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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 33NADBy similarityAdd BLAST25

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Gene namesi
Name:ADH1
OrganismiCeratitis capitata (Mediterranean fruit fly) (Tephritis capitata)
Taxonomic identifieri7213 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544481 – 257Alcohol dehydrogenase 1Add BLAST257

Proteomic databases

PRIDEiP48814

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP48814
SMRiP48814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002426 ADH_Ceratitis-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01169 CERATITISADH
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P48814-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAGKNVVF VGGLGFIAYE ACKYLMNNDL ASLFVFDVLD KPEAIKALQE
60 70 80 90 100
INPKTKVYYT KFDITNKESI KQSLADVISK VQHIDALING AGILTDPNVE
110 120 130 140 150
LTMNINLIGL INTTLEALPL MDKNKHGRGG VIVNIASVLG LEPCPPAAVY
160 170 180 190 200
CASKFGVVGF SRSLGDPFYY EHTGVAVVTF CPGLTDTPLK NNIGSKYTFD
210 220 230 240 250
YSKEIGEKLN SSKTQKPEVC GAHLAQAIEL MDNGAIYISN QGTLTKVKPS

VYWEPTY
Length:257
Mass (Da):27,922
Last modified:February 1, 1996 - v1
Checksum:i043F39AC1E09CACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30194 Genomic DNA Translation: CAA82926.1
RefSeqiXP_004536079.1, XM_004536022.2

Genome annotation databases

GeneIDi101454300

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30194 Genomic DNA Translation: CAA82926.1
RefSeqiXP_004536079.1, XM_004536022.2

3D structure databases

ProteinModelPortaliP48814
SMRiP48814
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP48814

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101454300

Family and domain databases

InterProiView protein in InterPro
IPR002426 ADH_Ceratitis-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01169 CERATITISADH
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_CERCA
AccessioniPrimary (citable) accession number: P48814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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