UniProtKB - P48973 (CXL10_RAT)
Protein
C-X-C motif chemokine 10
Gene
Cxcl10
Organism
Rattus norvegicus (Rat)
Status
Functioni
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292).By similarity2 Publications
GO - Molecular functioni
- chemoattractant activity Source: RGD
- chemokine activity Source: RGD
- CXCR3 chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
- cytokine activity Source: RGD
- heparin binding Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: RGD
- cellular response to heat Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- chemokine-mediated signaling pathway Source: RGD
- chemotaxis Source: UniProtKB
- defense response to virus Source: RGD
- endothelial cell activation Source: RGD
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: RGD
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: RGD
- leukocyte chemotaxis Source: GO_Central
- negative regulation of angiogenesis Source: RGD
- negative regulation of myoblast differentiation Source: RGD
- negative regulation of myoblast fusion Source: RGD
- neutrophil chemotaxis Source: GO_Central
- positive regulation of cell migration Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of leukocyte chemotaxis Source: RGD
- positive regulation of monocyte chemotaxis Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- positive regulation of T cell migration Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of cell population proliferation Source: UniProtKB
- regulation of endothelial tube morphogenesis Source: RGD
- regulation of T cell chemotaxis Source: RGD
- response to auditory stimulus Source: RGD
- response to bacterium Source: RGD
- response to cold Source: RGD
- response to gamma radiation Source: RGD
- response to lipopolysaccharide Source: RGD
- response to virus Source: RGD
- response to vitamin D Source: RGD
- T cell chemotaxis Source: RGD
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 10Alternative name(s): 10 kDa interferon gamma-induced protein Short name: Gamma-IP10 Short name: IP-10 Interferon-inducible protein 10 Protein Mob-1 Small-inducible cytokine B10 |
Gene namesi | Name:Cxcl10 Synonyms:Inp10, Mob1, Scyb10 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620209, Cxcl10 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: RGD
- extracellular space Source: RGD
Plasma Membrane
- external side of plasma membrane Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000005105 | 22 – 98 | C-X-C motif chemokine 10Add BLAST | 77 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | CitrullineBy similarity | 1 | |
Disulfide bondi | 30 ↔ 57 | By similarity | ||
Disulfide bondi | 32 ↔ 74 | By similarity |
Keywords - PTMi
Citrullination, Disulfide bondProteomic databases
PaxDbi | P48973 |
PRIDEi | P48973 |
Expressioni
Tissue specificityi
In the central nervous system, CXCL10 is predominantly localized to activated neurons (PubMed:30448292). Expressed in both microglia and astrocytes (PubMed:30257241).2 Publications
Gene expression databases
Bgeei | ENSRNOG00000022256, Expressed in spleen and 21 other tissues |
Genevisiblei | P48973, RN |
Interactioni
Subunit structurei
Monomer, dimer, and tetramer.
Interacts with CXCR3 (via N-terminus).
By similarityGO - Molecular functioni
- chemoattractant activity Source: RGD
- chemokine activity Source: RGD
- CXCR3 chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
- cytokine activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003649 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000161759 |
HOGENOMi | CLU_143902_2_2_1 |
InParanoidi | P48973 |
OMAi | IRCTCIE |
OrthoDBi | 1548456at2759 |
PhylomeDBi | P48973 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48973-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPSAAVVLC LVLLSLSGTQ GIPLARTVRC TCIDFHEQPL RPRAIGKLEI
60 70 80 90
IPASLSCPHV EIIATMKKNN EKRCLNPESE AIKSLLKAVS QRRSKRAP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | P → T in AAB60485 (PubMed:7809069).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17035 mRNA Translation: AAB60485.1 U22520 mRNA Translation: AAC52811.1 BC058444 mRNA Translation: AAH58444.1 |
RefSeqi | NP_620789.1, NM_139089.1 |
Genome annotation databases
Ensembli | ENSRNOT00000003075; ENSRNOP00000003649; ENSRNOG00000022256 |
GeneIDi | 245920 |
KEGGi | rno:245920 |
UCSCi | RGD:620209, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17035 mRNA Translation: AAB60485.1 U22520 mRNA Translation: AAC52811.1 BC058444 mRNA Translation: AAH58444.1 |
RefSeqi | NP_620789.1, NM_139089.1 |
3D structure databases
SMRi | P48973 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003649 |
Proteomic databases
PaxDbi | P48973 |
PRIDEi | P48973 |
Genome annotation databases
Ensembli | ENSRNOT00000003075; ENSRNOP00000003649; ENSRNOG00000022256 |
GeneIDi | 245920 |
KEGGi | rno:245920 |
UCSCi | RGD:620209, rat |
Organism-specific databases
CTDi | 3627 |
RGDi | 620209, Cxcl10 |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000161759 |
HOGENOMi | CLU_143902_2_2_1 |
InParanoidi | P48973 |
OMAi | IRCTCIE |
OrthoDBi | 1548456at2759 |
PhylomeDBi | P48973 |
TreeFami | TF333433 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P48973 |
Gene expression databases
Bgeei | ENSRNOG00000022256, Expressed in spleen and 21 other tissues |
Genevisiblei | P48973, RN |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL10_RAT | |
Accessioni | P48973Primary (citable) accession number: P48973 Secondary accession number(s): P70538, Q6GTC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families