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Protein

V-type proton ATPase subunit G

Gene

VMA10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Miscellaneous

Present with 2280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

  • vacuolar acidification Source: SGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31242-MONOMER
ReactomeiR-SCE-1222556 ROS, RNS production in phagocytes
R-SCE-77387 Insulin receptor recycling
R-SCE-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G
Short name:
V-ATPase subunit G
Alternative name(s):
V-ATPase 13 kDa subunit
Vacuolar proton pump subunit G
Gene namesi
Name:VMA10
Ordered Locus Names:YHR039C-A
ORF Names:YHR039BC, YHR039C-B
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR039C-A
SGDiS000002100 VMA10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001929162 – 114V-type proton ATPase subunit GAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP48836
PaxDbiP48836
PRIDEiP48836
TopDownProteomicsiP48836

PTM databases

iPTMnetiP48836

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36471, 37 interactors
ComplexPortaliCPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant
CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
DIPiDIP-2720N
IntActiP48836, 18 interactors
MINTiP48836
STRINGi4932.YHR039C-A

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 60Combined sources57
Helixi70 – 73Combined sources4
Beta strandi74 – 76Combined sources3
Helixi77 – 89Combined sources13
Helixi91 – 102Combined sources12

3D structure databases

ProteinModelPortaliP48836
SMRiP48836
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48836

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

HOGENOMiHOG000186416
InParanoidiP48836
KOiK02152
OMAiEFRTKRV
OrthoDBiEOG092C42X0

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKNGIATL LQAEKEAHEI VSKARKYRQD KLKQAKTDAA KEIDSYKIQK
60 70 80 90 100
DKELKEFEQK NAGGVGELEK KAEAGVQGEL AEIKKIAEKK KDDVVKILIE
110
TVIKPSAEVH INAL
Length:114
Mass (Da):12,713
Last modified:February 1, 1996 - v1
Checksum:i259660D440A933D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21240 mRNA Translation: AAA74570.1
U00062 Genomic DNA Translation: AAB68921.1
BK006934 Genomic DNA Translation: DAA06731.1
PIRiS70777
RefSeqiNP_011905.1, NM_001180027.1

Genome annotation databases

EnsemblFungiiYHR039C-A; YHR039C-A; YHR039C-A
GeneIDi856435
KEGGisce:YHR039C-A

Similar proteinsi

Entry informationi

Entry nameiVATG_YEAST
AccessioniPrimary (citable) accession number: P48836
Secondary accession number(s): D3DKY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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