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Protein

Aromatic-L-amino-acid decarboxylase

Gene

Ddc

Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei148Pyridoxal phosphate; via amide nitrogenBy similarity1
Binding sitei149Pyridoxal phosphateBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei246Pyridoxal phosphate; via carbonyl oxygenBy similarity1
Binding sitei300Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.28 3173

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:Ddc
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469481 – 508Aromatic-L-amino-acid decarboxylaseAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP48861

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP48861
SMRiP48861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

P48861-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPGDFKDFA KAMTDYITEY LENIRDRQVV PSVKPGYLRP LVPEQAPQQA
60 70 80 90 100
EPWTAVMADI ERVVMSGVTH WQSPRFHAYF PTANSYPSIV ADMLSGAIAC
110 120 130 140 150
IGFTWIASPA CTELEVVMLD WLGQMLGLPD QFLARSGGEG GGVIQGTASE
160 170 180 190 200
ATFVALLGAK SRMMHRVKEQ HPEWTETDIL GKLVGYCNQQ AHSSVERAGL
210 220 230 240 250
LGGVKLRSLK PDSKRRLRGD TLREAIDEDI RNGLIPFYVV ATLGTTSSCA
260 270 280 290 300
FDALDEIGDV CNASDIWLHV DAAYAGSAFI CPEYRHFMKG VEKADSFNFN
310 320 330 340 350
PHKWMLVNFD CSAMWLKQPR WIVDAFNVDP LYLKHEQQGS APDYRHWQIP
360 370 380 390 400
LGRRFRSLKL WFVLRLYGVE NLQKYIRKQI GFAHLFERLL TSDERFELFE
410 420 430 440 450
EVTMGLVCFR LKGSNEINEE LLRRINGRGK IHLVPSKVDD VYFLRLAICS
460 470 480 490 500
RFTEESDMHV SWEEIKDRLM MFLKSKGAVL IKIICSTTRR TKNILTYIKQ

NIFRDVGL
Length:508
Mass (Da):57,892
Last modified:February 1, 1996 - v1
Checksum:i87538994956A7C77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03909 mRNA Translation: AAC46604.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03909 mRNA Translation: AAC46604.1

3D structure databases

ProteinModelPortaliP48861
SMRiP48861
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP48861

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi4.1.1.28 3173

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDC_MANSE
AccessioniPrimary (citable) accession number: P48861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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