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Protein

Neurogenic differentiation factor 6

Gene

Neurod6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • dentate gyrus development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 6
Short name:
NeuroD6
Alternative name(s):
Helix-loop-helix protein mATH-2
Short name:
mATH2
Protein NEX-1
Protein atonal homolog 2
Gene namesi
Name:Neurod6
Synonyms:Ath2, Atoh2, Nex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106593 Neurod6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273941 – 337Neurogenic differentiation factor 6Add BLAST337

Proteomic databases

PaxDbiP48986
PRIDEiP48986

PTM databases

PhosphoSitePlusiP48986

Expressioni

Tissue specificityi

Specific to the nervous system of both embryos and adults. Highest levels in the cortical plate of the cerebrum.

Gene expression databases

BgeeiENSMUSG00000037984 Expressed in 106 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_NEUROD6
ExpressionAtlasiP48986 baseline and differential
GenevisibleiP48986 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047016

Structurei

3D structure databases

ProteinModelPortaliP48986
SMRiP48986
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 146bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 86Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 63Poly-Glu10

Phylogenomic databases

eggNOGiENOG410IQ4G Eukaryota
ENOG41118Y2 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiP48986
KOiK09080
OMAiGSPHFDG
OrthoDBiEOG091G15AI
PhylomeDBiP48986
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032650 Neurod6
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF9 PTHR19290:SF9, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P48986-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTLPFDESV VMPESQMCRK FARQCEDQKQ IKKPESFPKQ VVLRGKSIKR
60 70 80 90 100
APGEETEKEE EEEDREEEDE NGLSRRRGLR KKKTTKLRLE RVKFRRQEAN
110 120 130 140 150
ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL
160 170 180 190 200
RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT
210 220 230 240 250
RSPYSTFYPP YHSPELATPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE
260 270 280 290 300
CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
310 320 330
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
Length:337
Mass (Da):38,644
Last modified:February 1, 1996 - v1
Checksum:i35C18ACD8EE1EFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44480 Genomic DNA Translation: BAA07923.1
U29086 mRNA Translation: AAC14576.1
CCDSiCCDS20168.1
PIRiI48682
I57038
RefSeqiNP_033847.1, NM_009717.2
UniGeneiMm.5106

Genome annotation databases

EnsembliENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984
GeneIDi11922
KEGGimmu:11922
UCSCiuc009cav.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44480 Genomic DNA Translation: BAA07923.1
U29086 mRNA Translation: AAC14576.1
CCDSiCCDS20168.1
PIRiI48682
I57038
RefSeqiNP_033847.1, NM_009717.2
UniGeneiMm.5106

3D structure databases

ProteinModelPortaliP48986
SMRiP48986
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047016

PTM databases

PhosphoSitePlusiP48986

Proteomic databases

PaxDbiP48986
PRIDEiP48986

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984
GeneIDi11922
KEGGimmu:11922
UCSCiuc009cav.2 mouse

Organism-specific databases

CTDi63974
MGIiMGI:106593 Neurod6

Phylogenomic databases

eggNOGiENOG410IQ4G Eukaryota
ENOG41118Y2 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiP48986
KOiK09080
OMAiGSPHFDG
OrthoDBiEOG091G15AI
PhylomeDBiP48986
TreeFamiTF315153

Miscellaneous databases

PROiPR:P48986
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037984 Expressed in 106 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_NEUROD6
ExpressionAtlasiP48986 baseline and differential
GenevisibleiP48986 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032650 Neurod6
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF9 PTHR19290:SF9, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDF6_MOUSE
AccessioniPrimary (citable) accession number: P48986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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