UniProtKB - P49000 (MIS_RAT)
Protein
Muellerian-inhibiting factor
Gene
Amh
Organism
Rattus norvegicus (Rat)
Status
Functioni
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: RGD
- transforming growth factor beta receptor binding Source: MGI
GO - Biological processi
- aging Source: RGD
- gonadal mesoderm development Source: UniProtKB-KW
- Mullerian duct regression Source: RGD
- negative regulation of ovarian follicle development Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of NF-kappaB transcription factor activity Source: RGD
- preantral ovarian follicle growth Source: RGD
- response to drug Source: RGD
- response to organic cyclic compound Source: RGD
- urogenital system development Source: MGI
Keywordsi
Molecular function | Growth factor |
Biological process | Differentiation, Gonadal differentiation |
Enzyme and pathway databases
Reactomei | R-RNO-201451, Signaling by BMP |
Names & Taxonomyi
Protein namesi | Recommended name: Muellerian-inhibiting factorAlternative name(s): Anti-Muellerian hormone Short name: AMH Muellerian-inhibiting substance Short name: MIS |
Gene namesi | Name:Amh |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2108, Amh |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000033752 | 22 – ? | Sequence analysis | ||
ChainiPRO_0000033753 | ? – 553 | Muellerian-inhibiting factor |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 409 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 455 ↔ 519 | By similarity | ||
Disulfide bondi | 481 ↔ 550 | By similarity | ||
Disulfide bondi | 485 ↔ 552 | By similarity | ||
Disulfide bondi | 518 | InterchainBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P49000 |
PRIDEi | P49000 |
PTM databases
CarbonylDBi | P49000 |
GlyGeni | P49000, 2 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000019377, Expressed in female gonad and 16 other tissues |
Genevisiblei | P49000, RN |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: RGD
- transforming growth factor beta receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026220 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00390000006337 |
HOGENOMi | CLU_025681_1_0_1 |
InParanoidi | P49000 |
OMAi | DPAPLHD |
OrthoDBi | 516965at2759 |
PhylomeDBi | P49000 |
TreeFami | TF335595 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006799, AMH_N IPR029034, Cystine-knot_cytokine IPR021203, Muellerian-inhibiting_factor IPR001839, TGF-b_C IPR017948, TGFb_CS |
PANTHERi | PTHR15009, PTHR15009, 1 hit |
Pfami | View protein in Pfam PF04709, AMH_N, 1 hit PF00019, TGF_beta, 1 hit |
PIRSFi | PIRSF037270, Muellerian-inhibiting_factor, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P49000-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQGPHLSLLL LLLATMGAVL QADTVEELTN TRGLIFLEDG VWPPSSPPEP
60 70 80 90 100
LCLVAVRGEG DTSKASLTVV GGLHSYEHAF LEAVQESRWG PQDLATFGVC
110 120 130 140 150
STDSQTTLPA LQRLGAWLGE TGEQQLLVLH LAEVIWEPQL LLKFQEPPPG
160 170 180 190 200
GASRWEQALL VLYPGPGPQV TVTGAGLQGT QSLCPTRDTR YLVLTVHFPA
210 220 230 240 250
GAWSGSGLAL TLQPSKEGAT LTIAQLQAFL FGSDSRCFTR MTPTLVLLPP
260 270 280 290 300
TGPTPQPAHG QLDTVPFPQP GLSLEPEDLP HSADPFLETL TRLVRALRGP
310 320 330 340 350
LTRASNTRLA LDPGALASFP QGLVNLSDPV ALGRLLDGEE PLLLLLSPAA
360 370 380 390 400
ATVGEPMRLH SPTSAPWAAG LARRVAVELQ AAASELRDLP GLPPTAPPLL
410 420 430 440 450
SRLLALCPND SRSAGDPLRA LLLLKALQGL RAEWRGREGR GRAGRSKGTG
460 470 480 490 500
TDGLCALREL SVDLRAERSV LIPETYQANN CQGACAWPQS DRNPRYGNHV
510 520 530 540 550
VLLLKMQARG AALGRLPCCV PTAYTGKLLI SLSEEHISAH HVPNMVATEC
GCR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S98336 Genomic DNA Translation: AAB22104.1 |
PIRi | A42499 |
RefSeqi | NP_037034.1, NM_012902.1 |
Genome annotation databases
Ensembli | ENSRNOT00000026220; ENSRNOP00000026220; ENSRNOG00000019377 |
GeneIDi | 25378 |
KEGGi | rno:25378 |
UCSCi | RGD:2108, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S98336 Genomic DNA Translation: AAB22104.1 |
PIRi | A42499 |
RefSeqi | NP_037034.1, NM_012902.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026220 |
PTM databases
CarbonylDBi | P49000 |
GlyGeni | P49000, 2 sites |
Proteomic databases
PaxDbi | P49000 |
PRIDEi | P49000 |
Genome annotation databases
Ensembli | ENSRNOT00000026220; ENSRNOP00000026220; ENSRNOG00000019377 |
GeneIDi | 25378 |
KEGGi | rno:25378 |
UCSCi | RGD:2108, rat |
Organism-specific databases
CTDi | 268 |
RGDi | 2108, Amh |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00390000006337 |
HOGENOMi | CLU_025681_1_0_1 |
InParanoidi | P49000 |
OMAi | DPAPLHD |
OrthoDBi | 516965at2759 |
PhylomeDBi | P49000 |
TreeFami | TF335595 |
Enzyme and pathway databases
Reactomei | R-RNO-201451, Signaling by BMP |
Miscellaneous databases
PROi | PR:P49000 |
Gene expression databases
Bgeei | ENSRNOG00000019377, Expressed in female gonad and 16 other tissues |
Genevisiblei | P49000, RN |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006799, AMH_N IPR029034, Cystine-knot_cytokine IPR021203, Muellerian-inhibiting_factor IPR001839, TGF-b_C IPR017948, TGFb_CS |
PANTHERi | PTHR15009, PTHR15009, 1 hit |
Pfami | View protein in Pfam PF04709, AMH_N, 1 hit PF00019, TGF_beta, 1 hit |
PIRSFi | PIRSF037270, Muellerian-inhibiting_factor, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MIS_RAT | |
Accessioni | P49000Primary (citable) accession number: P49000 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families