Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 182 (02 Jun 2021)
Sequence version 1 (01 Feb 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Nucleoporin NUP57

Gene

NUP57

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.

7 Publications

Miscellaneous

Present with 9310 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-159227, Transport of the SLBP independent Mature mRNA
R-SCE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-SCE-3371453, Regulation of HSF1-mediated heat shock response
R-SCE-4085377, SUMOylation of SUMOylation proteins
R-SCE-4551638, SUMOylation of chromatin organization proteins
R-SCE-4570464, SUMOylation of RNA binding proteins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.1, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin NUP57
Alternative name(s):
Nuclear pore protein NUP57
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP57
Ordered Locus Names:YGR119C
ORF Names:G6320
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003351, NUP57

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YGR119C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048771 – 541Nucleoporin NUP57Add BLAST541

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48837

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48837

PRoteomics IDEntifications database

More...
PRIDEi
P48837

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP57 is part of the NUP57 subcomplex (NIC96, NSP1, NUP49, NUP57) interacting with NUP49 and NSP1.

Interacts through its FG repeats with karyopherins.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33364, 501 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-824, Nuclear pore complex

Database of interacting proteins

More...
DIPi
DIP-866N

Protein interaction database and analysis system

More...
IntActi
P48837, 27 interactors

Molecular INTeraction database

More...
MINTi
P48837

STRING: functional protein association networks

More...
STRINGi
4932.YGR119C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P48837, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48837

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 3FG 12
Repeati11 – 12FG 22
Repeati21 – 24FXFG 14
Repeati39 – 42FXFG 24
Repeati56 – 57FG 32
Repeati65 – 66FG 42
Repeati76 – 79GLFG 14
Repeati103 – 106GLFG 24
Repeati120 – 123GLFG 34
Repeati132 – 135GLFG 44
Repeati147 – 150GLFG 54
Repeati175 – 178GLFG 64
Repeati190 – 193GLFG 74
Repeati204 – 207GLFG 84
Repeati220 – 223GLFG 94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 261DisorderedSequence analysisAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili398 – 425Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 77Polar residuesSequence analysisAdd BLAST77
Compositional biasi84 – 261Polar residuesSequence analysisAdd BLAST178

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin GLFG family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3091, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023804_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48837

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRRKHLV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR024864, Nup54/Nup57/Nup44
IPR025712, Nup54_alpha-helical_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13000, PTHR13000, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13634, Nucleoporin_FG, 2 hits
PF13874, Nup54, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P48837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGFSGSNNG FGNKPAGSTG FSFGQNNNNT NTQPSASGFG FGGSQPNSGT
60 70 80 90 100
ATTGGFGANQ ATNTFGSNQQ SSTGGGLFGN KPALGSLGSS STTASGTTAT
110 120 130 140 150
GTGLFGQQTA QPQQSTIGGG LFGNKPTTTT GGLFGNSAQN NSTTSGGLFG
160 170 180 190 200
NKVGSTGSLM GGNSTQNTSN MNAGGLFGAK PQNTTATTGG LFGSKPQGST
210 220 230 240 250
TNGGLFGSGT QNNNTLGGGG LFGQSQQPQT NTAPGLGNTV STQPSFAWSK
260 270 280 290 300
PSTGSNLQQQ QQQQIQVPLQ QTQAIAQQQQ LSNYPQQIQE QVLKCKESWD
310 320 330 340 350
PNTTKTKLRA FVYNKVNETE AILYTKPGHV LQEEWDQAME KKPSPQTIPI
360 370 380 390 400
QIYGFEGLNQ RNQVQTENVA QARIILNHIL EKSTQLQQKH ELDTASRILK
410 420 430 440 450
AQSRNVEIEK RILKLGTQLA TLKNRGLPLG IAEEKMWSQF QTLLQRSEDP
460 470 480 490 500
AGLGKTNELW ARLAILKERA KNISSQLDSK LMVFNDDTKN QDSMSKGTGE
510 520 530 540
ESNDRINKIV EILTNQQRGI TYLNEVLEKD AAIVKKYKNK T
Length:541
Mass (Da):57,499
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB292ADF7B1D7E83C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81155 Genomic DNA Translation: CAA57053.1
X83099 Genomic DNA Translation: CAA58153.1
AY723815 Genomic DNA Translation: AAU09732.1
Z72904 Genomic DNA Translation: CAA97129.1
Z72905 Genomic DNA Translation: CAA97131.1
BK006941 Genomic DNA Translation: DAA08211.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51799

NCBI Reference Sequences

More...
RefSeqi
NP_011634.1, NM_001181248.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGR119C_mRNA; YGR119C; YGR119C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853016

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGR119C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81155 Genomic DNA Translation: CAA57053.1
X83099 Genomic DNA Translation: CAA58153.1
AY723815 Genomic DNA Translation: AAU09732.1
Z72904 Genomic DNA Translation: CAA97129.1
Z72905 Genomic DNA Translation: CAA97131.1
BK006941 Genomic DNA Translation: DAA08211.1
PIRiS51799
RefSeqiNP_011634.1, NM_001181248.1

3D structure databases

SMRiP48837
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33364, 501 interactors
ComplexPortaliCPX-824, Nuclear pore complex
DIPiDIP-866N
IntActiP48837, 27 interactors
MINTiP48837
STRINGi4932.YGR119C

Protein family/group databases

TCDBi1.I.1.1.1, the nuclear pore complex (npc) family

PTM databases

iPTMnetiP48837

Proteomic databases

MaxQBiP48837
PaxDbiP48837
PRIDEiP48837

Genome annotation databases

EnsemblFungiiYGR119C_mRNA; YGR119C; YGR119C
GeneIDi853016
KEGGisce:YGR119C

Organism-specific databases

SGDiS000003351, NUP57
VEuPathDBiFungiDB:YGR119C

Phylogenomic databases

eggNOGiKOG3091, Eukaryota
HOGENOMiCLU_023804_1_0_1
InParanoidiP48837
OMAiCRRKHLV

Enzyme and pathway databases

ReactomeiR-SCE-159227, Transport of the SLBP independent Mature mRNA
R-SCE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-SCE-3371453, Regulation of HSF1-mediated heat shock response
R-SCE-4085377, SUMOylation of SUMOylation proteins
R-SCE-4551638, SUMOylation of chromatin organization proteins
R-SCE-4570464, SUMOylation of RNA binding proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P48837
RNActiP48837, protein

Family and domain databases

InterProiView protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR024864, Nup54/Nup57/Nup44
IPR025712, Nup54_alpha-helical_dom
PANTHERiPTHR13000, PTHR13000, 2 hits
PfamiView protein in Pfam
PF13634, Nucleoporin_FG, 2 hits
PF13874, Nup54, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP57_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48837
Secondary accession number(s): D6VUQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again