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Protein

ADP/ATP translocase 1

Gene

Slc25a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart/skeletal muscle isoform T1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
mANC1
Gene namesi
Name:Slc25a4
Synonyms:Anc1, Ant1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1353495 Slc25a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000905752 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei147N6-succinyllysineCombined sources1
Modified residuei149PhosphoserineBy similarity1
Modified residuei150PhosphoserineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineCombined sources1
Modified residuei272N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP48962
MaxQBiP48962
PaxDbiP48962
PeptideAtlasiP48962
PRIDEiP48962
TopDownProteomicsiP48962

PTM databases

iPTMnetiP48962
PhosphoSitePlusiP48962
SwissPalmiP48962

Expressioni

Gene expression databases

BgeeiENSMUSG00000031633 Expressed in 290 organ(s), highest expression level in heart
GenevisibleiP48962 MM

Interactioni

Subunit structurei

Homodimer. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198105, 7 interactors
IntActiP48962, 19 interactors
MINTiP48962
STRINGi10090.ENSMUSP00000034049

Structurei

3D structure databases

ProteinModelPortaliP48962
SMRiP48962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP48962
KOiK05863
OMAiECFKRTA
OrthoDBiEOG091G0ULB
PhylomeDBiP48962
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48962-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGSS
160 170 180 190 200
QREFNGLGDC LTKIFKSDGL KGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTLDCWRK IAKDEGANAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Length:298
Mass (Da):32,904
Last modified:January 23, 2007 - v4
Checksum:i3A849FEAB0981462
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136F → L in AAC52837 (PubMed:8903724).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27315 mRNA Translation: AAC52837.1
X74510 mRNA Translation: CAA52616.1
AF240002 Genomic DNA Translation: AAF64470.1
BC003791 mRNA Translation: AAH03791.1
BC026925 mRNA Translation: AAH26925.1
CCDSiCCDS40333.1
PIRiS37210
RefSeqiNP_031476.3, NM_007450.4
UniGeneiMm.16228

Genome annotation databases

EnsembliENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633
GeneIDi11739
KEGGimmu:11739
UCSCiuc009lpz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27315 mRNA Translation: AAC52837.1
X74510 mRNA Translation: CAA52616.1
AF240002 Genomic DNA Translation: AAF64470.1
BC003791 mRNA Translation: AAH03791.1
BC026925 mRNA Translation: AAH26925.1
CCDSiCCDS40333.1
PIRiS37210
RefSeqiNP_031476.3, NM_007450.4
UniGeneiMm.16228

3D structure databases

ProteinModelPortaliP48962
SMRiP48962
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198105, 7 interactors
IntActiP48962, 19 interactors
MINTiP48962
STRINGi10090.ENSMUSP00000034049

PTM databases

iPTMnetiP48962
PhosphoSitePlusiP48962
SwissPalmiP48962

Proteomic databases

EPDiP48962
MaxQBiP48962
PaxDbiP48962
PeptideAtlasiP48962
PRIDEiP48962
TopDownProteomicsiP48962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633
GeneIDi11739
KEGGimmu:11739
UCSCiuc009lpz.2 mouse

Organism-specific databases

CTDi291
MGIiMGI:1353495 Slc25a4

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP48962
KOiK05863
OMAiECFKRTA
OrthoDBiEOG091G0ULB
PhylomeDBiP48962
TreeFamiTF300743

Enzyme and pathway databases

ReactomeiR-MMU-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRSiSlc25a4 mouse
PROiPR:P48962
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031633 Expressed in 290 organ(s), highest expression level in heart
GenevisibleiP48962 MM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiADT1_MOUSE
AccessioniPrimary (citable) accession number: P48962
Secondary accession number(s): Q62164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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