Slc25a4

Functionⁱ

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	80	ADPBy similarity	1
Binding siteⁱ	92	ADPBy similarity	1
Binding siteⁱ	235	ADPBy similarity	1

GO - Molecular functionⁱ

ATP:ADP antiporter activity Source: GO_Central
enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ADP transport Source: UniProtKB
apoptotic mitochondrial changes
Source: MGI
Inferred from genetic interactionⁱ
- 18350175
negative regulation of cardiac muscle cell apoptotic process Source: MGI
negative regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI
negative regulation of necroptotic process Source: MGI
positive regulation of cell growth involved in cardiac muscle cell development Source: MGI
positive regulation of oxidative phosphorylation uncoupler activity Source: MGI
regulation of mitochondrial membrane permeability Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-422356 Regulation of insulin secretion

Reactomeⁱ

R-MMU-422356 Regulation of insulin secretion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP/ATP translocase 1 Alternative name(s): ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 Adenine nucleotide translocator 1 Short name: ANT 1 Solute carrier family 25 member 4 mANC1
Gene namesⁱ	Name:Slc25a4 Synonyms:Anc1, Ant1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1353495 Slc25a4

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	8 – 37	Helical; Name=1By similarityAdd BLAST	30
Transmembraneⁱ	75 – 99	Helical; Name=2By similarityAdd BLAST	25
Transmembraneⁱ	110 – 130	Helical; Name=3By similarityAdd BLAST	21
Transmembraneⁱ	179 – 199	Helical; Name=4By similarityAdd BLAST	21
Transmembraneⁱ	211 – 231	Helical; Name=5By similarityAdd BLAST	21
Transmembraneⁱ	274 – 291	Helical; Name=6By similarityAdd BLAST	18

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000090575	2 – 298	ADP/ATP translocase 1Add BLAST		297

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineBy similarity	1
Modified residueⁱ	7	PhosphoserineBy similarity	1
Modified residueⁱ	147	N6-succinyllysineCombined sources	1
Modified residueⁱ	149	PhosphoserineBy similarity	1
Modified residueⁱ	150	PhosphoserineBy similarity	1
Modified residueⁱ	160	S-nitrosocysteineBy similarity	1
Modified residueⁱ	245	N6-succinyllysineCombined sources	1
Modified residueⁱ	272	N6-succinyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDⁱ	P48962
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P48962
PaxDbⁱ	P48962
PeptideAtlas More...PeptideAtlasⁱ	P48962
PRIDEⁱ	P48962
TopDownProteomicsⁱ	P48962

PTM databases

iPTMnetⁱ	P48962
PhosphoSitePlusⁱ	P48962
SwissPalmⁱ	P48962

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031633 Expressed in 290 organ(s), highest expression level in heart
Genevisibleⁱ	P48962 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP.1 Publication

GO - Molecular functionⁱ

enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198105, 7 interactors
IntActⁱ	P48962, 19 interactors
Molecular INTeraction database More...MINTⁱ	P48962
STRINGⁱ	10090.ENSMUSP00000034049

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P48962
SMRⁱ	P48962
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 98	Solcar 1Add BLAST	93
Repeatⁱ	111 – 201	Solcar 2Add BLAST	91
Repeatⁱ	212 – 297	Solcar 3Add BLAST	86

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	235 – 240	Important for transport activityBy similarity		6

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	235 – 240	Nucleotide carrier signature motifBy similarity		6

Domainⁱ

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0749 Eukaryota ENOG410XNW0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
HOVERGENⁱ	HBG108348
InParanoidⁱ	P48962
KEGG Orthology (KO) More...KOⁱ	K05863
OMAⁱ	ECFKRTA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ULB
PhylomeDBⁱ	P48962
TreeFamⁱ	TF300743

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P48962-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ 
        60         70         80         90        100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 
       110        120        130        140        150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGSS 
       160        170        180        190        200
QREFNGLGDC LTKIFKSDGL KGLYQGFSVS VQGIIIYRAA YFGVYDTAKG 
       210        220        230        240        250
MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM 
       260        270        280        290 
YTGTLDCWRK IAKDEGANAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV

Length:298

Mass (Da):32,904

Last modified:January 23, 2007 - v4

Checksum:ⁱ3A849FEAB0981462

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	136	F → L in AAC52837 (PubMed:8903724).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27315 mRNA Translation: AAC52837.1 X74510 mRNA Translation: CAA52616.1 AF240002 Genomic DNA Translation: AAF64470.1 BC003791 mRNA Translation: AAH03791.1 BC026925 mRNA Translation: AAH26925.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40333.1
PIRⁱ	S37210
NCBI Reference Sequences More...RefSeqⁱ	NP_031476.3, NM_007450.4
UniGeneⁱ	Mm.16228

Genome annotation databases

Ensemblⁱ	ENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633
GeneIDⁱ	11739
KEGGⁱ	mmu:11739
UCSC genome browser More...UCSCⁱ	uc009lpz.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48962	Putative ADP/ATP translocase (Fragment)		Daphnia magna		153	UniRef100_P48962

Protein	Similar proteins		Species	Score	Length	Source
P48962	ADP/ATP translocase 1		HUMAN		298	UniRef90_P12235
ADP/ATP translocase 1		RAT		298
ADP/ATP translocase 1		RABIT		298
ADP/ATP translocase 1	)	BOVIN		298
SLC25A4 isoform 1		PANTR		298
+119

Protein	Similar proteins		Species	Score	Length	Source
P48962	ADP/ATP translocase 1		HUMAN		298	UniRef50_P12235
ADP/ATP translocase 1		RAT		298
ADP/ATP translocase 1		RABIT		298
ADP/ATP translocase 1	)	BOVIN		298
ADP/ATP translocase 3		PIG		298
+590

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U27315 mRNA Translation: AAC52837.1 X74510 mRNA Translation: CAA52616.1 AF240002 Genomic DNA Translation: AAF64470.1 BC003791 mRNA Translation: AAH03791.1 BC026925 mRNA Translation: AAH26925.1
CCDSⁱ	CCDS40333.1
PIRⁱ	S37210
RefSeqⁱ	NP_031476.3, NM_007450.4
UniGeneⁱ	Mm.16228

3D structure databases

ProteinModelPortalⁱ	P48962
SMRⁱ	P48962
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198105, 7 interactors
IntActⁱ	P48962, 19 interactors
MINTⁱ	P48962
STRINGⁱ	10090.ENSMUSP00000034049

PTM databases

iPTMnetⁱ	P48962
PhosphoSitePlusⁱ	P48962
SwissPalmⁱ	P48962

Proteomic databases

EPDⁱ	P48962
MaxQBⁱ	P48962
PaxDbⁱ	P48962
PeptideAtlasⁱ	P48962
PRIDEⁱ	P48962
TopDownProteomicsⁱ	P48962

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633
GeneIDⁱ	11739
KEGGⁱ	mmu:11739
UCSCⁱ	uc009lpz.2 mouse

Organism-specific databases

CTDⁱ	291
MGIⁱ	MGI:1353495 Slc25a4

Phylogenomic databases

eggNOGⁱ	KOG0749 Eukaryota ENOG410XNW0 LUCA
GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
HOVERGENⁱ	HBG108348
InParanoidⁱ	P48962
KOⁱ	K05863
OMAⁱ	ECFKRTA
OrthoDBⁱ	EOG091G0ULB
PhylomeDBⁱ	P48962
TreeFamⁱ	TF300743

Enzyme and pathway databases

Reactomeⁱ	R-MMU-422356 Regulation of insulin secretion

Reactomeⁱ

R-MMU-422356 Regulation of insulin secretion

Miscellaneous databases

ChiTaRSⁱ	Slc25a4 mouse
Protein Ontology More...PROⁱ	PR:P48962
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031633 Expressed in 290 organ(s), highest expression level in heart
Genevisibleⁱ	P48962 MM

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADT1_MOUSE
Accessionⁱ	P48962Primary (citable) accession number: P48962 Secondary accession number(s): Q62164
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P48962 (ADT1_MOUSE)

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ADP/ATP translocase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ