ACADVL

Functionⁱ

Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Catalytic activityⁱ

A very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactorⁱ

FAD

Pathwayⁱ: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	223	Substrate; via carbonyl oxygenBy similarity	1
Binding siteⁱ	366	FADBy similarity	1
Active siteⁱ	462	Proton acceptorBy similarity	1
Binding siteⁱ	463	Substrate; via amide nitrogenBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	214 – 223	FADBy similarity	10
Nucleotide bindingⁱ	249 – 251	FADBy similarity	3
Nucleotide bindingⁱ	435 – 439	FADBy similarity	5
Nucleotide bindingⁱ	464 – 466	FADBy similarity	3

GO - Molecular functionⁱ

flavin adenine dinucleotide binding Source: InterPro
long-chain-acyl-CoA dehydrogenase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epithelial cell differentiation Source: Ensembl
fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: Ensembl
negative regulation of fatty acid biosynthetic process Source: Ensembl
negative regulation of fatty acid oxidation Source: Ensembl
regulation of cholesterol metabolic process Source: Ensembl
response to cold Source: Ensembl
temperature homeostasis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

Reactomeⁱ	R-BTA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA
UniPathwayⁱ	UPA00660

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.9) Short name: VLCAD
Gene namesⁱ	Name:ACADVL Synonyms:VLCAD
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 19

Organism-specific databases

VGNCⁱ	VGNC:50246 ACADVL

VGNCⁱ

VGNC:50246 ACADVL

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 40	MitochondrionBy similarityAdd BLAST		40
ChainⁱPRO_0000000514	41 – 655	Very long-chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST		615

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	71	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	71	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	195	N6-succinyllysineBy similarity	1
Modified residueⁱ	237	S-nitrosocysteineBy similarity	1
Modified residueⁱ	239	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	239	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	276	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	276	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	278	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	278	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	298	N6-acetyllysineBy similarity	1
Modified residueⁱ	331	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	331	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	372	N6-succinyllysineBy similarity	1
Modified residueⁱ	482	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	482	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	517	PhosphoserineBy similarity	1
Modified residueⁱ	522	PhosphoserineBy similarity	1
Modified residueⁱ	550	N6-acetyllysineBy similarity	1
Modified residueⁱ	556	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	556	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	639	N6-succinyllysineBy similarity	1

Post-translational modificationⁱ

S-nitrosylation at Cys-237 in liver improves catalytic efficiency.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbⁱ	P48818
PeptideAtlas More...PeptideAtlasⁱ	P48818
PRIDEⁱ	P48818

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000003072

Bgeeⁱ

ENSBTAG00000003072

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

IntActⁱ	P48818, 35 interactors
STRINGⁱ	9913.ENSBTAP00000003999

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P48818
SMRⁱ	P48818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	41 – 482	CatalyticAdd BLAST	442
Regionⁱ	338 – 341	Substrate bindingBy similarity	4
Regionⁱ	462 – 463	Substrate bindingBy similarity	2
Regionⁱ	483 – 516	Membrane-anchoringCuratedAdd BLAST	34

Sequence similaritiesⁱ

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0137 Eukaryota COG1960 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119007
HOGENOMⁱ	HOG000131665
HOVERGENⁱ	HBG050448
InParanoidⁱ	P48818
KEGG Orthology (KO) More...KOⁱ	K09479
OMAⁱ	NAFMGLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04BS
TreeFamⁱ	TF105053

Family and domain databases

Gene3Dⁱ	1.10.540.10, 1 hit
InterProⁱ	View protein in InterPro IPR006089 Acyl-CoA_DH_CS IPR006091 Acyl-CoA_Oxase/DH_cen-dom IPR036250 AcylCo_DH-like_C IPR009075 AcylCo_DH/oxidase_C IPR013786 AcylCoA_DH/ox_N IPR037069 AcylCoA_DH/ox_N_sf IPR009100 AcylCoA_DH/oxidase_NM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00441 Acyl-CoA_dh_1, 1 hit PF02770 Acyl-CoA_dh_M, 1 hit PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMⁱ	SSF47203 SSF47203, 2 hits SSF56645 SSF56645, 1 hit
PROSITEⁱ	View protein in PROSITE PS00072 ACYL_COA_DH_1, 1 hit PS00073 ACYL_COA_DH_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P48818-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRAARMAQST GRQLLRLRGV SSWPGELLGQ PRPGPARRPY ASGVAQAAVD 
        60         70         80         90        100
QSDSQPSEAS TREKRANSVS KSFAVGTFKG QLTTDQVFPY PSVLNEDQTQ 
       110        120        130        140        150
FLKELVGPVT RFFEEVNDAA KNDMLERVEE TTMQGLKELG AFGLQVPNEL 
       160        170        180        190        200
GGVGLCNTQY ARLVEIVGMY DLGVGIVLGA HQSIGFKGIL LFGTKAQKEK 
       210        220        230        240        250
YLPKLASGET IAAFCLTEPS SGSDAASIRS SAVPSPCGKY YTLNGSKIWI 
       260        270        280        290        300
SNGGLADIFT VFAKTPVTDT ATGAVKEKIT AFVVERSFGG VTHGPPEKKM 
       310        320        330        340        350
GIKASNTAEV YFDGVRVPAE NVLGEVGGGF KVAMHILNNG RFGMAAALAG 
       360        370        380        390        400
TMKGIIAKAV DHAANRTQFG EKIHNFGLIQ EKLARMAMLQ YVTESMAYMV 
       410        420        430        440        450
SANMDQGSTD FQIEAAISKI FGSEAAWKVT DECIQIMGGM GFMKEPGVER 
       460        470        480        490        500
VLRDLRIFRI FEGTNDILRL FVALQGCMDK GKELSGLGNA LKNPFGNAGL 
       510        520        530        540        550
LLGEAGKQLR RRAGLGSGLS LSGIVHQELS RSGELAVQAL EQFATVVEAK 
       560        570        580        590        600
LIKHKKDIIN EQFLLQRLAD SAIDLYAMVV VLSRASRSLS EGHPTAQHEK 
       610        620        630        640        650
MLCDSWCIEA AARIRENMTA LQSDPQQQEL FRNFKSISKA LVERGGVVTS 

NPLGF

Length:655

Mass (Da):70,649

Last modified:November 13, 2007 - v3

Checksum:ⁱ677FCBD01AD3DA8B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	R → Q in AAA74051 (Ref. 1) Curated	1
Sequence conflictⁱ	7 – 8	AQ → TA in AAA74051 (Ref. 1) Curated	2
Sequence conflictⁱ	10	T → L in AAA74051 (Ref. 1) Curated	1
Sequence conflictⁱ	13	Q → T in AAA74051 (Ref. 1) Curated	1
Sequence conflictⁱ	37	R → P in AAA74051 (Ref. 1) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30817 mRNA Translation: AAA74051.1 BT030546 mRNA Translation: ABQ12986.1 BC103104 mRNA Translation: AAI03105.1
NCBI Reference Sequences More...RefSeqⁱ	NP_776919.1, NM_174494.2
UniGeneⁱ	Bt.48920

Genome annotation databases

Ensemblⁱ	ENSBTAT00000003999; ENSBTAP00000003999; ENSBTAG00000003072
GeneIDⁱ	282130
KEGGⁱ	bta:282130

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P48818	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	)	HUMAN		655
UPI0007A704BA		MINNA		736
Acyl-CoA dehydrogenase very long chain		MYOLU		701
Acyl-CoA dehydrogenase very long chain		CANLF		687
UPI0004BD7CCC		EQUPR		656
+116

Protein	Similar proteins		Species	Score	Length
P48818	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	)	HUMAN		655
UPI0007A704BA		MINNA		736
Acyl-CoA dehydrogenase very long chain		MYOLU		701
Acyl-CoA dehydrogenase very long chain		CANLF		687
UPI000334589E		CONCR		656
+196

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30817 mRNA Translation: AAA74051.1 BT030546 mRNA Translation: ABQ12986.1 BC103104 mRNA Translation: AAI03105.1
NCBI Reference Sequences More...RefSeqⁱ	NP_776919.1, NM_174494.2
UniGeneⁱ	Bt.48920

3D structure databases

ProteinModelPortalⁱ	P48818
SMRⁱ	P48818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P48818, 35 interactors
STRINGⁱ	9913.ENSBTAP00000003999

Proteomic databases

PaxDbⁱ	P48818
PeptideAtlas More...PeptideAtlasⁱ	P48818
PRIDEⁱ	P48818

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000003999; ENSBTAP00000003999; ENSBTAG00000003072
GeneIDⁱ	282130
KEGGⁱ	bta:282130

Organism-specific databases

CTDⁱ	37
VGNCⁱ	VGNC:50246 ACADVL

Phylogenomic databases

eggNOGⁱ	KOG0137 Eukaryota COG1960 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119007
HOGENOMⁱ	HOG000131665
HOVERGENⁱ	HBG050448
InParanoidⁱ	P48818
KEGG Orthology (KO) More...KOⁱ	K09479
OMAⁱ	NAFMGLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04BS
TreeFamⁱ	TF105053

Enzyme and pathway databases

UniPathwayⁱ	UPA00660
Reactomeⁱ	R-BTA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA

Gene expression databases

Bgeeⁱ	ENSBTAG00000003072

Bgeeⁱ

ENSBTAG00000003072

Family and domain databases

Gene3Dⁱ	1.10.540.10, 1 hit
InterProⁱ	View protein in InterPro IPR006089 Acyl-CoA_DH_CS IPR006091 Acyl-CoA_Oxase/DH_cen-dom IPR036250 AcylCo_DH-like_C IPR009075 AcylCo_DH/oxidase_C IPR013786 AcylCoA_DH/ox_N IPR037069 AcylCoA_DH/ox_N_sf IPR009100 AcylCoA_DH/oxidase_NM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00441 Acyl-CoA_dh_1, 1 hit PF02770 Acyl-CoA_dh_M, 1 hit PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMⁱ	SSF47203 SSF47203, 2 hits SSF56645 SSF56645, 1 hit
PROSITEⁱ	View protein in PROSITE PS00072 ACYL_COA_DH_1, 1 hit PS00073 ACYL_COA_DH_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACADV_BOVIN
Accessionⁱ	P48818Primary (citable) accession number: P48818 Secondary accession number(s): A5D9C7, Q3SZ66
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	November 13, 2007
	Last modified:	March 28, 2018
	This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

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Proteomes

Annotation systems

Supporting data

UniProtKB - P48818 (ACADV_BOVIN)

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Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: mitochondrial fatty acid beta-oxidation

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: mitochondrial fatty acid beta-oxidation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ