UniProtKB - P48962 (ADT1_MOUSE)
Protein
ADP/ATP translocase 1
Gene
Slc25a4
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 80 | ADPBy similarity | 1 | |
Binding sitei | 92 | ADPBy similarity | 1 | |
Binding sitei | 235 | ADPBy similarity | 1 |
GO - Molecular functioni
- ATP:ADP antiporter activity Source: InterPro
- enzyme binding Source: MGI
GO - Biological processi
- ADP transport Source: UniProtKB
- apoptotic mitochondrial changes Source: MGI
- mitochondrial ADP transmembrane transport Source: InterPro
- mitochondrial ATP transmembrane transport Source: InterPro
- negative regulation of cardiac muscle cell apoptotic process Source: MGI
- negative regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI
- negative regulation of necroptotic process Source: MGI
- positive regulation of cell growth involved in cardiac muscle cell development Source: MGI
- positive regulation of oxidative phosphorylation uncoupler activity Source: MGI
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-MMU-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: ADP/ATP translocase 1Alternative name(s): ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 Adenine nucleotide translocator 1 Short name: ANT 1 Solute carrier family 25 member 4 mANC1 |
Gene namesi | Name:Slc25a4 Synonyms:Anc1, Ant1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353495, Slc25a4 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Membrane By similarity
Note: The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (PubMed:11809823). May localize to non-mitochondrial membranes (By similarity).By similarity1 Publication
Mitochondrion
- integral component of mitochondrial membrane Source: UniProtKB
- mitochondrial inner membrane Source: MGI
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: MGI
Other locations
- membrane Source: MGI
- membrane raft Source: MGI
- myelin sheath Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 37 | Helical; Name=1By similarityAdd BLAST | 30 | |
Transmembranei | 75 – 99 | Helical; Name=2By similarityAdd BLAST | 25 | |
Transmembranei | 110 – 130 | Helical; Name=3By similarityAdd BLAST | 21 | |
Transmembranei | 179 – 199 | Helical; Name=4By similarityAdd BLAST | 21 | |
Transmembranei | 211 – 231 | Helical; Name=5By similarityAdd BLAST | 21 | |
Transmembranei | 274 – 291 | Helical; Name=6By similarityAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000090575 | 2 – 298 | ADP/ATP translocase 1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 147 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineBy similarity | 1 | |
Modified residuei | 150 | PhosphoserineBy similarity | 1 | |
Modified residuei | 160 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 245 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 272 | N6-succinyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, Phosphoprotein, S-nitrosylationProteomic databases
EPDi | P48962 |
jPOSTi | P48962 |
MaxQBi | P48962 |
PaxDbi | P48962 |
PeptideAtlasi | P48962 |
PRIDEi | P48962 |
TopDownProteomicsi | P48962 |
PTM databases
iPTMneti | P48962 |
PhosphoSitePlusi | P48962 |
SwissPalmi | P48962 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031633, Expressed in heart and 304 other tissues |
Genevisiblei | P48962, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198105, 45 interactors |
IntActi | P48962, 21 interactors |
MINTi | P48962 |
STRINGi | 10090.ENSMUSP00000034049 |
Miscellaneous databases
RNActi | P48962, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 98 | Solcar 1Add BLAST | 93 | |
Repeati | 111 – 201 | Solcar 2Add BLAST | 91 | |
Repeati | 212 – 297 | Solcar 3Add BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 240 | Important for transport activityBy similarity | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 235 – 240 | Nucleotide carrier signature motifBy similarity | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P48962 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
PhylomeDBi | P48962 |
TreeFami | TF300743 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48962-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGSS
160 170 180 190 200
QREFNGLGDC LTKIFKSDGL KGLYQGFSVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTLDCWRK IAKDEGANAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | F → L in AAC52837 (PubMed:8903724).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27315 mRNA Translation: AAC52837.1 X74510 mRNA Translation: CAA52616.1 AF240002 Genomic DNA Translation: AAF64470.1 BC003791 mRNA Translation: AAH03791.1 BC026925 mRNA Translation: AAH26925.1 |
CCDSi | CCDS40333.1 |
PIRi | S37210 |
RefSeqi | NP_031476.3, NM_007450.4 |
Genome annotation databases
Ensembli | ENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633 |
GeneIDi | 11739 |
KEGGi | mmu:11739 |
UCSCi | uc009lpz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U27315 mRNA Translation: AAC52837.1 X74510 mRNA Translation: CAA52616.1 AF240002 Genomic DNA Translation: AAF64470.1 BC003791 mRNA Translation: AAH03791.1 BC026925 mRNA Translation: AAH26925.1 |
CCDSi | CCDS40333.1 |
PIRi | S37210 |
RefSeqi | NP_031476.3, NM_007450.4 |
3D structure databases
SMRi | P48962 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198105, 45 interactors |
IntActi | P48962, 21 interactors |
MINTi | P48962 |
STRINGi | 10090.ENSMUSP00000034049 |
PTM databases
iPTMneti | P48962 |
PhosphoSitePlusi | P48962 |
SwissPalmi | P48962 |
Proteomic databases
EPDi | P48962 |
jPOSTi | P48962 |
MaxQBi | P48962 |
PaxDbi | P48962 |
PeptideAtlasi | P48962 |
PRIDEi | P48962 |
TopDownProteomicsi | P48962 |
Protocols and materials databases
Antibodypediai | 28911, 152 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034049; ENSMUSP00000034049; ENSMUSG00000031633 |
GeneIDi | 11739 |
KEGGi | mmu:11739 |
UCSCi | uc009lpz.2, mouse |
Organism-specific databases
CTDi | 291 |
MGIi | MGI:1353495, Slc25a4 |
Phylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P48962 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
PhylomeDBi | P48962 |
TreeFami | TF300743 |
Enzyme and pathway databases
Reactomei | R-MMU-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 11739, 1 hit in 17 CRISPR screens |
ChiTaRSi | Slc25a4, mouse |
PROi | PR:P48962 |
RNActi | P48962, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031633, Expressed in heart and 304 other tissues |
Genevisiblei | P48962, MM |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT1_MOUSE | |
Accessioni | P48962Primary (citable) accession number: P48962 Secondary accession number(s): Q62164 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families