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Entry version 170 (13 Feb 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Short transient receptor potential channel 1

Gene

TRPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel activity Source: Reactome
  • cation channel activity Source: Reactome
  • inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.1.3 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPC1
Synonyms:TRP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144935.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12333 TRPC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602343 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48995

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 386CytoplasmicSequence analysisAdd BLAST386
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 415ExtracellularSequence analysis8
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 457CytoplasmicSequence analysisAdd BLAST21
Transmembranei458 – 475HelicalSequence analysisAdd BLAST18
Topological domaini476 – 539ExtracellularSequence analysisAdd BLAST64
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Topological domaini561 – 586CytoplasmicSequence analysisAdd BLAST26
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 616ExtracellularSequence analysis9
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7220

Open Targets

More...
OpenTargetsi
ENSG00000144935

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA357

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
486

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351302

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153031 – 793Short transient receptor potential channel 1Add BLAST793

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P48995

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P48995

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48995

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48995

PeptideAtlas

More...
PeptideAtlasi
P48995

PRoteomics IDEntifications database

More...
PRIDEi
P48995

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55952
55953 [P48995-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48995

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P48995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seems to be ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144935 Expressed in 213 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48995 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48995 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009387
HPA021130

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113071, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P48995

Database of interacting proteins

More...
DIPi
DIP-35698N

Protein interaction database and analysis system

More...
IntActi
P48995, 43 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273482

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P48995

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 75ANK 1Add BLAST30
Repeati83 – 111ANK 2Add BLAST29
Repeati112 – 138ANK 3Add BLAST27
Repeati158 – 187ANK 4Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3609 Eukaryota
ENOG410XQ0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020589

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG068337

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48995

KEGG Orthology (KO)

More...
KOi
K04964

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKTICYL

Database of Orthologous Groups

More...
OrthoDBi
1409318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48995

TreeFam database of animal gene trees

More...
TreeFami
TF313147

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: P48995-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,212
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4CC57ADDFA320AE
GO
Isoform Short (identifier: P48995-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,617
Checksum:iC67F2053F8574122
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C508H7C508_HUMAN
Short transient receptor potential ...
TRPC1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006560110 – 143Missing in isoform Short. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31110 mRNA Translation: AAA93251.1
U31110 mRNA Translation: AAA93252.1
X89066 mRNA Translation: CAA61447.1
Z73903 mRNA Translation: CAA98108.1
CH471052 Genomic DNA Translation: EAW78963.1
BC112338 mRNA Translation: AAI12339.1
BC113953 mRNA Translation: AAI13954.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3126.1 [P48995-2]
CCDS58856.1 [P48995-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68238

NCBI Reference Sequences

More...
RefSeqi
NP_001238774.1, NM_001251845.1 [P48995-1]
NP_003295.1, NM_003304.4 [P48995-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.250687
Hs.684389

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273482; ENSP00000273482; ENSG00000144935 [P48995-2]
ENST00000476941; ENSP00000419313; ENSG00000144935 [P48995-1]
ENST00000612385; ENSP00000481537; ENSG00000144935 [P48995-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7220

UCSC genome browser

More...
UCSCi
uc003evb.4 human [P48995-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31110 mRNA Translation: AAA93251.1
U31110 mRNA Translation: AAA93252.1
X89066 mRNA Translation: CAA61447.1
Z73903 mRNA Translation: CAA98108.1
CH471052 Genomic DNA Translation: EAW78963.1
BC112338 mRNA Translation: AAI12339.1
BC113953 mRNA Translation: AAI13954.1
CCDSiCCDS3126.1 [P48995-2]
CCDS58856.1 [P48995-1]
PIRiS68238
RefSeqiNP_001238774.1, NM_001251845.1 [P48995-1]
NP_003295.1, NM_003304.4 [P48995-2]
UniGeneiHs.250687
Hs.684389

3D structure databases

ProteinModelPortaliP48995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113071, 16 interactors
CORUMiP48995
DIPiDIP-35698N
IntActiP48995, 43 interactors
STRINGi9606.ENSP00000273482

Chemistry databases

GuidetoPHARMACOLOGYi486

Protein family/group databases

TCDBi1.A.4.1.3 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiP48995
PhosphoSitePlusiP48995
SwissPalmiP48995

Polymorphism and mutation databases

BioMutaiTRPC1
DMDMi1351302

Proteomic databases

EPDiP48995
jPOSTiP48995
MaxQBiP48995
PaxDbiP48995
PeptideAtlasiP48995
PRIDEiP48995
ProteomicsDBi55952
55953 [P48995-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273482; ENSP00000273482; ENSG00000144935 [P48995-2]
ENST00000476941; ENSP00000419313; ENSG00000144935 [P48995-1]
ENST00000612385; ENSP00000481537; ENSG00000144935 [P48995-2]
GeneIDi7220
KEGGihsa:7220
UCSCiuc003evb.4 human [P48995-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7220
DisGeNETi7220
EuPathDBiHostDB:ENSG00000144935.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TRPC1
HGNCiHGNC:12333 TRPC1
HPAiCAB009387
HPA021130
MIMi602343 gene
neXtProtiNX_P48995
OpenTargetsiENSG00000144935
PharmGKBiPA357

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00940000153138
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiP48995
KOiK04964
OMAiPKTICYL
OrthoDBi1409318at2759
PhylomeDBiP48995
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRPC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRPC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7220

Protein Ontology

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PROi
PR:P48995

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144935 Expressed in 213 organ(s), highest expression level in brain
ExpressionAtlasiP48995 baseline and differential
GenevisibleiP48995 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48995
Secondary accession number(s): Q14CE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 13, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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