.1
PIRiI38950
RefSeqiNP_001120690.1, NM_001127218.2
NP_001243808.1, NM_001256879.1
NP_006221.2, NM_006230.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E0JX-ray3.00A/C/E/G1-469[»]
6S1Melectron microscopy4.27B1-469[»]
6S1Nelectron microscopy4.86B1-469[»]
6S1Oelectron microscopy8.10B1-469[»]
6TNYelectron microscopy3.08B1-469[»]
6TNZelectron microscopy4.05B1-469[»]
AlphaFoldDBiP49005
SMRiP49005
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111421, 55 interactors
ComplexPortaliCPX-2097, DNA polymerase delta complex
CPX-994, DNA polymerase zeta complex
CORUMiP49005
IntActiP49005, 28 interactors
MINTiP49005
STRINGi9606.ENSP00000480186

Chemistry databases

ChEMBLiCHEMBL2363042

PTM databases

GlyGeniP49005, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP49005
PhosphoSitePlusiP49005

Genetic variation databases

BioMutaiPOLD2
DMDMi1352307

Proteomic databases

EPDiP49005
jPOSTiP49005
MassIVEiP49005
MaxQBiP49005
PaxDbiP49005
PeptideAtlasiP49005
PRIDEiP49005
ProteomicsDBi55954

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13259, 211 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		5425

Genome annotation databases

EnsembliENST00000406581.6; ENSP00000386105.2; ENSG00000106628.12
ENST00000452185.5; ENSP00000395231.1; ENSG00000106628.12
ENST00000610533.6; ENSP00000480186.2; ENSG00000106628.12
GeneIDi5425
KEGGihsa:5425
MANE-SelectiENST00000610533.6; ENSP00000480186.2; NM_006230.4; NP_006221.3
UCSCiuc010kxz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5425
DisGeNETi5425

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLD2
HGNCiHGNC:9176, POLD2
HPAiENSG00000106628, Low tissue specificity
MIMi600815, gene
neXtProtiNX_P49005
OpenTargetsiENSG00000106628
PharmGKBiPA33497
VEuPathDBiHostDB:ENSG00000106628

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2732, Eukaryota
GeneTreeiENSGT00390000006780
HOGENOMiCLU_021763_0_0_1
InParanoidiP49005
OMAiDPANFML
OrthoDBi736068at2759
PhylomeDBiP49005
TreeFamiTF101073

Enzyme and pathway databases

PathwayCommonsiP49005
ReactomeiR-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-174411, Polymerase switching on the C-strand of the telomere
R-HSA-174414, Processive synthesis on the C-strand of the telomere
R-HSA-174417, Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174437, Removal of the Flap Intermediate from the C-strand
R-HSA-5358565, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5656169, Termination of translesion DNA synthesis
R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400, Dual Incision in GG-NER
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-69091, Polymerase switching
R-HSA-69166, Removal of the Flap Intermediate
R-HSA-69183, Processive synthesis on the lagging strand
SignaLinkiP49005
SIGNORiP49005

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5425, 739 hits in 1085 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLD2, human
EvolutionaryTraceiP49005

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POLD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5425
PharosiP49005, Tbio

Protein Ontology

More...PROi		PR:P49005
RNActiP49005, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106628, Expressed in heart left ventricle and 244 other tissues
ExpressionAtlasiP49005, baseline and differential
GenevisibleiP49005, HS

Family and domain databases

CDDicd07387, MPP_PolD2_C, 1 hit
DisProtiDP01807
IDEALiIID00051
InterProiView protein in InterPro
IPR007185, DNA_pol_a/d/e_bsu
IPR040663, DNA_pol_D_N
IPR024826, DNA_pol_delta/II_ssu
IPR041863, PolD2_C
PANTHERiPTHR10416, PTHR10416, 1 hit
PfamiView protein in Pfam
PF18018, DNA_pol_D_N, 1 hit
PF04042, DNA_pol_E_B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P49005
Secondary accession number(s): A4D2J4, B2R5S4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 25, 2022
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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